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  1. Article ; Online: Novel Compound-Target Interactions Prediction for the Herbal Formula Hua-Yu-Qiang-Shen-Tong-Bi-Fang.

    Wang, Zihao / Lin, Hui-Heng / Linghu, Kegang / Huang, Run-Yue / Li, Guangyao / Zuo, Huali / Yu, Hua / Chan, Ging / Hu, Yuanjia

    Chemical & pharmaceutical bulletin

    2019  Volume 67, Issue 8, Page(s) 778–785

    Abstract: ... For example, the Hua-Yu-Qiang-Shen-Tong-Bi-Fang (TBF), an herbal formula of Chinese medicine, has been used ...

    Abstract Herbal formulae have a long history in clinical medicine in Asia. While the complexity of the formulae leads to the complex compound-target interactions and the resultant multi-target therapeutic effects, it is difficult to elucidate the molecular/therapeutic mechanism of action for the many formulae. For example, the Hua-Yu-Qiang-Shen-Tong-Bi-Fang (TBF), an herbal formula of Chinese medicine, has been used for treating rheumatoid arthritis. However, the target information of a great number of compounds from the TBF formula is missing. In this study, we predicted the targets of the compounds from the TBF formula via network analysis and in silico computing. Initially, the information of the phytochemicals contained in the plants of the herbal formula was collected, and subsequently computed to their corresponding fingerprints for the sake of structural similarity calculation. Then a compound structural similarity network infused with available target information was constructed. Five local similarity indices were used and compared for their performance on predicting the potential new targets of the compounds. Finally, the Preferential Attachment Index was selected for it having an area under curve (AUC) of 0.886, which outperforms the other four algorithms in predicting the compound-target interactions. This method could provide a promising direction for identifying the compound-target interactions of herbal formulae in silico.
    MeSH term(s) Algorithms ; Arthritis, Rheumatoid/drug therapy ; Drug Compounding ; Drug Interactions ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Chinese Traditional
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2019-07-31
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 213307-6
    ISSN 1347-5223 ; 0009-2363
    ISSN (online) 1347-5223
    ISSN 0009-2363
    DOI 10.1248/cpb.c18-00808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 770: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A network pharmacology-based approach to analyse potential targets of traditional herbal formulas: An example of Yu Ping Feng decoction.

    Zuo, Huali / Zhang, Qianru / Su, Shibing / Chen, Qilong / Yang, Fengqing / Hu, Yuanjia

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 11418

    Abstract: ... for their therapeutic effects at the level of molecular biology. By taking a classic herbal formula (Yu Ping Feng ...

    Abstract Herbal formulas from traditional Chinese medicines (TCMs) have been extensively used in clinics as effective therapies, but it is still a great challenge to demonstrate the scientific basis for their therapeutic effects at the level of molecular biology. By taking a classic herbal formula (Yu Ping Feng decoction, YPF) as an example, this study developed a novel network pharmacology based method to identify its potential therapeutic targets. First, this study constructed a "targets-(pathways)-targets" (TPT) network in which targets of YPF were connected by relevant pathways; then, this network was decomposed into separate modules with strong internal connections; lastly, the propensity of each module toward different diseases was assessed by a contribution score. On the basis of a significant association between network modules and therapeutic diseases validated by chi-square test (p-value < 0.001), this study identified the network module with the strongest propensity toward therapeutic diseases of YPF. Further, the targets with the highest centrality in this module are recommended as YPF's potential therapeutic targets. By integrating the complicated "multi-targets-multi-pathways-multi-diseases" relationship of herbal formulas, the method shows promise for identifying its potential therapeutic targets, which could contribute to the modern scientific illustration of TCMs' traditional clinical applications.
    MeSH term(s) Algorithms ; Disease ; Drugs, Chinese Herbal/pharmacology ; Humans ; Signal Transduction/drug effects
    Chemical Substances Drugs, Chinese Herbal ; yupingfeng
    Keywords covid19
    Language English
    Publishing date 2018-07-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-29764-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comprehensive characterization and quantification of multiple components in Dan-Huang-Qu-Yu capsule using a multivariate data processing approach based on microwave-assisted extraction with UHPLC and Q Exactive quadrupole-orbitrap high-resolution mass spectrometry.

    Yang, Bo / Ying, Yin / Zou, Jie / Ge, Shuyu / Zuo, Lihua

    Journal of separation science

    2019  Volume 42, Issue 11, Page(s) 2069–2079

    Abstract: Dan-Huang-Qu-Yu capsule, a Chinese herbal medicine compound preparation, is widely used for chronic ... Huang-Qu-Yu capsule. Among them, 35 major compounds were unambiguously detected by comparing ... them with reference standards and selected as quality control markers, which were simultaneously determined in Dan-Huang-Qu-Yu ...

