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Article ; Online: Stability Analysis of Switched Linear Singular Systems with Unstable and Stable Modes.

Xiong, Jiandong / Wang, Yidian / Huo, Yanfang / Zhao, Hongpeng

2023 Volume 25, Issue 9

Abstract: In this paper, stability is studied for a class of switched singular systems containing both stable and unstable modes. By introducing a time-varying piecewise Lyapunov function (TVPLF) and a mode-dependent average dwell time (ADT) switching rule, the ... ...

Abstract	In this paper, stability is studied for a class of switched singular systems containing both stable and unstable modes. By introducing a time-varying piecewise Lyapunov function (TVPLF) and a mode-dependent average dwell time (ADT) switching rule, the computable sufficient conditions for system stability are derived. The time-varying piecewise Lyapunov functions are piecewise continuously differentiable on every mode (but may not be differentiable at the interpolating points of the dwell time). This Lyapunov function method is particularly advantageous in overcoming the limitations of traditional multiple Lyapunov function (MLF) methods, which may not have a feasible solution when dealing with switched systems containing only unstable modes. As such, the TVPLF offers greater flexibility in application. Compared with the conventional ADT switching rule, the mode-dependent ADT switching rule not only enables each mode to have its own ADT but also allows for its own switching strategy. Specifically, the stable mode adopts a slow switching strategy while the unstable mode adopts a fast one, thereby reducing the conservatism of the ADT switching rule. Furthermore, based on the stability analysis, the time-varying controllers are proposed to stabilize the switched singular system, which can be expressed as the sequential linear combination of a series of linear state feedback on each mode. The proposed controllers are continuous for each mode, which are different from the controllers designed through the traditional MLF and MDLF methods, where the controllers designed by traditional MLF are the time-invariant linear state feedback in each mode while the controllers designed by the MDLF are piecewise continuous for each mode.
Language	English
Publishing date	2023-09-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e25091300
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Stability Analysis of Switched Linear Singular Systems with Unstable and Stable Modes

Jiandong Xiong / Yidian Wang / Yanfang Huo / Hongpeng Zhao

Entropy, Vol 25, Iss 1300, p

2023 Volume 1300

Abstract	In this paper, stability is studied for a class of switched singular systems containing both stable and unstable modes. By introducing a time-varying piecewise Lyapunov function (TVPLF) and a mode-dependent average dwell time (ADT) switching rule, the computable sufficient conditions for system stability are derived. The time-varying piecewise Lyapunov functions are piecewise continuously differentiable on every mode (but may not be differentiable at the interpolating points of the dwell time). This Lyapunov function method is particularly advantageous in overcoming the limitations of traditional multiple Lyapunov function (MLF) methods, which may not have a feasible solution when dealing with switched systems containing only unstable modes. As such, the TVPLF offers greater flexibility in application. Compared with the conventional ADT switching rule, the mode-dependent ADT switching rule not only enables each mode to have its own ADT but also allows for its own switching strategy. Specifically, the stable mode adopts a slow switching strategy while the unstable mode adopts a fast one, thereby reducing the conservatism of the ADT switching rule. Furthermore, based on the stability analysis, the time-varying controllers are proposed to stabilize the switched singular system, which can be expressed as the sequential linear combination of a series of linear state feedback on each mode. The proposed controllers are continuous for each mode, which are different from the controllers designed through the traditional MLF and MDLF methods, where the controllers designed by traditional MLF are the time-invariant linear state feedback in each mode while the controllers designed by the MDLF are piecewise continuous for each mode.
Keywords	switched systems ; stability analysis ; singular systems ; time-varying piecewise Lyapunov function ; Science ; Q ; Astrophysics ; QB460-466 ; Physics ; QC1-999
Subject code	629
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Construction of catalase@hollow silica nanosphere: Catalase with immobilized but not rigid state for improving catalytic performances.

Du, Yingjie / Zhao, Lixue / Geng, Zixin / Huo, Zibei / Li, Huihui / Shen, Xuejian / Peng, Xiaogang / Yan, Renyi / Cui, Jiandong / Jia, Shiru

International journal of biological macromolecules

2024 Volume 263, Issue Pt 2, Page(s) 130381

Abstract: Enzyme immobilization usually make use of nanomaterials to hold up biocatalysis stability in various unamiable reaction conditions, but also lead large discount on enzyme activity. Thus, there are abundant researches focus on how to deal with the ... ...

