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  1. Article ; Online: HIV Reservoirs and Treatment Strategies toward Curing HIV Infection.

    Matsuda, Kouki / Maeda, Kenji

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Combination antiretroviral therapy (cART) has significantly improved the prognosis of individuals living with human immunodeficiency virus (HIV). Acquired immunodeficiency syndrome has transformed from a fatal disease to a treatable chronic infection. ... ...

    Abstract Combination antiretroviral therapy (cART) has significantly improved the prognosis of individuals living with human immunodeficiency virus (HIV). Acquired immunodeficiency syndrome has transformed from a fatal disease to a treatable chronic infection. Currently, effective and safe anti-HIV drugs are available. Although cART can reduce viral production in the body of the patient to below the detection limit, it cannot eliminate the HIV provirus integrated into the host cell genome; hence, the virus will be produced again after cART discontinuation. Therefore, research into a cure (or remission) for HIV has been widely conducted. In this review, we focus on drug development targeting cells latently infected with HIV and assess the progress including our current studies, particularly in terms of the "Shock and Kill", and "Block and Lock" strategies.
    MeSH term(s) Humans ; HIV Infections ; Virus Latency ; HIV-1 ; Anti-HIV Agents/pharmacology ; Acquired Immunodeficiency Syndrome/drug therapy ; CD4-Positive T-Lymphocytes ; Virus Activation
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prenatal diagnosis of total anomalous pulmonary venous connection with vertical vein branching into two.

    Maeda, Takaaki / Morine, Mikio / Sugimoto, Tatsuro / Nagao, Aki / Yonetani, Naoto / Hinokio, Kenji / Maeda, Kazuhisa

    Journal of medical ultrasonics (2001)

    2024  

    Language English
    Publishing date 2024-03-11
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1396630-3
    ISSN 1613-2254 ; 0287-0592 ; 1346-4523
    ISSN (online) 1613-2254
    ISSN 0287-0592 ; 1346-4523
    DOI 10.1007/s10396-024-01411-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2695: Show issues Location:
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  3. Article ; Online: Kawasaki disease complicated with posterior reversible encephalopathy syndrome.

    Kinoshita, Yuki / Kobayashi, Osamu / Maeda, Tomoki / Ihara, Kenji

    Pediatrics international : official journal of the Japan Pediatric Society

    2023  Volume 65, Issue 1, Page(s) e15691

    MeSH term(s) Humans ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Posterior Leukoencephalopathy Syndrome/complications ; Posterior Leukoencephalopathy Syndrome/diagnosis ; Immunosuppressive Agents ; Magnetic Resonance Imaging
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2023-10-05
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15691
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  4. Article ; Online: Profiling the Mammalian Lipidome by Quantitative Shotgun Lipidomics.

    Foged, Mads Møller / Maeda, Kenji / Bilgin, Mesut

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2625, Page(s) 89–102

    Abstract: The emerging field of lipidomics presents the systems biology approach to identify and quantify the full lipid repertoire of cells, tissues, and organisms. The importance of the lipidome is demonstrated by a number of biological studies on dysregulation ... ...

    Abstract The emerging field of lipidomics presents the systems biology approach to identify and quantify the full lipid repertoire of cells, tissues, and organisms. The importance of the lipidome is demonstrated by a number of biological studies on dysregulation of lipid metabolism in human diseases such as cancer, diabetes, and neurodegenerative diseases. Exploring changes and regulations in the huge networks of lipids and their metabolic pathways requires a lipidomics methodology: advanced mass spectrometry that resolves the complexity of the lipidome. Here, we report a comprehensive protocol of quantitative shotgun lipidomics that enables identification and quantification of hundreds of molecular lipid species, covering a wide range of lipid classes, extracted from cultured mammalian cells.
    MeSH term(s) Animals ; Humans ; Lipids/chemistry ; Lipidomics ; Mass Spectrometry/methods ; Mammals ; Lipid Metabolism
    Chemical Substances Lipids
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2966-6_8
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  5. Article ; Online: Ventral Variant Posterior Cortical Atrophy with Occipito-temporal Accumulation of Tau Proteins/Astrocyte Gliosis.

    Shiio, Mihoko / Maeda, Nobuya / Iwata, Atsushi / Ishibashi, Kenji / Ishii, Kenji / Takuma, Hiroshi / Ishizaka, Yuko / Sakurai, Yasuhisa

    Internal medicine (Tokyo, Japan)

    2024  

    Abstract: A 73-year-old woman with posterior cortical atrophy (PCA) presented with progressive apperceptive visual agnosia, alexia, agraphia, ventral simultanagnosia, prosopagnosia, and allocentric (stimulus-centered) left-sided hemispatial neglect. All of these ... ...

