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Article ; Online: Editorial overview: Neurobiology of disease (2018).

Bagni, Claudia / Kreitzer, Anatol C

2018 Volume 48, Page(s) iv–vi

MeSH term(s)	Brain Diseases/physiopathology ; Humans ; Mental Disorders/physiopathology ; Neurobiology
Language	English
Publishing date	2018-01-30
Publishing country	England
Document type	Editorial
ZDB-ID	1078046-4
ISSN	1873-6882 ; 0959-4388
ISSN (online)	1873-6882
ISSN	0959-4388
DOI	10.1016/j.conb.2018.01.005
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Zs.A 3260: Show issues

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Article ; Online: Sequencing Diversity One Cell at a Time.

Oldham, Michael C / Kreitzer, Anatol C

Cell

2018 Volume 174, Issue 4, Page(s) 777–779

Abstract: Single-cell RNA sequencing provides a new approach to an old problem: how to study cellular diversity in complex biological systems. Three studies-Saunders et al., Zeisel et al., and Davie et al.-deploy this technique on an unprecedented scale to reveal ... ...

Abstract	Single-cell RNA sequencing provides a new approach to an old problem: how to study cellular diversity in complex biological systems. Three studies-Saunders et al., Zeisel et al., and Davie et al.-deploy this technique on an unprecedented scale to reveal transcriptional patterns that distinguish cells in the nervous systems of mice and flies.
MeSH term(s)	Animals ; Base Sequence ; Brain ; Drosophila ; Mice ; Sequence Analysis, RNA ; Transcriptome
Language	English
Publishing date	2018-08-10
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2018.07.024
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 58: Show issues

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Article ; Online: An open-source control system for in vivo fluorescence measurements from deep-brain structures.

Owen, Scott F / Kreitzer, Anatol C

Journal of neuroscience methods

2018 Volume 311, Page(s) 170–177

Abstract: Background: Intracranial photometry through chronically implanted optical fibers is a widely adopted technique for measuring signals from fluorescent probes in deep-brain structures. The recent proliferation of bright, photo-stable, and specific ... ...

Abstract	Background: Intracranial photometry through chronically implanted optical fibers is a widely adopted technique for measuring signals from fluorescent probes in deep-brain structures. The recent proliferation of bright, photo-stable, and specific genetically encoded fluorescent reporters for calcium and for other neuromodulators has greatly increased the utility and popularity of this technique. New method: Here we describe an open-source, cost-effective, microcontroller-based solution for controlling optical components in an intracranial photometry system and processing the resulting signal. Results: We show proof-of-principle that this system supports high quality intracranial photometry recordings from dorsal striatum in freely moving mice. A single system supports simultaneous fluorescence measurements in two independent color channels, but multiple systems can be integrated together if additional fluorescence channels are required. This system is designed to work in combination with either commercially available or custom-built optical components. Parts can be purchased for less than one tenth the cost of commercially available alternatives and complete assembly takes less than one day for an inexperienced user. Comparison with existing method(s): Currently available hardware draws on a variety of commercial, custom-built, or hybrid elements for both optical and electronic components. Many of these hardware systems are either specialized and inflexible, or over-engineered and expensive. Conclusions: This open-source system increases experimental flexibility while reducing cost relative to current commercially available components. All software and firmware are open-source and customizable, affording a degree of experimental flexibility that is not available in current commercial systems.
MeSH term(s)	Animals ; Calcium Signaling ; Corpus Striatum/diagnostic imaging ; Corpus Striatum/metabolism ; Equipment Design ; Fluorometry/instrumentation ; Fluorometry/methods ; Mice ; Optical Fibers ; Optical Imaging/instrumentation ; Optical Imaging/methods ; Software
Language	English
Publishing date	2018-10-17
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	282721-9
ISSN	1872-678X ; 0165-0270
ISSN (online)	1872-678X
ISSN	0165-0270
DOI	10.1016/j.jneumeth.2018.10.022
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Zs.A 1486: Show issues

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Article ; Online: Striatal Indirect Pathway Dysfunction Underlies Motor Deficits in a Mouse Model of Paroxysmal Dyskinesia.

