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Article: Environmental enrichment promotes resilience to neuropathic pain-induced depression and correlates with decreased excitability of the anterior cingulate cortex.

Falkowska, Marta / Ntamati, Niels R / Nevian, Natalie E / Nevian, Thomas / Acuña, Mario A

2023 Volume 17, Page(s) 1139205

Abstract: Depression is a common comorbidity of chronic pain with many patients being affected. However, efficient pharmacological treatment strategies are still lacking. Therefore, it is desirable to find additional alternative approaches. Environmental ... ...

Abstract	Depression is a common comorbidity of chronic pain with many patients being affected. However, efficient pharmacological treatment strategies are still lacking. Therefore, it is desirable to find additional alternative approaches. Environmental enrichment has been suggested as a method to alleviate pain-induced depression. However, the neuronal mechanisms of its beneficial effects are still elusive. The anterior cingulate cortex (ACC) plays a central role in processing pain-related negative affect and chronic pain-induced plasticity in this region correlates with depressive symptoms. We studied the consequences of different durations of environmental enrichment on pain sensitivity and chronic pain-induced depression-like behaviors in a mouse model of neuropathic pain. Furthermore, we correlated the behavioral outcomes to the activity levels of pyramidal neurons in the ACC by analyzing their electrophysiological properties
Language	English
Publishing date	2023-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452960-6
ISSN	1662-5153
ISSN	1662-5153
DOI	10.3389/fnbeh.2023.1139205
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Article ; Online: Principles of nociceptive coding in the anterior cingulate cortex.

Acuña, Mario A / Kasanetz, Fernando / De Luna, Paolo / Falkowska, Marta / Nevian, Thomas

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 23, Page(s) e2212394120

Abstract: The perception of pain is a multidimensional sensory and emotional/affective experience arising from distributed brain activity. However, the involved brain regions are not specific for pain. Thus, how the cortex distinguishes nociception from other ... ...

Abstract	The perception of pain is a multidimensional sensory and emotional/affective experience arising from distributed brain activity. However, the involved brain regions are not specific for pain. Thus, how the cortex distinguishes nociception from other aversive and salient sensory stimuli remains elusive. Additionally, the resulting consequences of chronic neuropathic pain on sensory processing have not been characterized. Using in vivo miniscope calcium imaging with cellular resolution in freely moving mice, we elucidated the principles of nociceptive and sensory coding in the anterior cingulate cortex, a region essential for pain processing. We found that population activity, not single-cell responses, allowed discriminating noxious from other sensory stimuli, ruling out the existence of nociception-specific neurons. Additionally, single-cell stimulus selectivity was highly dynamic over time, but stimulus representation at the population level remained stable. Peripheral nerve injury-induced chronic neuropathic pain led to dysfunctional encoding of sensory events by exacerbation of responses to innocuous stimuli and impairment of pattern separation and stimulus classification, which were restored by analgesic treatment. These findings provide a novel interpretation for altered cortical sensory processing in chronic neuropathic pain and give insights into the effects of systemic analgesic treatment in the cortex.
MeSH term(s)	Humans ; Mice ; Animals ; Gyrus Cinguli/diagnostic imaging ; Nociception/physiology ; Neuralgia ; Brain ; Nociceptors
Language	English
Publishing date	2023-05-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2212394120
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Article ; Online: Could biotransport be an important pathway in the transfer of phenol derivatives into the coastal zone and aquatic system of the Southern Baltic?

Staniszewska, Marta / Nehring, Iga / Falkowska, Lucyna / Bodziach, Karina

Environmental pollution (Barking, Essex : 1987)

2020 Volume 262, Page(s) 114358

Abstract: Bird guano and the faeces of marine mammals appear to be a significant yet undisclosed biotransporter of Endocrine Disrupting Compounds in the marine environment. The authors determined the concentration of bisphenol A (BPA), 4-tert-octylphenol (4-t-OP) ... ...

