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Article ; Online: Kidney Transplantation During COVID-19 Outbreak: Data From Public and Non-Public Dialysis Network.

Zawierucha, Jacek / Marcinkowski, Wojciech / Małyszko, Jacek / Małyszko, Jolanta

2024

Abstract: Background: The COVID-19 pandemic significantly affected medical services in Poland. All restrictions, additional procedures, and numerous infections among medical staff affected transplantation in the country. This study aimed to analyze reports ... ...

Abstract	Background: The COVID-19 pandemic significantly affected medical services in Poland. All restrictions, additional procedures, and numerous infections among medical staff affected transplantation in the country. This study aimed to analyze reports prepared by the Polish Transplant Coordination Center Poltransplant and internal Fresenius Nephrocare Poland to assess differences in the number of patients who qualified for kidney transplantation and transplanted during the pandemic compared with a pre-pandemic year. Methods: Official data from the Polish Transplant Coordinating Centre Poltransplant bulletin from 2019, 2020, and 2021 was analyzed to determine the number of patients on the waiting list for solid organ transplantation. The number of transplantations reported by Polish transplant centers was also considered. Results: During the SARS-CoV-2 outbreak, the number of qualified and transplanted patients was significantly lower than in the pre-pandemic period. The worst data concerns the new qualifications, which were significantly lower in the first year of the pandemic due to all the restrictions implemented. The number of kidney transplant procedures provided during the 2-year pandemic period decreased significantly (-20.8%) in 2020, and in the second year, the negative trend continued (-0.8%). For private dialysis providers, the number of active patients on the waiting list for kidney transplantation was a bit better-it decreased from 265 to 239 in 2020 (-9.8%) and increased to 259 in 2021 (+8.4%). The decline in the number of patients treated in Fresenius Nephrocare dialysis centers was more significant, decreasing by 27.8% in 2020 compared with 2019. In 2021, the number of transplanted patients slightly increased by about 2.5%. Conclusions: The decrease in qualified and transplanted patients during the SARS-CoV-2 outbreak clearly shows the need to undertake multidisciplinary discussions among all stakeholders to create new procedures and processes that will help protect the health care system and patients in future crisis situations.
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2024.03.008
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Article: Cancer and the kidney: dangereoux liasons or price paid for the progress in medicine?

Malyszko, Jolanta / Malyszko, Jacek

OncoTarget, 8(39):66601-66619

2017

Abstract: A long time ago, the links between renal disease and malignancy were observed, however, quite recently, their importance was recognized and ‘new’ subspecialty in nephrology, namely ‘onconephrology’ was established. In the XXI century, patients with ... ...

Abstract	A long time ago, the links between renal disease and malignancy were observed, however, quite recently, their importance was recognized and ‘new’ subspecialty in nephrology, namely ‘onconephrology’ was established. In the XXI century, patients with malignancy make up the most growing number of the subjects seen for nephrology consult and/or critical care nephrology services. A plethora of renal problems may be found in patients with malignancy. They may influence not only their short-term outcomes but also the adequate therapy of the underlying oncological problem. Thus, all these kidney-related issues pose an important challenge for both specialities: oncology and nephrology. In the review a spectrum of acute and chronic renal injury caused by the malignancy is presented as well as the associations between renal disease and cancer. Assessment of kidney function and its importance in patients with malignancy is also discussed as medical oncologists should check the appropriate dose of chemotherapeutic drugs in relation to the actual renal function before prescribing them to the patients. Moreover, effects of kidney function on outcomes in oncology is presented. In addition, nephrology services should better understand both the biology of malignancy with its treatment to become a valuable part treating team to yield the best possible outcome. It is important for nephrology services to be acknowledged and to take an active participation in care of oncology patients.
Keywords	chemotherapy ; chronic kidney disease ; acute kidney injury ; kidney function ; malignancy
Language	English
Document type	Article
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Article ; Online: Recurrence of Glomerulonephritis After Kidney Transplantation - Experience of One Center from 2020 to 2023.

Wieliczko, Monika / Nazarewski, Sławomir / Gałązka, Zbigniew / Małyszko, Jolanta

Transplantation proceedings

2024

Abstract: Background: Glomerulonephritis (GN) after kidney transplantation is a common problem. Many of them are recurrences of the primary disease in the transplanted kidney. The course and prognosis of individual types of glomerulonephritis (GN) are very ... ...

