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  1. AU=Boff Daiane
  2. AU="Michaels, Zachary"
  3. AU="Sovel, Mindy"
  4. AU="Lukyanov, Sergey"
  5. AU="Baptistella, Amanda"
  6. AU="Dichter, Gabriel S"
  7. AU="D Urbano, Vanessa"
  8. AU="Farhad Shirini"
  9. AU="Wu, Wenming"
  10. AU="Wiedermann, Christian J"
  11. AU="Corradin, Giampietro"
  12. AU="Guan, Xiaodong"
  13. AU=Burmester Gerd R.
  14. AU="Mańczak, Rafał"
  15. AU="Cristina Ceron"
  16. AU=Scardapane Arnaldo
  17. AU="Taylor, Daniel J"
  18. AU="Sabanadzovic, Sead"
  19. AU=Lee Yangsoon AU=Lee Yangsoon
  20. AU="Sahoo, Aditi"
  21. AU="Reyes, Peter Andrew C"
  22. AU="Collobert, Géromine"
  23. AU="Guevara, Katterine"
  24. AU=Ahmadivand Arash

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  1. Artikel ; Online: Pulmonary macrophages and their different roles in health and disease.

    Melo, Eliza Mathias / Oliveira, Vivian Louise Soares / Boff, Daiane / Galvão, Izabela

    The international journal of biochemistry & cell biology

    2021  Band 141, Seite(n) 106095

    Abstract: Macrophages are a heterogeneous population of myeloid cells with phenotype and function modulated according to the microenvironment in which they are found. The lung resident macrophages known as Alveolar Macrophages (AM) and Interstitial Macrophages (IM) ...

    Abstract Macrophages are a heterogeneous population of myeloid cells with phenotype and function modulated according to the microenvironment in which they are found. The lung resident macrophages known as Alveolar Macrophages (AM) and Interstitial Macrophages (IM) are localized in two different compartments. During lung homeostasis, macrophages can remove inhaled particulates, cellular debris and contribute to some metabolic processes. Macrophages may assume a pro-inflammatory phenotype after being classically activated (M1) or anti-inflammatory when being alternatively activated (M2). M1 and M2 have different transcription profiles and act by eliminating bacteria, viruses and fungi from the host or repairing the damage triggered by inflammation, respectively. Nevertheless, macrophages also may contribute to lung damage during persistent inflammation or continuous exposure to antigens. In this review, we discuss the origin and function of pulmonary macrophages in the context of homeostasis, infectious and non-infectious lung diseases.
    Mesh-Begriff(e) Animals ; Anti-Inflammatory Agents ; Lung ; Macrophage Activation ; Macrophages ; Macrophages, Alveolar
    Chemische Substanzen Anti-Inflammatory Agents
    Sprache Englisch
    Erscheinungsdatum 2021-10-13
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2021.106095
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Prophage-encoded methyltransferase drives adaptation of community-acquired methicillin-resistant

    Ulrich, Robert J / Podkowik, Magdalena / Tierce, Rebecca / Irnov, Irnov / Putzel, Gregory / Samhadaneh, Nora / Lacey, Keenan A / Boff, Daiane / Morales, Sabrina M / Makita, Sohei / Karagounis, Theodora K / Zwack, Erin E / Zhou, Chunyi / Kim, Randie / Drlica, Karl / Pironti, Alejandro / van Bakel, Harm / Torres, Victor J / Shopsin, Bo

    bioRxiv : the preprint server for biology

    2024  

    Abstract: We recently described the evolution of a community-acquired methicillin- ... ...

    Abstract We recently described the evolution of a community-acquired methicillin-resistant
    Sprache Englisch
    Erscheinungsdatum 2024-04-17
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.04.17.589803
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Pulmonary macrophages and their different roles in health and disease

    Melo, Eliza Mathias / Oliveira, Vivian Louise Soares / Boff, Daiane / Galvão, Izabela

    international journal of biochemistry & cell biology. 2021 Dec., v. 141

    2021  

    Abstract: Macrophages are a heterogeneous population of myeloid cells with phenotype and function modulated according to the microenvironment in which they are found. The lung resident macrophages known as Alveolar Macrophages (AM) and Interstitial Macrophages (IM) ...

