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  1. Article ; Online: Synthesis of Spirocyclic Pyrrolidine Compounds via Silver-Catalyzed Asymmetric [3 + 2] Cycloaddition Reaction of Imino Esters with α-Alkylidene Succinimides.

    Inoue, Ayana / Hosono, Kenya / Furuya, Shohei / Fukuzawa, Shin-Ichi

    The Journal of organic chemistry

    2024  Volume 89, Issue 2, Page(s) 1249–1255

    Abstract: In this study, the AgOAc/ThioClickFerrophos (TCF) complex was used to successfully catalyze asymmetric [3 + 2] cycloaddition between glycine imino esters and ... ...

    Abstract In this study, the AgOAc/ThioClickFerrophos (TCF) complex was used to successfully catalyze asymmetric [3 + 2] cycloaddition between glycine imino esters and CO
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c02456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
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  2. Article ; Online: γδ T-cell-mediated immune responses to malaria.

    Bayarsaikhan, Ganchimeg / Ibraheem, Yarob / Inoue, Shin-Ichi

    Microbiology and immunology

    2023  Volume 67, Issue 5, Page(s) 239–247

    Abstract: Malaria is one of the deadliest infectious diseases. Licensed vaccine have demonstrated just over 30% efficacy, and therefore, developing new vaccine candidates and understanding immune responses to Plasmodium have become necessary. γδ T cells have been ... ...

    Abstract Malaria is one of the deadliest infectious diseases. Licensed vaccine have demonstrated just over 30% efficacy, and therefore, developing new vaccine candidates and understanding immune responses to Plasmodium have become necessary. γδ T cells have been suggested to be associated with immune responses to malaria due to the observation of their expansion in patients with malaria and experimental models of malaria. γδ T cells act as both "innate-like" and "adaptive-like" cells during immune response to malaria. Studies have found that γδ T cells can recognize Plasmodium phosphoantigen, present the antigen, and initiate adaptive immune response during blood-stage Plasmodium infection. Recent reports also suggested the phagocytic and cytotoxic potential of γδ T cells. Furthermore, γδ T cells can provide protection upon immunization with whole parasite. In addition, γδ T cells during the liver-stage infection were able to prevent experimental cerebral malaria. Despite these new findings, questions related to γδ T-cell response during Plasmodium infection remain to be answered. However, investigating these cells in humans remains difficult in many ways; in this regard, rodent models of malarial infection enable us to study these cells in more detail. Insights from experimental malaria models give rise to new cues for development of malarial vaccine and adjunctive therapy for severe malaria. Here, we review our current knowledge of γδ T-cell immune function in human and experimental mouse malarial infection models; especially, we focus on the mechanisms underlying γδ T cells that are associated with protective immunity during malarial infection.
    MeSH term(s) Humans ; Animals ; Mice ; T-Lymphocytes ; Receptors, Antigen, T-Cell, gamma-delta ; Malaria/prevention & control ; Immunity
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2023-03-26
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 224792-6
    ISSN 1348-0421 ; 0385-5600
    ISSN (online) 1348-0421
    ISSN 0385-5600
    DOI 10.1111/1348-0421.13059
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    Ud II Zs.204: Show issues Location:
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  3. Article ; Online: Keep thinking about unanswered questions in primary care

    Daisuke Son / Kazuoki Inoue / Minako Kamimoto / Shin‐ichi Taniguchi

    Journal of General and Family Medicine, Vol 24, Iss 3, Pp 205-

    Cultivating negative capability

    2023  Volume 206

    Abstract: Negative capability or tolerance for uncertainty is important for primary care physicians. The 2022 edition of the Model Core Curriculum for Medical Education also states that the content of professionalism is to “keep thinking about unanswerable ... ...

    Abstract Negative capability or tolerance for uncertainty is important for primary care physicians. The 2022 edition of the Model Core Curriculum for Medical Education also states that the content of professionalism is to “keep thinking about unanswerable questions.”
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Keep thinking about unanswered questions in primary care: Cultivating negative capability.

    Son, Daisuke / Inoue, Kazuoki / Kamimoto, Minako / Taniguchi, Shin-Ichi

    Journal of general and family medicine

    2023  Volume 24, Issue 3, Page(s) 205–206

    Abstract: Negative capability or tolerance for uncertainty is important for primary care physicians. The 2022 edition of the Model Core Curriculum for Medical Education also states that the content of professionalism is to "keep thinking about unanswerable ... ...