Nelson, Alexandra B / Girasole, Allison E / Lee, Hsien-Yang / Ptáček, Louis J / Kreitzer, Anatol C

The Journal of neuroscience : the official journal of the Society for Neuroscience

2022 Volume 42, Issue 13, Page(s) 2835–2848

Abstract: Abnormal involuntary movements, or dyskinesias, are seen in many neurologic diseases, including disorders where the brain appears grossly normal. This observation suggests that alterations in neural activity or connectivity may underlie dyskinesias. One ... ...

Abstract	Abnormal involuntary movements, or dyskinesias, are seen in many neurologic diseases, including disorders where the brain appears grossly normal. This observation suggests that alterations in neural activity or connectivity may underlie dyskinesias. One influential model proposes that involuntary movements are driven by an imbalance in the activity of striatal direct and indirect pathway neurons (dMSNs and iMSNs, respectively). Indeed, in some animal models, there is evidence that dMSN hyperactivity contributes to dyskinesia. Given the many diseases associated with dyskinesia, it is unclear whether these findings generalize to all forms. Here, we used male and female mice in a mouse model of paroxysmal nonkinesigenic dyskinesia (PNKD) to assess whether involuntary movements are related to aberrant activity in the striatal direct and indirect pathways. In this model, as in the human disorder PNKD, animals experience dyskinetic attacks in response to caffeine or alcohol. Using optically identified striatal single-unit recordings in freely moving PNKD mice, we found a loss of iMSN firing during dyskinesia bouts. Further, chemogenetic inhibition of iMSNs triggered dyskinetic episodes in PNKD mice. Finally, we found that these decreases in iMSN firing are likely because of aberrant endocannabinoid-mediated suppression of glutamatergic inputs. These data show that striatal iMSN dysfunction contributes to the etiology of dyskinesia in PNKD, and suggest that indirect pathway hypoactivity may be a key mechanism for the generation of involuntary movements in other disorders.
MeSH term(s)	Animals ; Chorea/chemically induced ; Corpus Striatum ; Disease Models, Animal ; Dyskinesias/etiology ; Female ; Levodopa/adverse effects ; Male ; Mice ; Neurons
Chemical Substances	Levodopa (46627O600J)
Language	English
Publishing date	2022-02-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.1614-20.2022
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Zs.A 1668: Show issues

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Article ; Online: Frontostriatal Projections Regulate Innate Avoidance Behavior.

Loewke, Adrienne C / Minerva, Adelaide R / Nelson, Alexandra B / Kreitzer, Anatol C / Gunaydin, Lisa A

The Journal of neuroscience : the official journal of the Society for Neuroscience

2021 Volume 41, Issue 25, Page(s) 5487–5501

Abstract: The dorsomedial prefrontal cortex (dmPFC) has been linked to avoidance and decision-making under conflict, key neural computations altered in anxiety disorders. However, the heterogeneity of prefrontal projections has obscured identification of specific ... ...

Abstract	The dorsomedial prefrontal cortex (dmPFC) has been linked to avoidance and decision-making under conflict, key neural computations altered in anxiety disorders. However, the heterogeneity of prefrontal projections has obscured identification of specific top-down projections involved. While the dmPFC-amygdala circuit has long been implicated in controlling reflexive fear responses, recent work suggests that dmPFC-dorsomedial striatum (DMS) projections may be more important for regulating avoidance. Using fiber photometry recordings in both male and female mice during the elevated zero maze task, we show heightened neural activity in frontostriatal but not frontoamygdalar projection neurons during exploration of the anxiogenic open arms. Additionally, using optogenetics, we demonstrate that this frontostriatal projection preferentially excites postsynaptic D
MeSH term(s)	Animals ; Avoidance Learning/physiology ; Behavior, Animal/physiology ; Corpus Striatum/physiology ; Female ; Instinct ; Male ; Mice ; Mice, Inbred C57BL ; Neural Pathways/physiology ; Prefrontal Cortex/physiology
Language	English
Publishing date	2021-05-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.2581-20.2021
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Zs.A 1668: Show issues

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Article ; Online: Thermal constraints on in vivo optogenetic manipulations.

