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  1. Article: Clinical Pathogenesis, Molecular Mechanisms of Gastric Cancer Development.

    Wroblewski, Lydia E / Peek, Richard M

    Current topics in microbiology and immunology

    2024  Volume 444, Page(s) 25–52

    Abstract: The human pathogen Helicobacter pylori is the strongest known risk factor for gastric disease and cancer, and gastric cancer remains a leading cause of cancer-related death across the globe. Carcinogenic mechanisms associated with H. pylori are ... ...

    Abstract The human pathogen Helicobacter pylori is the strongest known risk factor for gastric disease and cancer, and gastric cancer remains a leading cause of cancer-related death across the globe. Carcinogenic mechanisms associated with H. pylori are multifactorial and are driven by bacterial virulence constituents, host immune responses, environmental factors such as iron and salt, and the microbiota. Infection with strains that harbor the cytotoxin-associated genes (cag) pathogenicity island, which encodes a type IV secretion system (T4SS) confer increased risk for developing more severe gastric diseases. Other important H. pylori virulence factors that augment disease progression include vacuolating cytotoxin A (VacA), specifically type s1m1 vacA alleles, serine protease HtrA, and the outer-membrane adhesins HopQ, BabA, SabA and OipA. Additional risk factors for gastric cancer include dietary factors such as diets that are high in salt or low in iron, H. pylori-induced perturbations of the gastric microbiome, host genetic polymorphisms, and infection with Epstein-Barr virus. This chapter discusses in detail host factors and how H. pylori virulence factors augment the risk of developing gastric cancer in human patients as well as how the Mongolian gerbil model has been used to define mechanisms of H. pylori-induced inflammation and cancer.
    MeSH term(s) Humans ; Stomach Neoplasms/genetics ; Epstein-Barr Virus Infections ; Herpesvirus 4, Human ; Cytotoxins ; Helicobacter pylori/genetics ; Iron ; Virulence Factors/genetics
    Chemical Substances Cytotoxins ; Iron (E1UOL152H7) ; Virulence Factors
    Language English
    Publishing date 2024-01-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 210099-X
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/978-3-031-47331-9_2
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  2. Article ; Online: COVID-19: Guidance for What Clinicians and Scientists Should Do and When.

    Corley, Douglas A / Peek, Richard M

    Gastroenterology

    2021  Volume 160, Issue 6, Page(s) 1922–1923

    MeSH term(s) COVID-19/epidemiology ; Gastroenterology ; Humans ; Physicians ; Practice Guidelines as Topic ; SARS-CoV-2
    Language English
    Publishing date 2021-05-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.04.011
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  3. Article ; Online: Helicobacter pylori: a stealth assassin.

    Wroblewski, Lydia E / Peek, Richard M

    Trends in cancer

    2021  Volume 7, Issue 9, Page(s) 807–808

    Abstract: Helicobacter pylori is a pathogen that confers the highest known risk for gastric cancer. Research directed at understanding the pathogenesis of H. pylori is crucial to identify colonized persons that may subsequently develop neoplasia. Imai et al. ... ...

    Abstract Helicobacter pylori is a pathogen that confers the highest known risk for gastric cancer. Research directed at understanding the pathogenesis of H. pylori is crucial to identify colonized persons that may subsequently develop neoplasia. Imai et al. describe how H. pylori elicits BRCAness and endows epithelial cells with the ability to evade apoptosis.
    MeSH term(s) Antigens, Bacterial ; Bacterial Proteins ; Epithelial Cells ; Gastric Mucosa ; Helicobacter pylori
    Chemical Substances Antigens, Bacterial ; Bacterial Proteins
    Language English
    Publishing date 2021-06-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2021.05.007
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  4. Article ; Online: Chemoprevention Against Gastric Cancer.

    Shah, Shailja C / Peek, Richard M

    Gastrointestinal endoscopy clinics of North America

    2021  Volume 31, Issue 3, Page(s) 519–542

    Abstract: Gastric cancer is the fifth most common cause of cancer and the third leading cause of cancer-related deaths globally. The number of gastric cancer-related deaths is only projected to increase, attributable primarily to the expanding aging population. ... ...

