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  1. Article ; Online: Letter to the Editor:

    Ciccullo, Arturo / Iannone, Valentina / Lombardi, Francesca / Borghetti, Alberto / Di Giambenedetto, Simona

    AIDS research and human retroviruses

    2024  

    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/AID.2023.0057
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    Zs.A 1928: Show issues Location:
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  2. Article ; Online: Real-life findings on the impact of the COVID-19 pandemic on HIV care.

    Ciccullo, Arturo / Baldin, Gianmaria / Borghetti, Alberto / Di Giambenedetto, Simona

    Antiviral therapy

    2021  Volume 26, Issue 3-5, Page(s) 84–86

    MeSH term(s) COVID-19 ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Influenza, Human/epidemiology ; Pandemics
    Language English
    Publishing date 2021-10-19
    Publishing country England
    Document type Letter
    ZDB-ID 1339842-8
    ISSN 2040-2058 ; 1359-6535
    ISSN (online) 2040-2058
    ISSN 1359-6535
    DOI 10.1177/13596535211052215
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    Zs.A 4877: Show issues Location:
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    Zs.MO 174: Show issues

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  3. Article ; Online: Early use of tecovirimat in a young man with severe mpox skin lesions: a case report.

    Iannone, Valentina / Ciccullo, Arturo / Farinacci, Damiano / Borghetti, Alberto / Visconti, Elena / Marchetti, Simona / Sanguinetti, Maurizio / Tamburrini, Enrica / Di Giambenedetto, Simona

    Journal of medical virology

    2023  Volume 95, Issue 2, Page(s) e28528

    MeSH term(s) Male ; Humans ; Mpox (monkeypox) ; Benzamides ; Isoindoles
    Chemical Substances Benzamides ; Isoindoles
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28528
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    Zs.A 1320: Show issues Location:
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  4. Article ; Online: Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant

    Passerotto, Rosa Anna / Lamanna, Francesco / Farinacci, Damiano / Dusina, Alex / Di Giambenedetto, Simona / Ciccullo, Arturo / Borghetti, Alberto

    Infectious medicine

    2023  Volume 2, Issue 2, Page(s) 143–147

    Abstract: We analyzed the case of a 49-year-old woman with HIV infection off-therapy with poor viro-immunological compensation, not vaccinated for SARS-COV-2, hospitalized for lobar pneumonia and severe COVID19-related respiratory failure in intensive care unit ( ... ...

    Abstract We analyzed the case of a 49-year-old woman with HIV infection off-therapy with poor viro-immunological compensation, not vaccinated for SARS-COV-2, hospitalized for lobar pneumonia and severe COVID19-related respiratory failure in intensive care unit (ICU). The hospitalization was complicated by bacteraemic ventilator-associated pneumonia (VAP) caused by multidrug-resistant
    Language English
    Publishing date 2023-03-04
    Publishing country China
    Document type Case Reports
    ISSN 2772-431X
    ISSN (online) 2772-431X
    DOI 10.1016/j.imj.2023.02.004
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  5. Article ; Online: Comment on: Long-term outcome of dolutegravir-containing regimens according to sex: data from the ICONA study.

    Ciccullo, Arturo / Baldin, Gianmaria / Sterrantino, Gaetana / Madeddu, Giordano / D'ettorre, Gabriella / Mussini, Cristina / Di Giambenedetto, Simona

    The Journal of antimicrobial chemotherapy

    2023  Volume 78, Issue 7, Page(s) 1808–1809

    MeSH term(s) Humans ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use ; Oxazines/therapeutic use ; Heterocyclic Compounds, 3-Ring/adverse effects ; Pyridones/therapeutic use
    Chemical Substances dolutegravir (DKO1W9H7M1) ; Anti-HIV Agents ; Oxazines ; Heterocyclic Compounds, 3-Ring ; Pyridones
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Research Support, Non-U.S. Gov't ; Letter ; Comment
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad151
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    Zs.A 1197: Show issues Location:
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    Zs.MO 124: Show issues

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  6. Article ; Online: Rapid improvement of severe Mpox lesions with oral tecovirimat.

    Raccagni, Angelo Roberto / Leoni, Davide / Ciccullo, Arturo / Verdenelli, Stefano / Cattelan, Anna Maria / Di Giambenedetto, Simona / Falcone, Marco / Mileto, Davide / Castagna, Antonella / Nozza, Silvia

    Journal of medical virology

    2023  Volume 95, Issue 6, Page(s) e28825

    MeSH term(s) Humans ; Mpox (monkeypox)
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28825
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    Zs.A 1320: Show issues Location:
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  7. Article: Efficacy of Lamivudine Plus Dolutegravir vs Dolutegravir-Based 3-Drug Regimens in People With HIV Who Are Virologically Suppressed.

