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Article: The price of seizure control: dynorphins in interictal and postictal psychosis.

Bortolato, Marco / Solbrig, Marylou V

2007 Volume 151, Issue 1-2, Page(s) 139–143

Abstract: Postictal and interictal psychoses are relatively common complicating factors in the clinical course of epilepsy, yet their neurobiological substrates are poorly understood. Recent evidence shows that kappa opioid receptor (KOR) activation elicits ... ...

Abstract	Postictal and interictal psychoses are relatively common complicating factors in the clinical course of epilepsy, yet their neurobiological substrates are poorly understood. Recent evidence shows that kappa opioid receptor (KOR) activation elicits anticonvulsant and psychotomimetic effects. In view of this background, here we introduce the hypothesis that epilepsy-related psychoses may partially result from excessive hippocampal dynorphin release and kappa opioid receptor overstimulation aimed at seizure control.
MeSH term(s)	Animals ; Anticonvulsants/metabolism ; Dynorphins/metabolism ; Epilepsy, Temporal Lobe/complications ; Epilepsy, Temporal Lobe/physiopathology ; Hippocampus/physiopathology ; Humans ; Kindling, Neurologic/physiology ; Psychotic Disorders/physiopathology ; Receptors, Opioid, kappa/physiology
Chemical Substances	Anticonvulsants ; Receptors, Opioid, kappa ; Dynorphins (74913-18-1)
Language	English
Publishing date	2007-05-30
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0165-1781 ; 0925-4927
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0165-1781 ; 0925-4927
DOI	10.1016/j.psychres.2006.11.004
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Article ; Online: Biolink Model: A universal schema for knowledge graphs in clinical, biomedical, and translational science.

Unni, Deepak R / Moxon, Sierra A T / Bada, Michael / Brush, Matthew / Bruskiewich, Richard / Caufield, J Harry / Clemons, Paul A / Dancik, Vlado / Dumontier, Michel / Fecho, Karamarie / Glusman, Gustavo / Hadlock, Jennifer J / Harris, Nomi L / Joshi, Arpita / Putman, Tim / Qin, Guangrong / Ramsey, Stephen A / Shefchek, Kent A / Solbrig, Harold /

Soman, Karthik / Thessen, Anne E / Haendel, Melissa A / Bizon, Chris / Mungall, Christopher J

Clinical and translational science

2022 Volume 15, Issue 8, Page(s) 1848–1855

Abstract: Within clinical, biomedical, and translational science, an increasing number of projects are adopting graphs for knowledge representation. Graph-based data models elucidate the interconnectedness among core biomedical concepts, enable data structures to ... ...

Abstract	Within clinical, biomedical, and translational science, an increasing number of projects are adopting graphs for knowledge representation. Graph-based data models elucidate the interconnectedness among core biomedical concepts, enable data structures to be easily updated, and support intuitive queries, visualizations, and inference algorithms. However, knowledge discovery across these "knowledge graphs" (KGs) has remained difficult. Data set heterogeneity and complexity; the proliferation of ad hoc data formats; poor compliance with guidelines on findability, accessibility, interoperability, and reusability; and, in particular, the lack of a universally accepted, open-access model for standardization across biomedical KGs has left the task of reconciling data sources to downstream consumers. Biolink Model is an open-source data model that can be used to formalize the relationships between data structures in translational science. It incorporates object-oriented classification and graph-oriented features. The core of the model is a set of hierarchical, interconnected classes (or categories) and relationships between them (or predicates) representing biomedical entities such as gene, disease, chemical, anatomic structure, and phenotype. The model provides class and edge attributes and associations that guide how entities should relate to one another. Here, we highlight the need for a standardized data model for KGs, describe Biolink Model, and compare it with other models. We demonstrate the utility of Biolink Model in various initiatives, including the Biomedical Data Translator Consortium and the Monarch Initiative, and show how it has supported easier integration and interoperability of biomedical KGs, bringing together knowledge from multiple sources and helping to realize the goals of translational science.
MeSH term(s)	Knowledge ; Pattern Recognition, Automated ; Translational Science, Biomedical
Language	English
Publishing date	2022-06-06
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2433157-0
ISSN	1752-8062 ; 1752-8054
ISSN (online)	1752-8062
ISSN	1752-8054
DOI	10.1111/cts.13302
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Article: Headache syndromes in Sierra Leone, West Africa.