Abstract	Enzyme immobilization usually make use of nanomaterials to hold up biocatalysis stability in various unamiable reaction conditions, but also lead large discount on enzyme activity. Thus, there are abundant researches focus on how to deal with the relation of enzyme molecules and supports. In this work, a new state of highly active enzymes has been established through facile and novel in situ immobilization and soft template removal method to construct enzyme contained hollow silica nanosphere (catalase@HSN) biocatalysts where enzymes in the cavity exhibit "immobilized but not rigid state". The obtained catalase@HSN was characterized by transmission electron microscopy, scanning electron microscopy and confocal laser scanning microscopy et al. Catalase@HSN exhibits excellent activity (about 80 % activity recovery rate) and stability suffers from extreme pH, temperature, and organic solvents. Moreover, the reusability and storage stability of catalase@HSN also are satisfactory. This proposed strategy provides a facile method for preparing biocatalysts under mild conditions, facilitating the applications of immobilized enzyme in the fields of real biocatalytic industry with high apparent activity and passable stability.
MeSH term(s)	Catalase/metabolism ; Silicon Dioxide/chemistry ; Nanospheres/chemistry ; Enzymes, Immobilized/chemistry ; Biocatalysis ; Enzyme Stability
Chemical Substances	Catalase (EC 1.11.1.6) ; Silicon Dioxide (7631-86-9) ; Enzymes, Immobilized
Language	English
Publishing date	2024-02-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.130381
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Article ; Online: Antigenic characterization of SARS-CoV-2 Omicron subvariants XBB.1.5, BQ.1, BQ.1.1, BF.7 and BA.2.75.2.

Zhu, Airu / Wei, Peilan / Man, Miao / Liu, Xuesong / Ji, Tianxing / Chen, Jiantao / Chen, Canjie / Huo, Jiandong / Wang, Yanqun / Zhao, Jincun

Signal transduction and targeted therapy

2023 Volume 8, Issue 1, Page(s) 125

MeSH term(s)	Humans ; COVID-19/genetics ; SARS-CoV-2/genetics
Language	English
Publishing date	2023-03-15
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2886872-9
ISSN	2059-3635 ; 2095-9907
ISSN (online)	2059-3635
ISSN	2095-9907
DOI	10.1038/s41392-023-01391-x
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Article ; Online: Production and Crystallization of Nanobodies in Complex with the Receptor Binding Domain of the SARS-CoV-2 Spike Protein.

Bas, Audrey Le / Mikolajek, Halina / Huo, Jiandong / Dormon, Joshua / Naismith, James H / Owens, Raymond J

Bio-protocol

2022 Volume 12, Issue 9, Page(s) e4406

Abstract: The receptor binding domain (RBD) of the spike protein of SARS-CoV-2 binds angiotensin converting enzyme-2 (ACE-2) on the surface of epithelial cells, leading to fusion, and entry of the virus into the cell. This interaction can be blocked by the binding ...

Abstract	The receptor binding domain (RBD) of the spike protein of SARS-CoV-2 binds angiotensin converting enzyme-2 (ACE-2) on the surface of epithelial cells, leading to fusion, and entry of the virus into the cell. This interaction can be blocked by the binding of llama-derived nanobodies (VHHs) to the RBD, leading to virus neutralisation. Structural analysis of VHH-RBD complexes by X-ray crystallography enables VHH epitopes to be precisely mapped, and the effect of variant mutations to be interpreted and predicted. Key to this is a protocol for the reproducible production and crystallization of the VHH-RBD complexes. Based on our experience, we describe a workflow for expressing and purifying the proteins, and the screening conditions for generating diffraction quality crystals of VHH-RBD complexes. Production and crystallization of protein complexes takes approximately twelve days, from construction of vectors to harvesting and freezing crystals for data collection.
Language	English
Publishing date	2022-05-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2833269-6
ISSN	2331-8325 ; 2331-8325
ISSN (online)	2331-8325
ISSN	2331-8325
DOI	10.21769/BioProtoc.4406
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Article: Humoral responses against SARS-CoV-2 Omicron BA.2.11, BA.2.12.1 and BA.2.13 from vaccine and BA.1 serum.