    Abstract Macrophages are a heterogeneous population of myeloid cells with phenotype and function modulated according to the microenvironment in which they are found. The lung resident macrophages known as Alveolar Macrophages (AM) and Interstitial Macrophages (IM) are localized in two different compartments. During lung homeostasis, macrophages can remove inhaled particulates, cellular debris and contribute to some metabolic processes. Macrophages may assume a pro-inflammatory phenotype after being classically activated (M1) or anti-inflammatory when being alternatively activated (M2). M1 and M2 have different transcription profiles and act by eliminating bacteria, viruses and fungi from the host or repairing the damage triggered by inflammation, respectively. Nevertheless, macrophages also may contribute to lung damage during persistent inflammation or continuous exposure to antigens. In this review, we discuss the origin and function of pulmonary macrophages in the context of homeostasis, infectious and non-infectious lung diseases.
    Schlagwörter biochemistry ; homeostasis ; inflammation ; lungs ; macrophages ; particulates ; phenotype
    Sprache Englisch
    Erscheinungsverlauf 2021-12
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2021.106095
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: The Therapeutic Treatment with the GAG-Binding Chemokine Fragment CXCL9(74-103) Attenuates Neutrophilic Inflammation and Lung Dysfunction during

    Boff, Daiane / Russo, Remo Castro / Crijns, Helena / de Oliveira, Vivian Louise Soares / Mattos, Matheus Silvério / Marques, Pedro Elias / Menezes, Gustavo Batista / Vieira, Angélica Thomaz / Teixeira, Mauro Martins / Proost, Paul / Amaral, Flávio Almeida

    International journal of molecular sciences

    2022  Band 23, Heft 11

    Abstract: Klebsiella ... ...

    Abstract Klebsiella pneumoniae
    Mesh-Begriff(e) Animals ; Chemokine CXCL2 ; Chemokines ; Cytokines ; Inflammation/drug therapy ; Klebsiella Infections/drug therapy ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/physiology ; Lung/microbiology ; Mice ; Neutrophils/microbiology ; Pneumonia, Bacterial/drug therapy ; Pneumonia, Bacterial/microbiology
    Chemische Substanzen Chemokine CXCL2 ; Chemokines ; Cytokines
    Sprache Englisch
    Erscheinungsdatum 2022-06-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23116246
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  5. Artikel ; Online: MRSA lineage USA300 isolated from bloodstream infections exhibit altered virulence regulation.

    Dyzenhaus, Sophie / Sullivan, Mitchell J / Alburquerque, Bremy / Boff, Daiane / van de Guchte, Adriana / Chung, Marilyn / Fulmer, Yi / Copin, Richard / Ilmain, Juliana K / O'Keefe, Anna / Altman, Deena R / Stubbe, François-Xavier / Podkowik, Magdalena / Dupper, Amy C / Shopsin, Bo / van Bakel, Harm / Torres, Victor J

    Cell host & microbe

    2023  Band 31, Heft 2, Seite(n) 228–242.e8

    Abstract: The epidemic community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) USA300 lineage has recently become a leading cause of hospital-associated bloodstream infections (BSIs). Here, we leveraged this recent introduction into hospitals ... ...

    Abstract The epidemic community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) USA300 lineage has recently become a leading cause of hospital-associated bloodstream infections (BSIs). Here, we leveraged this recent introduction into hospitals and the limited genetic variation across USA300 isolates to identify mutations that contribute to its success in a new environment. We found that USA300 BSI isolates exhibit altered virulence regulation. Using comparative genomics to delineate the genes involved in this phenotype, we discovered repeated and independent mutations in the transcriptional regulator sarZ. Mutations in sarZ resulted in increased virulence of USA300 BSI isolates in a murine model of BSI. The sarZ mutations derepressed the expression and production of the surface protein ClfB, which was critical for the pathogenesis of USA300 BSI isolates. Altogether, these findings highlight ongoing evolution of a major MRSA lineage and suggest USA300 strains can optimize their fitness through altered regulation of virulence.
    Mesh-Begriff(e) Animals ; Mice ; Methicillin-Resistant Staphylococcus aureus/genetics ; Virulence/genetics ; Staphylococcal Infections ; Cross Infection/epidemiology ; Sepsis
    Sprache Englisch
    Erscheinungsdatum 2023-01-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2022.12.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6578: Hefte anzeigen Standort:
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  6. Artikel ; Online: REGIMES DE FLEXIBILIZAÇÃO E SENTIDOS DO TRABALHO PARA DOCENTES DE ENSINO SUPERIOR EM INSTITUIÇÕES PÚBLICAS E PRIVADAS

    Anelise D’Arisbo / Daiane Boff / Andrea Poleto Oltramari / Julice Salvagni

    Trabalho, Educação e Saúde, Iss

    2018  

    Abstract: Resumo Este artigo objetivou compreender o sentido do trabalho para o docente de ensino superior em instituições públicas e privadas em seus diversos regimes de flexibilização do trabalho, com base na identificação de elementos da racionalidade ... ...