Abstract	Bird guano and the faeces of marine mammals appear to be a significant yet undisclosed biotransporter of Endocrine Disrupting Compounds in the marine environment. The authors determined the concentration of bisphenol A (BPA), 4-tert-octylphenol (4-t-OP) and 4-nonylphenol (4-NP) removed from birds and seals in their droppings into the coastal zone of the Gulf of Gdansk (Southern Baltic Sea).The research was carried out on samples of bird guano collected during the breeding season and after in 2016 at nesting sites, as well as on faecal samples from grey seals (Halichoerus grypus grypus) living in the Seal Centre of the Marine Station in Hel between 2014 and 2018. Measurements were carried out using high performance chromatography with fluorescence detector. Results have shown that the presence of seabird habitats and grey seal colonies in the coastal zone of the Gulf of Gdansk can have an impact on the pollution of the seashore (beach sand, bottom sediment and surface seawater) with phenol derivatives. The concentrations of BPA, 4-t-OP and 4-NP ranged from 0.1 to 32.97 ng∙g
MeSH term(s)	Animals ; Baltic States ; Ecosystem ; Environmental Monitoring ; Phenol ; Phenols/analysis ; Water Pollutants, Chemical/analysis
Chemical Substances	Phenols ; Water Pollutants, Chemical ; Phenol (339NCG44TV)
Language	English
Publishing date	2020-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2020.114358
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Zs.A 2599: Show issues

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Article: Analytical methods for determination of bisphenol A, 4-

Staniszewska, Marta / Nehring, Iga / Falkowska, Lucyna / Bodziach, Karina

MethodsX

2018 Volume 5, Page(s) 1124–1128

Abstract: The aim of this work was to develop the methods of determination for phenol derivatives: bisphenol A (BPA), 4- ...

Abstract	•The aim of this work was to develop the methods of determination for phenol derivatives: bisphenol A (BPA), 4-
Language	English
Publishing date	2018-09-21
Publishing country	Netherlands
Document type	Journal Article
ISSN	2215-0161
ISSN	2215-0161
DOI	10.1016/j.mex.2018.09.007
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Article ; Online: Distribution paths of endocrine disrupting phenolic compounds in waterbirds (Mergus merganser, Alca torda, Clangula hyemalis) from the Southern Baltic.

Bodziach, Karina / Staniszewska, Marta / Falkowska, Lucyna / Nehring, Iga / Ożarowska, Agnieszka / Zaniewicz, Grzegorz / Meissner, Włodzimierz

The Science of the total environment

2021 Volume 793, Page(s) 148556

Abstract: This study determined the distribution of phenol derivatives in the organisms of waterbirds and the factors influencing their bioaccumulation and affinity to specific tissues. Concentrations of bisphenol A (BPA), 4-tert-octylphenol (4-t-OP) and 4- ... ...

Abstract	This study determined the distribution of phenol derivatives in the organisms of waterbirds and the factors influencing their bioaccumulation and affinity to specific tissues. Concentrations of bisphenol A (BPA), 4-tert-octylphenol (4-t-OP) and 4-nonylphenol (4-NP) were determined in the brains, subcutaneous fat, kidneys, livers and pectoral muscles of goosanders Mergus merganser (GO), long-tailed ducks Clangula hyemalis (LO) and razorbills Alca torda (RA). The birds came from the winter by-catch (2014-2016) in the Southern Baltic. Different distribution routes of individual phenol derivatives in the birds were established, most likely due to their ability to bind to proteins and/or dissolve in lipids. BPA and 4-NP accumulated most in the muscles (BPA <2.0-223.0 ng
MeSH term(s)	Animals ; Benzhydryl Compounds/analysis ; Ducks ; Endocrine Disruptors/analysis ; Environmental Monitoring ; Phenols/analysis ; Water Pollutants, Chemical/analysis
Chemical Substances	Benzhydryl Compounds ; Endocrine Disruptors ; Phenols ; Water Pollutants, Chemical
Language	English
Publishing date	2021-06-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2021.148556
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Zs.A 949: Show issues

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Article ; Online: Osteopetrosis as a rare cause of anaemia in paediatric patients

Anna Fałkowska / Janina Marta Choma / Dominik Grabowski / Katarzyna Drabko

Pediatria i Medycyna Rodzinna, Vol 15, Iss 3, Pp 312-

a case report

2019 Volume 315

Abstract: Anaemia is a common manifestation in paediatric patients. The most common cause of anaemia is iron deficiency. In differential diagnosis not only the most common diseases resulting in haemoglobin decrease should be considered, but also those less common. ...

