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  1. Article ; Online: Therapeutic future of Fuchs endothelial corneal dystrophy: An ongoing way to explore.

    Liu, Jia-Xin / Chiang, Tung-Lin / Hung, Kai-Feng / Sun, Yi-Chen

    Taiwan journal of ophthalmology

    2024  Volume 14, Issue 1, Page(s) 15–26

    Abstract: Fuchs endothelial corneal dystrophy (FECD) is one of the most common corneal diseases that causes loss of visual acuity in the world. FECD is a genetically and pathogenetically heterogeneous disease that results in the failure of corneal endothelial ... ...

    Abstract Fuchs endothelial corneal dystrophy (FECD) is one of the most common corneal diseases that causes loss of visual acuity in the world. FECD is a genetically and pathogenetically heterogeneous disease that results in the failure of corneal endothelial cells to maintain fluid balance and functional homeostasis of the cornea. Corneal edema, central guttae formation, and bullae development are common corneal pathologies. Currently, the mainstay of FECD treatment is surgery. However, limited sources of corneal graft and postsurgical complications remain problematic. In recent years, with advances in medical science and technology, there have been a few promising trials of new treatment modalities for FECD. In addition to new surgical methods, novel modalities can be classified into pharmacological-associated treatment, cell therapy-associated treatment, and gene therapy-associated treatment. In this article, our primary focus is on the most recent clinical trials related to FECD, and we present a stepwise approach to enhance FECD management and ultimately improve patient outcomes. We thoroughly searched for FECD clinical trials and reviewed the study designs, methodologies, and outcomes of each trial conducted within the past decade. It is imperative for physicians to stay up-to-date with these cutting-edge treatment approaches.
    Language English
    Publishing date 2024-01-05
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2652841-1
    ISSN 2211-5072 ; 2211-5072
    ISSN (online) 2211-5072
    ISSN 2211-5072
    DOI 10.4103/tjo.TJO-D-23-00115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Corrigendum to "Human antigen R protein modulates vascular endothelial growth factor expression in human corneal epithelial cells under hypoxia" [J Formosan Med Assoc 119 (2020) 359-366].

    Hung, Kai-Feng / Sun, Yi-Chen / Liou, Hau-Min / Hu, Fung-Rong

    Journal of the Formosan Medical Association = Taiwan yi zhi

    2022  Volume 121, Issue 9, Page(s) 1884

    Language English
    Publishing date 2022-08-26
    Publishing country Singapore
    Document type Published Erratum
    ZDB-ID 2096659-3
    ISSN 1876-0821 ; 0929-6646
    ISSN (online) 1876-0821
    ISSN 0929-6646
    DOI 10.1016/j.jfma.2022.08.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1041: Show issues Location:
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  3. Article ; Online: Characterizing the Robustness of Distinct Clinical Assessments in Identifying Dry Eye Condition of Animal Models.

    Hsieh, Hsiu-Hui / Chang, Yu-An / Chan, Szemin / Lin, Zhi-Qian / Lin, Chung-Tien / Hu, Fung-Rong / Hung, Kai-Feng / Sun, Yi-Chen

    Current eye research

    2024  , Page(s) 1–9

    Abstract: Purpose: The study aims to characterize the robustness of distinct clinical assessments in identifying the underlying conditions of dry eye disease (DED), with a specific emphasis on the involvement of conjunctival goblet cells.: Methods: Seven ... ...

    Abstract Purpose: The study aims to characterize the robustness of distinct clinical assessments in identifying the underlying conditions of dry eye disease (DED), with a specific emphasis on the involvement of conjunctival goblet cells.
    Methods: Seven rabbits receiving surgical removal of the lacrimal and Harderian glands were divided into two groups, one with ablation of conjunctival goblet cells by topical soaking of trichloroacetic acid (TCA) to the bulbar conjunctiva (
    Results: Histopathological analysis revealed corneal epithelial thinning in both groups. While TCA soaking significantly decreased the density of conjunctival goblet cells, DED rabbits without TCA also showed a partial reduction in goblet cell density, potentially attributable to dacryoadenectomy. Both groups showed significant decreases in Schirmer test and TBUT, as well as an increase in tear osmolarity. In DED rabbits with TCA soaking, tear osmolarity increased markedly, suggesting that tear osmolarity is highly sensitive to loss and/or dysfunction of conjunctival goblet cells. Fluorescein staining was gradually and similarly increased in both groups, suggesting that fluorescein staining may not reveal an early disruption of the tear film until the prolonged progression of DED.
    Conclusion: The Schirmer test, TBUT, tear osmolarity, and NEI fluorescein grading are distinct, yet complementary, clinical assessments for the evaluation of DED. By performing these assessments in definitive DED rabbit models, both with and without ablation of conjunctival goblet cells, the role of these cells in the homeostasis of tear osmolarity is highlighted. Characterizing the robustness of these assessments in identifying the underlying conditions of DED will guide a more appropriate management for patients with DED.
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 82079-9
    ISSN 1460-2202 ; 0271-3683
    ISSN (online) 1460-2202
    ISSN 0271-3683
    DOI 10.1080/02713683.2024.2310614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1775: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Peripheral Nerve Denervation in Streptozotocin-Induced Diabetic Rats Is Reduced by Cilostazol.