Owen, Scott F / Liu, Max H / Kreitzer, Anatol C

Nature neuroscience

2019 Volume 22, Issue 7, Page(s) 1061–1065

Abstract: ... illumination protocols increased the temperature by 0.2-2 °C and suppressed spiking in multiple brain regions ...

Abstract	A key assumption of optogenetics is that light only affects opsin-expressing neurons. However, illumination invariably heats tissue, and many physiological processes are temperature-sensitive. Commonly used illumination protocols increased the temperature by 0.2-2 °C and suppressed spiking in multiple brain regions. In the striatum, light delivery activated an inwardly rectifying potassium conductance and biased rotational behavior. Thus, careful consideration of light-delivery parameters is required, as even modest intracranial heating can confound interpretation of optogenetic experiments.
MeSH term(s)	Action Potentials/drug effects ; Action Potentials/radiation effects ; Animals ; Barium Compounds/pharmacology ; Cerebral Cortex/cytology ; Cerebral Cortex/physiology ; Chlorides/pharmacology ; Corpus Striatum/cytology ; Corpus Striatum/physiology ; Hippocampus/cytology ; Hippocampus/physiology ; Hot Temperature ; Ion Transport/drug effects ; Ion Transport/radiation effects ; Light ; Mice ; Motor Activity/radiation effects ; Neurons/drug effects ; Neurons/physiology ; Neurons/radiation effects ; Optogenetics/methods ; Patch-Clamp Techniques ; Potassium/metabolism ; Potassium Channels, Inwardly Rectifying/drug effects ; Potassium Channels, Inwardly Rectifying/metabolism ; Potassium Channels, Inwardly Rectifying/radiation effects ; Research Design ; Temperature
Chemical Substances	Barium Compounds ; Chlorides ; Potassium Channels, Inwardly Rectifying ; barium chloride (0VK51DA1T2) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2019-06-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1420596-8
ISSN	1546-1726 ; 1097-6256
ISSN (online)	1546-1726
ISSN	1097-6256
DOI	10.1038/s41593-019-0422-3
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Zs.A 4891: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 67: Show issues

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Article ; Online: Cortico-Basal Ganglia Circuit Function in Psychiatric Disease.

Gunaydin, Lisa A / Kreitzer, Anatol C

Annual review of physiology

2016 Volume 78, Page(s) 327–350

Abstract: Circuit dysfunction models of psychiatric disease posit that pathological behavior results from abnormal patterns of electrical activity in specific cells and circuits in the brain. Many psychiatric disorders are associated with abnormal activity in the ... ...

Abstract	Circuit dysfunction models of psychiatric disease posit that pathological behavior results from abnormal patterns of electrical activity in specific cells and circuits in the brain. Many psychiatric disorders are associated with abnormal activity in the prefrontal cortex and in the basal ganglia, a set of subcortical nuclei implicated in cognitive and motor control. Here we discuss the role of the basal ganglia and connected prefrontal regions in the etiology and treatment of obsessive-compulsive disorder, anxiety, and depression, emphasizing mechanistic work in rodent behavioral models to dissect causal cortico-basal ganglia circuits underlying discrete behavioral symptom domains relevant to these complex disorders.
MeSH term(s)	Animals ; Basal Ganglia/physiopathology ; Humans ; Mental Disorders/physiopathology ; Neural Pathways/physiopathology ; Prefrontal Cortex/physiopathology
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	207933-1
ISSN	1545-1585 ; 0066-4278
ISSN (online)	1545-1585
ISSN	0066-4278
DOI	10.1146/annurev-physiol-021115-105355
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Uc I Zs.226: Show issues

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Article ; Online: A Direct Path to Action Initiation.

