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Article ; Online: Neurosonology during the COVID-19 pandemic (Editorial commentary from the chairs of the ultrasound panel of the European Academy of Neurology).

Školoudík, D / Mijajlović, M

2020 Volume 27, Issue 9, Page(s) 1774–1775

MeSH term(s)	COVID-19 ; Consensus ; Hemodynamics ; Humans ; Neurology ; Pandemics ; SARS-CoV-2 ; Stroke ; Ultrasonography, Doppler, Transcranial
Keywords	covid19
Language	English
Publishing date	2020-07-20
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.14410
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Article ; Online: D-dimers increase in acute ischemic stroke patients with the large artery occlusion, but do not depend on the time of artery recanalization.

Skoloudík, David / Bar, Michal / Sanák, Daniel / Bardon, Petr / Roubec, Martin / Langová, Katerina / Herzig, Roman / Kanovský, Petr

Journal of thrombosis and thrombolysis

2009 Volume 29, Issue 4, Page(s) 477–482

Abstract: D-dimers are one of the basic laboratory markers of fibrinolytic system activity. The aim ... of this prospective study was to detect changes in D-dimer levels in acute stroke patients as a function of the time ... blood tests (including D-dimers and fibrinogen) were performed on all patients on admission. The control ...

Abstract	D-dimers are one of the basic laboratory markers of fibrinolytic system activity. The aim of this prospective study was to detect changes in D-dimer levels in acute stroke patients as a function of the time of artery recanalization and the therapy used. During a 12-month period, 80 acute ischemic stroke patients admitted to the hospital within a 6-h time window were consecutively enrolled in the study. The clinical neurologic examination, brain computed tomography, neurosonologic examination, and biochemical and hematological blood tests (including D-dimers and fibrinogen) were performed on all patients on admission. The control examinations of D-dimer and fibrinogen blood levels were performed 3 (optional), 6, and 24 h after stroke onset. The Mann-Whitney test, Kruskal-Wallis test, ANOVA test, multiple comparison test, and Pearson test were used for statistical evaluation. Application of intravenous thrombolysis significantly increased the D-dimer levels and decreased the fibrinogen level 6 h after stroke onset in comparison with patients treated with antiplatelets or anticoagulants (P < 0.01), with normalization of blood levels over a 24 h period. The use of sonothrombotripsy showed a tendency to increase the D-dimer levels (P = 0.09) with a significant decrease of the fibrinogen level 6 h after stroke onset (P < 0.05). A significant increase in the D-dimer levels was detected in patients with strokes of cardioembolic and atherothrombotic etiologies, and patients with occlusion of cervical or large intracranial arteries (P < 0.05). There was no correlation between the changes in D-dimer or fibrinogen levels and age, gender, time to artery recanalization, risk factors, and the seriousness of neurologic deficits on admission (P > 0.05). D-dimer levels significantly increased during the first 6 h after stroke onset in patients with large artery occlusion and patients treated using intravenous thrombolysis. However, this increase was independent on the time of artery recanalization thus cannot be used as its marker.
MeSH term(s)	Acute Disease ; Adult ; Aged ; Aged, 80 and over ; Biomarkers/analysis ; Biomarkers/blood ; Brain Ischemia/blood ; Brain Ischemia/surgery ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Humans ; Intracranial Arterial Diseases/blood ; Intracranial Arterial Diseases/surgery ; Male ; Middle Aged ; Predictive Value of Tests ; Stroke/blood ; Stroke/surgery ; Time Factors
Chemical Substances	Biomarkers ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D
Language	English
Publishing date	2009-07-01
Publishing country	Netherlands
Document type	Clinical Trial ; Comparative Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-009-0372-9
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Article: Neurosonology during the COVID-19 pandemic (Editorial commentary from the chairs of the ultrasound panel of the European Academy of Neurology)

Skoloudík, D / Mijajlovic, M

Eur. j. neurol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #607810
Database	COVID19

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Article ; Online: Neurosonology during the COVID‐19 pandemic (Editorial commentary from the chairs of the ultrasound panel of the European Academy of Neurology)

Školoudík, D. / Mijajlović, M.

