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Article ; Online: Pulmonary sarcoidosis and immune-mediated necrotizing myopathy: an uncommon coincidence.

Martins, Ana / Pimenta, Sofia / Martins, Frederico Rajão / Samões, Beatriz / Nicolau, Rafaela / Mariz, Eva / Costa, Lúcia

ARP rheumatology

2024 Volume 2, Issue 4, Page(s) 341–344

Abstract: Introduction: Immune-mediated necrotizing myopathy (IMNM) is characterized by acute or subacute, severe proximal muscle weakness and myofiber necrosis with minimal inflammatory cell infiltrate observed on muscle biopsy. On the other hand, sarcoidosis is ...

Title translation	Pulmonary sarcoidosis and immune-mediated necrotizing myopathy: an uncommon coincidence.
Abstract	Introduction: Immune-mediated necrotizing myopathy (IMNM) is characterized by acute or subacute, severe proximal muscle weakness and myofiber necrosis with minimal inflammatory cell infiltrate observed on muscle biopsy. On the other hand, sarcoidosis is characterised by the presence of non-caseating granulomas that can develop in several organs. Case report: We present the unique case of a 49-year-old woman, with no previous medical history, who had a rare concomitant occurrence of IMNM and pulmonary sarcoidosis. This condition was successfully treated with a combination of corticosteroids and rituximab along with rehabilitation program. Discussion: This association has been reported in only two previous case reports. This highlights the importance of further research on the connection between sarcoidosis and other forms of inflammatory myopathies.
MeSH term(s)	Female ; Humans ; Middle Aged ; Sarcoidosis, Pulmonary/complications ; Myositis/complications ; Autoimmune Diseases/pathology ; Sarcoidosis/pathology ; Muscle Weakness ; Soft Tissue Injuries
Language	English
Publishing date	2024-01-04
Publishing country	Portugal
Document type	Case Reports ; Journal Article
ISSN	2795-4552
ISSN (online)	2795-4552
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Antibacterial activity of Thymus vulgaris (thyme) essential oil against strains of Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus saprophyticus isolated from meat product.

Diniz, A F / Santos, B / Nóbrega, L M M O / Santos, V R L / Mariz, W S / Cruz, P S C / Nóbrega, R O / Silva, R L / Paula, A F R / Santos, J R D A / Pessôa, H L F / Oliveira-Filho, A A

Brazilian journal of biology = Revista brasleira de biologia

2023 Volume 83, Page(s) e275306

Abstract: Meat products represent an important component of the human diet and are a good source of nutrients. Food-borne microorganisms are the main pathogens that cause human diseases as a result of food consumption, especially products of animal origin. The ... ...

Abstract	Meat products represent an important component of the human diet and are a good source of nutrients. Food-borne microorganisms are the main pathogens that cause human diseases as a result of food consumption, especially products of animal origin. The objective of the present research was to verify the antibacterial activity of the essential oil of Thymus vulgaris against strains of Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus saprophyticus isolated from meat products. For this, the analyses of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were performed in microdilution plates. The association of the product with antimicrobials was also studied using disk diffusion. And the anti-adherent activity, which was determined in the presence of sucrose, in glass tubes. Thyme oil showed a strong inhibitory activity against K. pneumoniae, P. aeruginosa and S. saprophyticus, with the MIC values ranging from 64 to 512 μg/mL, and bactericidal effect for most strains, with MBC values ranging from 256 to 1,024 μg/mL. T. vulgaris oil exhibited varied interactions in association with the antimicrobials, with synergistic (41.67%), indifferent (50%) and antagonistic (8.33%) effects. Regarding the anti-adherent activity, the test product was effective in inhibiting the adherence of all bacterial strains under study. Therefore, thyme oil presents itself as an antibacterial and anti-adherent agent against K. pneumoniae, P. aeruginosa and S. saprophyticus, being a natural product that can represent an interesting alternative in the efforts to combat foodborne diseases.
MeSH term(s)	Animals ; Humans ; Oils, Volatile/pharmacology ; Thymus Plant ; Pseudomonas aeruginosa ; Klebsiella pneumoniae ; Staphylococcus saprophyticus ; Meat Products ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Microbial Sensitivity Tests
Chemical Substances	Oils, Volatile ; thyme oil (2UK410MY6B) ; Anti-Bacterial Agents ; Anti-Infective Agents
Language	English
Publishing date	2023-08-11
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2036257-2
ISSN	1678-4375 ; 1519-6984
ISSN (online)	1678-4375
ISSN	1519-6984
DOI	10.1590/1519-6984.275306
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Article ; Online: Isolation of acute myeloid leukemia blasts from blood using a microfluidic device.

