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Article ; Online: The influence of physiological and lifestyle factors on essential mineral element isotopic compositions in the human body: implications for the design of isotope metallomics research.

Sullivan, Kaj V / Moore, Rebekah E T / Vanhaecke, Frank

Metallomics : integrated biometal science

2023 Volume 15, Issue 3

Abstract: In the last 20 years, the application of high-precision isotopic analysis of essential mineral elements (Mg, K, Ca, Fe, Cu, and Zn) to biomedicine (sometimes referred to as isotope metallomics) has revealed that their stable isotopic compositions are ... ...

Abstract	In the last 20 years, the application of high-precision isotopic analysis of essential mineral elements (Mg, K, Ca, Fe, Cu, and Zn) to biomedicine (sometimes referred to as isotope metallomics) has revealed that their stable isotopic compositions are altered by the metal dysregulation that is fundamental to the pathogenesis of many cancers and other diseases. Despite many published works showing the diagnostic and prognostic potential of this approach, a number of factors that may influence the stable isotopic composition of these essential mineral elements in healthy individuals remain unstudied. In this perspective article, we summarize the available evidence from trophic level studies, animal models, and ancient and modern humans, relating to physiological and lifestyle factors that appear likely (there is evidence indicating their influence) or unlikely (there is evidence indicating their lack of influence) to require controlling for when investigating variations in essential mineral element isotopic compositions in human subjects. We also discuss factors that require additional data to properly assess. There is evidence that sex, menopausal status, age, diet, vitamin and metal supplementation, genetic variation, and obesity influence the isotopic composition of at least one essential mineral element in the human body. The task of investigating potential influences on essential mineral element isotopic compositions in the human body is sizeable, but presents an exciting research opportunity, with each incremental advance helping to improve the quality of research output in the context of isotope metallomics.
MeSH term(s)	Animals ; Humans ; Human Body ; Isotopes ; Metals ; Minerals ; Life Style
Chemical Substances	Isotopes ; Metals ; Minerals
Language	English
Publishing date	2023-03-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2474317-3
ISSN	1756-591X ; 1756-5901
ISSN (online)	1756-591X
ISSN	1756-5901
DOI	10.1093/mtomcs/mfad012
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Article ; Online: Trajectories of brain development reveal times of risk and factors promoting resilience to alcohol use during adolescence.

Lannoy, S / Sullivan, E V

International review of neurobiology

2021 Volume 160, Page(s) 85–116

Abstract: Alcohol use disorder (AUD) is recognized as harmful for the developing brain. Numerous studies have sought environmental and genetic risk factors that predict the development of AUD, but recently identified resilience factors have emerged as protective. ... ...

Abstract	Alcohol use disorder (AUD) is recognized as harmful for the developing brain. Numerous studies have sought environmental and genetic risk factors that predict the development of AUD, but recently identified resilience factors have emerged as protective. This chapter reviews normal processes of brain development in adolescence and emerging adulthood, delineates disturbed growth neurotrajectories related to heavy drinking, and identifies potential endogenous, experiential, and time-linked brain markers of resilience. For example, concurrent high dorsolateral prefrontal activation serving inhibitory control and low nucleus accumbens activation serving reward functions engender positive adaptation and low alcohol use. Also discussed is the role that moderating factors have in promoting risk for or resilience to AUD. Longitudinal research on the effects of all levels of alcohol drinking on the developing brain remains crucial and should be pursued in the context of resilience, which is a promising direction for identifying protective biomarkers against developing AUDs.
MeSH term(s)	Adolescent ; Alcohol Drinking/adverse effects ; Alcohol Drinking/prevention & control ; Brain/drug effects ; Brain/growth & development ; Humans ; Protective Factors ; Risk Factors ; Time Factors
Language	English
Publishing date	2021-10-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	209876-3
ISSN	2162-5514 ; 0074-7742
ISSN (online)	2162-5514
ISSN	0074-7742
DOI	10.1016/bs.irn.2021.08.002
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Article ; Online: Molecularly imprinted polymer hydrogel sheets with metalloporphyrin-incorporated molecular recognition sites for protein capture.

