Article ; Online: Effectiveness of mRNA BNT162b2 and inactivated CoronaVac vaccines against severe COVID-19 outcomes among non-hospitalised children aged 1-3 years with SARS-CoV-2 Omicron infection.
International journal of antimicrobial agents
2024 Volume 63, Issue 3, Page(s) 107094
Abstract: Objectives: Clinical evidence on the effectiveness of COVID-19 vaccines for children aged 1-3 years is scarce. The effectiveness of COVID-19 vaccines was evaluated among non-hospitalised children aged 1-3 years with SARS-CoV-2 Omicron infection in Hong ... ...
| Abstract | Objectives: Clinical evidence on the effectiveness of COVID-19 vaccines for children aged 1-3 years is scarce. The effectiveness of COVID-19 vaccines was evaluated among non-hospitalised children aged 1-3 years with SARS-CoV-2 Omicron infection in Hong Kong. Methods: A retrospective cohort of all non-hospitalised children aged 1-3 years with confirmed SARS-CoV-2 infection between 4 August 2022 and 29 January 2023 in Hong Kong was analysed. Vaccinated group was defined as the recipients of one or more doses of CoronaVac or mRNA vaccine BNT162b2 (original, monovalent) at least 14 days prior to infection. Hazard ratios (HR) with 95% confidence intervals (95% CI) of study outcomes were estimated using Cox regression models. Effectiveness outcomes included 28-day all-cause mortality and COVID-19-related hospitalisation. Results: A total of 5552 vaccinated patients and 5552 propensity-score matched controls (unvaccinated patients) were included for analysis. The cumulative incidence of COVID-19-related hospitalisation over 28 days was 2.3% and 2.9% in the vaccinated and control groups, respectively. There were no deaths in both groups. COVID-19 vaccination was associated with a significant reduction in 28-day COVID-19-related hospitalisation risk (HR=0.785, 95% CI=0.626-0.985, P=0.037), particularly for children aged 3 years, those who had received two or more vaccine doses, and those who received CoronaVac as the last dose. Conclusion: COVID-19 vaccination is associated with a significantly lower risk of 28-day COVID-19-related hospitalisation among infected children aged 1-3 years, particularly those who had received two or more vaccine doses. This observation emphasises the importance of completing the full two-dose or three-dose series to optimise vaccine effectiveness. |
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| MeSH term(s) | Child ; Humans ; COVID-19 Vaccines ; BNT162 Vaccine ; COVID-19/prevention & control ; SARS-CoV-2/genetics ; Retrospective Studies ; RNA, Messenger ; Vaccines, Inactivated |
| Chemical Substances | sinovac COVID-19 vaccine ; COVID-19 Vaccines ; BNT162 Vaccine ; RNA, Messenger ; Vaccines, Inactivated |
| Language | English |
| Publishing date | 2024-01-23 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 1093977-5 |
| ISSN | 1872-7913 ; 0924-8579 |
| ISSN (online) | 1872-7913 |
| ISSN | 0924-8579 |
| DOI | 10.1016/j.ijantimicag.2024.107094 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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