Huo, Jiandong / Dijokaite-Guraliuc, Aiste / Nutalai, Rungtiwa / Das, Raksha / Zhou, Daming / Mentzer, Alexander J / Fry, Elizabeth E / Mongkolsapaya, Juthathip / Ren, Jingshan / Stuart, David I / Screaton, Gavin R

Cell discovery

2022 Volume 8, Issue 1, Page(s) 119

Language	English
Publishing date	2022-11-01
Publishing country	England
Document type	Letter
ISSN	2056-5968
ISSN	2056-5968
DOI	10.1038/s41421-022-00482-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of Chinese wolfberry and Astragalus extract on the antioxidant capacity of Tibetan pig liver.

Hao, Zhuang / Li, Zhen / Huo, Jinjin / Li, Jiandong / Liu, Fenghua / Yin, Peng

PloS one

2021 Volume 16, Issue 1, Page(s) e0245749

Abstract: The objective of this study is to determine the effect of Chinese wolfberry (Lycium barbarum) and Astragalus (Astragalus membranaceus) extract (WAE) on the antioxidant capacity of Tibetan pig liver, and discussed the regulatory effect of WAE on the liver ...

Abstract	The objective of this study is to determine the effect of Chinese wolfberry (Lycium barbarum) and Astragalus (Astragalus membranaceus) extract (WAE) on the antioxidant capacity of Tibetan pig liver, and discussed the regulatory effect of WAE on the liver antioxidant mechanism. Twelve healthy 120-day-old Tibetan black pigs (35±2 kg) were divided randomly into two groups. The WAE group was fed a basal diet supplemented with 1% WAE for 90 days. The control group was fed the same diet, but without the WAE. We found that liver superoxide dismutase 1 (SOD1) activity (P<0.05), total antioxidative capacity (T-AOC) (P<0.05), and catalase (CAT) activity (P<0.01) significantly increased in the WAE group compared with the control group; malondialdehyde (MDA) content decreased, but this was not significant (P >0.05). Transcriptome sequencing analysis detected 106 differentially expressed genes (DEGs) related to oxidative stress. GO enrichment analysis showed these DEGs were involved in the positive regulation of reactive oxygen metabolism and biosynthesis, process regulation, and regulation of the oxidative stress response. KEGG Pathway enrichment analysis showed they were enriched in the PI3K-Akt, AMPK, Rap1, and peroxisome signaling pathways. The expression levels of key peroxisome biosynthesis genes (e.g., PEX3 and PEX11B) and key antioxidant genes (e.g., CAT and SOD1) were significantly higher in the WAE group than in the control group. The PRDX1 and PRDX5 content also was significantly higher in the WAE group. This study showed that the WAE regulated the antioxidant and anti-stress ability of Tibetan pig liver through a "peroxisome antioxidant-oxidant stress" signaling pathway.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Astragalus Plant/chemistry ; Liver/drug effects ; Liver/metabolism ; Lycium/chemistry ; Peroxins/genetics ; Peroxins/metabolism ; Peroxisomes/metabolism ; Plant Extracts/pharmacology ; Signal Transduction ; Swine
Chemical Substances	Antioxidants ; Peroxins ; Plant Extracts
Language	English
Publishing date	2021-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0245749
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of Chinese wolfberry and Astragalus extract on the antioxidant capacity of Tibetan pig liver.

