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Article: Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers.

Córdoba-Lanús, Elizabeth / Montuenga, Luis M / Domínguez-de-Barros, Angélica / Oliva, Alexis / Mayato, Delia / Remírez-Sanz, Ana / Gonzalvo, Francisca / Celli, Bartolomé / Zulueta, Javier J / Casanova, Ciro

Antioxidants (Basel, Switzerland)

2024 Volume 13, Issue 2

Abstract: Lung cancer (LC) constitutes an important cause of death among patients with Chronic Obstructive Pulmonary Disease (COPD). Both diseases may share pathobiological mechanisms related to oxidative damage and cellular senescence. In this study, the ... ...

Abstract	Lung cancer (LC) constitutes an important cause of death among patients with Chronic Obstructive Pulmonary Disease (COPD). Both diseases may share pathobiological mechanisms related to oxidative damage and cellular senescence. In this study, the potential value of leucocyte telomere length, a hallmark of aging, and 8-OHdG concentrations, indicative of oxidative DNA damage, as risk biomarkers of LC was evaluated in COPD patients three years prior to LC diagnosis. Relative telomere length measured using qPCR and serum levels of 8-OHdG were determined at the baseline in 99 COPD smokers (33 with LC and 66 age-matched COPD without LC as controls). Of these, 21 COPD with LC and 42 controls had the biomarkers measured 3 years before. Single nucleotide variants (SNVs) in TERT, RTEL, and NAF1 genes were also determined. COPD cases were evaluated, which showed greater telomere length (
Language	English
Publishing date	2024-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox13020156
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Article ; Online: Eosinophil Subtypes in Adults with Asthma and Adults with Chronic Obstructive Pulmonary Disease.

Cabrera López, Carlos / Sánchez Santos, Alejandra / Lemes Castellano, Angelina / Cazorla Rivero, Sara / Breña Atienza, Joaquín / González Dávila, Enrique / Celli, Bartolomé / Casanova Macario, Ciro

American journal of respiratory and critical care medicine

2023 Volume 208, Issue 2, Page(s) 155–162

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Humans ; Adult ; Animals ; Mice ; Eosinophils ; Leukocyte Count ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Asthma ; Sialic Acid Binding Immunoglobulin-like Lectins/therapeutic use
Chemical Substances	Sialic Acid Binding Immunoglobulin-like Lectins
Language	English
Publishing date	2023-04-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202301-0149OC
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Article: Home noninvasive ventilation in severe COPD: in whom does it work and how?

Raveling, Tim / Vonk, Judith M / Hill, Nicholas S / Gay, Peter C / Casanova, Ciro / Clini, Enrico / Köhnlein, Thomas / Márquez-Martin, Eduardo / Schneeberger, Tessa / Murphy, Patrick B / Struik, Fransien M / Kerstjens, Huib A M / Duiverman, Marieke L / Wijkstra, Peter J

ERJ open research

2024 Volume 10, Issue 1

Abstract: Background: Not all hypercapnic COPD patients benefit from home noninvasive ventilation (NIV), and mechanisms through which NIV improves clinical outcomes remain uncertain. We aimed to identify "responders" to home NIV, denoted by a beneficial effect of ...

Abstract	Background: Not all hypercapnic COPD patients benefit from home noninvasive ventilation (NIV), and mechanisms through which NIV improves clinical outcomes remain uncertain. We aimed to identify "responders" to home NIV, denoted by a beneficial effect of NIV on arterial partial pressure of carbon dioxide ( Methods: We used individual patient data from previous published trials collated for a systematic review. Linear mixed-effect models were conducted to compare the effect of NIV on Findings: Data of 1142 participants from 16 studies were used. Participants treated with lower pressure support (<14 Interpretation: With greater pressure support and better daily NIV usage, a larger improvement in
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2827830-6
ISSN	2312-0541
ISSN	2312-0541
DOI	10.1183/23120541.00600-2023
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Article ; Online: The 7 Cardinal Sins of COPD in Spain.