Solbrig, M V

Headache

1991 Volume 31, Issue 6, Page(s) 419

MeSH term(s)	Headache/physiopathology ; Humans ; Sierra Leone ; Syndrome
Language	English
Publishing date	1991-06
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	410130-3
ISSN	1526-4610 ; 0017-8748
ISSN (online)	1526-4610
ISSN	0017-8748
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Book ; Online: Biolink Model

Unni, Deepak R. / Moxon, Sierra A. T. / Bada, Michael / Brush, Matthew / Bruskiewich, Richard / Clemons, Paul / Dancik, Vlado / Dumontier, Michel / Fecho, Karamarie / Glusman, Gustavo / Hadlock, Jennifer J. / Harris, Nomi L. / Joshi, Arpita / Putman, Tim / Qin, Guangrong / Ramsey, Stephen A. / Shefchek, Kent A. / Solbrig, Harold / Soman, Karthik /

Thessen, Anne T. / Haendel, Melissa A. / Bizon, Chris / Mungall, Christopher J. / Consortium, the Biomedical Data Translator

A Universal Schema for Knowledge Graphs in Clinical, Biomedical, and Translational Science

2022

Abstract: Within clinical, biomedical, and translational science, an increasing number of projects are adopting graphs for knowledge representation. Graph-based data models elucidate the interconnectedness between core biomedical concepts, enable data structures ... ...

Abstract	Within clinical, biomedical, and translational science, an increasing number of projects are adopting graphs for knowledge representation. Graph-based data models elucidate the interconnectedness between core biomedical concepts, enable data structures to be easily updated, and support intuitive queries, visualizations, and inference algorithms. However, knowledge discovery across these "knowledge graphs" (KGs) has remained difficult. Data set heterogeneity and complexity; the proliferation of ad hoc data formats; poor compliance with guidelines on findability, accessibility, interoperability, and reusability; and, in particular, the lack of a universally-accepted, open-access model for standardization across biomedical KGs has left the task of reconciling data sources to downstream consumers. Biolink Model is an open source data model that can be used to formalize the relationships between data structures in translational science. It incorporates object-oriented classification and graph-oriented features. The core of the model is a set of hierarchical, interconnected classes (or categories) and relationships between them (or predicates), representing biomedical entities such as gene, disease, chemical, anatomical structure, and phenotype. The model provides class and edge attributes and associations that guide how entities should relate to one another. Here, we highlight the need for a standardized data model for KGs, describe Biolink Model, and compare it with other models. We demonstrate the utility of Biolink Model in various initiatives, including the Biomedical Data Translator Consortium and the Monarch Initiative, and show how it has supported easier integration and interoperability of biomedical KGs, bringing together knowledge from multiple sources and helping to realize the goals of translational science.
Keywords	Computer Science - Databases
Subject code	400
Publishing date	2022-03-25
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Juvenile cannabinoid treatment induces frontostriatal gliogenesis in Lewis rats.

Bortolato, Marco / Bini, Valentina / Frau, Roberto / Devoto, Paola / Pardu, Alessandra / Fan, Yijun / Solbrig, Marylou V

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

2014 Volume 24, Issue 6, Page(s) 974–985

Abstract: Cannabis abuse in adolescence is associated with a broad array of phenotypical consequences, including a higher risk for schizophrenia and other mental disturbances related to dopamine (DA) imbalances. The great variability of these sequelae likely ... ...