Sullivan, Mark V / Nanalal, Sakshi / Dean, Bethanie E / Turner, Nicholas W

Talanta

2023 Volume 266, Issue Pt 2, Page(s) 125083

Abstract: Metalloporphyrins are often found in nature as coordination recognition sites within biological process, and synthetically offer the potential for use in therapeutic, catalytic and diagnostic applications. While porphyrin containing biological ... ...

Abstract	Metalloporphyrins are often found in nature as coordination recognition sites within biological process, and synthetically offer the potential for use in therapeutic, catalytic and diagnostic applications. While porphyrin containing biological recognition elements have stability limitations, molecularly imprinted polymers bearing these structures offer an alternative with excellent robustness and the ability to work in extreme conditions. In this work, we synthesised a polymerizable porphyrin and metalloporphyrin and have incorporated these as co-monomers within a hydrogel thin-sheet MIP for the specific recognition of bovine haemoglobin (BHb). The hydrogels were evaluated using Scatchard analysis, with K
MeSH term(s)	Metalloporphyrins ; Molecularly Imprinted Polymers ; Hydrogels ; Porphyrins ; Iron
Chemical Substances	Metalloporphyrins ; Molecularly Imprinted Polymers ; Hydrogels ; Porphyrins ; Iron (E1UOL152H7)
Language	English
Publishing date	2023-08-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2023.125083
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Article ; Online: Epigenetic Control of Cell Potency and Fate Determination during Mammalian Gastrulation

Sullivan, Adrienne E.

Genes (Basel). 2023 May 25, v. 14, no. 6

2023

Abstract: Pluripotent embryonic stem cells have a unique and characteristic epigenetic profile, which is critical for differentiation to all embryonic germ lineages. When stem cells exit the pluripotent state and commit to lineage-specific identities during the ... ...

Abstract	Pluripotent embryonic stem cells have a unique and characteristic epigenetic profile, which is critical for differentiation to all embryonic germ lineages. When stem cells exit the pluripotent state and commit to lineage-specific identities during the process of gastrulation in early embryogenesis, extensive epigenetic remodelling mediates both the switch in cellular programme and the loss of potential to adopt alternative lineage programmes. However, it remains to be understood how the stem cell epigenetic profile encodes pluripotency, or how dynamic epigenetic regulation helps to direct cell fate specification. Recent advances in stem cell culture techniques, cellular reprogramming, and single-cell technologies that can quantitatively profile epigenetic marks have led to significant insights into these questions, which are important for understanding both embryonic development and cell fate engineering. This review provides an overview of key concepts and highlights exciting new advances in the field.
Keywords	cell culture ; epigenetics ; gastrulation ; mammals ; stem cells
Language	English
Dates of publication	2023-0525
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14061143
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Nutrient Intakes and Gastrointestinal Symptoms Among Esophagogastric Cancer Survivors up to 5 Years Post-Surgery.

Bennett, A E / O'Neill, L / Doyle, S L / Guinan, E M / O'Sullivan, J / Reynolds, J V / Hussey, J

Nutrition and cancer

2024 Volume 76, Issue 5, Page(s) 442–451

Abstract: A cross-sectional analysis explored nutritional intakes and gastrointestinal (GI) symptoms among esophagogastric cancer survivors up to 12, 13-36, and 37+ months post-surgery. Participants were identified from the Upper GI Cancer Registry at St James' ... ...