Abstract	Background: Glomerulonephritis (GN) after kidney transplantation is a common problem. Many of them are recurrences of the primary disease in the transplanted kidney. The course and prognosis of individual types of glomerulonephritis (GN) are very different and their appearance may worsen the graft survival. World statistics show significant discrepancies regarding the incidence of GN recurrence depending on the adopted protocol (protocolar biopsy or due to symptoms). We analyzed the transplanted kidney biopsy results that are performed only in symptomatic patients. Methods: A group of 125 patients transplanted and treated in one medical center were observed. In this group, in 32 patients, the primary kidney disease was GN, confirmed by kidney biopsy before transplantation. Twenty three kidney biopsies were performed; in 8, cases the primary disease was GN. The indication for biopsy were hematuria and/or proteinuria and/or graft failure. Results: We diagnosed 5 cases of GN, including 4 cases of GN recurrence (12.5% in whole GN group, 50% in symptomatic GN group). In the relapse group, there was 1 case of IgA nephropathy (the earliest recurrence 1 month after transplantation), 1 case of focal segmental glomerulosclerosis, 1 case of membranous nephropathy, and 1 case of lupus nephritis (the latest recurrence 1 year and 4 months after transplantation). Conclusions: Our observation showed a high percentage of GN recurrences in symptomatic patients. This indicates the need to specify data regarding the diagnosis of recurrence depending on the adopted research method (protocolar or due to symptoms biopsy) to know which patients should be treated.
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2024.03.015
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Article ; Online: Acid-base balance in hemodialysis patients in everyday practice.

Wieliczko, Monika / Małyszko, Jolanta

Renal failure

2022 Volume 44, Issue 1, Page(s) 1090–1097

Abstract: Introduction: Abnormalities in blood bicarbonates (HCO: Material and methods: We enrolled 75 stable hemodialysis patients (mean age 65.5 years, 34 women), from a single Department of Nephrology. We assessed blood pressure, and acid-base balance ... ...

Abstract	Introduction: Abnormalities in blood bicarbonates (HCO Material and methods: We enrolled 75 stable hemodialysis patients (mean age 65.5 years, 34 women), from a single Department of Nephrology. We assessed blood pressure, and acid-base balance parameters before and after mid-week hemodialysis session. Results: We found significant differences in pH, HCO Conclusions: Despite the improvement in hemodialysis techniques, acid-base balance still remains a challenge. The individual selection of bicarbonate in bath, based on previous single tests, does not improve permanently the acid-base balance in the population of hemodialysis patients. New guidelines how to correct acid-base disorders in hemodialysis patients are needed to have less 'acidotic' patients before hemodialysis and less 'alkalotic' patients after the session.
MeSH term(s)	Acid-Base Equilibrium ; Aged ; Bicarbonates ; Female ; Humans ; Kidney Failure, Chronic/therapy ; Nephrology ; Renal Dialysis
Chemical Substances	Bicarbonates
Language	English
Publishing date	2022-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2022.2094805
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Zs.A 1331: Show issues

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Article ; Online: Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?

Zuzda, Konrad / Grycuk, Wiktoria / Małyszko, Jacek / Małyszko, Jolanta

Expert opinion on therapeutic targets

2022 Volume 26, Issue 11, Page(s) 995–1009

Abstract: Introduction: Altered lipid distribution and metabolism may lead to the development and/or progression of chronic kidney disease (CKD). Dyslipidemia is a major risk factor for CKD and increases the risk of cardiovascular events and mortality. Therefore, ...

