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  1. Article ; Online: The Emerging Era of Organ Transplantation and Anti-CD154mAb.

    Kwun, Jean / Kirk, Allan D / Knechtle, Stuart J

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2024  

    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1016/j.ajt.2024.04.008
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5542: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A pig kidney supporting human physiology.

    Knechtle, Stuart J / Ladowski, Joseph M / Kwun, Jean

    Kidney international

    2024  Volume 105, Issue 5, Page(s) 921–922

    Abstract: Because of the global shortage of donor kidneys, xenotransplantation emerges as a potential solution for individuals with kidney failure who face challenges in securing a suitable donor kidney. A study featured in this month's issue of Kidney ... ...

    Abstract Because of the global shortage of donor kidneys, xenotransplantation emerges as a potential solution for individuals with kidney failure who face challenges in securing a suitable donor kidney. A study featured in this month's issue of Kidney International assesses the kidney physiology of a porcine kidney transplanted into a brain-dead human with kidney failure, demonstrating life-sustaining physiological function for 7 days. Together with preclinical nonhuman primate studies, decedent models provide complementary data for development of clinical kidney xenotransplantation.
    MeSH term(s) Humans ; Animals ; Swine ; Kidney Transplantation/adverse effects ; Kidney/physiology ; Transplantation, Heterologous ; Tissue Donors ; Graft Rejection ; Renal Insufficiency ; Animals, Genetically Modified
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2024.02.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Complete genome sequence data of

    Yoon, J A / Kwun, S Y / Park, E H / Kim, M D

    Data in brief

    2023  Volume 47, Page(s) 108919

    Abstract: Kimchi, a traditional Korean fermented food, contains many lactic acid bacteria. ...

    Abstract Kimchi, a traditional Korean fermented food, contains many lactic acid bacteria.
    Language English
    Publishing date 2023-01-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409 ; 2352-3409
    ISSN (online) 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2023.108919
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  4. Article: Emergency department responses to nursing shortages.

    Hodgson, Nicole R / Kwun, Richard / Gorbatkin, Chad / Davies, Jeanie / Fisher, Jonathan

    International journal of emergency medicine

    2024  Volume 17, Issue 1, Page(s) 51

    Abstract: Background: The COVID-19 pandemic exacerbated the nursing shortage, which is predicted to continue to worsen with significant numbers of nurses planning to retire within the next 5 years. There remains a lack of published information regarding ... ...

    Abstract Background: The COVID-19 pandemic exacerbated the nursing shortage, which is predicted to continue to worsen with significant numbers of nurses planning to retire within the next 5 years. There remains a lack of published information regarding recommended interventions for emergency departments (EDs) facing a sudden nursing shortage.
    Methods: We queried emergency department leaders from the American College of Emergency Physicians to examine the impact of nursing shortages on EDs and to gather real-world interventions employed to mitigate the effects of the shortage.
    Results: Most respondents (98.5%) reported nursing shortages, with 83.3% describing prolonged shortages lasting more than 12 months, with negative impacts such as misses/near-misses (93.9%) and increasing left without being seen rates (90.9%). ED leaders reported a range of interventions, including operational flow changes, utilizing alternative staff to fill nurse roles, recruitment of new nurses, and retention strategies for existing nurses. They employed temporary and permanent pay increases as well as efforts to improve the ED work environment and techniques to hire new nurses from atypical pipelines.
    Conclusion: We report a patchwork of solutions ED leaders utilized which may have variable efficacy among different EDs; personalization is essential when selecting interventions during a sudden nursing shortage.
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2411462-5
    ISSN 1865-1380 ; 1865-1372
    ISSN (online) 1865-1380
    ISSN 1865-1372
    DOI 10.1186/s12245-024-00628-y
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  5. Article ; Online: Pharmacological approaches to antibody-mediated rejection-Are we getting closer?

    Kwun, Jean / Knechtle, Stuart

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2020  Volume 20, Issue 10, Page(s) 2637–2638

    MeSH term(s) Abatacept ; Animals ; Antibody Formation ; Bortezomib ; Graft Rejection/drug therapy ; Humans ; Kidney Transplantation ; Mice ; Tissue Donors
    Chemical Substances Bortezomib (69G8BD63PP) ; Abatacept (7D0YB67S97)
    Language English
    Publishing date 2020-08-15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.16061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5542: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Experimental modeling of desensitization: What have we learned about preventing AMR?

