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  1. Article: Adenoma arising from xanthoma in the transverse colon: a case report.

    Jung, Yu Jin / Lee, Jun / Kim, Seong Jung / Hong, Ran

    Gastroenterology report

    2023  Volume 11, Page(s) goad013

    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2710871-5
    ISSN 2052-0034
    ISSN 2052-0034
    DOI 10.1093/gastro/goad013
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  2. Article ; Online: Overcoming functional redundancy in three actin depolymerizing factor genes for rice pollen tube growth.

    Kim, Eui-Jung / Hong, Woo-Jong / Kang, Minseo / Jeon, Jong-Seong / Kim, Yu-Jin / Jung, Ki-Hong

    Plant physiology

    2024  

    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1093/plphys/kiae158
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    In stock of ZB MED Bonn / Germany

    Z 1193: Show issues

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  3. Article: Improvement effect of gemigliptin on salivary gland dysfunction in exogenous methylglyoxal-injected rats.

    Jung, Woo Kwon / Park, Su-Bin / Yu, Hwa Young / Kim, Junghyun

    Heliyon

    2024  Volume 10, Issue 8, Page(s) e29362

    Abstract: The symptom of hyposalivation associated with hypofunction of the salivary glands is a common feature of diabetes. Inadequate saliva production can cause tissue damage in the mouth, making it susceptible to infections and leading to oral health diseases. ...

    Abstract The symptom of hyposalivation associated with hypofunction of the salivary glands is a common feature of diabetes. Inadequate saliva production can cause tissue damage in the mouth, making it susceptible to infections and leading to oral health diseases. Previous studies have highlighted the harmful effects of methylglyoxal (MGO) and MGO-derived advanced glycation end products (AGEs) in diabetes. In this study, we investigated the protective effects of gemigliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, against MGO-induced salivary gland dysfunction. MGO treatment of immortalized human salivary gland acinar cells induced apoptosis via reactive oxygen species (ROS)-mediated pathways, but this effect was mitigated by gemigliptin. In vivo experiments involved the simultaneous administration of MGO (17.25 mg/kg) with aminoguanidine (100 mg/kg) and gemigliptin (10 and 100 mg/kg) daily to rats for two weeks. Gemigliptin increased the saliva volume and amylase levels in MGO-injected rats. Gemigliptin reduced the DPP-4 activity in both the salivary glands and serum of MGO-injected rats. Furthermore, gemigliptin exerted anti-glycation effects by reducing the accumulation of AGEs in the saliva, salivary glands, and serum and suppressing the expression of the receptor for AGEs. These actions protected the salivary gland cells from ROS-mediated apoptosis. Overall, gemigliptin protected the salivary gland cells from ROS-mediated cell death, reduced the accumulation of amylase and mucins in the salivary glands, and enhanced the salivary function by upregulating aquaporin 5 expression, and it exerted protective effects against MGO-induced salivary gland dysfunction by enhancing the anti-glycation, antioxidant, and salivary secretion activities. Our findings suggest gemigliptin as a potential therapeutic for patients with salivary gland dysfunction caused by the complications of diabetes.
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e29362
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  4. Article ; Online: Advance Care Planning in South Korea.

    Kim, Yu Jung / Kim, Sun-Hyun

    Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen

    2023  Volume 180, Page(s) 68–73

    Abstract: South Korea is an Asian country with a very low birth rate and a large elderly population. Nearly half of deaths are in the elderly over the age of 80, and cancer is the leading cause of all deaths. As the aging population increases, interest in end-of- ... ...

    Abstract South Korea is an Asian country with a very low birth rate and a large elderly population. Nearly half of deaths are in the elderly over the age of 80, and cancer is the leading cause of all deaths. As the aging population increases, interest in end-of-life (EOL) care and quality of death is growing, but South Korea is one of the Asian countries that traditionally feels burdened by discussing death openly. In particular, even when a person is suffering from an incurable disease and is about to die, it is customary for the family members to make decisions without directly informing the patient of the disease status or discussing life-sustaining treatment (LST). However, due to a series of social events, the importance of individual autonomy, good death, discontinuation of LSTs, and advance care planning (ACP) gradually spread, and eventually the Life-Sustaining Treatment Decisions Act was implemented in 2018. With the enactment of this law, patients' autonomy was enhanced in a short period of time, and a legal basis was established to discontinue LST at the EOL. However, there are still many areas to be improved, and it is fundamentally necessary to spread the concept of 'ACP' within society.
    MeSH term(s) Humans ; Aged ; Patient Preference ; Germany ; Advance Care Planning ; Terminal Care ; Republic of Korea
    Language English
    Publishing date 2023-06-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2412512-X
    ISSN 2212-0289 ; 1865-9217
    ISSN (online) 2212-0289
    ISSN 1865-9217
    DOI 10.1016/j.zefq.2023.04.014
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.110: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Chaenomelin, a New Phenolic Glycoside, and Anti-

