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Article ; Online: A molecular signature of lung-resident CD8

Suryadevara, Naveenchandra / Kumar, Amrendra / Ye, Xiang / Rogers, Meredith / Williams, John V / Wilson, John T / Karijolich, John / Joyce, Sebastian

Scientific reports

2022 Volume 12, Issue 1, Page(s) 19101

Abstract: Natural infection as well as vaccination with live or attenuated viruses elicit tissue resident, ... ...

Abstract	Natural infection as well as vaccination with live or attenuated viruses elicit tissue resident, CD8
MeSH term(s)	CD8-Positive T-Lymphocytes ; Immunologic Memory ; Vaccination ; Lung ; Vaccines, Subunit
Chemical Substances	Vaccines, Subunit
Language	English
Publishing date	2022-11-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-21620-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Real-time cell analysis: A high-throughput approach for testing SARS-CoV-2 antibody neutralization and escape.

Suryadevara, Naveenchandra / Gilchuk, Pavlo / Zost, Seth J / Mittal, Nikhil / Zhao, Li Leyna / Crowe, James E / Carnahan, Robert H

STAR protocols

2022 Volume 3, Issue 2, Page(s) 101387

Abstract: ... 2020) and Suryadevara et al. (2021). ...

Abstract	Real-time cell analysis (RTCA) enables high-throughput, quantitative kinetic measurements of cytopathic effect (CPE) in virus-infected cells. Here, we detail a RTCA approach for assessing antibody neutralization. We describe how to evaluate the neutralizing potency of monoclonal antibodies (mAbs) and identify viral escape mutants to antibody neutralization for severe respiratory syndrome coronavirus 2 (SARS-CoV-2). For complete details on the use and execution of this protocol, please refer to Zost et al. (2020) and Suryadevara et al. (2021).
MeSH term(s)	Antibodies, Monoclonal ; Antibodies, Viral ; COVID-19/diagnosis ; Humans ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-04-22
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	2666-1667
ISSN (online)	2666-1667
DOI	10.1016/j.xpro.2022.101387
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Real-time cell analysis

Naveenchandra Suryadevara / Pavlo Gilchuk / Seth J. Zost / Nikhil Mittal / Li Leyna Zhao / James E. Crowe, Jr. / Robert H. Carnahan

STAR Protocols, Vol 3, Iss 2, Pp 101387- (2022)

A high-throughput approach for testing SARS-CoV-2 antibody neutralization and escape

2022

Abstract: ... and Suryadevara et al. (2021). ...

Abstract	Summary: Real-time cell analysis (RTCA) enables high-throughput, quantitative kinetic measurements of cytopathic effect (CPE) in virus-infected cells. Here, we detail a RTCA approach for assessing antibody neutralization. We describe how to evaluate the neutralizing potency of monoclonal antibodies (mAbs) and identify viral escape mutants to antibody neutralization for severe respiratory syndrome coronavirus 2 (SARS-CoV-2).For complete details on the use and execution of this protocol, please refer to Zost et al. (2020) and Suryadevara et al. (2021).
Keywords	Cell-based Assays ; Health Sciences ; High Throughput Screening ; Immunology ; Microbiology ; Antibody ; Science (General) ; Q1-390
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode.

Wen, Xiaolin / Suryadevara, Naveenchandra / Kose, Nurgun / Liu, Jing / Zhan, Xiaoyan / Handal, Laura S / Williamson, Lauren E / Trivette, Andrew / Carnahan, Robert H / Jardetzky, Theodore S / Crowe, James E

Cell host & microbe

2023 Volume 31, Issue 8, Page(s) 1288–1300.e6

Abstract: Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) infections pose a significant health burden. Using pre-fusion conformation fusion (F) proteins, we isolated a panel of anti-F antibodies from a human donor. One antibody (RSV-199) ... ...

