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  1. Article ; Online: Two-End-Member Mixing in the Fluids Emitted From Mud Volcano Lei-Gong-Huo, Eastern Taiwan

    Hung-Chun Chao / Chen-Feng You / In-Tian Lin / Hou-Chun Liu / Ling-Ho Chung / Chun-Chang Huang / Chuan-Hsiung Chung

    Frontiers in Earth Science, Vol

    Evidence From Sr Isotopes

    2022  Volume 9

    Abstract: ... at depth. Mud volcano Lei-Gong-Huo (MV LGH) is a unique mud volcano, which is located on the mélange ...

    Abstract Mud volcano is one of the most important conduits for deep seated materials to migrate upward in sedimentary basins, convergent margins, and subduction zones. Understanding their temporal and spatial characteristics and variations provides us the important information on fluid sources and chemical compositions at depth. Mud volcano Lei-Gong-Huo (MV LGH) is a unique mud volcano, which is located on the mélange formation lying on the andesitic volcanic arc. Fluids emitted from 46 mud pools in MV LGH in eastern Taiwan were sampled and their major trace constitutes as well as H, O, and Sr isotopes (87Sr/86Sr and δ88Sr) were measured. Major constitutes of the fluids are Cl−, Na, and Ca. Compared with seawater, LGH fluids have lower Cl−, δD, δ18O, Na/Cl, K/Cl, and Mg/Cl but higher Ca/Cl ratios, indicating water–rock interaction of igneous rock and the ancient seawater at the source region. This interpretation is further supported by Sr isotopes, which show low value of 87Sr/86Sr ratio down to 0.70708. The result of spatial distribution showing strong negative correlation between Na and Ca concentration as well as Ca and 87Sr/86Sr ratios indicates that two end-member mixing is the major chemical characteristic. The fluids interacting with igneous rock carry high Ca, high δ88Sr, low Na, and low 87Sr/86Sr ratio, while those interacting with sedimentary rock carry low Ca, low δ88Sr, high Na, and high 87Sr/86Sr ratio. The source from the igneous region dominates the eastern and southeastern parts of the mud pools while sedimentary source dominates the western and northwestern parts. Most mud pools show mixing behavior between the two sources. Some of the sedimentary-dominated mud pools reveal existence of residual ancient water as indicated by 87Sr/86Sr. The major factor to fractionate the stable Sr isotopes in LGH waters is the source lithology. In summary, fluids emitted by mud pools in LGH originate from two sources, which are water–rock interactions of igneous rock with the ancient seawater from the east and sedimentary rock from the west at depth, resulting from the complex geologic background of mélange formation.
    Keywords mud volcano ; radiogenic Sr isotopes ; stable Sr isotopes ; sediment-hosted geothermal systems ; water–rock interaction ; Science ; Q
    Subject code 550
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model.

    Li, Qiaofeng / Lan, Taijin / He, Songhua / Chen, Weiwei / Li, Xiaolan / Zhang, Weiquan / Liu, Ying / Zhang, Qiuping / Chen, Xin / Han, Yaoyao / Su, Zhiheng / Zhu, Dan / Guo, Hongwei

    Chinese medicine

    2021  Volume 16, Issue 1, Page(s) 99

    Abstract: Background: Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang ...