European Journal of Neurology

2020 Volume 27, Issue 9, Page(s) 1774–1775

Keywords	Neurology ; Clinical Neurology ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.14410
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Article ; Online: Emergent microsurgical intervention for acute stroke after mechanical thrombectomy failure: a prospective study.

Fiedler, Jiří / Roubec, Martin / Grubhoffer, Marek / Ostrý, Svatopluk / Procházka, Václav / Langová, Kateřina / Školoudík, David

Journal of neurointerventional surgery

2022 Volume 15, Issue 5, Page(s) 439–445

Abstract: Background: Despite all the gains that have been achieved with endovascular mechanical thrombectomy revascularization and intravenous thrombolysis logistics since 2015, there is still a subgroup of patients with salvageable brain tissue for whom ... ...

Abstract	Background: Despite all the gains that have been achieved with endovascular mechanical thrombectomy revascularization and intravenous thrombolysis logistics since 2015, there is still a subgroup of patients with salvageable brain tissue for whom persistent emergent large vessel occlusion portends a catastrophic outcome. Objective: To test the safety and efficacy of emergent microsurgical intervention in patients with acute ischemic stroke and symptomatic middle cerebral artery occlusion after failure of mechanical thrombectomy. Methods: A prospective two-center cohort study was conducted. Patients with acute ischemic stroke and middle cerebral artery occlusion for whom recanalization failed at center 1 were randomly allocated to the microsurgical intervention group (MSIG) or control group 1 (CG1). All similar patients at center 2 were included in the control group 2 (CG2) with no surgical intervention. Microsurgical embolectomy and/or extracranial-intracranial bypass was performed in all MSIG patients at center 1. Results: A total of 47 patients were enrolled in the study: 22 at center 1 (12 allocated to the MSIG and 10 to the CG1) and 25 patients at center 2 (CG2). MSIG group patients showed a better clinical outcome on day 90 after the stroke, where a modified Rankin Scale score of 0-2 was reached in 7 (58.3%) of 12 patients compared with 1/10 (10.0%) patients in the CG1 and 3/12 (12.0%) in the CG2. Conclusions: This study demonstrated the potential for existing microsurgical techniques to provide good outcomes in 58% of microsurgically treated patients as a third-tier option.
MeSH term(s)	Humans ; Prospective Studies ; Infarction, Middle Cerebral Artery ; Cohort Studies ; Ischemic Stroke ; Carotid Artery, Internal/surgery ; Thrombectomy/adverse effects ; Thrombectomy/methods ; Treatment Outcome ; Stroke/diagnostic imaging ; Stroke/surgery ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/surgery ; Retrospective Studies ; Endovascular Procedures/methods
Language	English
Publishing date	2022-04-15
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/neurintsurg-2022-018643
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Article ; Online: Comparison of carotid endarterectomy and repeated carotid angioplasty and stenting for in-stent restenosis (CERCAS trial): a randomised study.

Hrbáč, Tomáš / Fiedler, Jiří / Procházka, Václav / Jonszta, Tomáš / Roubec, Martin / Pakizer, David / Václavík, Daniel / Netuka, David / Heryán, Tomáš / Školoudík, David

Stroke and vascular neurology

2023 Volume 8, Issue 5, Page(s) 399–404

Abstract: Background and aim: In-stent restenosis (ISR) belongs to an infrequent but potentially serious complication after carotid angioplasty and stenting in patients with severe carotid stenosis. Some of these patients might be contraindicated to repeat ... ...