Abstract	Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) infections pose a significant health burden. Using pre-fusion conformation fusion (F) proteins, we isolated a panel of anti-F antibodies from a human donor. One antibody (RSV-199) potently cross-neutralized 8 RSV and hMPV strains by recognizing antigenic site III, which is partially conserved in RSV and hMPV F. Next, we determined the cryoelectron microscopy (cryo-EM) structures of RSV-199 bound to RSV F trimers, hMPV F monomers, and an unexpected dimeric form of hMPV F. These structures revealed how RSV-199 engages both RSV and hMPV F proteins through conserved interactions of the antibody heavy-chain variable region and how variability within heavy-chain complementarity-determining region 3 (HCDR3) can be accommodated at the F protein interface in site-III-directed antibodies. Furthermore, RSV-199 offered enhanced protection against RSV A and B strains and hMPV in cotton rats. These findings highlight the mechanisms of broad neutralization and therapeutic potential of RSV-199.
MeSH term(s)	Humans ; Metapneumovirus/metabolism ; Antibodies, Neutralizing ; Antibodies, Viral ; Cryoelectron Microscopy ; Respiratory Syncytial Virus, Human ; Immunoglobulin Variable Region ; Viral Fusion Proteins
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin Variable Region ; Viral Fusion Proteins
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2278004-X
ISSN	1934-6069 ; 1931-3128
ISSN (online)	1934-6069
ISSN	1931-3128
DOI	10.1016/j.chom.2023.07.002
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Article ; Online: A molecular signature of lung-resident CD8+ T cells elicited by subunit vaccination

Naveenchandra Suryadevara / Amrendra Kumar / Xiang Ye / Meredith Rogers / John V. Williams / John T. Wilson / John Karijolich / Sebastian Joyce

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 17

Abstract: Abstract Natural infection as well as vaccination with live or attenuated viruses elicit tissue resident, CD8+ memory T cell (Trm) response. Trm cells so elicited act quickly upon reencounter with the priming agent to protect the host. These Trm cells ... ...

Abstract	Abstract Natural infection as well as vaccination with live or attenuated viruses elicit tissue resident, CD8+ memory T cell (Trm) response. Trm cells so elicited act quickly upon reencounter with the priming agent to protect the host. These Trm cells express a unique molecular signature driven by the master regulators—Runx3 and Hobit. We previously reported that intranasal instillation of a subunit vaccine in a prime boost vaccination regimen installed quick-acting, CD8+ Trm cells in the lungs that protected against lethal vaccinia virus challenge. It remains unexplored whether CD8+ Trm responses so elicited are driven by a similar molecular signature as those elicited by microbes in a real infection or by live, attenuated pathogens in conventional vaccination. We found that distinct molecular signatures distinguished subunit vaccine-elicited lung interstitial CD8+ Trm cells from subunit vaccine-elicited CD8+ effector memory and splenic memory T cells. Nonetheless, the transcriptome signature of subunit vaccine elicited CD8+ Trm resembled those elicited by virus infection or vaccination. Clues to the basis of tissue residence and function of vaccine specific CD8+ Trm cells were found in transcripts that code for chemokines and chemokine receptors, purinergic receptors, and adhesins when compared to CD8+ effector and splenic memory T cells. Our findings inform the utility of protein-based subunit vaccination for installing CD8+ Trm cells in the lungs to protect against respiratory infectious diseases that plague humankind.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SARS-CoV-2 antibodies from children exhibit broad neutralization and belong to adult public clonotypes.

Wall, Steven C / Suryadevara, Naveenchandra / Kim, Changil / Shiakolas, Andrea R / Holt, Clinton M / Irbe, Emma B / Wasdin, Perry T / Suresh, Yukthi P / Binshtein, Elad / Chen, Elaine C / Zost, Seth J / Canfield, Elizabeth / Crowe, James E / Thompson-Arildsen, Mary Ann / Sheward, Daniel J / Carnahan, Robert H / Georgiev, Ivelin S

Cell reports. Medicine

2023 Volume 4, Issue 11, Page(s) 101267

Abstract: From the beginning of the COVID-19 pandemic, children have exhibited different susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, reinfection, and disease compared with adults. Motivated by the established ... ...