    Abstract Background: Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang nationality, the largest ethnic minority among 56 nationalities in China. It consists of three herbs, namely Eclipta prostrata (L.) L., Smilax glabra Roxb, and Centella asiatica (L.) Urb. It has been widely used as health protection tea for hundreds of years to prevent hypertension in Guangxi Zhuang Autonomous Region. The purpose of this study is to validate the antihypertensive effect of LFG on the spontaneously hypertensive rat (SHR) model, and to further identify the effective components and anti-hypertension mechanism of LFG.
    Methods: The effects of LFG on blood pressure, body weight, and heart rate were investigated in vivo using the SHR model. The levels of NO, ANG II, and ET-1 in the serum were measured, and pathological changes in the heart were examined by H&E staining. The main active components of LFG, their corresponding targets, and hypertension associated pathways were discerned through network pharmacology analysis based on the Traditional Chinese Medicine Systems Pharmacology (TCMSP), Traditional Chinese Medicine Integrated Database (TCMID), and the Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine (BATMAN-TCM). Then the predicted results were further verified by molecular biology experiments such as RT-qPCR and western blot. Additionally, the potential active compounds were predicted by molecular docking technology, and the chemical constituents of LFG were analyzed and identified by UPLC-QTOF/MS technology. Finally, an in vitro assay was performed to investigate the protective effects of potential active compounds against hydrogen peroxide (H
    Results: LFG could effectively reduce blood pressure and increase serum NO content in SHR model. Histological results showed that LFG could ameliorate pathological changes such as cardiac hypertrophy and interstitial inflammation. From network pharmacology analysis, 53 candidate active compounds of LFG were collected, which linked to 765 potential targets, and 828 hypertension associated targets were retrieved, from which 12 overlapped targets both related to candidate active compounds from LFG and hypertension were screened and used as the potential targets of LFG on antihypertensive effect. The molecular biology experiments of the 12 overlapped targets showed that LFG could upregulate the mRNA and protein expressions of NOS3 and proto-oncogene tyrosine-protein kinase SRC (SRC) in the thoracic aorta. Pathway enrichment analysis showed that the PI3K-AKT signaling pathway was closely related to the expression of NOS3 and SRC. Moreover, western blot results showed that LFG significantly increased the protein expression levels of PI3K and phosphorylated AKT in SHR model, suggesting that LFG may active the PI3K-AKT signaling pathway to decrease hypertension. Molecular docking study further supported that p-hydroxybenzoic acid, cedar acid, shikimic acid, salicylic acid, nicotinic acid, linalool, and histidine can be well binding with NOS3, SRC, PI3K, and AKT. UPLC-QTOF/MS analysis confirmed that p-hydroxybenzoic acid, shikimic acid, salicylic acid, and nicotinic acid existed in LFG. Pre-treatment of HUVEC with nicotinic acid could alleviate the effect on cell viability induced by H
    Conclusions: LFG can reduce the blood pressure in SHR model, which might be attributed to increasing the NO level in serum for promoting vasodilation via upregulating SRC expression level and activating the PI3K-AKT-NOS3 signaling pathway. Nicotinic acid might be the potential compound for LFG antihypertensive effect.
    Language English
    Publishing date 2021-10-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2260322-0
    ISSN 1749-8546
    ISSN 1749-8546
    DOI 10.1186/s13020-021-00507-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Short-Term Effects of Bamboo Biochar and Oyster Shell Powder on Soil Organic Carbon Fraction, Microbial Respiration, and Enzymatic Stoichiometry in a Lei Bamboo Plantation

    Ji, Haonan / Yuan, Gensheng / Liu, Yang / Yu, Jinzhu / Li, Songhao / Wu, Qifeng / Qin, Hua / Chen, Junhui

    Forests. 2023 Apr. 21, v. 14, no. 4

    2023  

    Abstract: Both biochar and oyster shell powder have been known as promising amendments to ameliorate soil acidity and enhance soil fertility. However, it is still unclear how their application alone and in combination affect the soil organic carbon (C) fraction ... ...

    Abstract Both biochar and oyster shell powder have been known as promising amendments to ameliorate soil acidity and enhance soil fertility. However, it is still unclear how their application alone and in combination affect the soil organic carbon (C) fraction and microbial activity in subtropical bamboo plantations. Therefore, to investigate the effects of biochar and oyster shell powder on soil microbial respiration, organic C fractions, microbial biomass, and enzyme activities related to C, N and P cycling, topsoil samples were collected from plots in a bamboo (Phyllostachys praecox) plantation that has been amended with oyster shell powder at 4 t ha⁻¹ (T), bamboo biochar at 10 t ha⁻¹ (B), and their combination (TB, with 4 t ha⁻¹ T and 10 t ha⁻¹ B) for 8 months. Our results showed that T alone significantly increased soil microbial respiration by 21.5%, whereas B alone and TB significantly decreased soil microbial respiration and metabolic quotient compared with T. T alone also increased soil pH, the size of labile C pool and the activities of β−glucosidase and cellobiosidase, whereas TB rather than B increased soil pH, the recalcitrant C pool size and declined these enzyme activities relative to T. T alone significantly enhanced microbial C limitation by 28.6% and decreased P limitation by 13.0%, while TB decreased microbial C limitation and increased microbial C use efficiency (CUE). Structural equation modeling indicated that T enhanced soil microbial respiration through increasing soil pH and enzyme activity, while biochar co-addition weakened the stimulation of T on microbial respiration by increasing soil recalcitrant C pool size and microbial metabolic quotient. Our study suggests that adding bamboo biochar together with oyster shell powder could be a better strategy to decrease soil C loss and ameliorate soil acidity in bamboo plantations compared with the application of oyster shell powder alone.
    Keywords Phyllostachys violascens ; bamboos ; biochar ; carbon sinks ; enzyme activity ; enzymes ; equations ; microbial activity ; microbial biomass ; oyster shells ; soil fertility ; soil organic carbon ; soil pH ; stoichiometry ; topsoil
    Language English
    Dates of publication 2023-0421
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527081-3
    ISSN 1999-4907
    ISSN 1999-4907
    DOI 10.3390/f14040853
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Response of carbon uptake to abiotic and biotic drivers in an intensively managed Lei bamboo forest.