    Abstract Dan-Huang-Qu-Yu capsule, a Chinese herbal medicine compound preparation, is widely used for chronic pelvic inflammatory disease. In this study, a rapid, selective, and sensitive microwave-assisted extraction ultra-high-performance liquid chromatography-Q Exactive quadrupole-orbitrap high-resolution mass spectrometry method was developed for analyzing its chemical compositions. A total of 85 compounds, including 22 flavonoids, 8 terpenoids, 5 quinones, 5 phthaleolactone, 23 organic acids, and 22 other compounds were identified from Dan-Huang-Qu-Yu capsule. Among them, 35 major compounds were unambiguously detected by comparing them with reference standards and selected as quality control markers, which were simultaneously determined in Dan-Huang-Qu-Yu capsule. The established method was successfully validated and applied for simultaneous determination of 35 bioactive compounds in Dan-Huang-Qu-Yu capsule from ten sample batches. The quantitative data of the analytes were analyzed by principal component analysis for quality assessment of Dan-Huang-Qu-Yu capsule. Six compounds (e.g., astragaloside IV, salvianolic acid B, ellagic acid, chlorogenic acid, N-butylidenephthalide, and luteolin) were screened out and regarded as chemical markers for quality control of Dan-Huang-Qu-Yu capsule. The established method has been proved to be a novel and useful tool for rapid research of Dan-Huang-Qu-Yu capsule. This research will provide reference for the scientific research of traditional Chinese medicines.
    MeSH term(s) Capsules/chemistry ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Mass Spectrometry/methods ; Microwaves ; Principal Component Analysis ; Quality Control
    Chemical Substances Capsules ; Drugs, Chinese Herbal
    Language English
    Publishing date 2019-04-24
    Publishing country Germany
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 2047990-6
    ISSN 1615-9314 ; 1615-9306
    ISSN (online) 1615-9314
    ISSN 1615-9306
    DOI 10.1002/jssc.201801246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Shu mu pen jing zhi zuo yu yang hu

    Zhu, Yongyuan / Wan, Ruiming / Yu, Huizhen / Zuo, Binsen

    (Pen jing zhi zuo yu yang hu cong shu.)

    2003  

    Title translation How to make and maintain tree bonsai.
    Author's details zhu bian: Yu Huizhen ; bian zhu: Zhu Yongyuan, Wan Ruiming, Zuo Binsen
    Series title Pen jing zhi zuo yu yang hu cong shu.
    Keywords Penjing
    Language Chinese
    Size 9, 144 p., [4] p. of plates :, ill. ;, 21 cm.
    Edition Di 1 ban.
    Publisher Jiangsu ke xue ji shu chu ban she
    Publishing place Nanjing Shi
    Document type Book
    ISBN 7534537118 ; 9787534537110
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Comprehensive characterization and quantification of multiple components in Dan‐Huang‐Qu‐Yu capsule using a multivariate data processing approach based on microwave‐assisted extraction with UHPLC and Q Exactive quadrupole‐orbitrap high‐resolution mass spectrometry

    Yang, Bo / Ying, Yin / Zou, Jie / Ge, Shuyu / Zuo, Lihua

    Journal of separation science. 2019 June, v. 42, no. 11

    2019  

    Abstract: Dan‐Huang‐Qu‐Yu capsule, a Chinese herbal medicine compound preparation, is widely used for chronic ... Huang‐Qu‐Yu capsule. Among them, 35 major compounds were unambiguously detected by comparing ... them with reference standards and selected as quality control markers, which were simultaneously determined in Dan‐Huang‐Qu‐Yu ...