    Abstract Negative capability or tolerance for uncertainty is important for primary care physicians. The 2022 edition of the Model Core Curriculum for Medical Education also states that the content of professionalism is to "keep thinking about unanswerable questions."
    Language English
    Publishing date 2023-03-13
    Publishing country Japan
    Document type Journal Article
    ISSN 2189-7948
    ISSN (online) 2189-7948
    DOI 10.1002/jgf2.615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Host immunity to Plasmodium infection: Contribution of Plasmodium berghei to our understanding of T cell-related immune response to blood-stage malaria.

    Ibraheem, Yarob / Bayarsaikhan, Ganchimeg / Inoue, Shin-Ichi

    Parasitology international

    2022  Volume 92, Page(s) 102646

    Abstract: Malaria is a life-threatening disease caused by infection with Plasmodium parasites. The goal of developing an effective malaria vaccine is yet to be reached despite decades of massive research efforts. ... ...

    Abstract Malaria is a life-threatening disease caused by infection with Plasmodium parasites. The goal of developing an effective malaria vaccine is yet to be reached despite decades of massive research efforts. CD4
    MeSH term(s) Humans ; Animals ; Mice ; Plasmodium berghei ; T-Lymphocytes ; Malaria Vaccines ; Malaria ; Immunity, Cellular ; Disease Models, Animal
    Chemical Substances Malaria Vaccines
    Language English
    Publishing date 2022-08-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1363151-2
    ISSN 1873-0329 ; 1383-5769
    ISSN (online) 1873-0329
    ISSN 1383-5769
    DOI 10.1016/j.parint.2022.102646
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    Zs.B 2322: Show issues Location:
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  6. Article ; Online: Possibility of alleviating difficulties of health and social care professionals engaged in end‐of‐life care through Clinical Art program

    Minako Kamimoto / Daisuke Son / Kazuoki Inoue / Shin‐ichi Taniguchi

    Journal of General and Family Medicine, Vol 24, Iss 4, Pp 247-

    2023  Volume 253

    Abstract: Abstract Background Health and social care professionals experience high‐stress levels during end‐of‐life care. Various intervention programs have been proposed to reduce stress and prevent burnout among physicians and nurses, including arts‐based ... ...

    Abstract Abstract Background Health and social care professionals experience high‐stress levels during end‐of‐life care. Various intervention programs have been proposed to reduce stress and prevent burnout among physicians and nurses, including arts‐based activities that have shown potential. However, it is unclear how art programs can alleviate stress among healthcare professionals providing end‐of‐life care. This study aimed to explore the potential of Clinical Art programs to alleviate distress in professionals providing end‐of‐life care. Methods Two Clinical Art workshops, held in October and November 2020, were attended by local health and social care professionals. Focus groups were conducted with those who attended and consented to participate in the study. Verbatim transcripts were made, and a qualitative analysis of the text was conducted. Results Thirteen health and social work professionals participated in the study. Perceived difficulties in end‐of‐life care included the complexity and uncertainty of end‐of‐life care services, the approaches to patients and families, and the difficulties due to human aspects of healthcare providers. The positive effects of Clinical Art included pure enjoyment of art, empathic communication with patients and families and the application of an ontological view of human beings, which were identified as reasons for Clinical Art's effectiveness and applicability to care. Conclusions The results suggest that the Clinical Art program has a psychosocial moderating effect on health and social work professionals and can be used for empathic communication with patients and families in end‐of‐life care and for applying an ontological view of human beings in caring for patients.
    Keywords art program ; Clinical Art ; end‐of‐life care ; ontological view of human beings ; qualitative research ; Medicine (General) ; R5-920
    Subject code 700
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Possibility of alleviating difficulties of health and social care professionals engaged in end-of-life care through Clinical Art program.

    Kamimoto, Minako / Son, Daisuke / Inoue, Kazuoki / Taniguchi, Shin-Ichi

    Journal of general and family medicine

    2023  Volume 24, Issue 4, Page(s) 247–253

    Abstract: Background: Health and social care professionals experience high-stress levels during end-of-life care. Various intervention programs have been proposed to reduce stress and prevent burnout among physicians and nurses, including arts-based activities ... ...