    Borghetti, Alberto / Ciccullo, Arturo / Lombardi, Francesca / Giannarelli, Diana / Passerotto, Rosa Anna / Lamanna, Francesco / Carcagnì, Antonella / Farinacci, Damiano / Dusina, Alex / Baldin, Gianmaria / Zazzi, Maurizio / Di Giambenedetto, Simona

    Open forum infectious diseases

    2024  Volume 11, Issue 5, Page(s) ofae198

    Abstract: Background: Lamivudine + dolutegravir maintenance dual therapy (DT) could be less effective than 3-drug therapy (TT) in the context of resistance-associated mutations to nucleoside reverse transcriptase inhibitors (NRTIs). The ARCA database was queried ... ...

    Abstract Background: Lamivudine + dolutegravir maintenance dual therapy (DT) could be less effective than 3-drug therapy (TT) in the context of resistance-associated mutations to nucleoside reverse transcriptase inhibitors (NRTIs). The ARCA database was queried to test this hypothesis with a trial emulation strategy.
    Methods: People with HIV taking 2 NRTIs plus a protease inhibitor or a non-NRTI who switched to DT or dolutegravir-based TT were followed up from the first HIV RNA <50 copies/mL (baseline) to virologic failure (VF; ie, 2 consecutive HIV RNA ≥50 copies/mL or 1 HIV RNA ≥200 copies/mL). Those switching to DT within 6 months were assigned to the treatment arm and all other patients to the control arm. Each participant was also cloned, assigned to the opposite strategy, and censored at the time of deviation from that strategy. Using inverse probability of censoring weight Cox regression models, we calculated hazard ratios of VF for DT vs TT stratified for the presence of resistance-associated mutations.
    Results: Overall 626 people were analyzed: 204 with DT and 422 with TT (73% men; mean age, 44 years). Ten and 31 VFs occurred with DT and TT, respectively, over a median 5.8 years. When compared with a fully active TT, the DT had similar efficacy (adjusted hazard ratio, 0.88; 95% CI, .29-2.61;
    Conclusions: DT was not associated with a significantly higher risk of VF than dolutegravir-based TT.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofae198
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  8. Article ; Online: Clinical presentation of human monkeypox virus infection during the 2022 outbreak: descriptive case series from a large italian Research Hospital.

    Salvo, Pierluigi Francesco / Farinacci, Damiano / Lombardi, Francesca / Ciccullo, Arturo / Tamburrini, Enrica / Santangelo, Rosaria / Borghetti, Alberto / Di Giambenedetto, Simona

    Virology journal

    2023  Volume 20, Issue 1, Page(s) 214

    Abstract: Background: In May 2022, a new case of Monkeypox Virus (MPX) was reported in a non-endemic area, the United Kingdom, and since then, the number of confirmed cases in Europe has been increasing until WHO, on May 10 2023, declared that MPOX is no longer a ...

    Abstract Background: In May 2022, a new case of Monkeypox Virus (MPX) was reported in a non-endemic area, the United Kingdom, and since then, the number of confirmed cases in Europe has been increasing until WHO, on May 10 2023, declared that MPOX is no longer a public health emergency of international concern. We aimed to describe the clinical and microbiological characteristics of sixteen patients with a confirmed diagnosis of MPX followed by a single Italian clinical centre, the Fondazione Policlinico Universitario Agostino Gemelli, between May 20 and August 30.
    Materials and methods: A prospective observational study has been conducted, collecting microbiological samples during the time of the infection, as well as epidemiological and clinical data of the patients. All patients provided written informed consent.
    Results: During clinical practice, 16 individuals presenting with consistent symptoms tested positive for MPX on a polymerase chain reaction. All patients were men having sex with men (MSM). The most frequent clinical presentation was a vesicular erythematous cutaneous rash, mainly distributed on the genital and perianal area, but also regarding limbs, face, neck, chest and back in some of the patients. Systemic symptoms, such as fever or lymphadenopathy, involved eight patients. The symptom most frequently reported by patients was pruritus in the area of the vesicles. Thirteen patients also reported pain. Nine patients were HIV-1 coinfected, but no significant differences have been observed compared to other cohort patients. The median time between the onset of symptoms and the healing was 19.5 days (IQR 14.0-20.3).
    Conclusions: Our cohort of patients presented a mild manifestation of the disease with no complications and no need for antiviral therapy nor hospitalization. This population seems different from the ones reported in the literature during the previous outbreaks in endemic areas in epidemiological data and clinical manifestations but also from a cohort of patients described in the literature from the 2022 outbreak, suggesting the importance for healthcare workers to keep in mind the possibility of an MPX infection in the differential diagnosis of patients presenting with consistent symptoms, even in non-endemic areas, to ensure efficient isolation of the patient for infection control purposes and effective management of the infection preventing the development of MPOX-related complications.
    MeSH term(s) Male ; Humans ; Female ; Mpox (monkeypox)/diagnosis ; Mpox (monkeypox)/epidemiology ; Monkeypox virus/genetics ; Homosexuality, Male ; Sexual and Gender Minorities ; Hospitals ; Disease Outbreaks
    Language English
    Publishing date 2023-09-18
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2160640-7
    ISSN 1743-422X ; 1743-422X
    ISSN (online) 1743-422X
    ISSN 1743-422X
    DOI 10.1186/s12985-023-02178-w
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  9. Article ; Online: Blood telomere length gain in people living with HIV switching to dolutegravir plus lamivudine versus continuing triple regimen: a longitudinal, prospective, matched, controlled study.