    Abstract A 73-year-old woman with posterior cortical atrophy (PCA) presented with progressive apperceptive visual agnosia, alexia, agraphia, ventral simultanagnosia, prosopagnosia, and allocentric (stimulus-centered) left-sided hemispatial neglect. All of these symptoms were attributed to damage to the bilateral occipito-temporal cortices, consistent with ventral variant PCA. While the Pittsburgh compound B uptake was extensively distributed throughout the occipito-parietal (dorsal) and occipito-temporal (ventral) areas, the THK5351 (ligand binding to tau aggregates/astrocyte gliosis) accumulation was limited to the ventral area. These findings suggest that local accumulation of tau proteins and/or astrocyte gliosis over the occipito-temporal cortices can result in ventral variant PCA.
    Language English
    Publishing date 2024-02-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.2844-23
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    Zs.A 240: Show issues Location:
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  6. Article ; Online: Secular Trends in Obesity and Serum Lipid Values among Children in Oita City, Japan, during a 27-Year Period.

    Maeda, Miwako / Maeda, Tomoki / Ihara, Kenji

    Journal of atherosclerosis and thrombosis

    2022  Volume 29, Issue 12, Page(s) 1709–1726

    Abstract: Aims: We assessed 27-year trends in obesity and blood lipid levels of 10-year-old children to estimate the risk of metabolic syndrome in adulthood.: Methods: Based on a screening program for lifestyle-related diseases in school children in Oita City, ...

    Abstract Aims: We assessed 27-year trends in obesity and blood lipid levels of 10-year-old children to estimate the risk of metabolic syndrome in adulthood.
    Methods: Based on a screening program for lifestyle-related diseases in school children in Oita City, Japan, we evaluated secular trends in height, weight, percentage of overweight (POW), total cholesterol (TC), triglyceride (TG), HDL cholesterol (HDL-C), and non-HDL cholesterol (non-HDL-C) of fifth graders (median age: 10.8 years) in Oita City from 1991 to 2017. We focused on the secular trend in the percentage of children with inappropriate serum levels of each lipid. We also evaluated the long-term trends in the 95
    Results: A total of 58,699 boys and 56,864 girls were evaluated during the study period. The percentage of children with severe obesity (POW-50) consistently increased during these years, and the 95
    Conclusion: The number of children with severe obesity increased, and obese children had higher percentages of inappropriate lipid levels than non-obese children. The rate of dyslipidemia with low HDL levels gradually increased in all children in Oita City, Japan, over the past 27 years.
    MeSH term(s) Child ; Male ; Female ; Humans ; Adult ; Obesity, Morbid ; Japan/epidemiology ; Obesity/epidemiology ; Cholesterol, HDL ; Triglycerides ; Cholesterol ; Lipids ; Body Mass Index
    Chemical Substances Cholesterol, HDL ; Triglycerides ; Cholesterol (97C5T2UQ7J) ; Lipids
    Language English
    Publishing date 2022-01-29
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2011474-6
    ISSN 1880-3873 ; 1340-3478
    ISSN (online) 1880-3873
    ISSN 1340-3478
    DOI 10.5551/jat.63056
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    Zs.A 5192: Show issues Location:
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  7. Article ; Online: Long-term trends of pediatric type 1 diabetes incidence in Japan before and after the COVID-19 pandemic.

    Matsuda, Fumika / Itonaga, Tomoyo / Maeda, Miwako / Ihara, Kenji

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 5803

    Abstract: Type 1 diabetes incidence has increased worldwide, although the long-term trends on pediatric type 1 diabetes in Japan remain elusive. To investigate the incidence and secular trend of pediatric type 1 diabetes from 1999 to 2021, including the ... ...

    Abstract Type 1 diabetes incidence has increased worldwide, although the long-term trends on pediatric type 1 diabetes in Japan remain elusive. To investigate the incidence and secular trend of pediatric type 1 diabetes from 1999 to 2021, including the coronavirus disease 2019 (COVID-19) pandemic years, in Oita Prefecture, Japan. We investigated the number of newly diagnosed patients with type 1 diabetes aged < 15 years from 1999 to 2021. We surveyed hospital databases in Oita Prefecture in Japan. The type 1 diabetes incidence in children aged < 15 years increased annually by 5.3% among all children, especially in boys aged 10-14 years by 8.1%, over the past 23 years. The average incidence rate of 3.9/100,000/year was nearly consistent with the previous reports on Asian countries. No significant change was found in the increasing incidence trend of type 1 diabetes before and during the COVID-19 pandemic. The incidence of pediatric type 1 diabetes has significantly increased over the past 23 years in Oita Prefecture, Japan, which is consistent with the worldwide trend.
    MeSH term(s) Male ; Humans ; Child ; Incidence ; Pandemics ; Diabetes Mellitus, Type 1/epidemiology ; Japan/epidemiology ; COVID-19/epidemiology
    Language English
    Publishing date 2023-04-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-33037-x
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  8. Article ; Online: Early infantile spontaneous movement in very low birthweight infants is associated with sensory characteristics at the corrected age of 3 years.