    Kwun, Jean / Knechtle, Stuart

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2020  Volume 20 Suppl 4, Page(s) 2–11

    Abstract: During the past 5 decades, short-term outcomes in kidney transplant have significantly improved, in large part due to reduced rates and severity of acute rejection. Development of better immunosuppressive maintenance agents, as well as new induction ... ...

    Abstract During the past 5 decades, short-term outcomes in kidney transplant have significantly improved, in large part due to reduced rates and severity of acute rejection. Development of better immunosuppressive maintenance agents, as well as new induction therapies, helped make these advances. Nonhuman primate models provided a rigorous testing platform to evaluate candidate biologics during this process. However, antibody-mediated rejection remains a major cause of late failure of kidney allografts despite advances made in pharmacologic immunosuppression and strategies developed to facilitate improved donor-recipient matching. Our laboratory has been actively working to develop strategies to prevent and treat antibody-mediated rejection and immunologic sensitization in organ transplant, relying largely on a nonhuman primate model of kidney transplant. In this review, we will cover outcomes achieved by managing antibody-mediated rejection or sensitization in nonhuman primate models and discuss promises, limitations, and future directions for this model.
    MeSH term(s) Animals ; Graft Rejection/prevention & control ; Graft Survival ; Immunosuppressive Agents ; Kidney Transplantation ; Organ Transplantation
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2020-07-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.15873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Parallels between antibody-mediated rejection and ischemic kidney injury with respect to B cell activation.

    Knechtle, Stuart J / Kwun, Jean

    Annals of translational medicine

    2019  Volume 7, Issue Suppl 3, Page(s) S151

    Language English
    Publishing date 2019-09-25
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2019.06.36
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Diverse regulatory pathways modulate bet hedging of competence induction in epigenetically-differentiated phase variants of Streptococcus pneumoniae.

    Kwun, Min Jung / Ion, Alexandru V / Oggioni, Marco R / Bentley, Stephen D / Croucher, Nicholas J

    Nucleic acids research

    2023  Volume 51, Issue 19, Page(s) 10375–10394

    Abstract: Despite enabling Streptococcus pneumoniae to acquire antibiotic resistance and evade vaccine-induced immunity, transformation occurs at variable rates across pneumococci. Phase variants of isolate RMV7, distinguished by altered methylation patterns ... ...

    Abstract Despite enabling Streptococcus pneumoniae to acquire antibiotic resistance and evade vaccine-induced immunity, transformation occurs at variable rates across pneumococci. Phase variants of isolate RMV7, distinguished by altered methylation patterns driven by the translocating variable restriction-modification (tvr) locus, differed significantly in their transformation efficiencies and biofilm thicknesses. These differences were replicated when the corresponding tvr alleles were introduced into an RMV7 derivative lacking the locus. RNA-seq identified differential expression of the type 1 pilus, causing the variation in biofilm formation, and inhibition of competence induction in the less transformable variant, RMV7domi. This was partly attributable to RMV7domi's lower expression of ManLMN, which promoted competence induction through importing N-acetylglucosamine. This effect was potentiated by analogues of some proteobacterial competence regulatory machinery. Additionally, one of RMV7domi's phage-related chromosomal island was relatively active, which inhibited transformation by increasing expression of the stress response proteins ClpP and HrcA. However, HrcA increased competence induction in the other variant, with its effects depending on Ca2+ supplementation and heat shock. Hence the heterogeneity in transformation efficiency likely reflects the diverse signalling pathways by which it is affected. This regulatory complexity will modulate population-wide responses to synchronising quorum sensing signals to produce co-ordinated yet stochastic bet hedging behaviour.
    MeSH term(s) Bacterial Proteins/metabolism ; Biofilms ; Heat-Shock Proteins/metabolism ; Quorum Sensing ; Streptococcus pneumoniae/metabolism
    Chemical Substances Bacterial Proteins ; Heat-Shock Proteins
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkad760
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    Zs.A 1067: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: The learning curve of BiZact™ tonsillectomy.

    Dulku, Kiren / Toll, Edward / Kwun, Jin / van der Meer, Graeme

    International journal of pediatric otorhinolaryngology

    2022  Volume 158, Page(s) 111155

    Abstract: Objective: To evaluate the learning curve of BiZact™ tonsillectomy amongst trainees and fellows as a further technical skill.: Methods: Prospective audit of consecutive BiZact™ tonsillectomies undertaken by a trainee and fellow at Starship Children's ...