    Kim, Kyung Ah / Kang, Dong-Min / Ko, Yoon-Joo / Ra, Moon-Jin / Jung, Sang-Mi / Yu, Jeong-Nam / Ahn, Mi-Jeong / Kim, Ki Hyun

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 5

    Abstract: ... Salix ... ...

    Abstract Salix chaenomeloides
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13050701
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  6. Article ; Online: WD40-domain protein GORI is an integrative scaffold that is required for pollen tube growth in rice.

    Kim, Yu-Jin / Jung, Ki-Hong

    Plant signaling & behavior

    2022  Volume 18, Issue 1, Page(s) 2082678

    Abstract: The pollen tube plays a critical role in angiosperm plants by delivering sperm gametes for double fertilization. Although the molecular mechanisms underlying pollen tube germination and growth are crucial to crop plants, they are poorly understood. Here, ...

    Abstract The pollen tube plays a critical role in angiosperm plants by delivering sperm gametes for double fertilization. Although the molecular mechanisms underlying pollen tube germination and growth are crucial to crop plants, they are poorly understood. Here, we describe recent advancements in the understanding of the role of the WD40-domain protein in regulating pollen germination and discuss future directions to investigate its role in rice.
    MeSH term(s) Pollen Tube ; Oryza/genetics ; Oryza/metabolism ; Seeds/metabolism ; Arabidopsis Proteins/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Germination
    Chemical Substances Arabidopsis Proteins ; Plant Proteins
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1559-2324
    ISSN (online) 1559-2324
    DOI 10.1080/15592324.2022.2082678
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  7. Article ; Online: The Effects of

    Park, Su-Bin / Jung, Woo Kwon / Yu, Hwa Young / Kim, Junghyun

    Current issues in molecular biology

    2023  Volume 45, Issue 8, Page(s) 6583–6592

    Abstract: Hyperosmotic stress caused by tear hyposection is a leading cause of dry eye disease. We investigated the prevention of dry eye disease in corneal epithelial cells and in rats that were induced to develop dry eye disease via unilateral excision of their ... ...

    Abstract Hyperosmotic stress caused by tear hyposection is a leading cause of dry eye disease. We investigated the prevention of dry eye disease in corneal epithelial cells and in rats that were induced to develop dry eye disease via unilateral excision of their exorbital lacrimal gland using
    Language English
    Publishing date 2023-08-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45080415
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5122: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Delivery-mediated exosomal therapeutics in ischemia-reperfusion injury: advances, mechanisms, and future directions.

    Ding, Shengzhe / Kim, Yu-Jin / Huang, Kai-Yu / Um, Daniel / Jung, Youngmee / Kong, Hyunjoon

    Nano convergence

    2024  Volume 11, Issue 1, Page(s) 18

    Abstract: Ischemia-reperfusion injury (IRI) poses significant challenges across various organ systems, including the heart, brain, and kidneys. Exosomes have shown great potentials and applications in mitigating IRI-induced cell and tissue damage through ... ...

    Abstract Ischemia-reperfusion injury (IRI) poses significant challenges across various organ systems, including the heart, brain, and kidneys. Exosomes have shown great potentials and applications in mitigating IRI-induced cell and tissue damage through modulating inflammatory responses, enhancing angiogenesis, and promoting tissue repair. Despite these advances, a more systematic understanding of exosomes from different sources and their biotransport is critical for optimizing therapeutic efficacy and accelerating the clinical adoption of exosomes for IRI therapies. Therefore, this review article overviews the administration routes of exosomes from different sources, such as mesenchymal stem cells and other somatic cells, in the context of IRI treatment. Furthermore, this article covers how the delivered exosomes modulate molecular pathways of recipient cells, aiding in the prevention of cell death and the promotions of regeneration in IRI models. In the end, this article discusses the ongoing research efforts and propose future research directions of exosome-based therapies.
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2760386-6
    ISSN 2196-5404 ; 2196-5404
    ISSN (online) 2196-5404
    ISSN 2196-5404
    DOI 10.1186/s40580-024-00423-8
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  9. Article ; Online: Development of a Prediction Model for Delirium in Hospitalized Patients with Advanced Cancer.

