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  1. Article ; Online: Early urate-lowering therapy in gouty arthritis with acute flares

    Deng-Ho Yang / Hsiang-Cheng Chen / James Cheng-Chung Wei

    European Journal of Medical Research, Vol 28, Iss 1, Pp 1-

    a double-blind placebo controlled clinical trial

    2023  Volume 9

    Abstract: Abstract Background Gouty arthritis (GA) is a chronic systemic disease with recurrent acute monoarthritis. In a previous study, a higher incidence of acute flares was observed during the initial marked decrease in serum urate level. Our study evaluated ... ...

    Abstract Abstract Background Gouty arthritis (GA) is a chronic systemic disease with recurrent acute monoarthritis. In a previous study, a higher incidence of acute flares was observed during the initial marked decrease in serum urate level. Our study evaluated the effect of early urate-lowering therapy in patients with acute GA flares. Methods This study included 40 patients with acute GA; of them, 20 received colchicine 0.5 mg colchicine twice daily, while 20 received probenecid 500 mg and colchicine 0.5 mg twice daily. We evaluated GA severity and laboratory data for 2 weeks after the initial therapy. Medians and interquartile ranges (IQRs) were calculated to evaluate clinical presentations between these two groups. Results Rapidly decreasing median serum uric acid levels was found in the patients treated with probenecid and colchicine compared with the patients treated with colchicine alone on day 8 (− 1.9 [IQR, − 3.7 to 0] vs 0.8 [IQR, − 0.1–2.2]; P < 0.001). However, the median decrease in visual analog scale score did not differ significantly between the two groups (− 5.5 [IQR, − 8.0 to − 3.0] vs − 3.5 [IQR, − 5.9 to − 2.0]; P = 0.080). Conclusion No significant increase was noted in acute gout flare severity or duration among GA patients treated with early aggressive control of hyperuricemia using probenecid plus colchicine.
    Keywords Gout ; Gouty arthritis ; Uric acid ; Probenecid ; Urate-lowering therapy ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: IgG4-related tubulointerstitial nephritis.

    Tsai, Meng-Ko / Chen, Yen-Lin / Chen, Hsiang-Cheng / Liu, Feng-Cheng / Chang, Deh-Ming / Lu, Chun-Chi

    Annals of the rheumatic diseases

    2024  Volume 83, Issue 4, Page(s) 537–538

    MeSH term(s) Humans ; Immunoglobulin G ; Nephritis, Interstitial ; Kidney
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2023-224899
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  3. Article: Comb sign in a patient with ankylosing spondylitis.

    Chen, Yu-Hisu / Chen, Hsiang-Cheng

    The Indian journal of medical research

    2019  Volume 148, Issue 6, Page(s) 761–762

    MeSH term(s) Adenocarcinoma/diagnostic imaging ; Colonic Neoplasms/diagnostic imaging ; Colonoscopy ; Crohn Disease/diagnostic imaging ; Crohn Disease/drug therapy ; Diagnosis, Differential ; Humans ; Male ; Spondylitis, Ankylosing/diagnostic imaging ; Tomography, X-Ray Computed ; Young Adult
    Language English
    Publishing date 2019-02-19
    Publishing country India
    Document type Case Reports ; Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_1256_17
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  4. Article: Anti-citrullinated α-enolase peptide as a highly sensitive autoantigen in patients with rheumatoid arthritis.

    Yeh, Fu-Chiang / Cherng, Juin-Hong / Chang, Shu-Jen / Huang, Wei-Ting / Chen, Hsiang-Cheng

    Heliyon

    2023  Volume 9, Issue 12, Page(s) e22745

    Abstract: Rheumatoid arthritis (RA) is the most common autoimmune rheumatic disease in Taiwan. Anti-cyclic citrullinated peptide (anti-CCP) assay is widely used for RA diagnosis; however, not all anti-CCPs are detectable in RA-joint lesions. Citrullinated α- ... ...