    Abstract Background: Health and social care professionals experience high-stress levels during end-of-life care. Various intervention programs have been proposed to reduce stress and prevent burnout among physicians and nurses, including arts-based activities that have shown potential. However, it is unclear how art programs can alleviate stress among healthcare professionals providing end-of-life care. This study aimed to explore the potential of Clinical Art programs to alleviate distress in professionals providing end-of-life care.
    Methods: Two Clinical Art workshops, held in October and November 2020, were attended by local health and social care professionals. Focus groups were conducted with those who attended and consented to participate in the study. Verbatim transcripts were made, and a qualitative analysis of the text was conducted.
    Results: Thirteen health and social work professionals participated in the study. Perceived difficulties in end-of-life care included the complexity and uncertainty of end-of-life care services, the approaches to patients and families, and the difficulties due to human aspects of healthcare providers. The positive effects of Clinical Art included pure enjoyment of art, empathic communication with patients and families and the application of an ontological view of human beings, which were identified as reasons for Clinical Art's effectiveness and applicability to care.
    Conclusions: The results suggest that the Clinical Art program has a psychosocial moderating effect on health and social work professionals and can be used for empathic communication with patients and families in end-of-life care and for applying an ontological view of human beings in caring for patients.
    Language English
    Publishing date 2023-06-19
    Publishing country Japan
    Document type Journal Article
    ISSN 2189-7948
    ISSN (online) 2189-7948
    DOI 10.1002/jgf2.633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Fieldwork as a bridge between lectures and clinical clerkship

    Kazuoki Inoue / Daisuke Son / Junko Iida / Shin‐ichi Taniguchi

    Journal of General and Family Medicine, Vol 23, Iss 1, Pp 65-

    Medical students become the observer‐as‐participant

    2022  Volume 66

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Dihydroartemisinin Disrupts Zinc Homeostasis in

    Asahi, Hiroko / Niikura, Mamoru / Inoue, Shin-Ichi / Sendo, Fujiro / Kobayashi, Fumie / Wada, Akira

    ACS infectious diseases

    2023  Volume 9, Issue 7, Page(s) 1303–1309

    Abstract: Artemisinins have been used as first-line drugs worldwide to treat malaria caused ... ...

    Abstract Artemisinins have been used as first-line drugs worldwide to treat malaria caused by
    MeSH term(s) Animals ; Humans ; Antimalarials/pharmacology ; Plasmodium falciparum ; Artemisinins/pharmacology ; Malaria, Falciparum/drug therapy ; Malaria/drug therapy ; Parasites ; Homeostasis ; Folic Acid Antagonists ; Glutathione
    Chemical Substances Antimalarials ; artenimol (6A9O50735X) ; Artemisinins ; Folic Acid Antagonists ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.3c00031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Host-pathogen interaction in the tissue environment during Plasmodium blood-stage infection.

    Yui, Katsuyuki / Inoue, Shin-Ichi

    Parasite immunology

    2020  Volume 43, Issue 2, Page(s) e12763

    Abstract: Human malarial infection occurs after an infectious Anopheles mosquito bites. Following the initial liver-stage infection, parasites transform into merozoites, infecting red blood cells (RBCs). Repeated RBC infection then occurs during the blood-stage ... ...

    Abstract Human malarial infection occurs after an infectious Anopheles mosquito bites. Following the initial liver-stage infection, parasites transform into merozoites, infecting red blood cells (RBCs). Repeated RBC infection then occurs during the blood-stage infection, while patients experience various malarial symptoms. Protective immune responses are elicited by this systemic infection, but excessive responses are sometimes harmful for hosts. As parasites infect only RBCs and their immediate precursors during this stage, direct parasite-host interactions occur primarily in the environment surrounded by endothelial lining of blood vessels. The spleen is the major organ where the immune system encounters infected RBCs, causing immunological responses. Its tissue structure is markedly altered during malarial infection in mice and humans. Plasmodium falciparum parasites inside RBCs express proteins, such as PfEMP-1 and RIFIN, transported to the RBC surfaces in order to evade immunological attack by sequestering themselves in the peripheral vasculature avoiding spleen or by direct immune cell inhibition through inhibitory receptors. Host cell production of regulatory cytokines IL-10 and IL-27 limits excessive immune responses, avoiding tissue damage. The regulation of the protective and inhibitory immune responses through host-parasite interactions allows chronic Plasmodium infection. In this review, we discuss underlying interaction mechanisms relevant for developing effective strategies against malaria.
    MeSH term(s) Animals ; Anopheles/parasitology ; Cytokines/immunology ; Erythrocytes/parasitology ; Host-Parasite Interactions ; Humans ; Malaria/immunology ; Membrane Proteins/physiology ; Mice ; Plasmodium falciparum/physiology ; Protozoan Proteins/physiology ; Spleen/immunology
    Chemical Substances Cytokines ; Membrane Proteins ; Protozoan Proteins ; RIFIN protein, Plasmodium falciparum ; erythrocyte membrane protein 1, Plasmodium falciparum
    Language English
    Publishing date 2020-06-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 424444-8
    ISSN 1365-3024 ; 0141-9838
    ISSN (online) 1365-3024
    ISSN 0141-9838
    DOI 10.1111/pim.12763
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1509: Show issues Location:
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