    Kobayashi, Osamu / Maeda, Tomoki / Ihara, Kenji

    Brain & development

    2023  Volume 46, Issue 3, Page(s) 135–141

    Abstract: Aim: To clarify the relationship between early infantile spontaneous movement of very-low-birth-weight infants (VLBWIs) and sensory characteristics in childhood.: Study design: Prospective cohort study. We investigated the association between the ... ...

    Abstract Aim: To clarify the relationship between early infantile spontaneous movement of very-low-birth-weight infants (VLBWIs) and sensory characteristics in childhood.
    Study design: Prospective cohort study. We investigated the association between the Motor Optimality Score-Revised (MOS-R), a detailed assessment of general movements (GMs) at the corrected age of 9-17 weeks and the Infant/Toddler Sensory Profile Japanese version (ITSP-J) at the corrected age of 3 years. A multiple regression analysis was performed to examine the correlation of ITSP-J and MOS-R with patient clinical background factors.
    Subjects: Fifty-three VLBWIs (median gestational age: 28 weeks, 6 days; median birth weight: 997 g) who were managed at the NICU of Oita University from September 2013 to June 2019.
    Results: A multiple regression analysis revealed that the ITSP-J subscale in the sensory section of visual score was significantly correlated with the age-adequate movement repertoire subscore of MOS-R, and in the sensory section of vestibular score was correlated with the fidgety subscore of MOS-R. For both visual and vestibular section scores, intraventricular hemorrhage (IVH) showed an independent association with the MOS-R subscore.
    Conclusion: Spontaneous movement characteristics in early infancy were associated with sensory characteristics in early childhood.
    MeSH term(s) Infant, Newborn ; Infant ; Humans ; Child, Preschool ; Prospective Studies ; Movement ; Infant, Very Low Birth Weight ; Birth Weight ; Gestational Age
    Language English
    Publishing date 2023-11-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604822-5
    ISSN 1872-7131 ; 0387-7604
    ISSN (online) 1872-7131
    ISSN 0387-7604
    DOI 10.1016/j.braindev.2023.11.003
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    Zs.A 1788: Show issues Location:
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  9. Article: Asymptomatic 3-methylglutaconic aciduria type 1 detected by high C5-OH on newborn screening.

    Itonaga, Tomoyo / Maeda, Miwako / Koga, Hiroshi / Hasegawa, Yuki / Ihara, Kenji

    Molecular genetics and metabolism reports

    2023  Volume 38, Page(s) 101024

    Abstract: 3-Methylglutaconic aciduria type 1 (MGCA1) is an inborn error of leucine catabolism caused by pathogenic variants of ... ...

    Abstract 3-Methylglutaconic aciduria type 1 (MGCA1) is an inborn error of leucine catabolism caused by pathogenic variants of the
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2821908-9
    ISSN 2214-4269
    ISSN 2214-4269
    DOI 10.1016/j.ymgmr.2023.101024
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  10. Article ; Online: Spore-Forming Lactic Acid-Producing Bacterium

    Suzuki, Hideyuki / Fujiwara, Yuki / Thongbhubate, Kullathida / Maeda, Masahiro / Kanaori, Kenji

    Journal of agricultural and food chemistry

    2023  Volume 71, Issue 25, Page(s) 9868–9876

    Abstract: The effect of spermidine in extending healthy longevity has attracted attention. As people age, their ability to synthesize putrescine, the precursor of spermidine, declines, and its supplementation from the diet or gut bacteria is needed. Many bacteria ... ...

    Abstract The effect of spermidine in extending healthy longevity has attracted attention. As people age, their ability to synthesize putrescine, the precursor of spermidine, declines, and its supplementation from the diet or gut bacteria is needed. Many bacteria synthesize spermidine, but no strains have been reported to excrete
    MeSH term(s) Humans ; Spermidine ; Putrescine ; Bacillus coagulans ; Extracellular Space ; Lactic Acid ; Spores, Bacterial ; Bacteria
    Chemical Substances Spermidine (U87FK77H25) ; Putrescine (V10TVZ52E4) ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c02184
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