    Tseng, Kuang-Yi / Wang, Hung-Chen / Wang, Yi-Hsuan / Su, Miao-Pei / Cheng, Kai-Feng / Cheng, Kuang-I / Chang, Lin-Li

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 3

    Abstract: Background and Objective: ...

    Abstract Background and Objective:
    MeSH term(s) Rats ; Male ; Animals ; Cilostazol/therapeutic use ; Cilostazol/pharmacology ; Diabetic Neuropathies/drug therapy ; Rats, Sprague-Dawley ; Streptozocin/adverse effects ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Type 1 ; Calcitonin Gene-Related Peptide/adverse effects ; Calcitonin Gene-Related Peptide/analysis ; Sciatic Nerve/pathology ; Hyperalgesia/drug therapy ; Hyperalgesia/etiology ; Hyperalgesia/metabolism ; Denervation ; Hyperglycemia
    Chemical Substances Cilostazol (N7Z035406B) ; Streptozocin (5W494URQ81) ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
    Language English
    Publishing date 2023-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59030553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6270: Show issues Location:
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  5. Article ; Online: Structure-based approaches against COVID-19.

    Huang, Ta-Chou / Liang, Kung-Hao / Chang, Tai-Jay / Hung, Kai-Feng / Wang, Mong-Lien / Cheng, Yen-Fu / Liao, Yi-Ting / Yang, De-Ming

    Journal of the Chinese Medical Association : JCMA

    2023  Volume 87, Issue 2, Page(s) 139–141

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic has had a major impact on human life. This review highlights the versatile roles of both classical and modern structure-based approaches for COVID-19. X-ray crystallography, nuclear magnetic resonance ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic has had a major impact on human life. This review highlights the versatile roles of both classical and modern structure-based approaches for COVID-19. X-ray crystallography, nuclear magnetic resonance spectroscopy, and cryogenic electron microscopy are the three cornerstones of classical structural biology. These technologies have helped provide fundamental and detailed knowledge regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the related human host proteins as well as enabled the identification of its target sites, facilitating the cessation of its transmission. Further progress into protein structure modeling was made using modern structure-based approaches derived from homology modeling and integrated with artificial intelligence (AI), facilitating advanced computational simulation tools to actively guide the design of new vaccines and the development of anti-SARS-CoV-2 drugs. This review presents the practical contributions and future directions of structure-based approaches for COVID-19.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Artificial Intelligence ; COVID-19 Vaccines ; Computer Simulation
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-12-20
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 2107283-8
    ISSN 1728-7731 ; 1726-4901
    ISSN (online) 1728-7731
    ISSN 1726-4901
    DOI 10.1097/JCMA.0000000000001043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2699: Show issues Location:
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  6. Article ; Online: Correction to: The disposable bandage soft contact lenses therapy and anterior segment optical coherence tomography for management of ocular graft-versus-host disease.

    Sun, Yi-Chen / Inamoto, Yoshihiro / Wang, Ruikang K / Lee, Stephanie J / Hung, Kai-Feng / Shen, Tueng T

    BMC ophthalmology

    2022  Volume 22, Issue 1, Page(s) 38

    Language English
    Publishing date 2022-01-25
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2050436-6
    ISSN 1471-2415 ; 1471-2415
    ISSN (online) 1471-2415
    ISSN 1471-2415
    DOI 10.1186/s12886-021-02225-6
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  7. Article ; Online: A modified SELEX approach to identify DNA aptamers with binding specificity to the major histocompatibility complex presenting ovalbumin model antigen.

    Lin, Yang / Chen, Cho-Yi / Ku, Yu-Chia / Wang, Li-Chin / Hung, Chia-Chien / Lin, Zhi-Qian / Chen, Bing-Hong / Hung, Jui-Tse / Sun, Yi-Chen / Hung, Kai-Feng

    RSC advances

    2023  Volume 13, Issue 46, Page(s) 32681–32693

    Abstract: Aptamers have sparked significant interest in cell recognition because of their superior binding specificity and biocompatibility. Cell recognition can be mediated by targeting the major histocompatibility complex (MHC) that presents short peptides ... ...