Abstract	Introduction: Altered lipid distribution and metabolism may lead to the development and/or progression of chronic kidney disease (CKD). Dyslipidemia is a major risk factor for CKD and increases the risk of cardiovascular events and mortality. Therefore, lipid-lowering treatments may decrease cardiovascular risk and prevent death. Areas covered: Key players involved in regulating lipid accumulation in the kidney; contribution of lipids to CKD progression, lipotoxicity, and mitochondrial dysfunction in kidney disease; recent therapeutic approaches for dyslipidemia. Expert opinion: The precise mechanisms for regulating lipid metabolism, particularly in kidney disease, are poorly understood. Guidelines for lipid-lowering therapy for CKD are controversial. Several hypolipemic therapies are available, but compared to others, statin therapy is the most common. No clinical trial has evaluated the efficacy of proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) in preventing cardiovascular events or improving kidney function among patients with CKD or kidney transplant recipients. Attractive alternatives, such as PCSK9-small interfering RNA (siRNA) molecules or evinacumab are available. Additionally, several promising agents, such as cyclodextrins and the FXR/TGR5 dual agonist, INT-767, can improve renal lipid metabolism disorders and delay CKD progression. Drugs targeting mitochondrial dysfunction could be an option for the treatment of dyslipidemia and lipotoxicity, particularly in renal diseases.
MeSH term(s)	Humans ; Proprotein Convertase 9/metabolism ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Dyslipidemias/drug therapy ; Dyslipidemias/complications ; Dyslipidemias/metabolism ; Kidney/metabolism ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Lipids ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
Chemical Substances	PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Lipids ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2022-12-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2055208-7
ISSN	1744-7631 ; 1472-8222
ISSN (online)	1744-7631
ISSN	1472-8222
DOI	10.1080/14728222.2022.2161887
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Zs.A 5244: Show issues

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Article ; Online: Post-transplant lymphoproliferative disorder: risk factors and management.

Malyszko, Jolanta

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2019

Language	English
Publishing date	2019-10-09
Publishing country	England
Document type	Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfz207
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Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 329: Show issues

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Article ; Online: Continuous glucose monitoring in people with diabetes and end-stage kidney disease-review of association studies and Evidence-Based discussion.

Jakubowska, Zuzanna / Malyszko, Jolanta

Journal of nephrology

2023 Volume 37, Issue 2, Page(s) 267–279

Abstract: Diabetic nephropathy is currently the leading cause of end-stage kidney disease. The present methods of assessing diabetes control, such as glycated hemoglobin or self-monitoring of blood glucose, have limitations. Over the past decade, the field of ... ...

Abstract	Diabetic nephropathy is currently the leading cause of end-stage kidney disease. The present methods of assessing diabetes control, such as glycated hemoglobin or self-monitoring of blood glucose, have limitations. Over the past decade, the field of continuous glucose monitoring has been greatly improved and expanded. This review examines the use of continuous glucose monitoring in people with end-stage kidney disease treated with hemodialysis (HD), peritoneal dialysis (PD), or kidney transplantation. We assessed the use of both real-time continuous glucose monitoring and flash glucose monitoring technology in terms of hypoglycemia detection, glycemic variability, and efficacy, defined as an improvement in clinical outcomes and diabetes control. Overall, the use of continuous glucose monitoring in individuals with end-stage kidney disease may improve glycemic control and detection of hypoglycemia. However, most of the published studies were observational with no control group. Moreover, not all studies used the same assessment parameters. There are very few studies involving subjects on peritoneal dialysis. The small number of studies with limited numbers of participants, short follow-up period, and small number of manufacturers of continuous glucose monitoring systems are limitations of the review. More studies need to be performed to obtain more reliable results.
MeSH term(s)	Humans ; Kidney Failure, Chronic/therapy ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/complications ; Diabetic Nephropathies/therapy ; Diabetic Nephropathies/blood ; Diabetic Nephropathies/diagnosis ; Blood Glucose/metabolism ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring ; Renal Dialysis ; Peritoneal Dialysis ; Hypoglycemia/blood ; Hypoglycemia/diagnosis ; Kidney Transplantation ; Glycemic Control ; Evidence-Based Medicine ; Biomarkers/blood ; Continuous Glucose Monitoring
Chemical Substances	Blood Glucose ; Biomarkers
Language	English
Publishing date	2023-11-21
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-023-01802-w
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Article ; Online: Proenkephalin Levels and Its Determinants in Patients with End-Stage Kidney Disease Treated with Hemodialysis and Peritoneal Dialysis.

Grycuk, Wiktoria / Jakubowska, Zuzanna / Małyszko, Jolanta

International journal of molecular sciences

2023 Volume 24, Issue 19

Abstract: Recently, proenkephalin A (PENK A) has been shown to reflect glomerular dysfunction and to predict new-onset acute kidney injury and heart failure. While previous studies have investigated PENK A as a biomarker in individuals with preserved renal ... ...