    Abstract Dan‐Huang‐Qu‐Yu capsule, a Chinese herbal medicine compound preparation, is widely used for chronic pelvic inflammatory disease. In this study, a rapid, selective, and sensitive microwave‐assisted extraction ultra‐high‐performance liquid chromatography‐Q Exactive quadrupole‐orbitrap high‐resolution mass spectrometry method was developed for analyzing its chemical compositions. A total of 85 compounds, including 22 flavonoids, 8 terpenoids, 5 quinones, 5 phthaleolactone, 23 organic acids, and 22 other compounds were identified from Dan‐Huang‐Qu‐Yu capsule. Among them, 35 major compounds were unambiguously detected by comparing them with reference standards and selected as quality control markers, which were simultaneously determined in Dan‐Huang‐Qu‐Yu capsule. The established method was successfully validated and applied for simultaneous determination of 35 bioactive compounds in Dan‐Huang‐Qu‐Yu capsule from ten sample batches. The quantitative data of the analytes were analyzed by principal component analysis for quality assessment of Dan‐Huang‐Qu‐Yu capsule. Six compounds (e.g., astragaloside IV, salvianolic acid B, ellagic acid, chlorogenic acid, N‐butylidenephthalide, and luteolin) were screened out and regarded as chemical markers for quality control of Dan‐Huang‐Qu‐Yu capsule. The established method has been proved to be a novel and useful tool for rapid research of Dan‐Huang‐Qu‐Yu capsule. This research will provide reference for the scientific research of traditional Chinese medicines.
    Keywords Oriental traditional medicine ; astragalosides ; bioactive compounds ; chlorogenic acid ; ellagic acid ; herbal medicines ; information processing ; luteolin ; mass spectrometry ; microwave treatment ; principal component analysis ; quality control ; quinones ; reference standards ; salvianolic acid ; ultra-performance liquid chromatography
    Language English
    Dates of publication 2019-06
    Size p. 2069-2079.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2047990-6
    ISSN 1615-9314 ; 1615-9306
    ISSN (online) 1615-9314
    ISSN 1615-9306
    DOI 10.1002/jssc.201801246
    Database NAL-Catalogue (AGRICOLA)

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  6. Book: Guo yu yi zhu

    Wang, Liansheng / Xue, Anqin / Zuo, Xiuling

    (Xue shu xin kan ; 8 ; 學術新刊 ; 8)

    1995  

    Author's details Wang lian sheng, xue an qin zhu yi; zuo xiu ling jiao ding
    Series title Xue shu xin kan ; 8
    學術新刊 ; 8
    Language Chinese
    Size 3, 1, 11, 462 p
    Publisher Jian hong chu ban she
    Publishing place Tai bei
    Document type Book
    ISBN 9577245846 ; 9789577245847
    Database Former special subject collection: coastal and deep sea fishing

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  7. Book: Xin yi guo yu du ben

    Yi, Zhongtian / Zuo, Ming

    (Gu ji jin zhu xin yi cong shu ; 古籍今注新譯叢書)

    1995  

    Title variant Xin-yi guo-yu du-ben ; Guo yu du ben ; 國語讀本
    Author's details Yi zhong tian zhu yi; hou nai hui jiao yue
    Series title Gu ji jin zhu xin yi cong shu
    古籍今注新譯叢書
    Keywords China
    Language Chinese
    Size 19, 24, 892 S., 21 cm
    Edition Chu ban
    Publisher San min shu ju
    Publishing place Tai bei
    Document type Book
    Note In chines. Schr.
    ISBN 9571420441 ; 957142045X ; 9789571420448 ; 9789571420455
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  8. Book: Sorghum

    Zhao, Zuo-Yu / Dahlberg, Jeff

    methods and protocols

    (Methods in molecular biology ; 1931 ; Springer protocols)

    2019  

    Author's details edited by Zuo-Yu Zhao, Jeff Dahlberg
    Series title Methods in molecular biology ; 1931
    Springer protocols
    Collection
    Language English
    Size x, 281 Seiten, Illustrationen
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT019983043
    ISBN 978-1-4939-9038-2 ; 9781493990399 ; 1-4939-9038-1 ; 149399039X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1931- verfügbar in Königswinter Königswinter

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  9. Book: Zhong xue de yu xin li xue

    Zuo, Qipei

    (Ying yong xin li xue cong shu)

    1990  

    Title translation The psychology of moral education in highschool.
    Author's details Zuo Qipei zhu
    Series title Ying yong xin li xue cong shu
    MeSH term(s) Psychology, Adolescent ; Adolescent ; Adolescent Behavior ; Morals
    Language Chinese
    Size 3, 5, 6, 219 p.
    Edition Di 1 ban.
    Publisher Jilin jiao yu chu ban she
    Publishing place Changchun Shi
    Document type Book
    ISBN 9787538310658 ; 7538310657
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article ; Online: The Longitudinal Relationships among Casual Sex and Psychological Well-Being in Chinese College Student.

    Yu, Ke / Shen, Panyan / Zuo, Guoguo

    International journal of sexual health : official journal of the World Association for Sexual Health

    2024  Volume 36, Issue 2, Page(s) 177–188

    Abstract: This study integrates the important psychological well-being indicators (i.e., life satisfaction, psychological distress, and self-esteem) into a model framework. We used a cross-lagged panel design (CLPD) to examine the bidirectional relationship ... ...

    Abstract This study integrates the important psychological well-being indicators (i.e., life satisfaction, psychological distress, and self-esteem) into a model framework. We used a cross-lagged panel design (CLPD) to examine the bidirectional relationship between casual sex and psychological well-being among Chinese college students. Chinese college students (
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ISSN 1931-762X
    ISSN (online) 1931-762X
    DOI 10.1080/19317611.2024.2317195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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