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  1. Article ; Online: Infectious Complications of Immune Checkpoint Inhibitors.

    Abers, Michael S / Lionakis, Michail S

    Infectious disease clinics of North America

    2020  Volume 34, Issue 2, Page(s) 235–243

    Abstract: The clearance of both tumors and microbes depends on highly coordinated immune responses that are sufficiently potent to kill malignant or microbial cells while avoiding immunopathology from an overly exuberant inflammatory response. A molecular ... ...

    Abstract The clearance of both tumors and microbes depends on highly coordinated immune responses that are sufficiently potent to kill malignant or microbial cells while avoiding immunopathology from an overly exuberant inflammatory response. A molecular understanding of the immune pathways that regulate these responses paved the way for the development of checkpoint inhibitors (CPIs) as a therapeutic strategy to boost endogenous antitumor immunity. CPIs have demonstrated survival benefits across a wide spectrum of cancers. While infectious complications of CPIs are uncommon, immune-related adverse events occur frequently and often require immunosuppressive therapies that increase the risk of infection.
    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immune Checkpoint Inhibitors/therapeutic use ; Infection Control ; Infections/chemically induced ; Infections/epidemiology ; Neoplasms/drug therapy ; Neoplasms/immunology ; Risk Factors ; Signal Transduction/drug effects ; Tumor Microenvironment
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 1077676-x
    ISSN 1557-9824 ; 0891-5520
    ISSN (online) 1557-9824
    ISSN 0891-5520
    DOI 10.1016/j.idc.2020.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Procalcitonin as a Marker of Etiology in Community-Acquired Pneumonia.

    Abers, Michael S / Musher, Daniel M

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2018  Volume 66, Issue 10, Page(s) 1639

    MeSH term(s) Adult ; Community-Acquired Infections ; Humans ; Pneumonia ; Procalcitonin
    Chemical Substances Procalcitonin
    Language English
    Publishing date 2018-01-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/cix1089
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  3. Article ; Online: Checkpoint Inhibition and Infectious Diseases: A Good Thing?

    Abers, Michael S / Lionakis, Michail S / Kontoyiannis, Dimitrios P

    Trends in molecular medicine

    2019  Volume 25, Issue 12, Page(s) 1080–1093

    Abstract: The mammalian immune system has evolved the capacity to detect and destroy tumor cells. Tumors utilize multiple strategies to evade host immune surveillance, including the induction of the checkpoint molecules cytotoxic T lymphocyte-associated protein 4 ( ...

    Abstract The mammalian immune system has evolved the capacity to detect and destroy tumor cells. Tumors utilize multiple strategies to evade host immune surveillance, including the induction of the checkpoint molecules cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) to suppress antitumor immunity. Pharmacologic blockade of these molecules with checkpoint inhibitors (CPIs) restores T cell function and prolongs survival in patients with various malignancies. Emerging evidence suggests that the same checkpoint pathways may play a crucial role during infections. Indeed, CPIs appear promising as immunotherapeutic agents in infectious diseases, although their efficacy varies depending on pathogen-, cell-, and organ-specific factors. More research will be necessary to clarify the effects and safety of CPIs on clinically relevant outcomes of human infection.
    MeSH term(s) Animals ; Bacterial Infections/immunology ; Bacterial Infections/therapy ; CTLA-4 Antigen/immunology ; Humans ; Immunotherapy/methods ; Mycoses/immunology ; Mycoses/therapy ; Parasitic Diseases/immunology ; Parasitic Diseases/therapy ; Programmed Cell Death 1 Receptor/immunology ; T-Lymphocytes/immunology ; Virus Diseases/immunology ; Virus Diseases/therapy
    Chemical Substances CTLA-4 Antigen ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2019-09-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2019.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reply to Horowitz.

    Musher, Daniel M / Abers, Michael S / Bartlett, John G

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2018  Volume 67, Issue 3, Page(s) 482

    MeSH term(s) Humans ; Pneumonia ; Streptococcus pneumoniae
    Language English
    Publishing date 2018-02-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciy124
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  5. Article ; Online: Acute Infection and Myocardial Infarction. Reply.

    Musher, Daniel M / Abers, Michael S / Corrales-Medina, Vicente F

    The New England journal of medicine

    2019  Volume 380, Issue 15, Page(s) e21

    MeSH term(s) Humans ; Infections ; Myocardial Infarction
    Language English
    Publishing date 2019-03-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1901647
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  6. Article ; Online: Community-Acquired Pneumonia Requiring Hospitalization.

    Musher, Daniel M / Abers, Michael S

    The New England journal of medicine

    2015  Volume 373, Issue 24, Page(s) 2381

    MeSH term(s) Female ; Hospitalization/statistics & numerical data ; Humans ; Male ; Pneumonia/epidemiology
    Language English
    Publishing date 2015-12-10
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1511751#SA3
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  7. Article ; Online: Acute Infection and Myocardial Infarction.

    Musher, Daniel M / Abers, Michael S / Corrales-Medina, Vicente F

    The New England journal of medicine

    2019  Volume 380, Issue 2, Page(s) 171–176

    MeSH term(s) Acute Disease ; Humans ; Infection/complications ; Infection/pathology ; Infection/physiopathology ; Influenza Vaccines ; Myocardial Infarction/etiology ; Myocardial Infarction/prevention & control ; Myocardium/pathology ; Risk Factors ; Troponin/blood
    Chemical Substances Influenza Vaccines ; Troponin
    Language English
    Publishing date 2019-01-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra1808137
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  8. Article ; Online: Management and outcome of COVID-19 in CTLA-4 insufficiency.