    Abstract Objective: To evaluate the learning curve of BiZact™ tonsillectomy amongst trainees and fellows as a further technical skill.
    Methods: Prospective audit of consecutive BiZact™ tonsillectomies undertaken by a trainee and fellow at Starship Children's Hospital. Primary outcomes measured were operative time from gag open to gag closed, readmission and post tonsillectomy bleed rates. Secondary outcomes included need for bipolar rescue dissection, bipolar haemostasis including site and side, tonsil size (Brodsky grade 1-4) and depth (shallow or deep). Operative time was plotted against number of procedures performed and moving averages was used to investigate the learning curve. Generalised linear model was applied to examine the association between operation time and tonsil depth.
    Results: Mean operative time for the trainee and fellow was similar (07 min 34 s versus 07min and 37 s). We observed a trend of decreased operative time over number of procedures performed by the trainee but the learning curve was short. The fellow's initial time was lower than the trainee's and remained similar over time. No bipolar rescue dissection was required. Additional bipolar haemostasis was required 95% of the time, but the majority involved the superior pole only (87.5%, p = 0.0001). The overall operative time for shallow tonsils was shorter than for deep tonsils (06 min 31 s versus 08 min 09 s, p = 0.0066). A learning curve was evident for both shallow and deep tonsils for both surgeons combined but was steeper for deep. There were no primary bleeds and the secondary haemorrhage rate was 5.8% (3/51 cases) with no returns to theatre.
    Conclusion: This is the first study to investigate the BiZact™ tonsillectomy learning curve. BiZact™ tonsillectomy is safe and easy to learn. We observed a clear trend of shallow tonsils being quicker to remove than deep tonsils using this technique. The secondary bleed rate of 5.8% is comparable to the previously published Starship rate of 4.7% for all tonsillectomies performed over a 10 year period. Moving averages is a useful method to assess operative learning curves during training and beyond.
    MeSH term(s) Child ; Dissection/methods ; Humans ; Learning Curve ; Operative Time ; Palatine Tonsil/surgery ; Tonsillectomy/adverse effects ; Tonsillectomy/methods
    Language English
    Publishing date 2022-05-02
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 754501-0
    ISSN 1872-8464 ; 0165-5876
    ISSN (online) 1872-8464
    ISSN 0165-5876
    DOI 10.1016/j.ijporl.2022.111155
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    Zs.MO 134: Show issues

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  10. Article ; Online: Indole-3-carbinol induces apoptosis-like death in Escherichia coli on different contribution of respective reactive oxygen species.

    Kwun, Min Seok / Yun, JiEun / Lee, Dong Gun

    Life sciences

    2021  Volume 275, Page(s) 119361

    Abstract: Aims: Indole-3-carbinol (I3C) is a natural compound derived from brassica vegetables, displaying antibacterial activity. The study aims to elucidate the antibacterial mode of action(s) induced by indole-3-carbionol in Escherichia coli and enhance the ... ...

    Abstract Aims: Indole-3-carbinol (I3C) is a natural compound derived from brassica vegetables, displaying antibacterial activity. The study aims to elucidate the antibacterial mode of action(s) induced by indole-3-carbionol in Escherichia coli and enhance the understandings on the respective contribution of each reactive oxygen species (ROS), superoxide anion (O
    Main methods: The antibacterial activity of I3C was assessed through kinetic assay. The generation of ROS was measured by flow cytometer using H
    Key findings: I3C exhibited antibacterial activity in E. coli through accumulation of ROS and DNA damage, eventually leading to apoptosis-like death. Contribution of each ROS displayed respective manner, OH
    Significance: Our study is the first to link I3C to the bacterial apoptosis-like death and displays the potential of this agent as a candidate for potential drugs that could help regulating the E. coli, an opportunistic human pathogen. Moreover, the study focused on investigating the individual contribution of each ROS during the process, trying to enhance the understanding regarding ROS and cellular processes followed by oxidative stress in bacteria.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Apoptosis/drug effects ; Chromatin/drug effects ; DNA Damage/drug effects ; Escherichia coli/drug effects ; Escherichia coli/metabolism ; Hydrogen Peroxide/metabolism ; Hydroxyl Radical/metabolism ; Indoles/pharmacology ; Reactive Oxygen Species/metabolism ; Singlet Oxygen/metabolism
    Chemical Substances Anti-Bacterial Agents ; Chromatin ; Indoles ; Reactive Oxygen Species ; Singlet Oxygen (17778-80-2) ; Hydroxyl Radical (3352-57-6) ; Hydrogen Peroxide (BBX060AN9V) ; indole-3-carbinol (C11E72455F)
    Language English
    Publishing date 2021-03-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2021.119361
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