    Lombardi, Francesca / Sanfilippo, Alessia / Fabbiani, Massimiliano / Borghetti, Alberto / Ciccullo, Arturo / Tamburrini, Enrica / Di Giambenedetto, Simona

    The Journal of antimicrobial chemotherapy

    2023  Volume 78, Issue 9, Page(s) 2315–2322

    Abstract: Background: Blood telomere length (BTL) is a validated biomarker of aging. ART reduces immunosenescence and has benefits in terms of BTL in people living with HIV (PLWH). However, it has also been observed that ART containing NRTIs, such as tenofovir or ...

    Abstract Background: Blood telomere length (BTL) is a validated biomarker of aging. ART reduces immunosenescence and has benefits in terms of BTL in people living with HIV (PLWH). However, it has also been observed that ART containing NRTIs, such as tenofovir or abacavir, which are potent inhibitors of human telomerase activity in vitro, might negatively affect BTL. Here we investigated the effects on BTL 1 year after switching to a dual therapy (DT) with dolutegravir + lamivudine versus maintaining a standard triple therapy (TT) with a two-NRTI backbone and an anchor drug.
    Methods: This was a longitudinal, prospective, matched, controlled study that included virologically suppressed adults on stable three-drug ART who either switched at baseline (BL) to DT or maintained TT. The DT and TT groups were 1:1 matched for age, sex, years since HIV diagnosis, years on ART and anchor drug. BTL was assessed by a monochrome multiplex qPCR at BL and after 48 weeks (W48).
    Results: We enrolled 120 PLWH, i.e. 60 participants in each group. At BL, the BTL means were comparable between the two groups (P = 0.973). At W48, viro-immunological status was stable and an overall increase in the mean BTL was observed, i.e., +0.161 (95%CI, 0.054-0.268) (P = 0.004). However, the within-group analysis showed a significant mean BTL gain in the DT group (P = 0.003) but not in the TT group (P = 0.656).
    Conclusions: In this setting of virologically suppressed PLWH, simplifying to dolutegravir + lamivudine was associated with a higher gain in BTL than maintaining triple therapy after the 1 year follow-up. These findings suggest that as a simplification strategy dolutegravir + lamivudine might have a positive effect on BTL.
    MeSH term(s) Adult ; Humans ; Lamivudine/therapeutic use ; Lamivudine/pharmacology ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use ; Anti-HIV Agents/pharmacology ; Prospective Studies ; Oxazines/pharmacology ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Heterocyclic Compounds, 3-Ring/pharmacology ; Pyridones/pharmacology ; Telomere ; Viral Load
    Chemical Substances Lamivudine (2T8Q726O95) ; dolutegravir (DKO1W9H7M1) ; Anti-HIV Agents ; Oxazines ; Heterocyclic Compounds, 3-Ring ; Pyridones
    Language English
    Publishing date 2023-08-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad237
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    Zs.A 1197: Show issues Location:
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    Zs.MO 124: Show issues

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  10. Article ; Online: Comparative safety review of recommended, first-line single-tablet regimens in patients with HIV.

    Ciccullo, Arturo / Baldin, Gianmaria / Putaggio, Cristina / Di Giambenedetto, Simona / Borghetti, Alberto

    Expert opinion on drug safety

    2021  Volume 20, Issue 11, Page(s) 1317–1332

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Animals ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/adverse effects ; Anti-HIV Agents/pharmacology ; Drug Combinations ; HIV Infections/drug therapy ; HIV Infections/virology ; Humans ; Reverse Transcriptase Inhibitors/administration & dosage ; Reverse Transcriptase Inhibitors/adverse effects ; Reverse Transcriptase Inhibitors/pharmacology ; Tablets
    Chemical Substances Anti-HIV Agents ; Drug Combinations ; Reverse Transcriptase Inhibitors ; Tablets
    Language English
    Publishing date 2021-05-27
    Publishing country England
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 2088728-0
    ISSN 1744-764X ; 1474-0338
    ISSN (online) 1744-764X
    ISSN 1474-0338
    DOI 10.1080/14740338.2021.1931115
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    Zs.A 6096: Show issues Location:
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