    Abstract Gastric cancer is the fifth most common cause of cancer and the third leading cause of cancer-related deaths globally. The number of gastric cancer-related deaths is only projected to increase, attributable primarily to the expanding aging population. Prevention is a mainstay of gastric cancer control programs, particularly in the absence of accurate, noninvasive modalities for screening and early detection, and the absence of an infrastructure for this purpose in the majority of countries worldwide. Herein, we discuss the evidence for several chemopreventive agents, along with putative mechanisms. There remains a clear, unmet need for primary chemoprevention trials for gastric cancer.
    MeSH term(s) Aged ; Chemoprevention ; Helicobacter Infections/complications ; Helicobacter Infections/drug therapy ; Helicobacter pylori ; Humans ; Stomach Neoplasms/prevention & control
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1313994-0
    ISSN 1558-1950 ; 1052-5157
    ISSN (online) 1558-1950
    ISSN 1052-5157
    DOI 10.1016/j.giec.2021.03.006
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  5. Article ; Online: Examining Racial/Ethnic Disparities in Coping and Stress Within an Environmental Riskscape.

    Mair, Christine A / Peek, M Kristen / Slatcher, Richard B / Cutchin, Malcolm P

    Journal of immigrant and minority health

    2023  Volume 25, Issue 5, Page(s) 1033–1042

    Abstract: Existing research on racial/ethnic differences in stress and coping is limited by small samples, single-item measures, and lack of inclusion of Mexican Americans. We address these gaps by analyzing data from the Texas City Stress and Health Study, a ... ...

    Abstract Existing research on racial/ethnic differences in stress and coping is limited by small samples, single-item measures, and lack of inclusion of Mexican Americans. We address these gaps by analyzing data from the Texas City Stress and Health Study, a cross-sectional sample of Black (N = 257), White (N = 304), US-born (N = 689), and foreign-born (N = 749) Mexican Americans residing in proximity to a petrochemical complex. We compared active and avoidant coping by race/ethnicity and explored multivariable associations between coping and perceived stress. Black and foreign-born Mexican American respondents had the highest stressor exposure yet displayed different patterns of coping and perceived stress patterns. Active coping may be particularly effective for African Americans but may not offset extreme stress disparities. For Mexican Americans, the lack of association between coping and stress underscores the need for more work focused on the culturally diverse coping experiences.
    MeSH term(s) Humans ; Adaptation, Psychological ; Black or African American/psychology ; Cross-Sectional Studies ; Ethnicity/psychology ; Mexican Americans/psychology ; United States ; Stress, Psychological/ethnology ; Stress, Psychological/psychology ; Environment ; Neighborhood Characteristics ; Social Determinants of Health/ethnology ; White/psychology ; Emigrants and Immigrants/psychology ; Cross-Cultural Comparison ; Texas ; Racial Groups/psychology
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2220162-2
    ISSN 1557-1920 ; 1557-1912
    ISSN (online) 1557-1920
    ISSN 1557-1912
    DOI 10.1007/s10903-023-01458-5
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  6. Article ; Online: RNF43: A Biomarker With Potential Ramifications for Therapeutic Intervention in Gastric Cancer.

    Noto, Jennifer M / Peek, Richard M

    Cellular and molecular gastroenterology and hepatology

    2020  Volume 11, Issue 4, Page(s) 1202–1203

    MeSH term(s) Biomarkers ; Carcinogenesis ; Humans ; Stomach Neoplasms/therapy ; Ubiquitin-Protein Ligases ; Wnt Signaling Pathway
    Chemical Substances Biomarkers ; RNF43 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2020-12-19
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2020.11.014
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  7. Article ; Online: Election of Anil Rustgi and Raymond DuBois to the National Academy of Medicine.

