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  1. Article ; Online: Interactions between human immunodeficiency virus type 1 and polymorphonuclear neutrophils.

    Casulli, Sarah / Elbim, Carole

    Journal of innate immunity

    2013  Volume 6, Issue 1, Page(s) 13–20

    Abstract: Polymorphonuclear neutrophils (PMN) are the most abundant circulating leukocytes. They represent a first line of innate immunity against a large panel of microbial pathogens, pending development of specific immune responses. The role of PMN in human ... ...

    Abstract Polymorphonuclear neutrophils (PMN) are the most abundant circulating leukocytes. They represent a first line of innate immunity against a large panel of microbial pathogens, pending development of specific immune responses. The role of PMN in human immunodeficiency virus type 1 (HIV-1) disease has mainly been investigated from the point of view of the increased susceptibility of HIV-1-infected patients to bacterial and fungal infections. However, it is now clear that the relationship between PMN and HIV-1 is far more complex. This review examines both the beneficial and the detrimental effects of PMN during HIV infection.
    MeSH term(s) Animals ; HIV Infections/immunology ; HIV-1/immunology ; Host-Pathogen Interactions ; Humans ; Neutrophils/immunology
    Language English
    Publishing date 2013-07-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2454158-8
    ISSN 1662-8128 ; 1662-811X
    ISSN (online) 1662-8128
    ISSN 1662-811X
    DOI 10.1159/000353588
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  2. Article ; Online: Author Correction: Tissue damage from neutrophil-induced oxidative stress in COVID-19.

    Laforge, Mireille / Elbim, Carole / Frère, Corinne / Hémadi, Miryana / Massaad, Charbel / Nuss, Philippe / Benoliel, Jean- Jacques / Becker, Chrystel

    Nature reviews. Immunology

    2020  Volume 20, Issue 9, Page(s) 579

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords covid19
    Language English
    Publishing date 2020-08-10
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-020-00425-7
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  3. Article: Risks Related to the Use of Non-Steroidal Anti-Inflammatory Drugs in Community-Acquired Pneumonia in Adult and Pediatric Patients.

    Voiriot, Guillaume / Philippot, Quentin / Elabbadi, Alexandre / Elbim, Carole / Chalumeau, Martin / Fartoukh, Muriel

    Journal of clinical medicine

    2019  Volume 8, Issue 6

    Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to alleviate symptoms during community-acquired pneumonia (CAP), while neither clinical data nor guidelines encourage this use. Experimental data suggest that NSAIDs impair neutrophil ... ...

    Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to alleviate symptoms during community-acquired pneumonia (CAP), while neither clinical data nor guidelines encourage this use. Experimental data suggest that NSAIDs impair neutrophil intrinsic functions, their recruitment to the inflammatory site, and the resolution of inflammatory processes after acute pulmonary bacterial challenge. During CAP, numerous observational data collected in hospitalized children, hospitalized adults, and adults admitted to intensive care units (ICUs) support a strong association between pre-hospital NSAID exposure and a delayed hospital referral, a delayed administration of antibiotic therapy, and the occurrence of pleuropulmonary complications, even in the only study that has accounted for a protopathic bias. Other endpoints have been described including a longer duration of antibiotic therapy and a greater hospital length of stay. In all adult series, patients exposed to NSAIDs were younger and had fewer comorbidities. The mechanisms by which NSAID use would entail a complicated course in pneumonia still remain uncertain. The temporal hypothesis and the immunological hypothesis are the two main emerging hypotheses. Current data strongly support an association between NSAID intake during the outpatient treatment of CAP and a complicated course. This should encourage experts and scientific societies to strongly advise against the use of NSAIDs in the management of lower respiratory tract infections.
    Language English
    Publishing date 2019-06-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm8060786
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  4. Article ; Online: Tissue damage from neutrophil-induced oxidative stress in COVID-19.

    Laforge, Mireille / Elbim, Carole / Frère, Corinne / Hémadi, Miryana / Massaad, Charbel / Nuss, Philippe / Benoliel, Jean-Jacques / Becker, Chrystel

