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Article ; Online: Translating Natural Language Processing into Mainstream Schizophrenia Assessment.

Elvevåg, Brita / Cohen, Alex S

2022 Volume 48, Issue 5, Page(s) 936–938

MeSH term(s)	Humans ; Natural Language Processing ; Schizophrenia ; Schizophrenic Psychology ; Translating
Language	English
Publishing date	2022-09-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	439173-1
ISSN	1745-1701 ; 0586-7614
ISSN (online)	1745-1701
ISSN	0586-7614
DOI	10.1093/schbul/sbac087
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Article ; Online: Advancing ambulatory biobehavioral technologies beyond "proof of concept": Introduction to the special section.

Cohen, Alex S

Psychological assessment

2019 Volume 31, Issue 3, Page(s) 277–284

Abstract: Advancements in ambulatory biobehavioral technologies, for example, using portable psychophysiology, geolocation, facial, and speech analysis, have shown promise for a wide variety of applications. Their applications to biomedical sciences have led to ... ...

Abstract	Advancements in ambulatory biobehavioral technologies, for example, using portable psychophysiology, geolocation, facial, and speech analysis, have shown promise for a wide variety of applications. Their applications to biomedical sciences have led to dramatic improvements in some domains of assessment and practice. As yet, these technologies have not advanced beyond "proof of concept" for improving psychological assessment. More important, much of the current work in this space is being done outside of psychological science, and in many cases, outside of science altogether. This article introduces the special section on advancing biobehavioral technologies for psychological science. We provide a background on the potential role ambulatory biobehavioral technologies can play in improving feasibility, tolerability, reliability, and "individual-level" predictive accuracy for a broad range of psychological phenomena. We then provide a brief overview of the ambulatory biobehavioral literature, highlighting particular challenges and potential solutions for evaluating psychometrics of these measures. This special section is meant to stimulate interest and resources from the psychological assessment community to lend their unique talents and skills to advance this multidisciplinary endeavor. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
MeSH term(s)	Biomedical Technology/instrumentation ; Biomedical Technology/methods ; Humans ; Monitoring, Ambulatory/instrumentation ; Monitoring, Ambulatory/methods ; Proof of Concept Study ; Psychometrics/instrumentation ; Psychometrics/methods
Language	English
Publishing date	2019-02-23
Publishing country	United States
Document type	Introductory Journal Article
ZDB-ID	1000939-5
ISSN	1939-134X ; 1040-3590
ISSN (online)	1939-134X
ISSN	1040-3590
DOI	10.1037/pas0000694
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Article: Mutational scanning of

Shepherdson, James L / Granas, David M / Li, Jie / Shariff, Zara / Plassmeyer, Stephen P / Holehouse, Alex S / White, Michael A / Cohen, Barak A

bioRxiv : the preprint server for biology

2024

Abstract: Cone-Rod Homeobox, encoded ... ...

Abstract	Cone-Rod Homeobox, encoded by
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.21.585809
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Article ; Online: Computerized analysis of facial expression reveals objective indices of blunted facial affect.

Cowan, Tovah / Rodriguez, Zachary B / Strauss, Gregory P / Raugh, Ian M / Cohen, Alex S

European archives of psychiatry and clinical neuroscience

2023

Abstract: Blunted affect is associated with severe mental illness, particularly schizophrenia. Mechanisms of blunted affect are poorly understood, potentially due to a lack of phenomenological clarity. Here, we examine clinician rated blunted affect and ... ...

Abstract	Blunted affect is associated with severe mental illness, particularly schizophrenia. Mechanisms of blunted affect are poorly understood, potentially due to a lack of phenomenological clarity. Here, we examine clinician rated blunted affect and computerized facial metrics derived from ambulatory video assessment using machine learning. With high predictive accuracy (80-82%), we found that head orientation, eye movement, and facets of mouth movement were associated with clinical ratings of blunted affect. Features denoting larger muscle movements were associated with social cognition (R
Language	English
Publishing date	2023-10-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1045583-8
ISSN	1433-8491 ; 0175-758X ; 0940-1334
ISSN (online)	1433-8491
ISSN	0175-758X ; 0940-1334
DOI	10.1007/s00406-023-01696-6
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Article: The schizophrenia spectrum anhedonia paradox.

Strauss, Gregory P / Cohen, Alex S

World psychiatry : official journal of the World Psychiatric Association (WPA)

2018 Volume 17, Issue 2, Page(s) 221–222

Language	English
Publishing date	2018-05-31
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2236130-3
ISSN	2051-5545 ; 1723-8617
ISSN (online)	2051-5545
ISSN	1723-8617
DOI	10.1002/wps.20529
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Article ; Online: Risk of revision total knee arthroplasty for patients with prior bariatric surgery or class III obesity.

Kubsad, Sanjay / Bracey, Laurie / Agarwal, Amil R / Marrache, Majd / Gu, Alex / Cohen, Jordan S / Thakkar, Savyasachi C / Golladay, Gregory J

The Knee

2024 Volume 48, Page(s) 150–156

Abstract: Background: Bariatric surgery (BS) is indicated for select class III obesity patients undergoing total knee arthroplasty (TKA) to reduce obesity-related complications. This study assessed the effect of BS on TKA revision rates compared to the general ... ...

