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Article ; Online: Artemisinin-Resistant HRP2-Negative Malaria in Eritrea.

Bayih, Abebe G / Feleke, Sindew M / Pillai, Dylan R

2023 Volume 389, Issue 26, Page(s) 2497

MeSH term(s)	Humans ; Eritrea/epidemiology ; Prevalence ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/epidemiology ; Plasmodium falciparum/genetics ; Artemisinins/pharmacology ; Artemisinins/therapeutic use
Chemical Substances	artemisinin (9RMU91N5K2) ; Artemisinins
Language	English
Publishing date	2023-12-29
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2312559
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Article: Role of Hsp90 in Plasmodium falciparum Malaria.

Shahinas, Dea / Pillai, Dylan R

Advances in experimental medicine and biology

2021 Volume 1340, Page(s) 125–139

Abstract: Studies in mammalian and yeast chaperone systems have significantly advanced our understanding of the biochemistry of heat shock protein 90 (Hsp90), particularly as it pertains to structural details, interaction regulation, and function. Harnessing this ... ...

Abstract	Studies in mammalian and yeast chaperone systems have significantly advanced our understanding of the biochemistry of heat shock protein 90 (Hsp90), particularly as it pertains to structural details, interaction regulation, and function. Harnessing this body of knowledge, parasitologists have made tremendous steps in understanding the role of the Hsp90 chaperone machine in protozoal parasites, especially in malaria. Heat shock proteins are a crucial part of the signaling events involved in malaria parasite acclimatization in the host. Even though studies of the role of Hsp90 in malaria have been thorough and discovered some of the most intricate details of the utility of the Hsp90 interactome for pathogen-host interactions, the full and elaborate extent of the role of Hsp90 homologs in malaria remains to be uncovered. This chapter discusses the current knowledge about the biochemistry and cellular role of Hsp90 in Plasmodium falciparum malaria. In addition, the involvement of both parasitic and host Hsp90s by the parasite in the infected cell is discussed.
MeSH term(s)	Animals ; Antimalarials ; HSP70 Heat-Shock Proteins ; HSP90 Heat-Shock Proteins/genetics ; Malaria/drug therapy ; Malaria, Falciparum/drug therapy ; Plasmodium falciparum/genetics ; Protozoan Proteins/genetics
Chemical Substances	Antimalarials ; HSP70 Heat-Shock Proteins ; HSP90 Heat-Shock Proteins ; Protozoan Proteins
Language	English
Publishing date	2021-09-27
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-78397-6_5
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Article ; Online: The impact of the COVID-19 pandemic on malaria in returning travellers in Canada: a retrospective population-based cohort study.

Lieu, Anthony / Mah, Jordan / Desgagnés, Noémie / Pillai, Dylan R

Journal of travel medicine

2022 Volume 29, Issue 4

MeSH term(s)	COVID-19 ; Cohort Studies ; Humans ; Malaria/epidemiology ; Pandemics ; Retrospective Studies ; Travel
Language	English
Publishing date	2022-05-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taac061
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Zs.A 4120: Show issues

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Article ; Online: Clinical validation of loop-mediated isothermal amplification for the detection of

Peirano, Gisele / Castellanos, L Ricardo / Matsumura, Yasufumi / Chaffee, Ryan / Castañeda-Mogollón, Daniel / Pillai, Dylan R / Pitout, Johann D D

Journal of clinical microbiology

2024 Volume 62, Issue 3, Page(s) e0168723

Abstract: The dissemination of : Importance: We developed an accurate non-culture-based loop-mediated isothermal amplification (LAMP) methodology for the detection of (sequence type) STc131 ... ...

Abstract	The dissemination of Importance: We developed an accurate non-culture-based loop-mediated isothermal amplification (LAMP) methodology for the detection of (sequence type) STc131 among
MeSH term(s)	Humans ; Escherichia coli/genetics ; Drug Resistance, Multiple, Bacterial/genetics ; Escherichia coli Infections/epidemiology ; Nucleic Acid Amplification Techniques ; beta-Lactamases/genetics ; Anti-Bacterial Agents/pharmacology ; Molecular Diagnostic Techniques
Chemical Substances	beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/jcm.01687-23
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Zs.A 1188: Show issues

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Article ; Online: Amplicon Deep Sequencing Reveals Multiple Genetic Events Lead to Treatment Failure with Atovaquone-Proguanil in Plasmodium falciparum.

Castañeda-Mogollón, Daniel / Toppings, Noah B / Kamaliddin, Claire / Lang, Raynell / Kuhn, Susan / Pillai, Dylan R

Antimicrobial agents and chemotherapy

2023 Volume 67, Issue 6, Page(s) e0170922

Abstract: Atovaquone-proguanil (AP) is used as treatment for uncomplicated malaria, and as a chemoprophylactic agent against Plasmodium falciparum. Imported malaria remains one of the top causes of fever in Canadian returning travelers. Twelve sequential whole- ... ...