Donahue, Christopher H / Kreitzer, Anatol C

Neuron

2015 Volume 88, Issue 2, Page(s) 240–241

Abstract: In this issue of Neuron, Sippy et al. (2015) provide the clearest evidence to date that information is differentially encoded in the direct and indirect pathways of the striatum. The results support the classical notion that the direct pathway plays a ... ...

Abstract	In this issue of Neuron, Sippy et al. (2015) provide the clearest evidence to date that information is differentially encoded in the direct and indirect pathways of the striatum. The results support the classical notion that the direct pathway plays a critical role in initiating actions.
MeSH term(s)	Animals ; Corpus Striatum/cytology ; Corpus Striatum/physiology ; Goals ; Neurons/physiology ; Psychomotor Performance/physiology ; Reward
Language	English
Publishing date	2015-10-21
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2015.10.013
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Zs.A 2496: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 92: Show issues

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Article ; Online: Fast-Spiking Interneurons Supply Feedforward Control of Bursting, Calcium, and Plasticity for Efficient Learning.

Owen, Scott F / Berke, Joshua D / Kreitzer, Anatol C

Cell

2018 Volume 172, Issue 4, Page(s) 683–695.e15

Abstract: Fast-spiking interneurons (FSIs) are a prominent class of forebrain GABAergic cells implicated in two seemingly independent network functions: gain control and network plasticity. Little is known, however, about how these roles interact. Here, we use a ... ...

Abstract	Fast-spiking interneurons (FSIs) are a prominent class of forebrain GABAergic cells implicated in two seemingly independent network functions: gain control and network plasticity. Little is known, however, about how these roles interact. Here, we use a combination of cell-type-specific ablation, optogenetics, electrophysiology, imaging, and behavior to describe a unified mechanism by which striatal FSIs control burst firing, calcium influx, and synaptic plasticity in neighboring medium spiny projection neurons (MSNs). In vivo silencing of FSIs increased bursting, calcium transients, and AMPA/NMDA ratios in MSNs. In a motor sequence task, FSI silencing increased the frequency of calcium transients but reduced the specificity with which transients aligned to individual task events. Consistent with this, ablation of FSIs disrupted the acquisition of striatum-dependent egocentric learning strategies. Together, our data support a model in which feedforward inhibition from FSIs temporally restricts MSN bursting and calcium-dependent synaptic plasticity to facilitate striatum-dependent sequence learning.
MeSH term(s)	Animals ; Calcium Signaling/physiology ; Interneurons/cytology ; Interneurons/metabolism ; Learning/physiology ; Mice ; Mice, Transgenic ; N-Methylaspartate/metabolism ; Nerve Net/cytology ; Nerve Net/metabolism ; Neuronal Plasticity/physiology ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/metabolism
Chemical Substances	N-Methylaspartate (6384-92-5) ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (77521-29-0)
Language	English
Publishing date	2018-02-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2018.01.005
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 58: Show issues

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Article ; Online: Dopamine subsystems that track internal states.

Grove, James C R / Gray, Lindsay A / La Santa Medina, Naymalis / Sivakumar, Nilla / Ahn, Jamie S / Corpuz, Timothy V / Berke, Joshua D / Kreitzer, Anatol C / Knight, Zachary A

Nature

2022 Volume 608, Issue 7922, Page(s) 374–380

Abstract: Food and water are rewarding in part because they satisfy our internal ... ...

Abstract	Food and water are rewarding in part because they satisfy our internal needs
MeSH term(s)	Animals ; Cues ; Digestion ; Dopamine/metabolism ; Dopaminergic Neurons/physiology ; Eating ; Gastrointestinal Tract/metabolism ; Hypothalamus/cytology ; Hypothalamus/physiology ; Mesencephalon/cytology ; Mesencephalon/physiology ; Mice ; Neural Pathways ; Nutrients/metabolism ; Organism Hydration Status/drug effects ; Reward ; Time Factors ; Ventral Tegmental Area/cytology ; Ventral Tegmental Area/physiology ; Water/metabolism ; Water/pharmacology ; Water-Electrolyte Balance
Chemical Substances	Water (059QF0KO0R) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2022-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-04954-0
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

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