    Nature reviews. Immunology

    2020  Volume 20, Issue 9, Page(s) 515–516

    MeSH term(s) Acetylcysteine/therapeutic use ; Antioxidants/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Cytokines/genetics ; Cytokines/immunology ; Drug Therapy, Combination ; Extracellular Traps/drug effects ; Extracellular Traps/immunology ; Extracellular Traps/metabolism ; Gene Expression Regulation ; Glycine/analogs & derivatives ; Glycine/therapeutic use ; Host-Pathogen Interactions/drug effects ; Humans ; Immunity, Innate/drug effects ; Lung/drug effects ; Lung/immunology ; Lung/pathology ; Lung/virology ; Lymphocytes/drug effects ; Lymphocytes/immunology ; Lymphocytes/virology ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/immunology ; NF-kappa B/genetics ; NF-kappa B/immunology ; Neutrophils/drug effects ; Neutrophils/immunology ; Neutrophils/virology ; Oxidative Stress/drug effects ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; Proteinase Inhibitory Proteins, Secretory/therapeutic use ; Reactive Oxygen Species/antagonists & inhibitors ; Reactive Oxygen Species/immunology ; Reactive Oxygen Species/metabolism ; SARS-CoV-2 ; Severity of Illness Index ; Sulfonamides/therapeutic use ; Superoxide Dismutase/genetics ; Superoxide Dismutase/immunology
    Chemical Substances Antioxidants ; Cytokines ; NF-E2-Related Factor 2 ; NF-kappa B ; NFE2L2 protein, human ; Proteinase Inhibitory Proteins, Secretory ; Reactive Oxygen Species ; Sulfonamides ; sivelestat (DWI62G0P59) ; SOD3 protein, human (EC 1.15.1.1) ; Superoxide Dismutase (EC 1.15.1.1) ; Glycine (TE7660XO1C) ; Acetylcysteine (WYQ7N0BPYC)
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-020-0407-1
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  5. Article ; Online: Risks Related to the Use of Non-Steroidal Anti-Inflammatory Drugs in Community-Acquired Pneumonia in Adult and Pediatric Patients

    Guillaume Voiriot / Quentin Philippot / Alexandre Elabbadi / Carole Elbim / Martin Chalumeau / Muriel Fartoukh

    Journal of Clinical Medicine, Vol 8, Iss 6, p

    2019  Volume 786

    Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to alleviate symptoms during community-acquired pneumonia (CAP), while neither clinical data nor guidelines encourage this use. Experimental data suggest that NSAIDs impair neutrophil ... ...

    Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to alleviate symptoms during community-acquired pneumonia (CAP), while neither clinical data nor guidelines encourage this use. Experimental data suggest that NSAIDs impair neutrophil intrinsic functions, their recruitment to the inflammatory site, and the resolution of inflammatory processes after acute pulmonary bacterial challenge. During CAP, numerous observational data collected in hospitalized children, hospitalized adults, and adults admitted to intensive care units (ICUs) support a strong association between pre-hospital NSAID exposure and a delayed hospital referral, a delayed administration of antibiotic therapy, and the occurrence of pleuropulmonary complications, even in the only study that has accounted for a protopathic bias. Other endpoints have been described including a longer duration of antibiotic therapy and a greater hospital length of stay. In all adult series, patients exposed to NSAIDs were younger and had fewer comorbidities. The mechanisms by which NSAID use would entail a complicated course in pneumonia still remain uncertain. The temporal hypothesis and the immunological hypothesis are the two main emerging hypotheses. Current data strongly support an association between NSAID intake during the outpatient treatment of CAP and a complicated course. This should encourage experts and scientific societies to strongly advise against the use of NSAIDs in the management of lower respiratory tract infections.
    Keywords community-acquired pneumonia ; non-steroidal anti-inflammatory drugs ; pleural effusion ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2019-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Cytokines modulate neutrophil death.

    Elbim, Carole / Estaquier, Jérôme

    European cytokine network

    2010  Volume 21, Issue 1, Page(s) 1–6

    Abstract: Polymorphonuclear neutrophils (PMN) are terminally differentiated cells with a short life span, in the blood circulation. The prolongation of the life span of PMN is critical in their effectiveness against pathogens, in particular in the tissues. This ... ...

    Abstract Polymorphonuclear neutrophils (PMN) are terminally differentiated cells with a short life span, in the blood circulation. The prolongation of the life span of PMN is critical in their effectiveness against pathogens, in particular in the tissues. This review summarizes the effect of cytokines on PMN apoptosis and points to some examples of pathological situations characterized by inappropriate cytokine production associated with dysregulation of PMN apoptosis.
    MeSH term(s) Animals ; Cell Death ; Cytokines/metabolism ; Humans ; Immunomodulation ; Neutrophils/cytology ; Neutrophils/enzymology ; Neutrophils/metabolism
    Chemical Substances Cytokines
    Language English
    Publishing date 2010-03
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1118857-1
    ISSN 1952-4005 ; 1148-5493
    ISSN (online) 1952-4005
    ISSN 1148-5493
    DOI 10.1684/ecn.2009.0183
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    Zs.A 3447: Show issues Location:
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  7. Article ; Online: Impairment of neutrophil functions and homeostasis in COVID-19 patients: association with disease severity.

    Loyer, Chloé / Lapostolle, Arnaud / Urbina, Tomas / Elabbadi, Alexandre / Lavillegrand, Jean-Rémi / Chaigneau, Thomas / Simoes, Coraly / Dessajan, Julien / Desnos, Cyrielle / Morin-Brureau, Mélanie / Chantran, Yannick / Aucouturier, Pierre / Guidet, Bertrand / Voiriot, Guillaume / Ait-Oufella, Hafid / Elbim, Carole

    Critical care (London, England)

    2022  Volume 26, Issue 1, Page(s) 155

    Abstract: Background: A dysregulated immune response is emerging as a key feature of critical illness in COVID-19. Neutrophils are key components of early innate immunity that, if not tightly regulated, contribute to uncontrolled systemic inflammation. We sought ... ...