Zhuang Hao / Zhen Li / Jinjin Huo / Jiandong Li / Fenghua Liu / Peng Yin

PLoS ONE, Vol 16, Iss 1, p e

2021 Volume 0245749

Abstract	The objective of this study is to determine the effect of Chinese wolfberry (Lycium barbarum) and Astragalus (Astragalus membranaceus) extract (WAE) on the antioxidant capacity of Tibetan pig liver, and discussed the regulatory effect of WAE on the liver antioxidant mechanism. Twelve healthy 120-day-old Tibetan black pigs (35±2 kg) were divided randomly into two groups. The WAE group was fed a basal diet supplemented with 1% WAE for 90 days. The control group was fed the same diet, but without the WAE. We found that liver superoxide dismutase 1 (SOD1) activity (P<0.05), total antioxidative capacity (T-AOC) (P<0.05), and catalase (CAT) activity (P<0.01) significantly increased in the WAE group compared with the control group; malondialdehyde (MDA) content decreased, but this was not significant (P >0.05). Transcriptome sequencing analysis detected 106 differentially expressed genes (DEGs) related to oxidative stress. GO enrichment analysis showed these DEGs were involved in the positive regulation of reactive oxygen metabolism and biosynthesis, process regulation, and regulation of the oxidative stress response. KEGG Pathway enrichment analysis showed they were enriched in the PI3K-Akt, AMPK, Rap1, and peroxisome signaling pathways. The expression levels of key peroxisome biosynthesis genes (e.g., PEX3 and PEX11B) and key antioxidant genes (e.g., CAT and SOD1) were significantly higher in the WAE group than in the control group. The PRDX1 and PRDX5 content also was significantly higher in the WAE group. This study showed that the WAE regulated the antioxidant and anti-stress ability of Tibetan pig liver through a "peroxisome antioxidant-oxidant stress" signaling pathway.
Keywords	Medicine ; R ; Science ; Q
Subject code	630
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Antigenic characterization of SARS-CoV-2 Omicron subvariant BA.4.6.

Dijokaite-Guraliuc, Aiste / Das, Raksha / Nutalai, Rungtiwa / Zhou, Daming / Mentzer, Alexander J / Liu, Chang / Supasa, Piyada / Dunachie, Susanna J / Lambe, Teresa / Fry, Elizabeth E / Mongkolsapaya, Juthathip / Ren, Jingshan / Huo, Jiandong / Stuart, David I / Screaton, Gavin R

Cell discovery

2022 Volume 8, Issue 1, Page(s) 127

Language	English
Publishing date	2022-11-29
Publishing country	England
Document type	Letter
ISSN	2056-5968
ISSN	2056-5968
DOI	10.1038/s41421-022-00493-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of Chinese wolfberry and astragalus extracts on growth performance, pork quality, and unsaturated fatty acid metabolism regulation in Tibetan fragrant pigs.

Hao, Zhuang / Li, Zhen / Huo, Jinjin / Chu, Yaocheng / Li, Jiandong / Yu, Xiaohong / Liu, Fenghua / Yin, Peng

Animal science journal = Nihon chikusan Gakkaiho

2021 Volume 92, Issue 1, Page(s) e13581

Abstract: We studied the effects of wolfberry and astragalus extract on the growth performance, carcass traits, and meat quality of Tibetan fragrant pigs, and we want to explain the mechanism of the difference from the level of RNA Seq. Twelve healthy 120-day-old ... ...

Abstract	We studied the effects of wolfberry and astragalus extract on the growth performance, carcass traits, and meat quality of Tibetan fragrant pigs, and we want to explain the mechanism of the difference from the level of RNA Seq. Twelve healthy 120-day-old Tibetan fragrant pigs weighing 35 ± 2 kg were divided randomly into two groups, each with six pigs. The control group was fed a basal diet, and the wolfberry and astragalus extract (WAE) group was fed a basal diet +1‰ of WAE. The experimental period was 90 days. Compared with the control group, the growth performance of the WAE group was significantly improved (p < .05), pork marble score significantly improved (p < .05), vitamin E content significantly increased (p < .05), unsaturated fatty acid content significantly increased (p < .05). A total of 256 differentially expressed genes were obtained by transcriptome sequencing, among which 114 were up-regulated and 142 were down-regulated. GO analysis showed that the differentially expressed genes were related to biological functions, such as monounsaturated fatty acid biosynthesis, fatty acid metabolism, lipoprotein decomposition, and lipase activity. Pathway analysis showed that these differentially expressed genes were mainly involved in unsaturated fatty acid biosynthesis regulation, glycerin metabolism, and lipopolysaccharide regulation in fat. WAE improved Tibetan fragrant pigs growth performance. By intervening in key genes related to fatty acid metabolism, the unsaturated fatty acid contents in pork were regulated, which improved the nutritional value of the pork.
MeSH term(s)	Animal Feed/analysis ; Animals ; Astragalus Plant ; Body Composition ; Diet/veterinary ; Fatty Acids, Unsaturated ; Lycium ; Meat/analysis ; Plant Extracts ; Pork Meat ; Red Meat ; Swine/genetics ; Tibet
Chemical Substances	Fatty Acids, Unsaturated ; Plant Extracts
Language	English
Publishing date	2021-07-07
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2095161-9
ISSN	1740-0929 ; 1344-3941
ISSN (online)	1740-0929
ISSN	1344-3941
DOI	10.1111/asj.13581
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