Article: Senolytic therapy is neuroprotective and improves functional outcome long-term after traumatic brain injury in mice.
2023 Volume 17, Page(s) 1227705
Abstract: Introduction: Chronic neuroinflammation can exist for months to years following traumatic brain injury (TBI), although the underlying mechanisms remain poorly understood.: Methods: In the current study, we used a controlled cortical impact mouse ... ...
| Abstract | Introduction: Chronic neuroinflammation can exist for months to years following traumatic brain injury (TBI), although the underlying mechanisms remain poorly understood. Methods: In the current study, we used a controlled cortical impact mouse model of TBI to examine whether proinflammatory senescent cells are present in the brain long-term (months) after TBI and whether ablation of these cells via administration of senolytic drugs can improve long-term functional outcome after TBI. The results revealed that astrocytes and microglia in the cerebral cortex, hippocampus, corpus callosum and lateral posterior thalamus colocalized the senescent cell markers, p16 Discussion: Taken as a whole, these findings indicate there is robust and widespread induction of senescent cells in the brain long-term after TBI, and that senolytic drug treatment begun 1-month after TBI can efficiently ablate the senescent cells, reduce expression of proinflammatory SASP factors, reduce neurodegeneration, and rescue defects in reference memory, recognition memory, and depressive behavior. |
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| Language | English |
| Publishing date | 2023-07-27 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2411902-7 |
| ISSN | 1662-453X ; 1662-4548 |
| ISSN (online) | 1662-453X |
| ISSN | 1662-4548 |
| DOI | 10.3389/fnins.2023.1227705 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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