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Article ; Online: Can treatment adverse events be optimized by switching between different sphingosine 1-phosphate receptor modulators in multiple sclerosis? A case series.

Guerrieri, Simone / Rubin, Martina / Gattuso, Irene / Zanetta, Chiara / Genchi, Angela / Preziosa, Paolo / Rocca, Maria Assunta / Filippi, Massimo / Moiola, Lucia

Journal of neurology

2024

Language	English
Publishing date	2024-04-02
Publishing country	Germany
Document type	Letter
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-024-12342-z
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Article ; Online: Promoting exogenous repair in multiple sclerosis: myelin regeneration.

Bezukladova, Svetlana / Genchi, Angela / Panina-Bordignon, Paola / Martino, Gianvito

Current opinion in neurology

2022 Volume 35, Issue 3, Page(s) 313–318

Abstract: Purpose of the review: Despite the significant progress in the development of disease-modifying treatments for multiple sclerosis (MS), repair of existing damage is still poorly addressed. Current research focuses on stem cell-based therapies as a ... ...

Abstract	Purpose of the review: Despite the significant progress in the development of disease-modifying treatments for multiple sclerosis (MS), repair of existing damage is still poorly addressed. Current research focuses on stem cell-based therapies as a suitable alternative or complement to current drug therapies. Recent findings: Myelin damage is a hallmark of multiple sclerosis, and novel approaches leading to remyelination represent a promising tool to prevent neurodegeneration of the underlying axon. With increasing evidence of diminishing remyelination capacity of the MS brain with ageing and disease progression, exogenous cell transplantation is a promising therapeutic approach for restoration of oligodendrocyte precursor cell pool reserve and myelin regeneration. Summary: The present review summarizes recent developments of remyelinating therapies in multiple sclerosis, focusing on exogenous cell-based strategies and discussing related scientific, practical, and ethical concerns.
MeSH term(s)	Axons ; Humans ; Multiple Sclerosis/drug therapy ; Myelin Sheath ; Nerve Regeneration ; Remyelination ; Stem Cell Transplantation
Language	English
Publishing date	2022-06-21
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1182686-1
ISSN	1473-6551 ; 1350-7540
ISSN (online)	1473-6551
ISSN	1350-7540
DOI	10.1097/WCO.0000000000001062
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Zs.A 2524: Show issues

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Article ; Online: Fast but not furious: Rapid ocrelizumab infusion as a strategy to optimize multiple sclerosis patients' management.

Zanetta, Chiara / Faustino, Patricia / Guerrieri, Simone / Nozzolillo, Agostino / Genchi, Angela / Bucca, Chiara / Rocca, Maria A / Moiola, Lucia / Filippi, Massimo

Journal of the neurological sciences

2024 Volume 457, Page(s) 122897

Abstract: Objectives: Multiple sclerosis clinicians are continuously challenged to be innovative in delivering therapies and there is ongoing pressure to maximize day-hospital vacancies. We describe our single-center experience with ocrelizumab (OCR) rapid ... ...