Abstract	A cross-sectional analysis explored nutritional intakes and gastrointestinal (GI) symptoms among esophagogastric cancer survivors up to 12, 13-36, and 37+ months post-surgery. Participants were identified from the Upper GI Cancer Registry at St James' Hospital, Ireland. The Short Nutritional Assessment Questionnaire, European Prospective Investigation of Cancer Food Frequency Questionnaire, World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Score, and Gastrointestinal Symptoms Rating Scale assessed malnutrition risk, nutritional intake, adherence to (secondary) cancer prevention recommendations, and GI symptoms, respectively. Most (82.5%,
MeSH term(s)	Humans ; Male ; United States ; Middle Aged ; Aged ; Female ; Cancer Survivors ; Quality of Life ; Prospective Studies ; Cross-Sectional Studies ; Esophageal Neoplasms/surgery ; Stomach Neoplasms/surgery ; Eating ; Malnutrition/etiology ; Diet ; Risk Factors
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	424433-3
ISSN	1532-7914 ; 0163-5581
ISSN (online)	1532-7914
ISSN	0163-5581
DOI	10.1080/01635581.2024.2328380
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Article ; Online: Exercise care by general practitioners: Providing sustainable solutions for patients living with chronic disease.

Keating, Shelley E / Brown, Riley C C / Sullivan, Victoria / Ball, Lauren

Australian journal of general practice

2024 Volume 53, Issue 3, Page(s) 99–107

Abstract: Background: Most Australian adults are insufficiently physically active, creating an economic and moral imperative to support exercise care in general practice.: Objective: To provide an overview of exercise care in general practice to support ... ...

Abstract	Background: Most Australian adults are insufficiently physically active, creating an economic and moral imperative to support exercise care in general practice. Objective: To provide an overview of exercise care in general practice to support sustained solutions for patients living with chronic disease. Discussion: Exercise care should be considered a fundamental component of high-quality consultations, including assessing, advocating and monitoring for physical activity. Exercise levels and cardiorespiratory fitness can be considered 'vital signs' for tracking over time. Modest gains in physical activity levels have clinical benefits, warranting approaches that engage patients in any amount of time in exercise. Resources are available to support general practitioners (GPs) to incorporate exercise care into routine consultations. GPs can print or save the links provided in this paper and use platforms such as GoShare to connect patients to the resources. Over 15 exercise-specific clinical practice guides are available through The Royal Australian College of General Practitioners' Handbook of non-drug interventions.
MeSH term(s)	Adult ; Humans ; Australia ; Chronic Disease ; Exercise ; General Practice ; General Practitioners
Language	English
Publishing date	2024-03-04
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2924889-9
ISSN	2208-7958 ; 2208-794X
ISSN (online)	2208-7958
ISSN	2208-794X
DOI	10.31128/AJGP-05-23-6846
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Article ; Online: Prioritizing patient values for chronic pain care: a path out of the pain reduction regime?

Sullivan, Mark D / Vowles, Kevin E / Powelson, Elisabeth B / Patel, Kushang V / Reid, M Carrington

Family practice

2023 Volume 40, Issue 5-6, Page(s) 611–614

MeSH term(s)	Humans ; Chronic Pain/therapy ; Pain Management ; Long-Term Care ; Patients
Language	English
Publishing date	2023-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	605939-9
ISSN	1460-2229 ; 0263-2136
ISSN (online)	1460-2229
ISSN	0263-2136
DOI	10.1093/fampra/cmad002
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Article: The impact of physician leadership development on behaviour and work-related changes.

Sakelaris, Vania / Sullivan, Erin E / Harris, Devin

Healthcare management forum

2023 Volume 36, Issue 6, Page(s) 373–377

Abstract: In this article, we present findings from a retrospective survey of 117 physician leadership development program graduates at the Sauder School of Business at the University of British Columbia in Vancouver. The survey was designed to assess how the ... ...

Abstract	In this article, we present findings from a retrospective survey of 117 physician leadership development program graduates at the Sauder School of Business at the University of British Columbia in Vancouver. The survey was designed to assess how the program contributed to graduates' leadership development, specifically in terms of behaviour change and work-related changes. The themes resulting from the analysis of the open-ended questions reflected that the program led to changes in graduates' leadership behaviour and their ability to lead change in their respective organizations. The study highlighted the benefits of investment in training for physician leaders to advance transformation and improvement initiatives in a changing world.
MeSH term(s)	Humans ; Retrospective Studies ; Leadership ; Physicians ; Surveys and Questionnaires
Language	English
Publishing date	2023-06-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2140831-2
ISSN	2352-3883 ; 0840-4704
ISSN (online)	2352-3883
ISSN	0840-4704
DOI	10.1177/08404704231185550
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Article ; Online: Employee attitudes toward suicide prevention and Counseling on Access to Lethal Means: initial findings from an academic medical center implementing the Zero Suicide framework.