    Abstract Rheumatoid arthritis (RA) is the most common autoimmune rheumatic disease in Taiwan. Anti-cyclic citrullinated peptide (anti-CCP) assay is widely used for RA diagnosis; however, not all anti-CCPs are detectable in RA-joint lesions. Citrullinated α-enolase peptide (CEP), which has a unique immunodominant epitope, can be detected in synovial fluid. Here, we aimed to evaluate the potential of anti-CEP as a serologic marker for the early diagnosis of RA and a prognostic predictor of joint destruction. We also determined the association of single-nucleotide polymorphisms (SNPs) in genes with the serological status and clinical characteristics of RA. Clinical records of 30 patients with RA were collected, and their serum and DNA samples were evaluated using enzyme-linked immunosorbent assay (ELISA) and SNP cross-reaction analysis. A considerable amount of anti-CEP was detected in patients with RA, a trend similar to that of anti-CCP. Moreover, anti-CEP was considerably associated with the protein-arginine deiminase type-2 SNP rs1005753.
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e22745
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  5. Article ; Online: Streptococcus agalactiae pyomyositis in a patient with primary biliary cholangitis: A case report.

    Wang, Yi-Jie / Lin, Chia-Hua / Lu, Chun-Chi / Chen, Hsiang-Cheng / Yeh, Fu-Chiang

    International journal of rheumatic diseases

    2023  Volume 26, Issue 7, Page(s) 1358–1362

    Abstract: Pyomyositis is an uncommon clinical scenario; it is usually associated with predisposing factors, including poorly controlled diabetes mellitus, trauma history, and immunocompromise. We discuss the case of an elderly woman with a 20-year history of ... ...

    Abstract Pyomyositis is an uncommon clinical scenario; it is usually associated with predisposing factors, including poorly controlled diabetes mellitus, trauma history, and immunocompromise. We discuss the case of an elderly woman with a 20-year history of diabetes mellitus and remissive breast cancer after modified radical mastectomy and subsequent chemotherapy 28 years previously. The patient presented with severe shoulder pain and gradual swelling. After examination, pyomyositis was diagnosed and debridement surgery was performed. Culture of the wound samples showed the growth of Streptococcus agalactiae. During hospitalization, primary biliary cholangitis (PBC) was diagnosed incidentally, accompanied by poor glycemic control. After treatment with antibiotics for pyomyositis and ursodeoxycholic acid for PBC, the infection resolved in 8 weeks, and her glycemic control was improved after PBC treatment. It is possible that the long-term untreated PBC worsened insulin resistance and aggravated diabetes mellitus in this patient. To the best of our knowledge, this is the first reported case of pyomyositis caused by an unusual pathogen, S. agalactiae, in a patient with newly diagnosed PBC.
    MeSH term(s) Humans ; Female ; Aged ; Pyomyositis/diagnosis ; Pyomyositis/drug therapy ; Liver Cirrhosis, Biliary ; Streptococcus agalactiae ; Breast Neoplasms/complications ; Mastectomy/adverse effects
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Case Reports
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.14612
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    Zs.A 6098: Show issues Location:
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  6. Article ; Online: Case report: Dysgeusia in a senile male systemic lupus erythematosus patient with serious cytomegalovirus infection.

    Tsai, I-Ting / Lin, Hung-Hsin / Lin, Chia-Hua / Liu, Feng-Cheng / Chen, Hsiang-Cheng / Yeh, Fu-Chiang

    International journal of rheumatic diseases

    2023  Volume 27, Issue 3, Page(s) e15115

    MeSH term(s) Male ; Humans ; Dysgeusia ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/drug therapy
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.15115
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    Zs.A 6098: Show issues Location:
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  7. Book: T'ai-wan t'u-ti li-yung t'u-chi. Ch'en Cheng-hsiang

    Chen, Cheng-hsiang

    Atlas of land utilization in Taiwan

    1950  

    Title variant Atlas of land utilization in Taiwan
    Author's details by Cheng-siang Chen
    Language Chinese ; English
    Size 8 S. Abb., 121 S. Kart., 16 Bl. Reg
    Publisher Kuo-li T'ai-wan ta-hsüeh nung-yeh ti-li yen-chiu-shih
    Publishing place Taipei
    Document type Book
    Note Published by the National Taiwan Univesity, [Übergeklebt]: the Institute of Agricultural Geography 1950 ; Text chines. u. engl.
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article ; Online: Functional Role of Mitochondrial DNA in Cancer Progression