Abstract	Cannabis abuse in adolescence is associated with a broad array of phenotypical consequences, including a higher risk for schizophrenia and other mental disturbances related to dopamine (DA) imbalances. The great variability of these sequelae likely depends on the key influence of diverse genetic vulnerability factors. Inbred rodent strains afford a highly informative tool to study the contribution of genetic determinants to the long-term effects of juvenile cannabinoid exposure. In this study, we analyzed the phenotypical impact of the synthetic cannabinoid agonist WIN 55,212-2 (WIN; 2mg/kg/day from postnatal day 35-48) in adolescent Lewis rats, an inbred strain exhibiting resistance to psychotomimetic effects of environmental manipulations. At the end of this treatment, WIN-injected animals displayed increased survival of new cells (mainly oligodendroglia precursors) in the striatum and prefrontal cortex (PFC), two key terminal fields of DAergic pathways. To test whether these changes may be associated with enduring behavioral alterations, we examined the consequences of adolescent WIN treatment in adulthood (postnatal days 60-70), with respect to DA levels and metabolism as well as multiple behavioral paradigms. Rats injected with WIN exhibited increased turnover, but not levels, of striatal DA. In addition, cannabinoid-treated animals displayed increases in acoustic startle latency and novel-object exploration; however, WIN treatment failed to induce overt deficits of sensorimotor gating and social interaction. These results indicate that, in Lewis rats, juvenile cannabinoid exposure leads to alterations in frontostriatal gliogenesis, as well as select behavioral alterations time-locked to high DAergic metabolism, but not overt schizophrenia-related deficits.
MeSH term(s)	Animals ; Benzoxazines/pharmacology ; Cannabinoids/adverse effects ; Cell Survival/drug effects ; Corpus Striatum/drug effects ; Corpus Striatum/growth & development ; Corpus Striatum/pathology ; Corpus Striatum/physiopathology ; Dopamine/metabolism ; Exploratory Behavior/drug effects ; Exploratory Behavior/physiology ; Male ; Maze Learning/drug effects ; Maze Learning/physiology ; Morpholines/pharmacology ; Naphthalenes/pharmacology ; Neurogenesis/drug effects ; Neurogenesis/physiology ; Neuroglia/drug effects ; Neuroglia/pathology ; Neuroglia/physiology ; Phenotype ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/growth & development ; Prefrontal Cortex/pathology ; Prefrontal Cortex/physiopathology ; Prepulse Inhibition/drug effects ; Prepulse Inhibition/physiology ; Rats, Inbred Lew ; Sensory Gating/drug effects ; Sensory Gating/physiology ; Social Behavior
Chemical Substances	Benzoxazines ; Cannabinoids ; Morpholines ; Naphthalenes ; (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone (5H31GI9502) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2014-01-18
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1082947-7
ISSN	1873-7862 ; 0924-977X
ISSN (online)	1873-7862
ISSN	0924-977X
DOI	10.1016/j.euroneuro.2013.12.011
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Zs.A 3288: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Polymer nanoparticles for immunotherapy from encapsulated tumor-associated antigens and whole tumor cells.

Solbrig, C M / Saucier-Sawyer, J K / Cody, V / Saltzman, W M / Hanlon, D J

Molecular pharmaceutics

2007 Volume 4, Issue 1, Page(s) 47–57

Abstract: Encapsulation of tumor-associated antigens (TAA) in polymer nanoparticles is a promising approach to increasing the efficiency of antigen (Ag) delivery for antitumor vaccines. We optimized a polymer preparation method to deliver both defined tumor- ... ...

Abstract	Encapsulation of tumor-associated antigens (TAA) in polymer nanoparticles is a promising approach to increasing the efficiency of antigen (Ag) delivery for antitumor vaccines. We optimized a polymer preparation method to deliver both defined tumor-associated proteins and the complex mixtures of tumor Ags present in tumors. Tumor Ags were encapsulated in a biodegradable, 50:50 poly(D,L-lactide co-glycolide) copolymer (PLGA) by emulsification and solvent extraction. Two particular Ags were studied, gp100 (a melanoma-associated antigen) and ovalbumin (OVA), as well as mixtures of proteins and lysates of tumor cells. The efficiency of encapsulation was measured by protein assays of dissolved nanoparticles. Ag stability after release from nanoparticles was verified by SDS-acrylamide gel electrophoresis and Western blot analysis. Molecular weight and protein loading interact to define the encapsulation efficiency and release rate of nanoparticles formulated from 50:50 PLGA. A midrange molecular weight polymer had more desirable release properties at 100 mg/mL than at 50 mg/mL protein loading, indicating the need for optimization of nanoparticle formulation for preparations with different particle loadings. Mixtures of proteins derived from cell lysates were reliably encapsulated into nanoparticles, which released the spectrum of proteins contained in lysates. Antigenic proteins were co-encapsulated with cell lysate and released from nanoparticles; these Ags retained their antigenicity and functioned better than soluble Ags when tested in in vitro assays of T cell cytokine formation and in vivo tumor vaccination challenge.
MeSH term(s)	Animals ; Antigens, Neoplasm/immunology ; CD8-Positive T-Lymphocytes/immunology ; Dendritic Cells/immunology ; Female ; Immunotherapy ; Lactic Acid/immunology ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred C57BL ; Molecular Weight ; Nanoparticles/therapeutic use ; Nanoparticles/ultrastructure ; Neoplasms/immunology ; Neoplasms/pathology ; Ovalbumin/immunology ; Polyglycolic Acid ; Polymers ; gp100 Melanoma Antigen
Chemical Substances	Antigens, Neoplasm ; Membrane Glycoproteins ; Polymers ; Si protein, mouse ; gp100 Melanoma Antigen ; polylactic acid-polyglycolic acid copolymer ; Polyglycolic Acid (26009-03-0) ; Lactic Acid (33X04XA5AT) ; Ovalbumin (9006-59-1)
Language	English
Publishing date	2007-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/mp060107e
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Article ; Online: Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone.