    Liu, Yuli / Zhou, Guomo / Du, Huaqiang / Berninger, Frank / Mao, Fangjie / Li, Xuejian / Chen, Liang / Cui, Lu / Li, Yangguang / Zhu, Di'en / Xu, Lin

    Journal of environmental management

    2018  Volume 223, Page(s) 713–722

    Abstract: Lei bamboo (Phyllostachys praecox) is widely distributed in southeastern China. We used eddy ... covariance to analyze carbon sequestration capacity of a Lei bamboo forest (2011-2013) and to identify ...

    Abstract Lei bamboo (Phyllostachys praecox) is widely distributed in southeastern China. We used eddy covariance to analyze carbon sequestration capacity of a Lei bamboo forest (2011-2013) and to identify the seasonal biotic and abiotic determinants of carbon fluxes. A machine learning algorithm called random forest (RF) was used to identify factors that affected carbon fluxes. The RF model predicted well the gross ecosystem productivity (GEP), ecosystem respiration (RE) and net ecosystem exchange (NEE), and displayed variations in the drivers between different seasons. Mean annual NEE, RE, and GEP were -105.2 ± 23.1, 1264.5 ± 45.2, and 1369.6 ± 52.5 g C m
    MeSH term(s) Carbon ; Carbon Cycle ; Carbon Dioxide ; Carbon Sequestration ; China ; Ecosystem ; Models, Theoretical
    Chemical Substances Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0)
    Language English
    Publishing date 2018-07-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2018.06.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Application of Convolutional Neural Network on Lei Bamboo Above-Ground-Biomass (AGB) Estimation Using Worldview-2

    Dong, Luofan / Du, Huaqiang / Han, Ning / Li, Xuejian / Zhu, Di’en / Mao, Fangjie / Zhang, Meng / Zheng, Junlong / Liu, Hua / Huang, Zihao / He, Shaobai

    Remote Sensing. 2020 Mar. 16, v. 12, no. 6

    2020  

    Abstract: Above-ground biomass (AGB) directly relates to the productivity of forests. Precisely, AGB mapping for regional forests based on very high resolution (VHR) imagery is widely needed for evaluation of productivity. However, the diversity of variables and ... ...

    Abstract Above-ground biomass (AGB) directly relates to the productivity of forests. Precisely, AGB mapping for regional forests based on very high resolution (VHR) imagery is widely needed for evaluation of productivity. However, the diversity of variables and algorithms and the difficulties inherent in high resolution optical imagery make it complex. In this paper, we explored the potentials of the state-of-art algorithm convolutional neural networks (CNNs), which are widely used for its high-level representation, but rarely applied for AGB estimation. Four experiments were carried out to compare the performance of CNNs and other state-of-art Machine Learning (ML) algorithms: (1) performance of CNN using bands, (2) performance of Random Forest (RF), support vector regression (SVR), artificial neural network (ANN) on bands, and vegetation indices (VIs). (3) Performance of RF, SVR, and ANN on gray-level co-occurrence matrices (GLCM), and exploratory spatial data analysis (ESDA), and (4) performance of RF, SVR, and ANN based on all combined data and ESDA+VIs. CNNs reached satisfactory results (with R² = 0.943) even with limited input variables (i.e., only bands). In comparison, RF and SVR with elaborately designed data obtained slightly better accuracy than CNN. For examples, RF based on GLCM textures reached an R² of 0.979 and RF based on all combined data reached a close R² of 0.974. However, the results of ANN were much worse (with the best R² of 0.885).
    Keywords aboveground biomass ; algorithms ; artificial intelligence ; bamboos ; forests ; neural networks ; regression analysis ; remote sensing ; spatial data ; vegetation index
    Language English
    Dates of publication 2020-0316
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2513863-7
    ISSN 2072-4292
    ISSN 2072-4292
    DOI 10.3390/rs12060958
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Application of Convolutional Neural Network on Lei Bamboo Above-Ground-Biomass (AGB) Estimation Using Worldview-2

    Luofan Dong / Huaqiang Du / Ning Han / Xuejian Li / Di’en Zhu / Fangjie Mao / Meng Zhang / Junlong Zheng / Hua Liu / Zihao Huang / Shaobai He

    Remote Sensing, Vol 12, Iss 6, p

    2020  Volume 958

    Abstract: Above-ground biomass (AGB) directly relates to the productivity of forests. Precisely, AGB mapping for regional forests based on very high resolution (VHR) imagery is widely needed for evaluation of productivity. However, the diversity of variables and ... ...

