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  1. Book ; Online: Peritoneal Dialysis and Its Local and Systemic Complications: From the Bench to the Clinic

    Lopez-Cabrera, Manuel / Witowski, Janusz / Isaac Aguilera, Abelardo

    2020  

    Keywords Science: general issues ; Physiology ; peritoneal dialysis ; mesothelial cells ; renal replacement therapy ; peritonitis ; peritoneum
    Size 1 electronic resource (164 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230275
    ISBN 9782889636440 ; 2889636445
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Thesis: Effect of interleukin-17 on chemokine synthesis by human peritoneal mesothelial cells

    Witowski, Janusz

    2004  

    Author's details vorgelegt von Janusz Witowski
    Language German
    Size 91 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Diss., 2004
    HBZ-ID HT014024185
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 D 2939 order for loan Magazin

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  3. Article: Peritoneal Dialysis and Its Local and Systemic Complications: From the Bench to the Clinic.

    Witowski, Janusz / López-Cabrera, Manuel

    Frontiers in physiology

    2020  Volume 11, Page(s) 188

    Language English
    Publishing date 2020-02-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2020.00188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Seasonal Influence on Salivary Myeloperoxidase Diurnal Variations in Young Healthy Subjects: A Preliminary Study.

    Nijakowski, Kacper / Rutkowski, Rafał / Gruszczyński, Dawid / Witowski, Janusz / Surdacka, Anna / Kanikowska, Dominika

    Frontiers in bioscience (Landmark edition)

    2024  Volume 29, Issue 1, Page(s) 10

    Abstract: Background: The interaction between oxidative status markers and biological rhythms is considered particularly important in the pathogenesis of many diseases and more effective therapies. We aimed to determine if the salivary secretion of ... ...

    Abstract Background: The interaction between oxidative status markers and biological rhythms is considered particularly important in the pathogenesis of many diseases and more effective therapies. We aimed to determine if the salivary secretion of myeloperoxidase exhibits diurnal variations, and if the potential daily variability differs seasonally.
    Methods: The study was performed in Poznan, Poland (52,25°N, 16,58°E) in 10 healthy male volunteers (age median 23.5 years). Whole mixed unstimulated saliva was collected in summer (August) and winter (December) during 36 h at 2-h intervals starting at 6 a.m. on Saturday and ending at 6 p.m. on Sunday, in the domestic setting. The samples were analysed for myeloperoxidase (MPO) and cortisol by immunoassays. The presence of the circadian rhythm of cortisol secretion in saliva confirmed the rhythmicity of the volunteers.
    Results: For salivary MPO, significantly higher concentrations compared to midnight and noon were observed for 4 a.m. in both summer and winter. Using the cosinor analysis, the variations in salivary MPO levels showed a moderate fit for the 12-h period rhythm (acrophases: in summer 05:37/17:37, in winter 06:16/18:16), without significant differences in the rhythm parameters in summer and winter. However, higher self-reported Global Seasonal Score (which may predispose to seasonal affective disorder) was associated with significantly stronger relative amplitude (RS = 0.811) in winter season only.
    Conclusions: In conclusion, our findings suggest the possible ultradian rhythm for MPO in saliva, with two peaks during the day, regardless of the season.
    MeSH term(s) Humans ; Male ; Young Adult ; Circadian Rhythm ; Healthy Volunteers ; Hydrocortisone/analysis ; Peroxidase ; Seasons ; Ultradian Rhythm
    Chemical Substances Hydrocortisone (WI4X0X7BPJ) ; Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2024-01-29
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2901010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Treatment regimens and disease activity could alter salivary myeloperoxidase levels in patients with inflammatory bowel diseases.

    Nijakowski, Kacper / Motylewska, Barbara / Banasik, Estera / Rutkowski, Rafał / Tsaryk, Vasili / Łuczak, Joanna / Korybalska, Katarzyna / Witowski, Janusz / Surdacka, Anna / Eder, Piotr

    Polish archives of internal medicine

    2024  Volume 134, Issue 1

    Abstract: Introduction: Inflammatory bowel diseases (IBDs) present with alternating periods of exacerbation and remission; therefore, it is necessary to develop noninvasive diagnostic tools to control the disease activity and improve therapeutic effectiveness. ... ...