Abstract	Background and aim: In-stent restenosis (ISR) belongs to an infrequent but potentially serious complication after carotid angioplasty and stenting in patients with severe carotid stenosis. Some of these patients might be contraindicated to repeat percutaneous transluminal angioplasty with or without stenting (rePTA/S). The purpose of the study is to compare the safety and effectiveness of carotid endarterectomy with stent removal (CEASR) and rePTA/S in patients with carotid ISR. Methods: Consecutive patients with carotid ISR (≥80%) were randomly allocated to the CEASR or rePTA/S group. The incidence of restenosis after intervention, stroke, transient ischaemic attack myocardial infarction and death 30 days and 1 year after intervention and restenosis 1 year after intervention between patients in CEASR and rePTA/S groups were statistically evaluated. Results: A total of 31 patients were included in the study; 14 patients (9 males; mean age 66.3±6.6 years) were allocated to CEASR and 17 patients (10 males; mean age 68.8±5.6 years) to the rePTA/S group. The implanted stent in carotid restenosis was successfully removed in all patients in the CEASR group. No clinical vascular event was recorded periproceduraly, 30 days and 1 year after intervention in both groups. Only one patient in the CEASR group had asymptomatic occlusion of the intervened carotid artery within 30 days and one patient died in the rePTA/S group within 1 year after intervention. Restenosis after intervention was significantly greater in the rePTA/S group (mean 20.9%) than in the CEASR group (mean 0%, p=0.04), but all stenoses were <50%. Incidence of 1-year restenosis that was ≥70% did not differ between the rePTA/S and CEASR groups (4 vs 1 patient; p=0.233). Conclusion: CEASR seems to be effective and save procedures for patients with carotid ISR and might be considered as a treatment option. Trial registration number: NCT05390983.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Endarterectomy, Carotid/adverse effects ; Constriction, Pathologic ; Coronary Restenosis ; Risk Factors ; Treatment Outcome ; Carotid Arteries ; Angioplasty ; Stents
Language	English
Publishing date	2023-03-27
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2059-8696
ISSN (online)	2059-8696
DOI	10.1136/svn-2022-002075
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Article: Changes in Cognitive Functions after Carotid Endarterectomy and Carotid Stenting: A Decade-Apart Comparison.

Václavík, Daniel / Pakizer, David / Hrbáč, Tomáš / Roubec, Martin / Procházka, Václav / Jonszta, Tomáš / Herzig, Roman / Školoudík, David

Biomedicines

2023 Volume 12, Issue 1

Abstract: Background: This study investigates changes in cognitive function in patients with severe carotid stenosis who underwent carotid endarterectomy (CEA) and carotid stenting (CAS) over two decades.: Methods: We compared cognitive function within 30 days ...

Abstract	Background: This study investigates changes in cognitive function in patients with severe carotid stenosis who underwent carotid endarterectomy (CEA) and carotid stenting (CAS) over two decades. Methods: We compared cognitive function within 30 days after the procedure in 267 patients (first 100 each for CEA and CAS in two periods: 2008-2012 and 2018-2022) in a single institution. Assessments used Adenbrooke's Cognitive Examination-Revised (ACE-R), the Mini-Mental State Examination (MMSE), Speech Fluency Test (SFT), and Clock Drawing Test (CDT), conducted before and 30 ± 2 days after surgery. Results: Patients (mean age 67.2 years, 70%+ carotid stenosis) exhibited different cognitive changes over periods. In 2008-2012, significant declines in MMSE (CEA, Conclusion: Over a decade, advances in interventional techniques and patient management have reduced risks of cognitive decline in patients with asymptomatic carotid stenosis and also have improved cognitive functions in both symptomatic and asymptomatic individuals.
Language	English
Publishing date	2023-12-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12010013
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Article: The relationship between atherosclerosis and dementia.

Central European journal of public health

2024 Volume 32, Issue 1, Page(s) 9–15

Abstract: Objective: The main objective is to confirm a hypothesis that atherosclerosis, through various mechanisms, considerably influences cognitive impairment and significantly increases the risk for developing dementia. Complete sample should be 920 ... ...