Abstract	Atovaquone-proguanil (AP) is used as treatment for uncomplicated malaria, and as a chemoprophylactic agent against Plasmodium falciparum. Imported malaria remains one of the top causes of fever in Canadian returning travelers. Twelve sequential whole-blood samples before and after AP treatment failure were obtained from a patient diagnosed with P. falciparum malaria upon their return from Uganda and Sudan. Ultradeep sequencing was performed on the
MeSH term(s)	Humans ; Plasmodium falciparum/genetics ; Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Sepharose/therapeutic use ; Canada ; Proguanil/pharmacology ; Proguanil/therapeutic use ; Atovaquone/pharmacology ; Atovaquone/therapeutic use ; Malaria, Falciparum/prevention & control ; Drug Combinations ; Treatment Failure ; Tetrahydrofolate Dehydrogenase ; High-Throughput Nucleotide Sequencing ; Recurrence
Chemical Substances	atovaquone, proguanil drug combination ; Antimalarials ; Sepharose (9012-36-6) ; Proguanil (S61K3P7B2V) ; Atovaquone (Y883P1Z2LT) ; Drug Combinations ; Tetrahydrofolate Dehydrogenase (EC 1.5.1.3)
Language	English
Publishing date	2023-05-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.01709-22
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Einzelsignatur: Show issues

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Article ; Online: Ultrasensitive Reverse Transcriptase Loop-Mediated Isothermal Amplification (US-LAMP)-Based Detection of Malaria Infection from Dried Blood Spots.

Mohon, Abu Naser / Toppings, Noah / Castañeda-Mogollón, Daniel / Kamaliddin, Claire / Pillai, Dylan R

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2621, Page(s) 325–337

Abstract: Submicroscopic malaria diagnosis requires highly sensitive tools instead of the conventional microscopy and rapid diagnostic tests (RDTs). While polymerase chain reaction (PCR) is more sensitive than RDTs and microscopy, the required capital cost and ... ...

Abstract	Submicroscopic malaria diagnosis requires highly sensitive tools instead of the conventional microscopy and rapid diagnostic tests (RDTs). While polymerase chain reaction (PCR) is more sensitive than RDTs and microscopy, the required capital cost and technical expertise hinder implementation of PCR in low- and middle-income countries. This chapter describes an ultrasensitive reverse transcriptase loop-mediated isothermal amplification (US-LAMP) test for malaria with a high sensitivity and specificity, while also being practical to implement in low-complexity laboratory settings. The workflow combines a silica spin column-based total nucleic extraction from dried blood spots (DBS) with US-LAMP amplifying the Plasmodium (Pan-LAMP) target and subsequent identification Plasmodium falciparum (Pf-LAMP).
MeSH term(s)	Humans ; Malaria, Falciparum ; Sensitivity and Specificity ; Malaria/diagnosis ; Plasmodium falciparum
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2950-5_19
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Article ; Online: Digital Droplet PCR to Track SARS-CoV-2 Outbreak in a Hospital Transitional Care Unit.

Linton, Kathryn / Oberding, Lisa K / Ward, Linda / Kim, Joseph / Pillai, Dylan R

American journal of infection control

2022 Volume 51, Issue 2, Page(s) 231–233

Abstract: We describe an outbreak of SARS-CoV-2 on a transition unit composed of elderly patients awaiting placement. Environmental and patient sample analyses using digital droplet PCR (ddPCR) suggested possible fomite transmission and a high viral burden source ... ...

Abstract	We describe an outbreak of SARS-CoV-2 on a transition unit composed of elderly patients awaiting placement. Environmental and patient sample analyses using digital droplet PCR (ddPCR) suggested possible fomite transmission and a high viral burden source from a few individual patients. This outbreak illustrates challenges inherent to this specific patient population.
MeSH term(s)	Humans ; Aged ; SARS-CoV-2/genetics ; COVID-19 ; Transitional Care ; Polymerase Chain Reaction ; Disease Outbreaks ; Hospitals ; RNA, Viral/analysis ; COVID-19 Testing
Chemical Substances	RNA, Viral
Language	English
Publishing date	2022-06-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2022.06.010
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Zs.A 1773: Show issues

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Article ; Online: The Role of Subgenomic RNA in Discordant Results From Reverse Transcription-Polymerase Chain Reaction Tests for COVID-19.

Toppings, Noah B / Oberding, Lisa K / Lin, Yi-Chan / Evans, David / Pillai, Dylan R

Archives of pathology & laboratory medicine

2022 Volume 146, Issue 7, Page(s) 805–813

Abstract: Context.—: Reverse transcription-polymerase chain reaction (RT-PCR) is the standard method of diagnosing COVID-19. An inconclusive test result occurs when 1 RT-PCR target is positive for SARS-CoV-2 and 1 RT-PCR target is negative for SARS-CoV-2 within ... ...