Abstract	Background: Bariatric surgery (BS) is indicated for select class III obesity patients undergoing total knee arthroplasty (TKA) to reduce obesity-related complications. This study assessed the effect of BS on TKA revision rates compared to the general population and class III obesity patients without a history of BS. Methods: A national database identified patients who had primary TKA. They were divided into two groups: those with BS prior to TKA and those without. Patients without BS formed two control groups, a matched general population, and a matched class III obese cohort. The BS group was matched with controls based on age, Charlson Comorbidity Index (CCI), gender, and diabetes mellitus. Revision rates were analyzed using Kaplan-Meier survival analysis and hazard ratios (HR), calculated using Cox proportional hazard modeling. Results: 14,292 BS patients were compared to 57,006 matched general population controls, and 19,504 BS patients were compared to 77,846 matched class III obesity control patients. BS patients had a higher risk of 5-year all-cause revision (HR: 1.13; P = 0.014) and revision due to periprosthetic fracture (HR: 1.39; P < 0.001) compared to the general population. Compared to class III obesity controls, BS patients had a lower risk of 5-year revision due to prosthetic joint infection (HR: 0.77; P = 0.001), with no difference in all-cause revision (P = 0.362). Conclusion: BS does not reduce all-cause TKA revision risk compared to the general or matched class III obesity population. However, it lowers the risk of revision due to prosthetic joint infection when compared to patients with class III obesity. Level of evidence: IV.
Language	English
Publishing date	2024-04-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1200476-5
ISSN	1873-5800 ; 0968-0160
ISSN (online)	1873-5800
ISSN	0968-0160
DOI	10.1016/j.knee.2024.03.010
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Article ; Online: A framework for language technologies in behavioral research and clinical applications: Ethical challenges, implications, and solutions.

Diaz-Asper, Catherine / Hauglid, Mathias K / Chandler, Chelsea / Cohen, Alex S / Foltz, Peter W / Elvevåg, Brita

The American psychologist

2024 Volume 79, Issue 1, Page(s) 79–91

Abstract: Technological advances in the assessment and understanding of speech and language within the domains of automatic speech recognition, natural language processing, and machine learning present a remarkable opportunity for psychologists to learn more about ...

Abstract	Technological advances in the assessment and understanding of speech and language within the domains of automatic speech recognition, natural language processing, and machine learning present a remarkable opportunity for psychologists to learn more about human thought and communication, evaluate a variety of clinical conditions, and predict cognitive and psychological states. These innovations can be leveraged to automate traditionally time-intensive assessment tasks (e.g., educational assessment), provide psychological information and care (e.g., chatbots), and when delivered remotely (e.g., by mobile phone or wearable sensors) promise underserved communities greater access to health care. Indeed, the automatic analysis of speech provides a wealth of information that can be used for patient care in a wide range of settings (e.g., mHealth applications) and for diverse purposes (e.g., behavioral and clinical research, medical tools that are implemented into practice) and patient types (e.g., numerous psychological disorders and in psychiatry and neurology). However, automation of speech analysis is a complex task that requires the integration of several different technologies within a large distributed process with numerous stakeholders. Many organizations have raised awareness about the need for robust systems for ensuring transparency, oversight, and regulation of technologies utilizing artificial intelligence. Since there is limited knowledge about the ethical and legal implications of these applications in psychological science, we provide a balanced view of both the optimism that is widely published on and also the challenges and risks of use, including discrimination and exacerbation of structural inequalities. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
MeSH term(s)	Humans ; Behavioral Research ; Artificial Intelligence ; Language ; Technology ; Communication
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	209464-2
ISSN	1935-990X ; 0003-066X
ISSN (online)	1935-990X
ISSN	0003-066X
DOI	10.1037/amp0001195
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Article ; Online: Negative schizotypy attenuates the effect of momentary stress on social dysfunction related to COVID-19 social distancing.

Masucci, Michael D / Martin, Victoria / Le, Thanh P / Cohen, Alex S

Schizophrenia research

2022 Volume 243, Page(s) 24–31

Abstract: Schizotypy is associated with a broad range of motivational and social dysfunctions. However, there is reason to suspect that negative schizotypy may limit social dysfunction in specific contexts that typically increase isolation and loneliness. We ... ...

Abstract	Schizotypy is associated with a broad range of motivational and social dysfunctions. However, there is reason to suspect that negative schizotypy may limit social dysfunction in specific contexts that typically increase isolation and loneliness. We analyzed whether positive, negative and disorganized facets of schizotypy would mitigate detrimental reactions to stress in the context of a global stressor (the COVID-19 pandemic) that has widely necessitated social and physical isolation. Responses to two measures of schizotypy were compared to ecological momentary assessments of social dysfunction for 85 undergraduates using multilevel modelling techniques. Negative schizotypy moderated the relation between momentary stress and loss of social support, such that negative schizotypy limited the magnitude of social dysfunction stemming from increases in momentary stress. This pattern was not seen for other facets of schizotypy. Implications for the treatment and measurement of schizotypy symptoms are discussed.
MeSH term(s)	COVID-19 ; Humans ; Loneliness ; Pandemics ; Physical Distancing ; Schizotypal Personality Disorder
Language	English
Publishing date	2022-02-26
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	639422-x
ISSN	1573-2509 ; 0920-9964
ISSN (online)	1573-2509
ISSN	0920-9964
DOI	10.1016/j.schres.2022.02.028
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Article: Pediatric Gender Diversity Beyond the Binary: An Exploration of Gender-Affirming Care for Nonbinary and Genderqueer Youth Seen Over Time at a Single Institution Gender Center.