Abstract	Anaemia is a common manifestation in paediatric patients. The most common cause of anaemia is iron deficiency. In differential diagnosis not only the most common diseases resulting in haemoglobin decrease should be considered, but also those less common. In an outpatient care physician’s practice, interview, physical examination and routine periodic preventative examinations play a very important role. They make it possible to detect chronic diseases, including congenital metabolic diseases. These include osteopetrosis, which manifests with impaired haematopoiesis. Osteopetrosis also causes stunted growth, bone deformation and neurological disorders. We present the case of a boy with diagnosed osteopetrosis, in whom anaemia was the first manifestation of the disease.
Keywords	anaemia ; haematopoiesis ; osteopetrosis ; albers-schönberg disease ; marble bone disease ; Medicine ; R
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	Medical Communications Sp. z o.o.
Document type	Article ; Online
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Article ; Online: Gastrointestinal and respiratory exposure of water birds to endocrine disrupting phenolic compounds.

Bodziach, Karina / Staniszewska, Marta / Falkowska, Lucyna / Nehring, Iga / Ożarowska, Agnieszka / Zaniewicz, Grzegorz / Meissner, Włodzimierz

The Science of the total environment

2020 Volume 754, Page(s) 142435

Abstract: Aquatic birds found at the top of the trophic chain are exposed to xenobiotics present both in food and inhaled air. The aim of this study was to indicate and assess the routes and levels of exposure of aquatic birds to bisphenol A (BPA), 4-tert- ... ...

Abstract	Aquatic birds found at the top of the trophic chain are exposed to xenobiotics present both in food and inhaled air. The aim of this study was to indicate and assess the routes and levels of exposure of aquatic birds to bisphenol A (BPA), 4-tert-octylphenol (4-t-OP) and 4-nonylphenol (4-NP). The birds constituting the study material (Clangula hyemalis, Alca torda, Mergus merganser) originated from by-catches (winter 2014-2016) in the Southern Baltic. The studies show that the exposure of birds to phenol derivatives is determined by the specifics of a compound, the habitat area, trophic level and food consumed. BPA was characterized by the highest intestinal concentrations in all birds (6.6-1176.2 ng
MeSH term(s)	Animals ; Benzhydryl Compounds ; Birds ; Endocrine Disruptors/toxicity ; Environmental Monitoring ; Phenol ; Phenols/toxicity ; Water ; Water Pollutants, Chemical/toxicity
Chemical Substances	Benzhydryl Compounds ; Endocrine Disruptors ; Phenols ; Water Pollutants, Chemical ; Water (059QF0KO0R) ; Phenol (339NCG44TV)
Language	English
Publishing date	2020-09-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2020.142435
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Article: Could biotransport be an important pathway in the transfer of phenol derivatives into the coastal zone and aquatic system of the Southern Baltic?

Staniszewska, Marta / Nehring, Iga / Falkowska, Lucyna / Bodziach, Karina

Environmental pollution. 2020 July, v. 262

2020

Abstract	Bird guano and the faeces of marine mammals appear to be a significant yet undisclosed biotransporter of Endocrine Disrupting Compounds in the marine environment. The authors determined the concentration of bisphenol A (BPA), 4-tert-octylphenol (4-t-OP) and 4-nonylphenol (4-NP) removed from birds and seals in their droppings into the coastal zone of the Gulf of Gdansk (Southern Baltic Sea).The research was carried out on samples of bird guano collected during the breeding season and after in 2016 at nesting sites, as well as on faecal samples from grey seals (Halichoerus grypus grypus) living in the Seal Centre of the Marine Station in Hel between 2014 and 2018. Measurements were carried out using high performance chromatography with fluorescence detector. Results have shown that the presence of seabird habitats and grey seal colonies in the coastal zone of the Gulf of Gdansk can have an impact on the pollution of the seashore (beach sand, bottom sediment and surface seawater) with phenol derivatives. The concentrations of BPA, 4-t-OP and 4-NP ranged from 0.1 to 32.97 ng∙g−1dw in sediment and beach sand, and from 0.23 to over 800 ng dm−3 in seawater. In the cases of bisphenol A and 4-tert-octylphenol safe concentration levels in the waters were exceeded. Bisphenol A concentrations were almost always found to be the highest. This was also noted in bird guano and seal faeces, although it was found to be much higher in the seal faeces - average 10149.79 ng g−1 dw, than in bird guano. An experiment conducted to assess BPA, 4-t-OP, 4-NP leaching from bird guano and seal faeces into seawater, also confirmed the importance of animal excrement in the circulation of these compounds in the marine ecosystem. The highest % of leaching related to BPA was noted at 20 °C and reached 84%. The lowest % of leaching was for 4-nonylphenol (44%).
Keywords	Halichoerus grypus ; animal manures ; bisphenol A ; breeding season ; chromatography ; coasts ; endocrine-disrupting chemicals ; feces ; fluorescence ; habitats ; leaching ; marine ecosystems ; marine environment ; nesting sites ; phenol ; pollution ; sand ; seabirds ; seals ; seawater ; Baltic Sea
Language	English
Dates of publication	2020-07
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2020.114358
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Article: Treatment Outcomes of Adolescents Compared to Younger Pediatric Patients with Acute Myeloid Leukemia: Do They Need a Special Approach?