    Abstract Resumo Este artigo objetivou compreender o sentido do trabalho para o docente de ensino superior em instituições públicas e privadas em seus diversos regimes de flexibilização do trabalho, com base na identificação de elementos da racionalidade instrumental e subjetiva. Assim, a coleta de dados contou com fontes múltiplas, tais como a análise documental das instituições e dos contratos de trabalho dos docentes, a observação direta e as entrevistas realizadas presencialmente. Como resultado, percebeu-se que: há preponderância do sentido laboral substantivo sobre o sentido instrumental; a flexibilização altera a percepção da atuação individual e interfere no seu sentido substantivo; e a vida é arranjada a partir da organização do trabalho flexibilizado.
    Schlagwörter sentido do trabalho ; docência ; flexibilização ; Education (General) ; L7-991 ; Medicine (General) ; R5-920
    Sprache Spanisch
    Erscheinungsdatum 2018-04-01T00:00:00Z
    Verlag Fundação Oswaldo Cruz, Escola Politécnica de Saúde Joaquim Venâncio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: The Therapeutic Treatment with the GAG-Binding Chemokine Fragment CXCL9(74–103) Attenuates Neutrophilic Inflammation and Lung Dysfunction during Klebsiella pneumoniae Infection in Mice

    Daiane Boff / Remo Castro Russo / Helena Crijns / Vivian Louise Soares de Oliveira / Matheus Silvério Mattos / Pedro Elias Marques / Gustavo Batista Menezes / Angélica Thomaz Vieira / Mauro Martins Teixeira / Paul Proost / Flávio Almeida Amaral

    International Journal of Molecular Sciences, Vol 23, Iss 6246, p

    2022  Band 6246

    Abstract: Klebsiella pneumoniae is an important pathogen associated with hospital-acquired pneumonia (HAP). Bacterial pneumonia is characterized by a harmful inflammatory response with a massive influx of neutrophils, production of cytokines and chemokines, and ... ...

    Abstract Klebsiella pneumoniae is an important pathogen associated with hospital-acquired pneumonia (HAP). Bacterial pneumonia is characterized by a harmful inflammatory response with a massive influx of neutrophils, production of cytokines and chemokines, and consequent tissue damage and dysfunction. Targeted therapies to block neutrophil migration to avoid tissue damage while keeping the antimicrobial properties of tissue remains a challenge in the field. Here we tested the effect of the anti-inflammatory properties of the chemokine fragment CXCL9(74–103) in pneumonia induced by Klebsiella pneumoniae in mice. Mice were infected by intratracheal injection of Klebsiella pneumoniae and 6 h after infection were treated systemically with CXCL9(74–103). The recruitment of leukocytes, levels of cytokines and chemokines, colony-forming units (CFU), and lung function were evaluated. The treatment with CXCL9(74–103) decreased neutrophil migration to the airways and the production of the cytokine interleukin-1β (IL-1β) without affecting bacterial control. In addition, the therapeutic treatment improved lung function in infected mice. Our results indicated that the treatment with CXCL9(74–103) reduced inflammation and improved lung function in Klebsiella pneumoniae -induced pneumonia.
    Schlagwörter pneumonia ; Klebsiella pneumoniae ; neutrophils ; chemokines ; inflammation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Neutrophils: Beneficial and Harmful Cells in Septic Arthritis.

    Boff, Daiane / Crijns, Helena / Teixeira, Mauro M / Amaral, Flavio A / Proost, Paul

    International journal of molecular sciences

    2018  Band 19, Heft 2

    Abstract: Septic arthritis is an inflammatory joint disease that is induced by pathogens such ... ...