Abstract	From the beginning of the COVID-19 pandemic, children have exhibited different susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, reinfection, and disease compared with adults. Motivated by the established significance of SARS-CoV-2-neutralizing antibodies in adults, here we characterize SARS-CoV-2-specific antibody repertoires in a young cohort of individuals aged from 5 months to 18 years old. Our results show that neutralizing antibodies in children possess similar genetic features compared to antibodies identified in adults, with multiple antibodies from children belonging to previously established public antibody clonotypes in adults. Notably, antibodies from children show potent neutralization of circulating SARS-CoV-2 variants that have cumulatively resulted in resistance to virtually all approved monoclonal antibody therapeutics. Our results show that children can rely on similar SARS-CoV-2 antibody neutralization mechanisms compared to adults and are an underutilized source for the discovery of effective antibody therapeutics to counteract the ever-evolving pandemic.
MeSH term(s)	Humans ; Adult ; Child ; Pandemics ; SARS-CoV-2/genetics ; COVID-19 ; Antibodies, Viral ; Antibodies, Neutralizing/therapeutic use
Chemical Substances	Antibodies, Viral ; Antibodies, Neutralizing
Language	English
Publishing date	2023-11-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2023.101267
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Structural mapping of antibody landscapes to human betacoronavirus spike proteins.

Bangaru, Sandhya / Antanasijevic, Aleksandar / Kose, Nurgun / Sewall, Leigh M / Jackson, Abigail M / Suryadevara, Naveenchandra / Zhan, Xiaoyan / Torres, Jonathan L / Copps, Jeffrey / de la Peña, Alba Torrents / Crowe, James E / Ward, Andrew B

Science advances

2022 Volume 8, Issue 18, Page(s) eabn2911

Abstract: Preexisting immunity against seasonal coronaviruses (CoVs) represents an important variable in predicting antibody responses and disease severity to severe acute respiratory syndrome CoV-2 (SARS-CoV-2) infections. We used electron microscopy-based ... ...

Abstract	Preexisting immunity against seasonal coronaviruses (CoVs) represents an important variable in predicting antibody responses and disease severity to severe acute respiratory syndrome CoV-2 (SARS-CoV-2) infections. We used electron microscopy-based polyclonal epitope mapping (EMPEM) to characterize the antibody specificities against β-CoV spike proteins in prepandemic (PP) sera or SARS-CoV-2 convalescent (SC) sera. We observed that most PP sera had antibodies specific to seasonal human CoVs (HCoVs) OC43 and HKU1 spike proteins while the SC sera showed reactivity across all human β-CoVs. Detailed molecular mapping of spike-antibody complexes revealed epitopes that were differentially targeted by preexisting antibodies and SC serum antibodies. Our studies provide an antigenic landscape to β-HCoV spikes in the general population serving as a basis for cross-reactive epitope analyses in SARS-CoV-2-infected individuals.
MeSH term(s)	Antibodies, Viral ; COVID-19 ; Coronavirus OC43, Human ; Epitopes ; Humans ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
Chemical Substances	Antibodies, Viral ; Epitopes ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abn2911
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Discovery and Characterization of a Pan-betacoronavirus S2-binding antibody.

Johnson, Nicole V / Wall, Steven C / Kramer, Kevin J / Holt, Clinton M / Periasamy, Sivakumar / Richardson, Simone / Suryadevara, Naveenchandra / Andreano, Emanuele / Paciello, Ida / Pierleoni, Giulio / Piccini, Giulia / Huang, Ying / Ge, Pan / Allen, James D / Uno, Naoko / Shiakolas, Andrea R / Pilewski, Kelsey A / Nargi, Rachel S / Sutton, Rachel E /

Abu-Shmais, Alexandria A / Parks, Robert / Haynes, Barton F / Carnahan, Robert H / Crowe, James E / Montomoli, Emanuele / Rappuoli, Rino / Bukreyev, Alexander / Ross, Ted M / Sautto, Giuseppe A / McLellan, Jason S / Georgiev, Ivelin S

bioRxiv : the preprint server for biology

2024

Abstract: Three coronaviruses have spilled over from animal reservoirs into the human population and caused deadly epidemics or pandemics. The continued emergence of coronaviruses highlights the need for pan-coronavirus interventions for effective pandemic ... ...