Mellin, Cassidy S / Braun, Mitchell / Walch, Abby / Cohen, Jessie Rose / Kaufman, Misha / Seligman, Molly / Percelay, Rachel / Tang, Alex F / Lee, Janet Y

Transgender health

2024 Volume 9, Issue 2, Page(s) 107–117

Abstract: Purpose: The nonbinary and genderqueer (NBGQ) youth population is growing, yet scant research focuses on this distinct group. We aim to gain a deeper understanding of desired gender-affirming care and interventions pursued by NBGQ youth.: Methods: A ... ...

Abstract	Purpose: The nonbinary and genderqueer (NBGQ) youth population is growing, yet scant research focuses on this distinct group. We aim to gain a deeper understanding of desired gender-affirming care and interventions pursued by NBGQ youth. Methods: A retrospective chart review of NBGQ patients seen at the University of California, San Francisco Child and Adolescent Gender Center from January 1, 2009, to December 31, 2020, was performed. Demographic information, desired gender-affirming care, and gender-affirming interventions pursued at initial and most recent visits were collected. Results: Initial visit charts of 116 NBGQ youth who attended more than one clinic visit were reviewed. In total, 48 unique genders were documented; gender evolved over time for some youth, as did desired gender-affirming care. At the most recent visit, 15 youth (12.9%) had a binary gender, and 101 youth (87.1%) had an NBGQ gender. At the initial visit, 56 youth (48.3%) were interested in gender-affirming hormone therapy, compared with 75 youth (65.6%) at the most recent visit. In addition, 21 (18.1%) and 49 (42.2%) youth were interested in surgery at the initial and most recent visits, respectively. In general, interest in interventions was higher than pursuit of interventions. Conclusion: There is vast diversity of gender and differences in desired gender-affirming care within the NBGQ youth population. Desires for gender-affirming care within the cohort changed over time, and not all those who expressed a desire for an intervention received it. The reasons are likely multifactorial, highlighting the need for expectation-free and patient-specific affirming care and research on the NBGQ youth population, while also considering barriers to care.
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ISSN	2688-4887
ISSN	2688-4887
DOI	10.1089/trgh.2021.0199
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Article ; Online: Attentional biases in facial emotion processing in individuals at clinical high risk for psychosis.

Williams, Trevor F / Cohen, Alex S / Sanchez-Lopez, Alvaro / Joormann, Jutta / Mittal, Vijay A

European archives of psychiatry and clinical neuroscience

2023 Volume 273, Issue 8, Page(s) 1825–1835

Abstract: Individuals at clinical high risk (CHR) for psychosis exhibit altered facial emotion processing (FEP) and poor social functioning. It is unclear whether FEP deficits result from attentional biases, and further, how these abnormalities are linked to ... ...

Abstract	Individuals at clinical high risk (CHR) for psychosis exhibit altered facial emotion processing (FEP) and poor social functioning. It is unclear whether FEP deficits result from attentional biases, and further, how these abnormalities are linked to symptomatology (e.g., negative symptoms) and highly comorbid disorders that are also tied to abnormal FEP (e.g., depression). In the present study, we employed an eye-tracking paradigm to assess attentional biases and clinical interviews to examine differences between CHR (N = 34) individuals and healthy controls (HC; N = 46), as well as how such biases relate to symptoms and functioning in CHR individuals. Although no CHR-HC differences emerged in attentional biases, within the CHR group, symptoms and functioning were related to biases. Depressive symptoms were related to some free-view attention switching biases (e.g., to and from fearful faces, r = .50). Negative symptoms were related to more slowly disengaging from happy faces (r = .44), spending less time looking at neutral faces (r = - .42), and more time looking at no face (Avolition, r = .44). In addition, global social functioning was related to processes that overlapped with both depression and negative symptoms, including time looking at no face (r = - .68) and free-view attention switching with fearful faces (r = - .40). These findings are consistent with previous research, indicating that negative symptoms play a prominent role in the CHR syndrome, with distinct mechanisms relative to depression. Furthermore, the results suggest that attentional bias indices from eye-tracking paradigms may be predictive of social functioning.
MeSH term(s)	Humans ; Attentional Bias ; Emotions ; Attention ; Fear ; Psychotic Disorders/complications ; Facial Expression
Language	English
Publishing date	2023-03-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1045583-8
ISSN	1433-8491 ; 0175-758X ; 0940-1334
ISSN (online)	1433-8491
ISSN	0175-758X ; 0940-1334
DOI	10.1007/s00406-023-01582-1
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