Jasperson, Rachael A / Sullivan, Emily / Goldstein, Evan V

Frontiers in public health

2023 Volume 11, Page(s) 1268300

Abstract: Introduction: Zero Suicide is a strategic framework designed to transform a healthcare system's suicide prevention activities. In 2020, University of Utah Health launched a Zero Suicide program and Counseling on Access to Lethal Means (CALM) training ... ...

Abstract	Introduction: Zero Suicide is a strategic framework designed to transform a healthcare system's suicide prevention activities. In 2020, University of Utah Health launched a Zero Suicide program and Counseling on Access to Lethal Means (CALM) training for its employees. In 2022, the healthcare system surveyed its workforce's attitudes toward suicide prevention and CALM. We sought to evaluate employees' attitudes and behaviors toward suicide prevention and CALM training following the launch of the Zero Suicide program. Methods: A Zero Suicide Workforce Survey was administered online through REDCap to all University of Utah Health employees. The analytic sample included 3,345 respondents. We used two-portion z-tests to compare the proportions of respondents who (1) completed CALM training and (2) did not yet complete the CALM training because they felt it was irrelevant to their position by different employee characteristics. Results: More than half of the respondents in the analytic sample were directly interacting with patients who may be at risk for suicide (57.6%). About 8.4% of the respondents had completed CALM training. Among those who had not yet completed CALM training, 9.5% indicated they did not think CALM was relevant to their job. Respondents knowledgeable about warning signs for suicide and respondents who were confident in their ability to respond when suspecting elevated suicide risk were significantly more likely to complete CALM training. Discussion: This evaluation provides important insights from the workforce of a large academic medical center implementing a Zero Suicide program, including insights on opportunities for improving program implementation and evaluation.
MeSH term(s)	Humans ; Suicide Prevention ; Suicide/psychology ; Counseling ; Attitude of Health Personnel ; Health Personnel/education
Language	English
Publishing date	2023-11-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1268300
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Article ; Online: Species and individual rhinoceros affect the bacterial communities, metabolites, and nutrient composition in faeces from Southern black rhinoceros (Diceros bicornis minor) and Southern white rhinoceros (Ceratotherium simum simum) under managed care.

Cersosimo, Laura M / Sullivan, Kathleen E / Valdes, Eduardo V

Journal of animal physiology and animal nutrition

2021 Volume 106, Issue 1, Page(s) 181–193

Abstract: Gut microbiota are essential to nutrient metabolism and the maintenance of hindgut health. The characterization of faecal bacterial communities from healthy individuals is important for the establishment of baseline data that can be compared to periods ... ...

Abstract	Gut microbiota are essential to nutrient metabolism and the maintenance of hindgut health. The characterization of faecal bacterial communities from healthy individuals is important for the establishment of baseline data that can be compared to periods of gut dysbiosis. Diet is a key determinant of the faecal microbial community structure and generation of volatile fatty acids, a main energy source for the host. While rhinoceroses are herbivores, black rhinoceroses are browsers and white rhinoceroses are grazers. The objective of our study was to characterize and compare diets, faecal bacterial communities, nutrients and metabolites between and amongst Southern white rhinoceroses and Southern black rhinoceroses (n = 3 rhinos/species) managed at Disney's Animal Kingdom
MeSH term(s)	Animals ; Feces ; Managed Care Programs ; Nutrients ; Perissodactyla ; Species Specificity
Language	English
Publishing date	2021-03-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	232729-6
ISSN	1439-0396 ; 0044-3565 ; 0931-2439
ISSN (online)	1439-0396
ISSN	0044-3565 ; 0931-2439
DOI	10.1111/jpn.13520
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