Abstract	Context.—: Reverse transcription-polymerase chain reaction (RT-PCR) is the standard method of diagnosing COVID-19. An inconclusive test result occurs when 1 RT-PCR target is positive for SARS-CoV-2 and 1 RT-PCR target is negative for SARS-CoV-2 within the same sample. An inconclusive result generally requires retesting. One reason why a sample may yield an inconclusive result is that one target is at a higher concentration than another target. Objective.—: To understand the role of subgenomic RNA transcripts in discordant results from RT-PCR tests for COVID-19. Design.—: A panel of 6 droplet digital PCR assays was designed to quantify the ORF1, E-gene, and N-gene of SARS-CoV-2. This panel was used to quantify viral cultures of SARS-CoV-2 that were harvested during the eclipse phase and at peak infectivity. Eleven clinical nasopharyngeal swabs were also tested with this panel. Results.—: In culture, infected cells showed higher N-gene/ORF1 copy ratios than culture supernatants. The same trends in the relative abundance of copies across different targets observed in infected cells were observed in clinical samples, although trends were more pronounced in infected cells. Conclusions.—: This study showed that a greater copy number of N-gene relative to E-gene and ORF1 transcripts could potentially explain inconclusive results for some RT-PCR tests on low viral load samples. The use of N-gene RT-PCR target(s) as opposed to ORF1 targets for routine testing is supported by these data.
MeSH term(s)	COVID-19/diagnosis ; Humans ; RNA ; RNA, Viral/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Reverse Transcription ; SARS-CoV-2/genetics
Chemical Substances	RNA, Viral ; RNA (63231-63-0)
Language	English
Publishing date	2022-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	194119-7
ISSN	1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
ISSN (online)	1543-2165
ISSN	0363-0153 ; 0096-8528 ; 0003-9985
DOI	10.5858/arpa.2021-0630-SA
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Article ; Online: Clostridioides difficile Near-Patient Testing Versus Centralized Testing: A Pragmatic Cluster Randomized Crossover Trial.

Doolan, Cody P / Sahragard, Babak / Leal, Jenine / Sharma, Anuj / Kim, Joseph / Spackman, Eldon / Hollis, Aidan / Pillai, Dylan R

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2023 Volume 76, Issue 11, Page(s) 1911–1918

Abstract: Background: Management of suspected Clostridioides difficile infection (CDI) in the hospital setting typically results in patient isolation, laboratory testing, infection control, and presumptive treatment. We investigated whether implementation of ... ...

Abstract	Background: Management of suspected Clostridioides difficile infection (CDI) in the hospital setting typically results in patient isolation, laboratory testing, infection control, and presumptive treatment. We investigated whether implementation of rapid near-patient testing (NPT) reduced patient isolation time, hospital length of stay (LOS), antibiotic usage, and cost. Methods: A 2-period pragmatic cluster randomized crossover trial was conducted. Thirty-nine wards were randomized into 2 study arms. The primary outcome measure was effect of NPT on patient isolation time using a mixed-effects generalized linear regression model. Secondary outcomes examined were hospital LOS and antibiotic therapy based on a negative binomial regression model. Natural experiment (NE), intention-to-treat (ITT), and per-protocol (PP) analyses were conducted. Results: During the entire study period, a total of 656 patients received NPT for CDI and 1667 received standard-of-care testing. For the primary outcome, a significant decrease of patient isolation time with NPT was observed (NE, 9.4 hours [P < .01]; ITT, 2.3 hours [P < .05]; PP, 6.7 hours [P < .1]). A significant reduction in hospital LOS was observed with NPT for short stay (NE, 47.4% [P < .01]; ITT, 18.4% [P < .01]; PP, 34.2% [P < .01]). Each additional hour delay for a negative result increased metronidazole use (24 defined daily doses per 1000 patients; P < .05) and non-CDI-treating antibiotics by 70.13 mg (P < .01). NPT was found to save 25.48 US dollars per patient when including test cost to the laboratory and patient isolation in the hospital. Conclusions: This pragmatic cluster randomized crossover trial demonstrated that implementation of CDI NPT can contribute to significant reductions in isolation time, hospital LOS, antibiotic usage, and healthcare cost. Clinical Trials Registration. NCT03857464.
MeSH term(s)	Humans ; Clostridioides difficile ; Clostridioides ; Cross-Over Studies ; Anti-Bacterial Agents/therapeutic use ; Metronidazole/therapeutic use ; Clostridium Infections/diagnosis ; Clostridium Infections/drug therapy
Chemical Substances	Anti-Bacterial Agents ; Metronidazole (140QMO216E)
Language	English
Publishing date	2023-01-13
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciad046
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Reply to Awandu et al.

Golassa, Lemu / Cheaveau, James / Mohon, Abu Naser / Pillai, Dylan R

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2019 Volume 69, Issue 8, Page(s) 1464–1465

MeSH term(s)	Cross-Sectional Studies ; Humans ; Malaria ; Prevalence
Language	English
Publishing date	2019-02-08
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciz148
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Zs.MO 480: Show issues

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