    Abstract Introduction: Inflammatory bowel diseases (IBDs) present with alternating periods of exacerbation and remission; therefore, it is necessary to develop noninvasive diagnostic tools to control the disease activity and improve therapeutic effectiveness. Recently, we have found that patients with ulcerative colitis (UC) who qualified for biologic therapy had significantly lower salivary myeloperoxidase (MPO) levels.
    Objectives: This cross‑sectional study aimed to assess the impact of IBD activity and applied treatment on salivary antioxidant system as reflected by the levels of catalase, total antioxidant status, and MPO.
    Patients and methods: The study group comprised 99 patients diagnosed with Crohn disease (CD) and 61 patients with UC. The Crohn Disease Activity Index and modified Mayo scale were used to estimate the clinical activity of CD and UC, respectively. Unstimulated whole mixed saliva was collected. Salivary levels of selected markers were measured with enzyme‑linked immunosorbent assays and colorimetric assays.
    Results: The patients with clinically active UC showed significantly decreased median (interquartile range) salivary MPO levels (79.4 [30.1-157.5] vs 94.8 [58.2-274.7] ng/ml) with significant correlations with the endoscopic stage on the Mayo scale (R = 0.423; P = 0.02). Receiver operating characteristic analysis confirmed a potential usefulness of MPO concentrations in predicting clinically active UC (area under the curve = 0.654; P = 0.03; cutoff <210.4 ng/ml). Moreover, in the patients treated with biologics and without steroid therapy, salivary MPO concentrations negatively correlated with neutrophil counts in the individuals with UC and positively with C‑reactive protein level in the patients with CD.
    Conclusions: Salivary MPO levels changed depending on the disease activity in the patients with UC. Decreased MPO concentration in the saliva could be a predictor of clinically active UC.
    MeSH term(s) Humans ; Antioxidants ; Colitis, Ulcerative/metabolism ; Crohn Disease/metabolism ; Cross-Sectional Studies ; Inflammatory Bowel Diseases/drug therapy ; Peroxidase
    Chemical Substances Antioxidants ; Peroxidase (EC 1.11.1.7) ; MPO protein, human (EC 1.11.1.7)
    Language English
    Publishing date 2024-01-02
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 360: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Increased Myeloperoxidase Concentrations in Saliva could Reflect Increased Body Mass and Oral Microinflammation.

    Nijakowski, Kacper / Lehmann, Anna / Rutkowski, Rafał / Korybalska, Katarzyna / Witowski, Janusz / Surdacka, Anna

    Frontiers in bioscience (Landmark edition)

    2023  Volume 28, Issue 8, Page(s) 168

    Abstract: Background: Increased myeloperoxidase (MPO) levels in saliva are thought to reflect ongoing periodontal inflammation. Less clear is whether and to what extent salivary MPO is increased as a result of systemic inflammation.: Methods: In the present ... ...

    Abstract Background: Increased myeloperoxidase (MPO) levels in saliva are thought to reflect ongoing periodontal inflammation. Less clear is whether and to what extent salivary MPO is increased as a result of systemic inflammation.
    Methods: In the present study, we aimed to determine which demographic, anthropometric, biochemical, and dental parameters affect the level of MPO in whole mixed saliva in healthy adults with no apparent inflammatory lesions in the oral cavity. Thus, 113 individuals, aged 20-61 years (including 30.1% men and 23.9% smokers), were examined.
    Results: In the univariate analysis, higher levels of MPO in saliva were found to be associated with age, an increased body mass index (BMI), higher levels of cytokines tumour necrosis factor-α and interleukin-6, as well as poorer oral hygiene, gingival status, and lower saliva flow. Multivariate logistic regression analysis determined that the main predictors of MPO concentration in saliva were BMI and stimulated saliva flow rate.
    Conclusions: Overall, an increase in MPO in saliva could be related to an increase in BMI, possibly as a result of subclinical chronic microinflammation, which also involves the gingiva.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Cytokines ; Inflammation ; Interleukin-6 ; Peroxidase ; Saliva ; Young Adult ; Middle Aged ; Body Mass Index
    Chemical Substances Cytokines ; Interleukin-6 ; Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2023-02-20
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2808168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Setting up research in peritoneal dialysis.

    Witowski, Janusz

    Contributions to nephrology

    2012  Volume 178, Page(s) 200–204

    Abstract: Over the past 30 years, peritoneal dialysis (PD) not only developed into a valuable treatment modality, but also stimulated basic science research. Here, we summarize some of such PD-inspired studies that addressed more general aspects of immunology and ... ...

    Abstract Over the past 30 years, peritoneal dialysis (PD) not only developed into a valuable treatment modality, but also stimulated basic science research. Here, we summarize some of such PD-inspired studies that addressed more general aspects of immunology and pathology and helped us to appreciate the complexity of peritoneal biology.
    MeSH term(s) Animals ; Biomedical Research ; Epithelial-Mesenchymal Transition ; Foreign Bodies ; Humans ; Interleukin-6/physiology ; Peritoneal Dialysis ; Peritoneum/pathology ; Transforming Growth Factor beta1/physiology
    Chemical Substances Interleukin-6 ; Transforming Growth Factor beta1
    Language English
    Publishing date 2012-05-25
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1662-2782 ; 0302-5144
    ISSN (online) 1662-2782
    ISSN 0302-5144
    DOI 10.1159/000337853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Role of NOX2-Derived Reactive Oxygen Species in the Induction of Endothelin-Converting Enzyme-1 by Angiotensin II.