Pawińska-Wąsikowska, Katarzyna / Czogała, Małgorzata / Bukowska-Strakova, Karolina / Surman, Marta / Rygielska, Monika / Książek, Teofila / Sadowska, Beata / Pac, Agnieszka / Skalska-Sadowska, Jolanta / Samborska, Magdalena / Wachowiak, Jacek / Ciebiera, Małgorzata / Chaber, Radosław / Tomaszewska, Renata / Szczepański, Tomasz / Zielezińska, Karolina / Urasiński, Tomasz / Moj-Hackemer, Małgorzata / Kałwak, Krzysztof /

Cancers

2024 Volume 16, Issue 6

Abstract: Background: The reports of studies that compare the survival of adolescents and young adults with younger children with acute myeloid leukemia (AML) are contradictory.: Patients and methods: We retrospectively analyzed 220 AML patients aged 0-18 ... ...

Abstract	Background: The reports of studies that compare the survival of adolescents and young adults with younger children with acute myeloid leukemia (AML) are contradictory. Patients and methods: We retrospectively analyzed 220 AML patients aged 0-18 years treated in pediatric oncologic centers in Poland from 2015 to 2022. The evaluated group included 31 infants (below 1 year), 91 younger children (1-9.9 years), 59 older children (10-14.9 years), and 39 adolescents (15-18 years). Results: A 5-year overall survival for adolescents was not significantly inferior compared to younger and older children (74.3 ± 7.6% vs. 80.5 ± 4.4% vs. 77.9 ± 5.1, Conclusions: Although we have not found that age over 15 years is an unfavorable factor for overall survival, the optimal approach to therapy in adolescents, as in other age groups, is to adjust the intensity of therapy to individual genetic risk and introduce targeted therapies when indicated.
Language	English
Publishing date	2024-03-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16061145
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Article ; Online: Human Hair, Baltic Grey Seal (Halichoerus grypus) Fur and Herring Gull (Larus argentatus) Feathers as Accumulators of Bisphenol A and Alkylphenols.

Nehring, Iga / Staniszewska, Marta / Falkowska, Lucyna

Archives of environmental contamination and toxicology

2017 Volume 72, Issue 4, Page(s) 552–561

Abstract: The purpose of the study was to determine the concentration of bisphenol A (BPA), 4-tert-octylphenol (OP), and 4-nonylphenol (NP), in human hair, the fur of Baltic grey seals and the feathers of herring gulls. Hair was collected from 42 volunteers, while ...

Abstract	The purpose of the study was to determine the concentration of bisphenol A (BPA), 4-tert-octylphenol (OP), and 4-nonylphenol (NP), in human hair, the fur of Baltic grey seals and the feathers of herring gulls. Hair was collected from 42 volunteers, while grey seal fur (n = 17) came from the seal centre in Hel (Marine Station of Institute of Oceanography, University of Gdansk) and gull covert feathers (n = 26) were collected from dead herring gulls along the Southern Baltic coast. Assays of phenol derivatives were conducted using the high performance liquid chromatography with fluorescence detection technique. In human hair, the mean BPA concentration amounted to 411.2 ng g
MeSH term(s)	Animals ; Benzhydryl Compounds/metabolism ; Charadriiformes/metabolism ; Environmental Monitoring ; Phenols/metabolism ; Seals, Earless/metabolism ; Water Pollutants, Chemical/metabolism
Chemical Substances	Benzhydryl Compounds ; Phenols ; Water Pollutants, Chemical ; 4-nonylphenol (I03GBV4WEL) ; 4-tert-octylphenol (IOY9FVU3J3) ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2017-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	185986-9
ISSN	1432-0703 ; 0090-4341
ISSN (online)	1432-0703
ISSN	0090-4341
DOI	10.1007/s00244-017-0402-0
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