Abstract	Recently, proenkephalin A (PENK A) has been shown to reflect glomerular dysfunction and to predict new-onset acute kidney injury and heart failure. While previous studies have investigated PENK A as a biomarker in individuals with preserved renal function, PENK A concentration in patients with end-stage kidney disease (ESKD) was not investigated. Plasma PENK A concentration was assessed in 88 patients with ESKD treated with hemodialysis (HD) or peritoneal dialysis (PD), and its associations with kidney function and heart failure indicators were investigated. In HD patients, the difference in PENK A levels before and after hemodialysis, was measured and further assessed for an association with the type of HD membrane used. PENK A levels did not differ significantly between HD and PD patients. In HD patients, the median PENK A concentration was significantly higher before than after hemodialysis (1.368 vs. 2.061,
MeSH term(s)	Humans ; Renal Dialysis/adverse effects ; Kidney Failure, Chronic/complications ; Heart Failure ; Peritoneal Dialysis ; Biomarkers ; Acute Kidney Injury/etiology
Chemical Substances	proenkephalin ; Biomarkers
Language	English
Publishing date	2023-10-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241915015
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Article ; Online: Proenkephalin A 119-159, a Possible Early Biomarker of Acute Kidney Injury in Complex Endovascular Aortic Repair: a Single Centre Observational, Cross Sectional Study.

Walczak-Wieteska, Paulina / Zuzda, Konrad / Szczęsna, Karolina / Ziętalewicz, Joanna / Andruszkiewicz, Paweł / Małyszko, Jolanta

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2024

Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1225869-6
ISSN	1532-2165 ; 1078-5884
ISSN (online)	1532-2165
ISSN	1078-5884
DOI	10.1016/j.ejvs.2024.01.084
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Zs.A 2283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Resistant hypertension in dialysis.

Symonides, Bartosz / Lewandowski, Jacek / Małyszko, Jolanta

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2023 Volume 38, Issue 9, Page(s) 1952–1959

Abstract: Hypertension is the most common finding in chronic kidney disease patients, with prevalence ranging from 60% to 90% depending on the stage and etiology of the disease. It is also a significant independent risk factor for cardiovascular disease, ... ...

Abstract	Hypertension is the most common finding in chronic kidney disease patients, with prevalence ranging from 60% to 90% depending on the stage and etiology of the disease. It is also a significant independent risk factor for cardiovascular disease, progression to end-stage kidney disease and mortality. According to the current guidelines, resistant hypertension is defined in the general population as uncontrolled blood pressure on three or more antihypertensive drugs in adequate doses or when patients are on four or more antihypertensive drug categories irrespective of the blood pressure control, providing that antihypertensive treatment included diuretics. The currently established definitions of resistant hypertension are not directly applicable to the end-stage kidney disease setting. The diagnosis of true resistant hypertension requires confirmation of adherence to therapy and confirmation of uncontrolled blood pressure values by ambulatory blood pressure measurement or home blood pressure measurement. In addition, the term "apparent treatment-resistant hypertension," defined as an uncontrolled blood pressure on three or more antihypertensive medication classes, or use of four or more medications regardless of blood pressure level was introduced. In this comprehensive review we focused on the definitions of hypertension, and therapeutic targets in patients on renal replacement therapy, including the limitations and biases. We discussed the issue of pathophysiology and assessment of blood pressure in the dialyzed population, management of resistant hypertension as well as available data on prevalence of apparent treatment-resistant hypertension in end-stage kidney disease. To conclude, larger sample-size and even higher quality studies about drug adherence should be conducted in the population of patients with the end-stage kidney disease who are on dialysis. It also should be determined how and when blood pressure should be measured in the group of dialysis patients. Additionally, it should be stated what the target blood pressure values in this group of patients really are. The definition of resistant hypertension in this group should be revisited, and its relationship to both subclinical and clinical endpoints should be established.
MeSH term(s)	Humans ; Antihypertensive Agents/therapeutic use ; Antihypertensive Agents/pharmacology ; Renal Dialysis/adverse effects ; Blood Pressure Monitoring, Ambulatory ; Hypertension/drug therapy ; Hypertension/epidemiology ; Hypertension/etiology ; Blood Pressure/physiology ; Kidney Failure, Chronic/therapy ; Kidney Failure, Chronic/drug therapy
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2023-03-09
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfad047
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