Abstract	Objectives: Multiple sclerosis clinicians are continuously challenged to be innovative in delivering therapies and there is ongoing pressure to maximize day-hospital vacancies. We describe our single-center experience with ocrelizumab (OCR) rapid infusion (OCR-RI) in patients with MS (pwMS). Methods: For pwMS with prior exposure to OCR standard infusion (OCR-SI) for at least one year/two cycles, infusion time was reduced from 3.5 to 2.0 h. A comparative analysis between OCR-RI vs OCR-SI patients was conducted. Results: 283 (76.7%) out of 369 OCR-treated pwMS performed OCR-RI; 86 subjects did not start OCR-RI due to infusion-related reactions (IRR) occurring with OCR-SI (n = 13) or OCR-treatment duration shorter than one year (n = 73). Disease duration was longer in OCR-RI (p < 0.001). Median numbers of overall-OCR and OCR-RI cycles were 7 (IQR = 5-8) and 4 (IQR = 2-5) (p < 0.001). Overall, 38 (10.3%) IRR were reported, 25 (8.8%) in OCR-RI and 13 (15.1%) in OCR-SI group. IRR frequency did not differ between the two groups (p = 0.106). IRR included throat irritation, rash, hypotension, fever and gastrointestinal symptoms. IRR severity was mild (81.6%) or moderate (18.4%), all resolved and did not differ in distribution between the two groups. When IRR occurred, infusions were temporarily stopped, hydration and/or symptomatic medications were given and infusions were subsequently resumed at standard velocity. OCR-RI was not a risk factor for IRR (OR 0.55, 95% CI: 0.27-1.13, p = 0.096). Conclusions: In our cohort, IRR frequency, severity and management were comparable to literature. No severe IRR were observed. RI protocols represent a strategy to optimize patients' management in the clinic.
MeSH term(s)	Humans ; Multiple Sclerosis/drug therapy ; Antibodies, Monoclonal, Humanized/adverse effects ; Drug-Related Side Effects and Adverse Reactions
Chemical Substances	ocrelizumab (A10SJL62JY) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2024-01-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2024.122897
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Zs.A 308: Show issues

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Article ; Online: Letter by Semerano et al Regarding Article, "Platelet-Rich Emboli in Cerebral Large Vessel Occlusion Are Associated With a Large Artery Atherosclerosis Source".

Semerano, Aurora / Strambo, Davide / Genchi, Angela / Bacigaluppi, Marco

Stroke

2019 Volume 50, Issue 10, Page(s) e297

MeSH term(s)	Arteries ; Atherosclerosis ; Cerebrovascular Disorders ; Embolism ; Humans
Language	English
Publishing date	2019-09-13
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.119.026662
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Zs.A 448: Show issues

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Article ; Online: Ocrelizumab extended-interval dosing in multiple sclerosis during SARS-CoV-2 pandemic: a real-world experience.

Guerrieri, Simone / Bucca, Chiara / Nozzolillo, Agostino / Genchi, Angela / Zanetta, Chiara / Cetta, Ilaria / Rugarli, Giulia / Gattuso, Irene / Azzimonti, Matteo / Rocca, Maria Assunta / Moiola, Lucia / Filippi, Massimo

European journal of neurology

2023 Volume 30, Issue 9, Page(s) 2859–2864

Abstract: Background and purpose: During the COVID-19 pandemic, ocrelizumab administration was frequently postponed because of a lack of safety information and to favour vaccination. The clinical implications of ocrelizumab administration delay in multiple ... ...

Abstract	Background and purpose: During the COVID-19 pandemic, ocrelizumab administration was frequently postponed because of a lack of safety information and to favour vaccination. The clinical implications of ocrelizumab administration delay in multiple sclerosis (MS) patients were assessed. Methods: Relapsing (RMS) and primary progressive (PPMS) MS patients receiving ocrelizumab for at least 6 months at our centre were retrospectively classified, according to the possible occurrence of a delay (≥4 weeks) in treatment administration. Patients were categorized in the extended-interval dosing (EID) group in the presence of at least one delayed infusion; otherwise they were considered as part of the standard interval dosing (SID) cohort. MS history, magnetic resonance imaging examinations and B-cell counts were also retrospectively collected and analysed. Results: A total of 213 RMS and 61 PPMS patients were enrolled; 115 RMS and 29 PPMS patients had been treated according to the SID regimen, whilst 98 RMS and 32 PPMS patients were included in the EID cohort. Average follow-up after delay was 1.28 ± 0.7 years in the EID cohort. In RMS, comparing SID and EID patients, no differences were found considering the occurrence of clinical relapses (9.6% vs. 16.3%, p = 0.338), magnetic resonance imaging activity (9.8% vs. 14.1%, p = 0.374) or disability progression (11.3% vs. 18.4%, p = 0.103). Similar findings were observed in PPMS patients. In the pooled EID group, treatment delay correlated with CD19-positive relative (r = 0.530, p < 0.001) and absolute (r = 0.491, p < 0.001) cell counts, without implications on disease activity. Conclusions: Sporadic ocrelizumab administration delay granted sustained treatment efficacy in our cohort. Prospective data should be obtained to confirm these observations and set up systematic extended-interval regimens.
MeSH term(s)	Humans ; Multiple Sclerosis/drug therapy ; SARS-CoV-2 ; Pandemics ; Retrospective Studies ; Prospective Studies ; Immunologic Factors/therapeutic use ; Immunologic Factors/adverse effects ; COVID-19 ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; Multiple Sclerosis, Chronic Progressive/drug therapy
Chemical Substances	ocrelizumab (A10SJL62JY) ; Immunologic Factors
Language	English
Publishing date	2023-06-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.15891
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Zs.A 4738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Corpus callosum infarction: radiological and histological findings.