    Abstract Aptamers have sparked significant interest in cell recognition because of their superior binding specificity and biocompatibility. Cell recognition can be mediated by targeting the major histocompatibility complex (MHC) that presents short peptides derived from intracellular antigens. Although numerous antibodies have demonstrated a specific affinity for the peptide-MHC complex, the number of aptamers that exhibit comparable characteristics is limited. Aptamers are usually selected from large libraries
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra04686a
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  8. Article: Sciatic Nerve Intrafascicular Injection Induces Neuropathy by Activating the Matrix Modulators MMP-9 and TIMP-1.

    Tseng, Kuang-Yi / Wang, Hung-Chen / Cheng, Kai-Feng / Wang, Yi-Hsuan / Chang, Lin-Li / Cheng, Kuang-I

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 859982

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-05-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.859982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cancer stem cell theory: Are we moving past the mist?

    Hung, Kai-Feng / Yang, Ting / Kao, Shou-Yen

    Journal of the Chinese Medical Association : JCMA

    2019  Volume 82, Issue 11, Page(s) 814–818

    Abstract: Cancer stem cells (CSC) are a subpopulation of tumor cells that have superior capacities of self-renewal, metastatic dissemination, and chemoresistance. These characteristics resemble, to some extent, the outcome of certain biological processes, ... ...

    Abstract Cancer stem cells (CSC) are a subpopulation of tumor cells that have superior capacities of self-renewal, metastatic dissemination, and chemoresistance. These characteristics resemble, to some extent, the outcome of certain biological processes, including epithelial-mesenchymal transition (EMT), autophagy, and cellular stress response. Indeed, it has been shown that the stimuli that induce these processes and CSC are overlapping, and CSC and tumor cells that underwent EMT or autophagy are much alike. However, as the cross talk between CSC, EMT, autophagy, and cellular stress is further explored, these processes are also found to have an opposing role in CSC, depending on the condition and status of cells. This contextual effect is likely due to overwhelming reliance on CSC markers for their identification, and/or discrepancies in recognition of CSC as a particular cell population or cellular state. In this review, we summarize how EMT, autophagy, and cellular stress response are tied or unwound with CSC. We also discuss the current view of CSC theory evolved from the emphasis of heterogenicity and plasticity of CSC.
    MeSH term(s) Animals ; Autophagy/physiology ; Cell Plasticity ; Epithelial-Mesenchymal Transition ; Humans ; Neoplastic Stem Cells/physiology ; Stress, Physiological/physiology
    Language English
    Publishing date 2019-08-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2107283-8
    ISSN 1728-7731 ; 1726-4901
    ISSN (online) 1728-7731
    ISSN 1726-4901
    DOI 10.1097/JCMA.0000000000000186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2699: Show issues Location:
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  10. Article ; Online: The 6-4 photoproduct is the trigger of UV-induced replication blockage and ATR activation.

    Hung, Kai-Feng / Sidorova, Julia M / Nghiem, Paul / Kawasumi, Masaoki

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 23, Page(s) 12806–12816

    Abstract: The most prevalent human carcinogen is sunlight-associated ultraviolet (UV), a physiologic dose of which generates thousands of DNA lesions per cell, mostly of two types: cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs). It has not ... ...

    Abstract The most prevalent human carcinogen is sunlight-associated ultraviolet (UV), a physiologic dose of which generates thousands of DNA lesions per cell, mostly of two types: cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs). It has not been possible, in living cells, to precisely characterize the respective contributions of these two lesion types to the signals that regulate cell cycle progression, DNA replication, and cell survival. Here we coupled multiparameter flow cytometry with lesion-specific photolyases that eliminate either CPDs or 6-4PPs and determined their respective contributions to DNA damage responses. Strikingly, only 6-4PP lesions activated the ATR-Chk1 DNA damage response pathway. Mechanistically, 6-4PPs, but not CPDs, impeded DNA replication across the genome as revealed by microfluidic-assisted replication track analysis. Furthermore, single-stranded DNA accumulated preferentially at 6-4PPs during DNA replication, indicating selective and prolonged replication blockage at 6-4PPs. These findings suggest that 6-4PPs, although eightfold fewer in number than CPDs, are the trigger for UV-induced DNA damage responses.
    MeSH term(s) Animals ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Cells, Cultured ; Checkpoint Kinase 1/metabolism ; DNA Damage ; DNA Repair ; DNA Replication ; HCT116 Cells ; Humans ; Pyrimidine Dimers/genetics ; Ultraviolet Rays
    Chemical Substances Pyrimidine Dimers ; pyrimidine-pyrimidone dimer ; ATR protein, human (EC 2.7.11.1) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; CHEK1 protein, human (EC 2.7.11.1) ; Checkpoint Kinase 1 (EC 2.7.11.1)
    Language English
    Publishing date 2020-05-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1917196117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
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