    Jung, Eun Hee / Yoo, Shin Hye / Lee, Si Won / Kang, Beodeul / Kim, Yu Jung

    Cancer research and treatment

    2024  

    Abstract: Purpose: Delirium is a common neurocognitive disorder in patients with advanced cancer and is associated with poor clinical outcomes. As a potentially reversible phenomenon, early recognition of delirium by identifying the risk factors demands attention. ...

    Abstract Purpose: Delirium is a common neurocognitive disorder in patients with advanced cancer and is associated with poor clinical outcomes. As a potentially reversible phenomenon, early recognition of delirium by identifying the risk factors demands attention. To develop a model to predict the occurrence of delirium in hospitalized patients with advanced cancer.
    Materials and methods: This retrospective study included patients with advanced cancer admitted to the oncology ward of four tertiary cancer centers in Korea for supportive cares and excluded those discharged due to death. The primary endpoint was occurrence of delirium. Sociodemographic characteristics, clinical characteristics, laboratory findings, and concomitant medication were investigated for associating variables. The predictive model developed using multivariate logistic regression was internally validated by bootstrapping.
    Results: From January 2019 to December 2020, 2,152 patients were enrolled. The median age of patients was 64 years, and 58.4% were male. A total of 127 patients (5.9%) developed delirium during hospitalization. In multivariate logistic regression, age, body mass index, hearing impairment, previous delirium history, length of hospitalization, chemotherapy during hospitalization, blood urea nitrogen and calcium levels, and concomitant anti-depressant use were significantly associated with the occurrence of delirium. The predictive model combining all four categorized variables showed the best performance among the developed models (area under the curve 0.831, sensitivity 80.3%, and specificity 72.0%). The calibration plot showed optimal agreement between predicted and actual probabilities through internal validation of the final model.
    Conclusion: We proposed a successful predictive model for the risk of delirium in hospitalized patients with advanced cancer.
    Language English
    Publishing date 2024-02-26
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2133613-1
    ISSN 2005-9256 ; 1598-2998
    ISSN (online) 2005-9256
    ISSN 1598-2998
    DOI 10.4143/crt.2023.1243
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7043: Show issues Location:
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  10. Article ; Online: Inconsistency in steroid use as antiemetics in clinical trial protocols involving immune checkpoint inhibitors combined with chemotherapy.

    Park, Soh Mee / Kim, Yu Jung / Lee, Ju-Yeun

    Cancer medicine

    2024  Volume 13, Issue 7, Page(s) e7142

    Abstract: Objectives: This study aims to investigate the use of steroids as antiemetics in clinical trials involving immune checkpoint inhibitors with chemotherapy.: Methods: Focusing on phase III trials registered before August 2023, it evaluated the ... ...

    Abstract Objectives: This study aims to investigate the use of steroids as antiemetics in clinical trials involving immune checkpoint inhibitors with chemotherapy.
    Methods: Focusing on phase III trials registered before August 2023, it evaluated the consistency of steroid use guidelines.
    Results: Out of 3452 trials screened, 44 were selected for in-depth review. The findings indicate a considerable variation: 13 trials did not specify the use of antiemetics, while 31 provided criteria for antiemetics, with 13 conforming to local standards, six to international guidelines, and five allowing either. Seven trials recommended effective antiemetics without detailed criteria. This inconsistency led to a range of steroid dosages, with only 11 trials advocating for minimizing or avoiding steroids for antiemetic purposes.
    Conclusion: The research highlights the lack of uniformity in antiemetic steroid use in trials, reflecting diverse clinical practices and underscoring the need for further research to understand the implications on treatment outcomes.
    MeSH term(s) Humans ; Antiemetics/therapeutic use ; Immune Checkpoint Inhibitors/therapeutic use ; Treatment Outcome ; Steroids/therapeutic use ; Vomiting/chemically induced ; Vomiting/drug therapy ; Vomiting/prevention & control
    Chemical Substances Antiemetics ; Immune Checkpoint Inhibitors ; Steroids
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.7142
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