    Ochoa, Sebastian / Abers, Michael S / Rosen, Lindsey B / Rump, Amy / Howe, Katherine / Lieberman, Jay A / Wright, Benjamin L / Suez, Daniel / Krausz, Máté / Grimbacher, Bodo / Lionakis, Michail S / Uzel, Gulbu

    Blood advances

    2023  Volume 7, Issue 19, Page(s) 5743–5751

    Abstract: ... CoV-2, with no severe vaccine-related adverse effects. Although median anti-S titers following ...

    Abstract Despite the high incidence of COVID-19 worldwide, clinical experience with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in inborn errors of immunity remains limited. Recent studies have shown that patients with defects in type 1 interferon (IFN)-related pathways or those with autoantibodies against type 1 IFNs develop severe COVID-19. We reported the clinical course of 22 patients with CTLA-4 insufficiency and COVID-19 and retrospectively examined autoantibodies against type 1 IFNs at baseline. Data were obtained from the patient interviews and chart reviews. Screening for anti-IFN autoantibodies was performed using a multiplex particle-based assay. Student t test, Mann Whitney, analysis of variance, or χ2 tests were used where appropriate. Twenty-two patients aged from 8 months to 54 years, with genetically confirmed CLTA-4 insufficiency, developed COVID-19 from 2020 to 2022. The most common symptoms were fever, cough, and nasal congestion, and the median duration of illness was 7.5 days. Twenty patients (91%) developed mild COVID-19 and were treated as outpatients. Two patients were hospitalized because of COVID-19 pneumonia but did not require mechanical ventilation. Ten (45%) patients were vaccinated at the time of their first COVID-19 infection. Eleven patients received outpatient treatment with monoclonal antibodies against the SARS-CoV-2 spike protein. During the study period, 17 patients were vaccinated against SARS-CoV-2, with no severe vaccine-related adverse effects. Although median anti-S titers following vaccination or infection were lower in patients receiving immunoglobulin replacement therapy (IGRT) (349 IU/dL) than in those not receiving IGRT (2594 IU/dL; P = .15); 3 of 9 patients on IGRT developed titers >2000 IU/dL. All patients tested negative for autoantibodies against IFN-α, IFN-β, and IFN-ω at baseline. Most patients with CTLA-4 insufficiency and COVID-19 had nonsevere disease, lacked autoantibodies against type 1 IFNs, and tolerated messenger RNA vaccines with few adverse effects. Whether our findings can be extrapolated to patients receiving CTLA-4-targeting checkpoint inhibitors requires further studies.
    MeSH term(s) Humans ; Autoantibodies ; COVID-19 ; CTLA-4 Antigen ; Retrospective Studies ; SARS-CoV-2
    Chemical Substances Autoantibodies ; CTLA-4 Antigen ; spike protein, SARS-CoV-2 ; CTLA4 protein, human
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023010105
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  9. Article ; Online: The yield of sputum culture in bacteremic pneumococcal pneumonia after initiation of antibiotics.

    Abers, Michael S / Musher, Daniel M

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2014  Volume 58, Issue 12, Page(s) 1782–1783

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Gentian Violet ; Humans ; Phenazines ; Pneumonia, Pneumococcal/drug therapy ; Pneumonia, Pneumococcal/microbiology ; Sputum/microbiology ; Streptococcus pneumoniae/isolation & purification ; Time Factors
    Chemical Substances Anti-Bacterial Agents ; Gram's stain ; Phenazines ; Gentian Violet (J4Z741D6O5)
    Language English
    Publishing date 2014-06
    Publishing country United States
    Document type Letter
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciu140
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  10. Article ; Online: Evolving Understanding of the Causes of Pneumonia in Adults, With Special Attention to the Role of Pneumococcus.

    Musher, Daniel M / Abers, Michael S / Bartlett, John G

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2017  Volume 65, Issue 10, Page(s) 1736–1744

    Abstract: Before 1945, Streptococcus pneumoniae caused more than 90% of cases of pneumonia in adults. After 1950, the proportion of pneumonia caused by pneumococcus began to decline. Pneumococcus has continued to decline; at present, this organism is identified in ...

    Abstract Before 1945, Streptococcus pneumoniae caused more than 90% of cases of pneumonia in adults. After 1950, the proportion of pneumonia caused by pneumococcus began to decline. Pneumococcus has continued to decline; at present, this organism is identified in fewer than fewer10%-15% of cases. This proportion is higher in Europe, a finding likely related to differences in vaccination practices and smoking. Gram-negative bacilli, Staphylococcus aureus, Chlamydia, Mycoplasma, and Legionella are each identified in 2%-5% of patients with pneumonia who require hospitalization. Viruses are found in 25% of patients, up to one-third of these have bacterial coinfection. Recent studies fail to identify a causative organism in more than 50% of cases, which remains the most important challenge to understanding lower respiratory infection. Our findings have important implications for antibiotic stewardship and should be considered as new policies for empiric pneumonia management are developed.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; Community-Acquired Infections ; Humans ; Pneumonia/drug therapy ; Pneumonia/epidemiology ; Pneumonia/microbiology ; Pneumonia/virology ; Pneumonia, Pneumococcal ; Streptococcus pneumoniae
    Chemical Substances Anti-Bacterial Agents
    Keywords covid19
    Language English
    Publishing date 2017-10-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/cix549
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