    Corley, Douglas E / Peek, Richard M

    Gastroenterology

    2020  Volume 158, Issue 5, Page(s) 1196

    MeSH term(s) History, 20th Century ; History, 21st Century ; National Academies of Science, Engineering, and Medicine, U.S., Health and Medicine Division/history ; National Academies of Science, Engineering, and Medicine, U.S., Health and Medicine Division/organization & administration ; United States
    Language English
    Publishing date 2020-03-04
    Publishing country United States
    Document type Editorial ; Historical Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.02.057
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  8. Article ; Online: COVID-19: What Should Clinicians and Scientists Do and When?

    Corley, Douglas A / Peek, Richard M

    Gastroenterology

    2020  Volume 158, Issue 8, Page(s) 2020–2023

    MeSH term(s) Betacoronavirus/pathogenicity ; Biomedical Research ; COVID-19 ; Communicable Disease Control/methods ; Communicable Disease Control/organization & administration ; Congresses as Topic ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Global Burden of Disease ; Health Personnel/organization & administration ; Humans ; Mass Screening/methods ; Mass Screening/organization & administration ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Research Personnel/organization & administration ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-03-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.03.026
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  9. Article ; Online: Paradigm-Shifting Research in Gastroenterology, Hepatology, and Nutrition: A Top 20 List of Articles Published in 2020.

    Corley, Douglas A / Peek, Richard M / Simpson, Brook A

    Gastroenterology

    2021  Volume 160, Issue 4, Page(s) 979–981

    MeSH term(s) Gastroenterology/methods ; Gastroenterology/trends ; Humans ; Publishing/trends
    Language English
    Publishing date 2021-01-14
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.01.023
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  10. Article ; Online: New Biology to New Treatment of Helicobacter pylori-Induced Gastric Cancer.

    Peek, Richard M

    Digestive diseases (Basel, Switzerland)

    2016  Volume 34, Issue 5, Page(s) 510–516

    Abstract: Background: Helicobacter pylori is a bacterial carcinogen that is supposed to have the highest known level of risk for the development of gastric cancer, a disease that claims hundreds of thousands of lives per year. Approximately 89% of the global ... ...

    Abstract Background: Helicobacter pylori is a bacterial carcinogen that is supposed to have the highest known level of risk for the development of gastric cancer, a disease that claims hundreds of thousands of lives per year. Approximately 89% of the global gastric cancer burden and 5.5% of malignancies worldwide are attributed to H. pylori-induced inflammation and injury. However, only a fraction of colonized persons ever develop neoplasia, and disease risk involves well-choreographed interactions between pathogen and host, which are dependent upon strain-specific bacterial factors, host genotypic traits, and/or environmental conditions.
    Key messages: One H. pylori strain-specific virulence determinant that augments the risk for gastric cancer is the cag pathogenicity island, a secretion system that injects the bacterial oncoprotein CagA into host cells. Host polymorphisms within genes that regulate immunity and oncogenesis also heighten the risk for gastric cancer, in conjunction with H. pylori strain-specific constituents. Further, conditions such as iron deficiency and high salt intake can influence H. pylori phenotypes that lower the threshold for disease.
    Conclusions: Delineation of bacterial, host, and environmental mediators that augment gastric cancer risk has profound ramifications for both physicians and biomedical researchers as such findings will not only focus prevention approaches that target H. pylori-infected human populations at increased risk for stomach cancer, but will also provide mechanistic insights into inflammatory carcinomas that develop beyond the gastric niche.
    MeSH term(s) Anti-Infective Agents/therapeutic use ; Cell Transformation, Neoplastic/genetics ; Helicobacter Infections/complications ; Helicobacter Infections/drug therapy ; Helicobacter Infections/microbiology ; Helicobacter pylori ; Humans ; Risk Factors ; Stomach Neoplasms/microbiology ; Virulence Factors
    Chemical Substances Anti-Infective Agents ; Virulence Factors
    Language English
    Publishing date 2016
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 632798-9
    ISSN 1421-9875 ; 0257-2753
    ISSN (online) 1421-9875
    ISSN 0257-2753
    DOI 10.1159/000445231
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