Luis Izquierdo, José / Casanova, Ciro / Celli, Bartolomé / Santos, Salud / Sibila, Oriol / Sobradillo, Patricia / Agusti, Alvar

Archivos de bronconeumologia

2022 Volume 58, Issue 6, Page(s) 498–503

Abstract: Chronic obstructive pulmonary disease (COPD) is a public health problem due to its high prevalence (11% in the adult population in Spain), increasing incidence, and great social and economic impact. Despite this, it is underdiagnosed (and, therefore, ... ...

Abstract	Chronic obstructive pulmonary disease (COPD) is a public health problem due to its high prevalence (11% in the adult population in Spain), increasing incidence, and great social and economic impact. Despite this, it is underdiagnosed (and, therefore, undertreated) at a rate of around 80%. In this paper, a group of respiratory physicians specializing in COPD discuss 7 fundamental problems ("cardinal sins") that contribute to this situation, with the explicit aim of proposing specific solutions that may help to improve this unfavorable state of affairs.
MeSH term(s)	Adult ; Humans ; Incidence ; Prevalence ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/therapy ; Spain/epidemiology
Language	Spanish
Publishing date	2022-01-07
Publishing country	Spain
Document type	Journal Article
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2021.12.008
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Article: Unravelling young COPD and pre-COPD in the general population.

Cosío, Borja G / Casanova, Ciro / Soler-Cataluña, Juan José / Soriano, Joan B / García-Río, Francisco / de Lucas, Pilar / Alfageme, Inmaculada / Rodríguez González-Moro, José Miguel / Sánchez, Guadalupe / Ancochea, Julio / Miravitlles, Marc

ERJ open research

2023 Volume 9, Issue 1

Abstract: Background: Chronic obstructive pulmonary disease (COPD) is commonly diagnosed when the airflow limitation is well established and symptomatic. We aimed to identify individuals at risk of developing COPD according to the concept of pre-COPD and compare ... ...

Abstract	Background: Chronic obstructive pulmonary disease (COPD) is commonly diagnosed when the airflow limitation is well established and symptomatic. We aimed to identify individuals at risk of developing COPD according to the concept of pre-COPD and compare their clinical characteristics with 1) those who have developed the disease at a young age, and 2) the overall population with and without COPD. Methods: The EPISCAN II study is a cross-sectional, population-based study that aims to investigate the prevalence of COPD in Spain in subjects ≥40 years of age. Pre-COPD was defined as the presence of emphysema >5% and/or bronchial thickening by computed chromatography (CT) scan and/or diffusing capacity of the lung for carbon monoxide ( Results: Among the 1077 individuals with FEV Conclusions: 22.3% of the studied population was at risk of developing COPD, with similar symptomatic and structural changes to those with well-established disease without airflow obstruction. This COPD at-risk population is different from those that develop COPD at a young age.
Language	English
Publishing date	2023-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2827830-6
ISSN	2312-0541
ISSN	2312-0541
DOI	10.1183/23120541.00334-2022
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Article: Circulating levels of mitochondrial oxidative stress-related peptides MOTS-c and Romo1 in stable COPD: A cross-sectional study.

Amado, Carlos A / Martín-Audera, Paula / Agüero, Juan / Lavín, Bernardo A / Guerra, Armando R / Boucle, Daymara / Ferrer-Pargada, Diego / Berja, Ana / Martín, Fernando / Casanova, Ciro / García-Unzueta, Mayte

Frontiers in medicine

2023 Volume 10, Page(s) 1100211

Abstract: Background: MOTS-c and Romo1 are mitochondrial peptides that are modulated by oxidative stress. No previous studies have explored circulating levels of MOTS-c in patients with chronic obstructive pulmonary disease (COPD).: Methods: We enrolled 142 ... ...