Howlett, Patrick J / Walder, Anna R / Lisk, Durodami R / Fitzgerald, Felicity / Sevalie, Stephen / Lado, Marta / N'jai, Abdul / Brown, Colin S / Sahr, Foday / Sesay, Foday / Read, Jonathon M / Steptoe, Paul J / Beare, Nicholas A V / Dwivedi, Reena / Solbrig, Marylou / Deen, Gibrilla F / Solomon, Tom / Semple, Malcolm G / Scott, Janet T

Emerging infectious diseases

2018 Volume 24, Issue 8, Page(s) 1412–1421

Abstract: We describe a case series of 35 Ebola virus disease (EVD) survivors during the epidemic in West Africa who had neurologic and accompanying psychiatric sequelae. Survivors meeting neurologic criteria were invited from a cohort of 361 EVD survivors to ... ...

Abstract	We describe a case series of 35 Ebola virus disease (EVD) survivors during the epidemic in West Africa who had neurologic and accompanying psychiatric sequelae. Survivors meeting neurologic criteria were invited from a cohort of 361 EVD survivors to attend a preliminary clinic. Those whose severe neurologic features were documented in the preliminary clinic were referred for specialist neurologic evaluation, ophthalmologic examination, and psychiatric assessment. Of 35 survivors with neurologic sequelae, 13 had migraine headache, 2 stroke, 2 peripheral sensory neuropathy, and 2 peripheral nerve lesions. Of brain computed tomography scans of 17 patients, 3 showed cerebral and/or cerebellar atrophy and 2 confirmed strokes. Sixteen patients required mental health followup; psychiatric disorders were diagnosed in 5. The 10 patients who experienced greatest disability had co-existing physical and mental health conditions. EVD survivors may have ongoing central and peripheral nervous system disorders, including previously unrecognized migraine headaches and stroke.
MeSH term(s)	Adult ; Cohort Studies ; Epidemics ; Female ; Hemorrhagic Fever, Ebola/complications ; Hemorrhagic Fever, Ebola/epidemiology ; Humans ; Male ; Migraine Disorders/etiology ; Peripheral Nervous System Diseases/etiology ; Sierra Leone/epidemiology ; Stroke/etiology ; Young Adult
Language	English
Publishing date	2018-07-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2408.171367
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Article: Acute parkinsonism in suspected herpes simplex encephalitis.

Solbrig, M V / Nashef, L

Movement disorders : official journal of the Movement Disorder Society

1993 Volume 8, Issue 2, Page(s) 233–234

MeSH term(s)	Adult ; Antibodies, Viral/analysis ; Female ; Herpes Simplex/diagnosis ; Herpes Simplex/physiopathology ; Humans ; Immunoglobulin G/analysis ; Meningoencephalitis/diagnosis ; Meningoencephalitis/physiopathology ; Neurologic Examination ; Parkinson Disease, Postencephalitic/diagnosis ; Parkinson Disease, Postencephalitic/physiopathology ; Simplexvirus/immunology
Chemical Substances	Antibodies, Viral ; Immunoglobulin G
Language	English
Publishing date	1993-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.870080226
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Zs.A 2555: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis.

Solbrig, Marylou V / Adrian, Russell / Wechsler, Steven L / Koob, George F

European journal of pharmacology

2007 Volume 555, Issue 1, Page(s) 23–29

Abstract: ... withdrawal. Given that delta antagonists as well as kappa opioid agonists in hippocampus enhance potassium M ... currents (I(M)), we tested the effect of the I(M) augmenter flupirtine. Flupirtine (20 mg/kg i.p ...