    Abstract Septic arthritis is an inflammatory joint disease that is induced by pathogens such as
    Mesh-Begriff(e) Anti-Bacterial Agents/therapeutic use ; Arthritis, Infectious/immunology ; Arthritis, Infectious/microbiology ; Arthritis, Infectious/surgery ; Arthritis, Infectious/therapy ; Arthrocentesis/methods ; Arthroscopy/methods ; Cell Movement/immunology ; Chemokines/immunology ; Chemokines/metabolism ; Humans ; Inflammation ; Joints/drug effects ; Joints/immunology ; Joints/microbiology ; Joints/surgery ; Leukotrienes/immunology ; Leukotrienes/metabolism ; Neutrophil Infiltration/drug effects ; Neutrophils/drug effects ; Neutrophils/immunology ; Neutrophils/pathology ; Staphylococcal Infections/immunology ; Staphylococcal Infections/microbiology ; Staphylococcal Infections/surgery ; Staphylococcal Infections/therapy ; Staphylococcus aureus ; Suction/methods
    Chemische Substanzen Anti-Bacterial Agents ; Chemokines ; Leukotrienes
    Sprache Englisch
    Erscheinungsdatum 2018-02-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19020468
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Neutrophils

    Daiane Boff / Helena Crijns / Mauro M. Teixeira / Flavio A. Amaral / Paul Proost

    International Journal of Molecular Sciences, Vol 19, Iss 2, p

    Beneficial and Harmful Cells in Septic Arthritis

    2018  Band 468

    Abstract: Septic arthritis is an inflammatory joint disease that is induced by pathogens such as Staphylococcus aureus. Infection of the joint triggers an acute inflammatory response directed by inflammatory mediators including microbial danger signals and ... ...

    Abstract Septic arthritis is an inflammatory joint disease that is induced by pathogens such as Staphylococcus aureus. Infection of the joint triggers an acute inflammatory response directed by inflammatory mediators including microbial danger signals and cytokines and is accompanied by an influx of leukocytes. The recruitment of these inflammatory cells depends on gradients of chemoattractants including formylated peptides from the infectious agent or dying cells, host-derived leukotrienes, complement proteins and chemokines. Neutrophils are of major importance and play a dual role in the pathogenesis of septic arthritis. On the one hand, these leukocytes are indispensable in the first-line defense to kill invading pathogens in the early stage of disease. However, on the other hand, neutrophils act as mediators of tissue destruction. Since the elimination of inflammatory neutrophils from the site of inflammation is a prerequisite for resolution of the acute inflammatory response, the prolonged stay of these leukocytes at the inflammatory site can lead to irreversible damage to the infected joint, which is known as an important complication in septic arthritis patients. Thus, timely reduction of the recruitment of inflammatory neutrophils to infected joints may be an efficient therapy to reduce tissue damage in septic arthritis.
    Schlagwörter neutrophil ; septic arthritis ; chemoattractant ; Staphylococcus aureus ; tissue damage ; infection ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2018-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Endogenous modification of the chemoattractant CXCL5 alters receptor usage and enhances its activity toward neutrophils and monocytes.

    Metzemaekers, Mieke / Mortier, Anneleen / Vacchini, Alessandro / Boff, Daiane / Yu, Karen / Janssens, Rik / Farina, Floriana M / Milanesi, Samantha / Berghmans, Nele / Pörtner, Noëmie / Van Damme, Jo / Allegretti, Marcello / Teixeira, Mauro M / Locati, Massimo / Borroni, Elena M / Amaral, Flavio A / Proost, Paul

    Science signaling

    2021  Band 14, Heft 673

    Abstract: The inflammatory human chemokine CXCL5 interacts with the G protein-coupled receptor CXCR2 to induce chemotaxis and activation of neutrophils. CXCL5 also has weak agonist activity toward CXCR1. The N-terminus of CXCL5 can be modified by proteolytic ... ...

    Abstract The inflammatory human chemokine CXCL5 interacts with the G protein-coupled receptor CXCR2 to induce chemotaxis and activation of neutrophils. CXCL5 also has weak agonist activity toward CXCR1. The N-terminus of CXCL5 can be modified by proteolytic cleavage or deimination of Arg
    Mesh-Begriff(e) Animals ; Chemokine CXCL5/genetics ; Chemotactic Factors ; Humans ; Interleukin-8 ; Mice ; Monocytes ; Neutrophils ; Receptors, Interleukin-8A/genetics ; THP-1 Cells
    Chemische Substanzen CXCL5 protein, human ; Chemokine CXCL5 ; Chemotactic Factors ; Interleukin-8 ; Receptors, Interleukin-8A
    Sprache Englisch
    Erscheinungsdatum 2021-03-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2417226-1
    ISSN 1937-9145 ; 1945-0877
    ISSN (online) 1937-9145
    ISSN 1945-0877
    DOI 10.1126/scisignal.aax3053
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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