Abstract	Background: MOTS-c and Romo1 are mitochondrial peptides that are modulated by oxidative stress. No previous studies have explored circulating levels of MOTS-c in patients with chronic obstructive pulmonary disease (COPD). Methods: We enrolled 142 patients with stable COPD and 47 smokers with normal lung function in an observational cross-sectional study. We assessed serum levels of both MOTS-c and Romo1 and associated these findings with clinical characteristics of COPD. Results: Compared with smokers with normal lung function, patients with COPD had lower levels of MOTS-c ( Conclusions: Reduced levels of circulating MOTS-c and increased levels of Romo1 were detected in patients diagnosed with COPD. Low levels of MOTS-c were associated with oxygen desaturation and poorer exercise capacity using 6 min walk test. Romo1 was associated with current smoking and baseline oxygen saturation. Trial registration: www.clinicaltrials.gov; No.: NCT04449419; URL: www.clinicaltrials.gov. Date of registration: June 26, 2020.
Language	English
Publishing date	2023-02-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1100211
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Article ; Online: What's New in GOLD 2017?

Sobradillo Ecenarro, Patricia / Casanova Macario, Ciro

Archivos de bronconeumologia

2017 Volume 53, Issue 3, Page(s) 85–86

Title translation	¿Qué hay de nuevo en la GOLD 2017?
MeSH term(s)	Disease Progression ; Humans ; Practice Guidelines as Topic ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/prevention & control ; Pulmonary Disease, Chronic Obstructive/therapy
Language	Spanish
Publishing date	2017
Publishing country	Spain
Document type	Editorial
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2017.02.002
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Article ; Online: Circulating miR-206 and miR-1246 as Markers in the Early Diagnosis of Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease.

Córdoba-Lanús, Elizabeth / Domínguez de-Barros, Angélica / Oliva, Alexis / Mayato, Delia / Gonzalvo, Francisca / Remírez-Sanz, Ana / Zulueta, Javier J / Celli, Bartolomé / Casanova, Ciro

International journal of molecular sciences

2023 Volume 24, Issue 15

Abstract: Lung cancer (LC) is the most common cause of cancer death, with 75% of cases being diagnosed in late stages. This study aimed to determine potential miRNAs as biomarkers for the early detection of LC in chronic obstructive pulmonary disease (COPD) cases. ...

Abstract	Lung cancer (LC) is the most common cause of cancer death, with 75% of cases being diagnosed in late stages. This study aimed to determine potential miRNAs as biomarkers for the early detection of LC in chronic obstructive pulmonary disease (COPD) cases. Ninety-nine patients were included, with registered clinical and lung function parameters followed for 6 years. miRNAs were determined in 16 serum samples from COPD patients (four with LC and four controls) by next generation sequencing (NGS) at LC diagnosis and 3 years before. The validation by qPCR was performed in 33 COPD-LC patients and 66 controls at the two time points. Over 170 miRNAs (≥10 TPM) were identified; among these, miR-224-5p, miR-206, miR-194-5p, and miR-1246 were significantly dysregulated (
MeSH term(s)	Humans ; Gene Expression Profiling ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; MicroRNAs/genetics ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/genetics ; Early Detection of Cancer
Chemical Substances	MicroRNAs ; MIRN1246 microRNA, human ; MIRN206 microRNA, human ; MIRN224 microRNA, human
Language	English
Publishing date	2023-08-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241512437
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Article ; Online: Dissociation between physical capacity and daily physical activity in COPD patients. A population-based approach.

García-Río, Francisco / Miravitlles, Marc / Soriano, Joan B / Cosío, Borja G / Soler-Cataluña, Juan José / Casanova, Ciro / de Lucas, Pilar / Alfageme, Inmaculada / González-Moro, José Miguel Rodríguez / Sánchez Herrero, María Guadalupe / Ancochea, Julio

Respiratory medicine

2023 Volume 207, Page(s) 107115

Abstract: Badkground: Physical capacity (PC) and daily physical activity (PA) are two crucial factors in the clinical course of COPD, although they do not always maintain a close relationship. The objectives were to evaluate the frequency of PC-PA dissociation in ...