Teixeira, Alexandra / Sousa-Silva, Maria / Chícharo, Alexandre / Oliveira, Kevin / Moura, André / Carneiro, Adriana / Piairo, Paulina / Águas, Hugo / Sampaio-Marques, Belém / Castro, Isabel / Mariz, José / Ludovico, Paula / Abalde-Cela, Sara / Diéguez, Lorena

The Analyst

2024

Abstract: Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and associated with poor prognosis. Unfortunately, most of the patients that achieve clinical complete remission after the treatment will ultimately relapse due to the ... ...

Abstract	Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and associated with poor prognosis. Unfortunately, most of the patients that achieve clinical complete remission after the treatment will ultimately relapse due to the persistence of minimal residual disease (MRD), that is not measurable using conventional technologies in the clinic. Microfluidics is a potential tool to improve the diagnosis by providing early detection of MRD. Herein, different designs of microfluidic devices were developed to promote lateral and vertical mixing of cells in microchannels to increase the contact area of the cells of interest with the inner surface of the device. Possible interactions between the cells and the surface were studied using fluid simulations. For the isolation of leukemic blasts, a positive selection strategy was used, targeting the cells of interest using a panel of specific biomarkers expressed in immature and aberrant blasts. Finally, once the optimisation was complete, the best conditions were used to process patient samples for downstream analysis and benchmarking, including phenotypic and genetic characterisation. The potential of these microfluidic devices to isolate and detect AML blasts may be exploited for the monitoring of AML patients at different stages of the disease.
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d4an00158c
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Zs.A 2423: Show issues

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Article ; Online: Comparison of the whole slide imaging and conventional light microscopy in the grading of oral epithelial dysplasia: a multi-institutional study.

Diniz, P-B / Sena-Filho, M / Graner, K-M / Mariz, B-A / Reis, L-A / Almeida, O-P / Jorge, J

Medicina oral, patologia oral y cirugia bucal

2021 Volume 26, Issue 1, Page(s) e8–e13

Abstract: Background: Whole Slide Imaging (WSI) is an alternative method to light microscopy (LM). However, few studies have compared the diagnostic agreement between WSI and LM, especially to grade oral epithelial dysplasia (OED). The purpose of this study was ... ...

Abstract	Background: Whole Slide Imaging (WSI) is an alternative method to light microscopy (LM). However, few studies have compared the diagnostic agreement between WSI and LM, especially to grade oral epithelial dysplasia (OED). The purpose of this study was to evaluate the variability in grading OED by the World Health Organization grading system, using WSI and conventional LM, and to investigate whether the access to clinical information, and psychologic or physical states of the pathologists could interfere with the diagnosis. Material and methods: eleven experienced pathologists from seven Brazilian universities independently evaluated twenty-five OED cases. The analyses were performed in duplicate for each method, with an interval of at least 30 days, and the time consumed in each analysis was measured. Physical and psychologic states were evaluated by blood pressure levels, heart rate and two questionnaires: State-Trait Anxiety Inventory and Perceived Stress Scale. Clinical information was provided after the second evaluation using WSI and the pathologist could change their diagnostic decision or not. Results: LM showed a higher inter-examiner agreement (k=0.53) than WSI (k=0.45) and a smaller time consumed by the pathologists (mean of 65.53 seconds compared to 91.02 seconds in WSI). In the first analysis using conventional microscopy, there was a positive correlation between kappa values and anxiety (r=0.47, p=0.02), and stress (r=0.64, p<0.01), and an inverse correlation with heart rate (r=-0.48, p=0.02). In the digital analysis, there was also a positive correlation between kappa values and anxiety (r=0.75, p<0.001). After clinical information was given, there was a slight change in 11.3% of the cases, and a great discrepancy in 1.1% of the cases, mainly increasing the OED grade. Conclusions: both microscopy systems had similar results, although LM had slightly higher kappa values, and WSI was more time consuming.
MeSH term(s)	Brazil ; Humans ; Hyperplasia ; Image Interpretation, Computer-Assisted ; Microscopy ; Observer Variation
Language	English
Publishing date	2021-01-01
Publishing country	Spain
Document type	Journal Article ; Multicenter Study
ZDB-ID	2171573-7
ISSN	1698-6946 ; 1698-4447
ISSN (online)	1698-6946
ISSN	1698-4447
DOI	10.4317/medoral.23854
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Article ; Online: New Insights for the Pathogenesis of COVID-19-Related Dysgeusia.