Abstract	Objective: The main objective is to confirm a hypothesis that atherosclerosis, through various mechanisms, considerably influences cognitive impairment and significantly increases the risk for developing dementia. Complete sample should be 920 individuals. The present study aimed to analyse epidemiological data from a questionnaire survey. Methods: The work was carried out in the form of an epidemiological case control study. Subjects are enrolled in the study based on results of the following examinations carried out in neurology departments and outpatient centres during the project NU20-09-00119 from 2020 to 2023. Respondents were divided into four research groups according to the results of clinical examination for the presence of atherosclerosis and dementia. The survey was mainly concerned with risk factors for both atherosclerosis and dementia. It contained questions on lifestyle factors, cardiovascular risk factors, leisure activities, and hobbies. Results: Analysis of the as yet incomplete sample of 877 subjects has yielded the following selected results: on average, 16% of subjects without dementia had primary education while the proportion was 45.2% in the group with both dementia and atherosclerosis. Subjects with dementia did mainly physical work. Low physical activity was more frequently noted in dementia groups (Group 2 - 54.4% and Group 3 - 47.2%) than in subjects without dementia (Group 1 - 19.6% and Group 4 - 25.8%). Coronary heart disease was more frequently reported by dementia patients (33.95%) than those without dementia (16.05%). Conclusion: Cognitively impaired individuals, in particular those with vascular cognitive impairment, have poorer quality of life and shorter survival. Risk factors contributing to such impairment are similar to those for ischaemic or haemorrhagic stroke. It may be concluded that most of the analysed risk factors play a role in the development of both atherosclerosis and dementia.
MeSH term(s)	Humans ; Female ; Dementia/epidemiology ; Male ; Atherosclerosis/epidemiology ; Aged ; Risk Factors ; Case-Control Studies ; Middle Aged ; Surveys and Questionnaires ; Aged, 80 and over ; Life Style
Language	English
Publishing date	2024-04-26
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	1176053-9
ISSN	1803-1048 ; 1210-7778 ; 0022-1732
ISSN (online)	1803-1048
ISSN	1210-7778 ; 0022-1732
DOI	10.21101/cejph.a7848
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Article ; Online: Risk of MRI-detected cerebral infarction and vascular events after carotid endarterectomy and carotid stenting one decade apart.

Hrbáč, Tomáš / Roubec, Martin / Procházka, Václav / Jonszta, Tomáš / Pakizer, David / Heryán, Tomáš / Herzig, Roman / Školoudík, David

The British journal of surgery

2023 Volume 110, Issue 8, Page(s) 987–988

MeSH term(s)	Humans ; Endarterectomy, Carotid/adverse effects ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/surgery ; Cerebral Infarction/diagnostic imaging ; Cerebral Infarction/etiology ; Magnetic Resonance Imaging ; Stents ; Stroke ; Treatment Outcome ; Risk Factors
Language	English
Publishing date	2023-04-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znad116
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Article: Peak systolic velocity ratio for evaluation of internal carotid artery stenosis correlated with plaque morphology: substudy results of the ANTIQUE study.

Pakizer, David / Vybíralová, Anna / Jonszta, Tomáš / Roubec, Martin / Král, Michal / Chovanec, Vendelín / Herzig, Roman / Heryán, Tomáš / Školoudík, David

Frontiers in neurology

2023 Volume 14, Page(s) 1206483

Abstract: Background: Accurate assessment of carotid stenosis severity is important for proper patient management. The present study aimed to compare the evaluation of carotid stenosis severity using four duplex sonography (DUS) measurements, including peak ... ...

Abstract	Background: Accurate assessment of carotid stenosis severity is important for proper patient management. The present study aimed to compare the evaluation of carotid stenosis severity using four duplex sonography (DUS) measurements, including peak systolic velocity (PSV), PSV ratio in stenosis and distal to stenosis (PSV Methods: Consecutive patients with carotid stenosis of ≥40% examined using DUS and CTA were included. Plaque morphology was also determined using magnetic resonance imaging. Spearman's correlation and Kendall's rank correlation were used to evaluate the results. Results: A total of 143 cases of internal carotid artery stenosis of ≥40% based on DUS were analyzed. The PSV Conclusion: PSV, PSV
Language	English
Publishing date	2023-11-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1206483
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