Abstract	Badkground: Physical capacity (PC) and daily physical activity (PA) are two crucial factors in the clinical course of COPD, although they do not always maintain a close relationship. The objectives were to evaluate the frequency of PC-PA dissociation in patients with COPD and subjects without airflow limitation (AL) and to identify its risk factors. Methods: A sample of 319 COPD patients and 399 subjects without AL was consecutively obtained from a population-based sample of 9092 subjects evaluated in the EPISCAN II study. Baseline evaluation included clinical questionnaires, lung function testing, blood analysis and low-dose computed tomography (CT) scan with evaluation of lung density and airway wall thickness. A distance walked in 6 min > 70% predicted was considered an indicator of normal PC, while a Yale Physical Activity Survey summary index score <51 was used to identify with sedentary lifestyle. Results: 166 COPD patients (52.0%) reported a sedentary lifestyle with evidence of preserved PC, while this phenomenon was present in 188 (47.1%) subjects without AL. In the COPD group, symptoms of chronic bronchitis, depression and elevated hematocrit and blood eosinophil count were identified as independent risk factors for PC-PA dissociation. In turn, in the subjects without AL, the risk factors for PC-PA dissociation were low fat-free mass, obesity and anxiety, as well as reduced levels of HDL-cholesterol and the absence of osteoporosis. Conclusions: Almost half of COPD patients and subjects without airflow limitation with preserved PC maintain a sedentary lifestyle, with different risk factors for sedentarism between both groups.
MeSH term(s)	Humans ; Pulmonary Disease, Chronic Obstructive ; Lung ; Exercise ; Walking ; Respiratory Function Tests
Language	English
Publishing date	2023-01-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003348-8
ISSN	1532-3064 ; 0954-6111
ISSN (online)	1532-3064
ISSN	0954-6111
DOI	10.1016/j.rmed.2023.107115
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Article ; Online: Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study.

Garcia-Rio, Francisco / Miravitlles, Marc / Soriano, Joan B / Cosío, Borja G / Soler-Cataluña, Juan José / Casanova, Ciro / de Lucas, Pilar / Alfageme, Inmaculada / Rodríguez González-Moro, José Miguel / Sánchez Herrero, María Guadalupe / Ancochea, Julio

BMJ open respiratory research

2023 Volume 10, Issue 1

Abstract: Background: Population distribution of reduced diffusing capacity of the lungs for carbon monoxide (DLCO) in smokers and main consequences are not properly recognised. The objectives of this study were to describe the prevalence of reduced DLCO in a ... ...

Abstract	Background: Population distribution of reduced diffusing capacity of the lungs for carbon monoxide (DLCO) in smokers and main consequences are not properly recognised. The objectives of this study were to describe the prevalence of reduced DLCO in a population-based sample of current and former smoker subjects without airflow limitation and to describe its morphological, functional and clinical implications. Methods: A sample of 405 subjects aged 40 years or older with postbronchodilator forced expiratory volume in 1 s/forced vital capacity (FVC) >0.70 was obtained from a random population-based sample of 9092 subjects evaluated in the EPISCAN II study. Baseline evaluation included clinical questionnaires, exhaled carbon monoxide (CO) measurement, spirometry, DLCO determination, 6 min walk test, routine blood analysis and low-dose CT scan with evaluation of lung density and airway wall thickness. Results: In never, former and current smokers, prevalence of reduced DLCO was 6.7%, 14.4% and 26.7%, respectively. Current and former smokers with reduced DLCO without airflow limitation were younger than the subjects with normal DLCO, and they had greater levels of dyspnoea and exhaled CO, greater pulmonary artery diameter and lower spirometric parameters, 6 min walk distance, daily physical activity and plasma albumin levels (all p<0.05), with no significant differences in other chronic respiratory symptoms or CT findings. FVC and exhaled CO were identified as independent risk factors for low DLCO. Conclusion: Reduced DLCO is a frequent disorder among smokers without airflow limitation, associated with decreased exercise capacity and with CT findings suggesting that it may be a marker of smoking-induced early vascular damage. Trial registration number: NCT03028207.
MeSH term(s)	Humans ; Pulmonary Disease, Chronic Obstructive ; Smokers ; Carbon Monoxide ; Prevalence ; Lung/diagnostic imaging ; Tomography, X-Ray Computed
Chemical Substances	Carbon Monoxide (7U1EE4V452)
Language	English
Publishing date	2023-02-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2736454-9
ISSN	2052-4439 ; 2052-4439
ISSN (online)	2052-4439
ISSN	2052-4439
DOI	10.1136/bmjresp-2022-001468
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