Gelibter, Stefano / Genchi, Angela / Callea, Marcella / Anzalone, Nicoletta / Galantucci, Sebastiano / Volonté, Maria Antonietta / Filippi, Massimo

Journal of neurology

2020 Volume 267, Issue 11, Page(s) 3418–3420

MeSH term(s)	Cerebral Infarction/diagnostic imaging ; Corpus Callosum/diagnostic imaging ; Humans ; Infarction/diagnostic imaging ; Magnetic Resonance Imaging
Language	English
Publishing date	2020-09-17
Publishing country	Germany
Document type	Letter
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-020-10224-8
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Article ; Online: Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology.

Gullotta, Giorgia Serena / De Feo, Donatella / Friebel, Ekaterina / Semerano, Aurora / Scotti, Giulia Maria / Bergamaschi, Andrea / Butti, Erica / Brambilla, Elena / Genchi, Angela / Capotondo, Alessia / Gallizioli, Mattia / Coviello, Simona / Piccoli, Marco / Vigo, Tiziana / Della Valle, Patrizia / Ronchi, Paola / Comi, Giancarlo / D'Angelo, Armando / Maugeri, Norma /

Roveri, Luisa / Uccelli, Antonio / Becher, Burkhard / Martino, Gianvito / Bacigaluppi, Marco

Nature immunology

2023 Volume 24, Issue 6, Page(s) 925–940

Abstract: Aging accounts for increased risk and dismal outcome of ischemic stroke. Here, we investigated the impact of age-related changes in the immune system on stroke. Upon experimental stroke, compared with young mice, aged mice had increased neutrophil ... ...

Abstract	Aging accounts for increased risk and dismal outcome of ischemic stroke. Here, we investigated the impact of age-related changes in the immune system on stroke. Upon experimental stroke, compared with young mice, aged mice had increased neutrophil clogging of the ischemic brain microcirculation, leading to worse no-reflow and outcomes. Aged mice showed an enhanced granulopoietic response to stroke that led to the accumulation of CD101
MeSH term(s)	Mice ; Animals ; Neutrophils ; Leukocytes ; Stroke/pathology ; Aging ; Ischemic Stroke/pathology
Language	English
Publishing date	2023-05-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-023-01505-1
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Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Immune Reconstitution Following Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis: A Review on Behalf of the EBMT Autoimmune Diseases Working Party.

Cencioni, Maria Teresa / Genchi, Angela / Brittain, Gavin / de Silva, Thushan I / Sharrack, Basil / Snowden, John Andrew / Alexander, Tobias / Greco, Raffaella / Muraro, Paolo A

Frontiers in immunology

2022 Volume 12, Page(s) 813957

Abstract: Multiple sclerosis (MS) is a central nervous system (CNS) disorder, which is mediated by an abnormal immune response coordinated by T and B cells resulting in areas of inflammation, demyelination, and axonal loss. Disease-modifying treatments (DMTs) are ... ...