Abstract	Three coronaviruses have spilled over from animal reservoirs into the human population and caused deadly epidemics or pandemics. The continued emergence of coronaviruses highlights the need for pan-coronavirus interventions for effective pandemic preparedness. Here, using LIBRA-seq, we report a panel of 50 coronavirus antibodies isolated from human B cells. Of these antibodies, 54043-5 was shown to bind the S2 subunit of spike proteins from alpha-, beta-, and deltacoronaviruses. A cryo-EM structure of 54043-5 bound to the pre-fusion S2 subunit of the SARS-CoV-2 spike defined an epitope at the apex of S2 that is highly conserved among betacoronaviruses. Although non-neutralizing, 54043-5 induced Fc-dependent antiviral responses, including ADCC and ADCP. In murine SARS-CoV-2 challenge studies, protection against disease was observed after introduction of Leu234Ala, Leu235Ala, and Pro329Gly (LALA-PG) substitutions in the Fc region of 54043-5. Together, these data provide new insights into the protective mechanisms of non-neutralizing antibodies and define a broadly conserved epitope within the S2 subunit.
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.15.575741
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Co-delivery of Peptide Neoantigens and Stimulator of Interferon Genes Agonists Enhances Response to Cancer Vaccines.

Shae, Daniel / Baljon, Jessalyn J / Wehbe, Mohamed / Christov, Plamen P / Becker, Kyle W / Kumar, Amrendra / Suryadevara, Naveenchandra / Carson, Carcia S / Palmer, Christian R / Knight, Frances C / Joyce, Sebastian / Wilson, John T

ACS nano

2020 Volume 14, Issue 8, Page(s) 9904–9916

Abstract: Cancer vaccines targeting patient-specific neoantigens have emerged as a promising strategy for improving responses to immune checkpoint blockade. However, neoantigenic peptides are poorly immunogenic and inept at stimulating ... ...

Abstract	Cancer vaccines targeting patient-specific neoantigens have emerged as a promising strategy for improving responses to immune checkpoint blockade. However, neoantigenic peptides are poorly immunogenic and inept at stimulating CD8
MeSH term(s)	Animals ; Antigens, Neoplasm ; Cancer Vaccines ; Humans ; Interferons ; Mice ; Neoplasms/drug therapy ; Peptides
Chemical Substances	Antigens, Neoplasm ; Cancer Vaccines ; Peptides ; Interferons (9008-11-1)
Language	English
Publishing date	2020-07-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.0c02765
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Natural Killer T Cells: An Ecological Evolutionary Developmental Biology Perspective.

Kumar, Amrendra / Suryadevara, Naveenchandra / Hill, Timothy M / Bezbradica, Jelena S / Van Kaer, Luc / Joyce, Sebastian

Frontiers in immunology

2017 Volume 8, Page(s) 1858

Abstract: Type I natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens presented by the MHC class I-like protein CD1d. Agonistic activation of NKT cells leads to rapid pro-inflammatory and immune modulatory cytokine and ... ...

Abstract	Type I natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens presented by the MHC class I-like protein CD1d. Agonistic activation of NKT cells leads to rapid pro-inflammatory and immune modulatory cytokine and chemokine responses. This property of NKT cells, in conjunction with their interactions with antigen-presenting cells, controls downstream innate and adaptive immune responses against cancers and infectious diseases, as well as in several inflammatory disorders. NKT cell properties are acquired during development in the thymus and by interactions with the host microbial consortium in the gut, the nature of which can be influenced by NKT cells. This latter property, together with the role of the host microbiota in cancer therapy, necessitates a new perspective. Hence, this review provides an initial approach to understanding NKT cells from an ecological evolutionary developmental biology (eco-evo-devo) perspective.
Language	English
Publishing date	2017
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2017.01858
Database	MEDical Literature Analysis and Retrieval System OnLINE

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