    Abstract Above-ground biomass (AGB) directly relates to the productivity of forests. Precisely, AGB mapping for regional forests based on very high resolution (VHR) imagery is widely needed for evaluation of productivity. However, the diversity of variables and algorithms and the difficulties inherent in high resolution optical imagery make it complex. In this paper, we explored the potentials of the state-of-art algorithm convolutional neural networks (CNNs), which are widely used for its high-level representation, but rarely applied for AGB estimation. Four experiments were carried out to compare the performance of CNNs and other state-of-art Machine Learning (ML) algorithms: (1) performance of CNN using bands, (2) performance of Random Forest (RF), support vector regression (SVR), artificial neural network (ANN) on bands, and vegetation indices (VIs). (3) Performance of RF, SVR, and ANN on gray-level co-occurrence matrices (GLCM), and exploratory spatial data analysis (ESDA), and (4) performance of RF, SVR, and ANN based on all combined data and ESDA+VIs. CNNs reached satisfactory results (with R 2 = 0.943) even with limited input variables (i.e., only bands). In comparison, RF and SVR with elaborately designed data obtained slightly better accuracy than CNN. For examples, RF based on GLCM textures reached an R 2 of 0.979 and RF based on all combined data reached a close R 2 of 0.974. However, the results of ANN were much worse (with the best R 2 of 0.885).
    Keywords deep learning (dl) ; machine learning (ml) ; above ground biomass (agb) ; very high-resolution imagery ; textures ; Science ; Q
    Subject code 006 ; 333
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model

    Qiaofeng Li / Taijin Lan / Songhua He / Weiwei Chen / Xiaolan Li / Weiquan Zhang / Ying Liu / Qiuping Zhang / Xin Chen / Yaoyao Han / Zhiheng Su / Dan Zhu / Hongwei Guo

    Chinese Medicine, Vol 16, Iss 1, Pp 1-

    2021  Volume 21

    Abstract: Abstract Background Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang ...

    Abstract Abstract Background Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang nationality, the largest ethnic minority among 56 nationalities in China. It consists of three herbs, namely Eclipta prostrata (L.) L., Smilax glabra Roxb, and Centella asiatica (L.) Urb. It has been widely used as health protection tea for hundreds of years to prevent hypertension in Guangxi Zhuang Autonomous Region. The purpose of this study is to validate the antihypertensive effect of LFG on the spontaneously hypertensive rat (SHR) model, and to further identify the effective components and anti-hypertension mechanism of LFG. Methods The effects of LFG on blood pressure, body weight, and heart rate were investigated in vivo using the SHR model. The levels of NO, ANG II, and ET-1 in the serum were measured, and pathological changes in the heart were examined by H&E staining. The main active components of LFG, their corresponding targets, and hypertension associated pathways were discerned through network pharmacology analysis based on the Traditional Chinese Medicine Systems Pharmacology (TCMSP), Traditional Chinese Medicine Integrated Database (TCMID), and the Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine (BATMAN-TCM). Then the predicted results were further verified by molecular biology experiments such as RT-qPCR and western blot. Additionally, the potential active compounds were predicted by molecular docking technology, and the chemical constituents of LFG were analyzed and identified by UPLC-QTOF/MS technology. Finally, an in vitro assay was performed to investigate the protective effects of potential active compounds against hydrogen peroxide (H2O2) induced oxidative damage in human umbilical vein endothelial cells (HUVEC). Results LFG could effectively reduce blood pressure and increase serum NO content in SHR model. Histological results showed that LFG could ameliorate pathological changes such as cardiac hypertrophy and interstitial inflammation. From network ...
    Keywords Centella asiatica (L.) Urb ; Eclipta prostrata (L.) L ; Smilax glabra Roxb ; Hypertension ; Network pharmacology ; Other systems of medicine ; RZ201-999
    Subject code 500
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Lei-Shi Li: a giant in international nephrology.