    Yang-Hsiang Lin / Siew-Na Lim / Cheng-Yi Chen / Hsiang-Cheng Chi / Chau-Ting Yeh / Wey-Ran Lin

    International Journal of Molecular Sciences, Vol 23, Iss 1659, p

    2022  Volume 1659

    Abstract: Mitochondrial DNA (mtDNA) has been identified as a significant genetic biomarker in disease, cancer and evolution. Mitochondria function as modulators for regulating cellular metabolism. In the clinic, mtDNA variations (mutations/single nucleotide ... ...

    Abstract Mitochondrial DNA (mtDNA) has been identified as a significant genetic biomarker in disease, cancer and evolution. Mitochondria function as modulators for regulating cellular metabolism. In the clinic, mtDNA variations (mutations/single nucleotide polymorphisms) and dysregulation of mitochondria-encoded genes are associated with survival outcomes among cancer patients. On the other hand, nuclear-encoded genes have been found to regulate mitochondria-encoded gene expression, in turn regulating mitochondrial homeostasis. These observations suggest that the crosstalk between the nuclear genome and mitochondrial genome is important for cellular function. Therefore, this review summarizes the significant mechanisms and functional roles of mtDNA variations (DNA level) and mtDNA-encoded genes (RNA and protein levels) in cancers and discusses new mechanisms of crosstalk between mtDNA and the nuclear genome.
    Keywords mitochondria ; SNP ; mutation ; ncRNA ; prognostic marker ; cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  9. Article ; Online: Corticosteroid-Induced Liver Injury in Adult-Onset Still's Disease.

    Lee, Chin-Chi / Peng, Yi-Jen / Lu, Chun-Chi / Chen, Hsiang-Cheng / Yeh, Fu-Chiang

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 2

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Adrenal Cortex Hormones/adverse effects ; Adult ; Arthritis ; Chemical and Drug Induced Liver Injury, Chronic/complications ; Chemical and Drug Induced Liver Injury, Chronic/drug therapy ; Female ; Humans ; Still's Disease, Adult-Onset/complications ; Still's Disease, Adult-Onset/diagnosis ; Still's Disease, Adult-Onset/drug therapy
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58020191
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    Zs.A 6270: Show issues Location:
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  10. Article ; Online: Anti-citrullinated α-enolase peptide as a highly sensitive autoantigen in patients with rheumatoid arthritis

    Fu-Chiang Yeh / Juin-Hong Cherng / Shu-Jen Chang / Wei-Ting Huang / Hsiang-Cheng Chen

    Heliyon, Vol 9, Iss 12, Pp e22745- (2023)

    2023  

    Abstract: Rheumatoid arthritis (RA) is the most common autoimmune rheumatic disease in Taiwan. Anti-cyclic citrullinated peptide (anti-CCP) assay is widely used for RA diagnosis; however, not all anti-CCPs are detectable in RA-joint lesions. Citrullinated α- ... ...

    Abstract Rheumatoid arthritis (RA) is the most common autoimmune rheumatic disease in Taiwan. Anti-cyclic citrullinated peptide (anti-CCP) assay is widely used for RA diagnosis; however, not all anti-CCPs are detectable in RA-joint lesions. Citrullinated α-enolase peptide (CEP), which has a unique immunodominant epitope, can be detected in synovial fluid. Here, we aimed to evaluate the potential of anti-CEP as a serologic marker for the early diagnosis of RA and a prognostic predictor of joint destruction. We also determined the association of single-nucleotide polymorphisms (SNPs) in genes with the serological status and clinical characteristics of RA. Clinical records of 30 patients with RA were collected, and their serum and DNA samples were evaluated using enzyme-linked immunosorbent assay (ELISA) and SNP cross-reaction analysis. A considerable amount of anti-CEP was detected in patients with RA, a trend similar to that of anti-CCP. Moreover, anti-CEP was considerably associated with the protein-arginine deiminase type-2 SNP rs1005753.
    Keywords Anti-citrullinated α-enolase peptide ; Rheumatoid arthritis ; Single nucleotide polymorphism ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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