    Adu-Gyamfi, Michael / Goettsch, Claudia / Kamhieh-Milz, Julian / Chen, Lei / Pfefferkorn, Anna Maria / Hofmann, Anja / Brunssen, Coy / Müller, Gregor / Walther, Thomas / Ashraf, Muhammad Imtiaz / Morawietz, Henning / Witowski, Janusz / Catar, Rusan

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: Endothelin-1 is a key regulator of vascular tone and blood pressure in health and disease. We have recently found that ET-1 production in human microvascular endothelial cells (HMECs) can be promoted by angiotensin II (Ang II) through a novel mechanism ... ...

    Abstract Endothelin-1 is a key regulator of vascular tone and blood pressure in health and disease. We have recently found that ET-1 production in human microvascular endothelial cells (HMECs) can be promoted by angiotensin II (Ang II) through a novel mechanism involving octamer-binding transcription factor-1 (Oct-1), NADPH oxidase-2 (NOX2), and superoxide anions. As the formation of bioactive ET-1 also depends on endothelin-converting enzyme-1 (ECE-1), we investigated the transcriptional regulation of the
    Language English
    Publishing date 2024-04-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13040500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Potential Salivary Markers for Differential Diagnosis of Crohn's Disease and Ulcerative Colitis.

    Nijakowski, Kacper / Rutkowski, Rafał / Eder, Piotr / Simon, Marek / Korybalska, Katarzyna / Witowski, Janusz / Surdacka, Anna

    Life (Basel, Switzerland)

    2021  Volume 11, Issue 9

    Abstract: The properties of the saliva of patients with inflammatory bowel disease (IBD) are poorly recognized. Likewise, the diagnostic potential of saliva for differentiating various forms of IBD is largely unexplored. Therefore, we compared the concentrations ... ...

    Abstract The properties of the saliva of patients with inflammatory bowel disease (IBD) are poorly recognized. Likewise, the diagnostic potential of saliva for differentiating various forms of IBD is largely unexplored. Therefore, we compared the concentrations of several parameters in unstimulated whole mixed saliva collected in a standardized manner from patients with active IBD unresponsive to conventional therapy. The samples were received from 27 patients with Crohn's disease (CD), 24 patients with ulcerative colitis (UC), and 51 healthy individuals. Compared to the controls, the salivary concentrations of S100A8/calprotectin, myeloperoxidase, and IgA were significantly decreased in both CD and UC patients. In addition, patients with UC had decreased levels of TNF-R1 and decreased catalase activity. Interestingly, the concentrations of myeloperoxidase and TNF-R1 showed a high differentiation potential for CD and UC (AUC = 0.690 and 0.672, respectively). All these findings are discussed in the context of host defense in the oral cavity, patients' prior treatment regimens, and smoking habits.
    Language English
    Publishing date 2021-09-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life11090943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Changes in Salivary Parameters of Oral Immunity after Biologic Therapy for Inflammatory Bowel Disease.

    Nijakowski, Kacper / Rutkowski, Rafał / Eder, Piotr / Korybalska, Katarzyna / Witowski, Janusz / Surdacka, Anna

    Life (Basel, Switzerland)

    2021  Volume 11, Issue 12

    Abstract: We previously observed that inflammatory bowel disease (IBD) may compromise oral host defense, as assessed by decreased salivary levels of immunoglobulin A (IgA) and myeloperoxidase (MPO). Biologic therapy with inhibitors of cytokines or adhesion ... ...

    Abstract We previously observed that inflammatory bowel disease (IBD) may compromise oral host defense, as assessed by decreased salivary levels of immunoglobulin A (IgA) and myeloperoxidase (MPO). Biologic therapy with inhibitors of cytokines or adhesion molecules is increasingly used for patients with IBD. Little is known, however, about how this treatment modality affects the release and properties of saliva. Here, we aimed to determine how biologic therapy in patients who had not responded to previous standard treatment with conventional drugs affected the salivary concentration of IgA and MPO. To this end, unstimulated whole mixed saliva was collected before treatment or after 10-12 weeks of therapy from 27 patients with Crohn's disease (CD) and 24 patients with ulcerative colitis (UC). After the induction phase of therapy with biologics, salivary levels of IgA and MPO increased significantly in UC, but not in CD patients. These increases were approximately 8-fold and 6-fold, for IgA and MPO, respectively. Moreover, these effects occurred in UC patients who responded successfully to therapy, but not in those who failed to improve. Furthermore, the relative increases in salivary IgA and MPO correlated with the relative decrease in UC severity, as assessed by the Mayo scale. These data indicate that the successful therapy with biologics in UC patients results also in improved oral host defense. However, it remains to be determined why such an effect does not occur during therapy for CD.
    Language English
    Publishing date 2021-12-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life11121409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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