    Liu, Zhi-Hong / Dworkin, Lance D / Atkins, Robert C

    Kidney international

    2010  Volume 77, Issue 12, Page(s) 1051–1052

    MeSH term(s) Biomedical Research/history ; China ; History, 20th Century ; History, 21st Century ; Nephrology/history
    Language English
    Publishing date 2010-06
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1038/ki.2010.133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Response of carbon uptake to abiotic and biotic drivers in an intensively managed Lei bamboo forest

    Liu, Yuli / Zhou, Guomo / Du, Huaqiang / Berninger, Frank / Mao, Fangjie / Li, Xuejian / Chen, Liang / Cui, Lu / Li, Yangguang / Zhu, Di'en / Xu, Lin

    Journal of environmental management. 2018 Oct. 01, v. 223

    2018  

    Abstract: Lei bamboo (Phyllostachys praecox) is widely distributed in southeastern China. We used eddy ... covariance to analyze carbon sequestration capacity of a Lei bamboo forest (2011–2013) and to identify ...

    Abstract Lei bamboo (Phyllostachys praecox) is widely distributed in southeastern China. We used eddy covariance to analyze carbon sequestration capacity of a Lei bamboo forest (2011–2013) and to identify the seasonal biotic and abiotic determinants of carbon fluxes. A machine learning algorithm called random forest (RF) was used to identify factors that affected carbon fluxes. The RF model predicted well the gross ecosystem productivity (GEP), ecosystem respiration (RE) and net ecosystem exchange (NEE), and displayed variations in the drivers between different seasons. Mean annual NEE, RE, and GEP were −105.2 ± 23.1, 1264.5 ± 45.2, and 1369.6 ± 52.5 g C m−2, respectively. Climate warming increased RE more than GEP when water inputs were not limiting. Summer drought played little role in suppressing GEP, but low soil moisture contents suppressed RE and increased the carbon sink during drought in the summer. The most important drivers of NEE were soil temperature in spring, summer, and winter, and photosynthetically active radiation in autumn. Air and soil temperature were important drivers of GEP in all seasons.
    Keywords Phyllostachys violascens ; air ; air temperature ; algorithms ; artificial intelligence ; autumn ; bamboos ; carbon ; carbon sequestration ; carbon sinks ; drought ; ecosystem respiration ; ecosystems ; eddy covariance ; forests ; global warming ; models ; net ecosystem exchange ; photosynthetically active radiation ; soil temperature ; spring ; summer ; winter ; China
    Language English
    Dates of publication 2018-1001
    Size p. 713-722.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2018.06.046
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Comparing Simulated Carbon Budget of a Lei Bamboo Forest with Flux Tower Data

    Xuehe Lu / Hong Jiang / Jinxun Liu / Cheng Sun / Ying Wang / Jiaxin Jin

    Terrestrial, Atmospheric and Oceanic Sciences, Vol 25, Iss 3, p

    2014  Volume 359

    Abstract: ... Biosphere Simulator (IBIS) according the management of Lei bamboo forest. Some management, like ... compared model results with the observation data from a Lei bamboo flux tower. The simulated and observed ... results had achieved good consistency. Our simulated Lei bamboo forest yearly net ecosystem productivity ...

    Abstract Bamboo forest ecosystem is the part of the forest ecosystem. The distribution area of bamboo forest is limited, but in somewhere, like south China, it has been cultivate for a long time with human management. As the climate change has been take great effect on forest carbon budget, many researchers pay attention to the carbon budget in bamboo forest. Moreover cultivative management had a significant impact on the bamboo forest carbon budget. In this study, we modified a terrestrial ecosystem model named Integrated Biosphere Simulator (IBIS) according the management of Lei bamboo forest. Some management, like fertilization, shoots harvesting and organic mulching in winter, had been incorporated into model. Then we had compared model results with the observation data from a Lei bamboo flux tower. The simulated and observed results had achieved good consistency. Our simulated Lei bamboo forest yearly net ecosystem productivity (NEP) was 0.41 kgC a-1 of carbon, which is very close to the observation data 0.45 kgC a-1 of carbon. And the monthly simulated results can take the change of carbon budget in each month, similar to the data we got from flux tower. It reflects that the modified IBIS model can characterize the growth of bamboo forest and perform the simulation well. And then two groups of simulations were set to evaluate effects of cultivative managements on Lei bamboo forests carbon budget. And results showed that both fertilization and organic mulching had taken positive effects on Lei bamboo forests carbon sequestration.
    Keywords Lei bamboo forest ; Carbon budget ; Flux tower ; Ecological model ; Geography (General) ; G1-922 ; Geology ; QE1-996.5
    Subject code 550
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Chinese Geoscience Union
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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