Abstract	Opioid systems in hippocampus regulate excitability and kappa opioids have a role in anticonvulsant protection, but their mechanisms of action are incompletely understood. We examined the ability of opioid and nonopioid agents with overlapping ionic mechanisms and actions similar to kappa opioid agonists, to block seizures in rat models of encephalitis due to Borna Disease virus and Herpes Simplex Virus Type-1. Naltrindole, a delta antagonist and thus a kappa opioid sparing agent, (10 mg/kg s.c.) blocked spontaneous and naloxone (opioid antagonist)-induced seizures in the models, but produced somatic signs similar to opioid withdrawal. Given that delta antagonists as well as kappa opioid agonists in hippocampus enhance potassium M currents (I(M)), we tested the effect of the I(M) augmenter flupirtine. Flupirtine (20 mg/kg i.p.) prevented seizures in Borna and herpes infected rats, without signs of withdrawal, hypotonia or sedation. The results support the efficacy of opioid and nonopioid drugs in modulating naloxone-induced seizures in critical illness due to viral encephalitis and by analogy, opioid withdrawal seizures.
MeSH term(s)	Aminopyridines/pharmacology ; Analgesics/pharmacology ; Animals ; Anticonvulsants/pharmacology ; Borna Disease/drug therapy ; Encephalitis, Viral/drug therapy ; Encephalitis, Viral/physiopathology ; Herpes Simplex/drug therapy ; Herpesvirus 1, Human ; Male ; Naloxone ; Naltrexone/analogs & derivatives ; Naltrexone/pharmacology ; Narcotic Antagonists/pharmacology ; Potassium/physiology ; Rats ; Rats, Inbred Lew ; Receptors, Opioid, delta/antagonists & inhibitors ; Seizures/chemically induced ; Seizures/prevention & control ; Substance Withdrawal Syndrome/etiology ; Substance Withdrawal Syndrome/prevention & control
Chemical Substances	Aminopyridines ; Analgesics ; Anticonvulsants ; Narcotic Antagonists ; Receptors, Opioid, delta ; Naloxone (36B82AMQ7N) ; Naltrexone (5S6W795CQM) ; naltrindole (G167Z38QA4) ; flupirtine (MOH3ET196H) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2007-01-19
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2006.10.025
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Article: Cocaine sensitivity in Borna disease virus-infected rats.

Solbrig, M V / Koob, G F / Lipkin, W I

Pharmacology, biochemistry, and behavior

1998 Volume 59, Issue 4, Page(s) 1047–1052

Abstract: Borna disease virus (BDV) is a neurotropic RNA virus that infects warm-blooded animals to cause disturbances of movement and behavior. Studies in infected rats have demonstrated behavioral sensitivity to direct and indirect dopamine (DA) agonists; ... ...

Abstract	Borna disease virus (BDV) is a neurotropic RNA virus that infects warm-blooded animals to cause disturbances of movement and behavior. Studies in infected rats have demonstrated behavioral sensitivity to direct and indirect dopamine (DA) agonists; however, behavioral responses to an indirect DA agonist with a pure presynaptic effect have not been analyzed. Rats infected with BDV had an enhanced response to the locomotor, behavioral, and convulsant effects of cocaine at intraperitoneal doses of 7.5, 15, and 30 mg/kg. The basis for this sensitivity was examined by striatal DA uptake site and D1 and D2 receptor autoradiography. DA uptake sites, labeled with [3H] mazindol, were reduced in medial caudate-putamen (CP), and binding of [3H] raclopride to D2 sites was reduced in medial and ventral striatal areas. The topography of DA uptake and D2 site loss corresponds to the distribution of BDV viral nucleic acids in CP and overlays the medial striatal areas that function in conditioned reward. The BDV-infected rat provides a model of cocaine sensitivity based on viral central nervous system infection and may have relevance for studies of cocaine abuse in the context of other viral encephalopathies, such as those associated with HIV infection.
MeSH term(s)	Animals ; Autoradiography ; Behavior, Animal/drug effects ; Borna Disease/psychology ; Caudate Nucleus/drug effects ; Caudate Nucleus/metabolism ; Cocaine/pharmacology ; Dopamine Uptake Inhibitors/pharmacology ; In Situ Hybridization ; Male ; Mazindol/pharmacology ; Motor Activity/drug effects ; Putamen/drug effects ; Putamen/metabolism ; Rats ; Rats, Inbred Lew
Chemical Substances	Dopamine Uptake Inhibitors ; Mazindol (C56709M5NH) ; Cocaine (I5Y540LHVR)
Language	English
Publishing date	1998-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	191042-5
ISSN	1873-5177 ; 0091-3057
ISSN (online)	1873-5177
ISSN	0091-3057
DOI	10.1016/s0091-3057(97)00507-8
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