    Abstract Background: A dysregulated immune response is emerging as a key feature of critical illness in COVID-19. Neutrophils are key components of early innate immunity that, if not tightly regulated, contribute to uncontrolled systemic inflammation. We sought to decipher the role of neutrophil phenotypes, functions, and homeostasis in COVID-19 disease severity and outcome.
    Methods: By using flow cytometry, this longitudinal study compares peripheral whole-blood neutrophils from 90 COVID-19 ICU patients with those of 22 SARS-CoV-2-negative patients hospitalized for severe community-acquired pneumonia (CAP) and 38 healthy controls. We also assessed correlations between these phenotypic and functional indicators and markers of endothelial damage as well as disease severity.
    Results: At ICU admission, the circulating neutrophils of the COVID-19 patients showed continuous basal hyperactivation not seen in CAP patients, associated with higher circulating levels of soluble E- and P-selectin, which reflect platelet and endothelial activation. Furthermore, COVID-19 patients had expanded aged-angiogenic and reverse transmigrated neutrophil subsets-both involved in endothelial dysfunction and vascular inflammation. Simultaneously, COVID-19 patients had significantly lower levels of neutrophil oxidative burst in response to bacterial formyl peptide. Moreover patients dying of COVID-19 had significantly higher expansion of aged-angiogenic neutrophil subset and greater impairment of oxidative burst response than survivors.
    Conclusions: These data suggest that neutrophil exhaustion may be involved in the pathogenesis of severe COVID-19 and identify angiogenic neutrophils as a potentially harmful subset involved in fatal outcome.
    MeSH term(s) Aged ; COVID-19 ; Community-Acquired Infections ; Homeostasis ; Humans ; Inflammation ; Longitudinal Studies ; Neutrophils/physiology ; Pneumonia/pathology ; SARS-CoV-2 ; Severity of Illness Index
    Language English
    Publishing date 2022-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-022-04002-3
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    Zs.A 5517: Show issues Location:
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  8. Article ; Online: Monitoring cellular immune markers in HIV infection: from activation to exhaustion.

    Sauce, Delphine / Elbim, Carole / Appay, Victor

    Current opinion in HIV and AIDS

    2013  Volume 8, Issue 2, Page(s) 125–131

    Abstract: Purpose of review: The pathogenesis of HIV infection is highly complex and involves numerous actors of the immune system. On the one hand, our immunity has a predominant role in limiting HIV replication and the depletion of its targets, but on the other ...

    Abstract Purpose of review: The pathogenesis of HIV infection is highly complex and involves numerous actors of the immune system. On the one hand, our immunity has a predominant role in limiting HIV replication and the depletion of its targets, but on the other hand, the persistent infection established by the virus is associated with chronic immune activation and inflammation, potentially resulting in the progressive exhaustion of the host immune resources, and in the onset of non-AIDS-defining comorbidities. The thorough study of HIV pathogenesis is increasingly more challenging.
    Recent findings: New knowledge together with technological advances offers the possibility to monitor a constellation of cellular immune markers. Here, we discuss the relevance of studying these markers in order to assess the efficacy to control HIV, the inflammatory response to HIV infection, and the alteration and exhaustion of the immune compartments.
    Summary: Monitoring these cellular immune markers is important to reach a deeper understanding of HIV pathogenesis and to perform a comprehensive clinical follow-up of HIV-infected patients.
    MeSH term(s) Biomarkers ; HIV/immunology ; HIV/pathogenicity ; HIV Infections/immunology ; HIV Infections/pathology ; Humans ; Monitoring, Immunologic
    Chemical Substances Biomarkers
    Language English
    Publishing date 2013-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0b013e32835d08a9
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  9. Article: Tissue damage from neutrophil-induced oxidative stress in COVID-19

    Laforge, Mireille / Elbim, Carole / Frère, Corinne / Hémadi, Miryana / Massaad, Charbel / Nuss, Philippe / Benoliel, Jean-Jacques / Becker, Chrystel

    Nat Rev Immunol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #690707
    Database COVID19

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  10. Article ; Online: Author Correction

    Laforge, Mireille / Elbim, Carole / Frère, Corinne / Hémadi, Miryana / Massaad, Charbel / Nuss, Philippe / Benoliel, Jean- Jacques / Becker, Chrystel

    Nature Reviews Immunology

    Tissue damage from neutrophil-induced oxidative stress in COVID-19

    2020  Volume 20, Issue 9, Page(s) 579–579

    Keywords Immunology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-020-00425-7
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