Abstract	Multiple sclerosis (MS) is a central nervous system (CNS) disorder, which is mediated by an abnormal immune response coordinated by T and B cells resulting in areas of inflammation, demyelination, and axonal loss. Disease-modifying treatments (DMTs) are available to dampen the inflammatory aggression but are ineffective in many patients. Autologous hematopoietic stem cell transplantation (HSCT) has been used as treatment in patients with a highly active disease, achieving a long-term clinical remission in most. The rationale of the intervention is to eradicate inflammatory autoreactive cells with lympho-ablative regimens and restore immune tolerance. Immunological studies have demonstrated that autologous HSCT induces a renewal of TCR repertoires, resurgence of immune regulatory cells, and depletion of proinflammatory T cell subsets, suggesting a "resetting" of immunological memory. Although our understanding of the clinical and immunological effects of autologous HSCT has progressed, further work is required to characterize the mechanisms that underlie treatment efficacy. Considering that memory B cells are disease-promoting and stem-like T cells are multipotent progenitors involved in self-regeneration of central and effector memory cells, investigating the reconstitution of B cell compartment and stem and effector subsets of immunological memory following autologous HSCT could elucidate those mechanisms. Since all subjects need to be optimally protected from vaccine-preventable diseases (including COVID-19), there is a need to ensure that vaccination in subjects undergoing HSCT is effective and safe. Additionally, the study of vaccination in HSCT-treated subjects as a means of evaluating immune responses could further distinguish broad immunosuppression from immune resetting.
MeSH term(s)	Adaptive Immunity ; Autoimmunity ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Immune Tolerance ; Immunity, Innate ; Immunologic Memory ; Lymphocyte Subsets/immunology ; Lymphocyte Subsets/metabolism ; Multiple Sclerosis, Chronic Progressive/immunology ; Multiple Sclerosis, Chronic Progressive/metabolism ; Multiple Sclerosis, Chronic Progressive/surgery ; Multiple Sclerosis, Relapsing-Remitting/immunology ; Multiple Sclerosis, Relapsing-Remitting/metabolism ; Multiple Sclerosis, Relapsing-Remitting/surgery ; Phenotype ; Transplantation, Autologous ; Treatment Outcome
Language	English
Publishing date	2022-02-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.813957
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Article ; Online: Correction to: Refractory anti‑NMDAR encephalitis successfully treated with bortezomib and associated movements disorders controlled with tramadol: a case report with literature review.

Lazzarin, Serena Marita / Vabanesi, Marco / Cecchetti, Giordano / Fazio, Raffaella / Fanelli, Giovanna Franca / Volonté, Maria Antonietta / Genchi, Angela / Giordano, Antonino / Martinelli, Vittorio / Colombo, Sergio / Beccaria, Paolo / Mucci, Milena / Peccatori, Jacopo / Filippi, Massimo / Minicucci, Fabio

Journal of neurology

2021 Volume 268, Issue 2, Page(s) 741–742

Language	English
Publishing date	2021-01-08
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-020-10370-z
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Article ; Online: Fishing an anemone in the brain: embolized cardiac fibroelastoma revealed after stroke thrombectomy.

Semerano, Aurora / Saliou, Guillaume / Sanvito, Francesca / Genchi, Angela / Gullotta, Giorgia Serena / Michel, Patrik / Filippi, Massimo / Martino, Gianvito / Strambo, Davide / Bacigaluppi, Marco

European heart journal

2021 Volume 42, Issue 39, Page(s) 4094–4095

MeSH term(s)	Anemone ; Brain ; Brain Ischemia ; Fibroma/complications ; Heart Neoplasms/complications ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/surgery ; Humans ; Stroke/etiology ; Thrombectomy
Language	English
Publishing date	2021-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehab019
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Zs.MO 640: Show issues

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