Mariz, B A L A / Brandão, T B / Ribeiro, A C P / Lopes, M A / Santos-Silva, A R

Journal of dental research

2020 Volume 99, Issue 10, Page(s) 1206

MeSH term(s)	Asymptomatic Infections ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Dysgeusia ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Salivary Glands
Keywords	covid19
Language	English
Publishing date	2020-06-12
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80207-4
ISSN	1544-0591 ; 0022-0345
ISSN (online)	1544-0591
ISSN	0022-0345
DOI	10.1177/0022034520936638
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Article ; Online: MutSα expression predicts a lower disease-free survival in malignant salivary gland tumors: an immunohistochemical study.

Amaral-Silva, G-K / Dias, L-M / Mariz, B-A / Fonseca, F-P / Rangel, A-L / Zanella, V-G / Castilho, R-M / Martins, M-D / Vargas, P-A / Wagner, V-P

Medicina oral, patologia oral y cirugia bucal

2022 Volume 27, Issue 2, Page(s) e164–e173

Abstract: Background: Appropriate DNA replication is vital to maintain cell integrity at the genomic level. Malfunction on DNA repair mechanisms can have implications related to tumor behavior. Our aim was to evaluate the expression of key complexes of the DNA ... ...

Abstract	Background: Appropriate DNA replication is vital to maintain cell integrity at the genomic level. Malfunction on DNA repair mechanisms can have implications related to tumor behavior. Our aim was to evaluate the expression of key complexes of the DNA mismatch-repair system MutSα (hMSH2-hMSH6) and MutSβ (hMSH2-hMSH3) in a panel comprising the most common benign and malignant salivary gland tumors (SGT), and to determine their association with disease-free survival. Material and methods: Ten cases of normal salivary gland (NSG) and 92 of SGT (54 benign and 38 malignant) were retrieved. Immunohistochemistry was performed for hMSH2, hMSH3, hMSH6. Scanned slides were digitally analyzed based on the percentage of positive cells with nuclear staining. Cases were further classified in MutSαhigh and MutSβhigh based on hMSH2-hMSH6 and hMSH3-hMSH6 expression, respectively. Results: hMSH3 expression was lower in malignant SGT compared to NSG and benign cases. Adenoid cystic carcinoma (ACC) cases with perineural invasion presented a lower percentage of hMSH3 positive cells. hMSH6 was downregulated in both benign and malignant SGT compared to NSG. Malignant SGT cases with MutSαhigh expression had lower disease-free survival compared to MutSαlow cases. A 10.26-fold increased risk of presenting local recurrence was observed. Conclusions: Our findings suggest that a lack of hMSH3 protein function is associated with a more aggressive phenotype (malignancy and perineural invasion) and that MutSα overexpression predicts a poor clinical outcome in malignant SGT.
MeSH term(s)	DNA Repair ; Disease-Free Survival ; Humans ; Immunohistochemistry ; MutS Homolog 2 Protein ; Salivary Gland Neoplasms
Chemical Substances	MutS Homolog 2 Protein (EC 3.6.1.3)
Language	English
Publishing date	2022-03-01
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2171573-7
ISSN	1698-6946 ; 1698-4447
ISSN (online)	1698-6946
ISSN	1698-4447
DOI	10.4317/medoral.25138
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Article ; Online: Scientific approaches toward improving cervical cancer elimination strategies.

Lehtinen, Matti / Bruni, Laia / Elfström, Miriam / Gray, Penelope / Logel, Margaret / Mariz, Filipe Colaço / Baussano, Iacopo / Vänskä, Simopekka / Franco, Eduardo L / Dillner, Joakim

International journal of cancer

2024 Volume 154, Issue 9, Page(s) 1537–1548

Abstract: ... and HPV screening. Furthermore, hepatitis B vaccination experiences indicate that elimination cannot ...

Abstract	At the 2023 EUROGIN workshop scientific basis for strategies to accelerate the elimination of cervical cancer and its causative agent, human papillomavirus (HPV) were reviewed. Although some countries have reached key performance indicators toward elimination (>90% of girls HPV vaccinated and >70% of women HPV screened), most are yet to reach these targets, implying a need for improved strategies. Gender-neutral vaccination, even with moderate vaccination coverage was highlighted as a strategy to achieve elimination more rapidly. It is more resilient against major disturbances in vaccination delivery, such as what happened during the coronavirus pandemic. Further, an analysis of ethical/legal issues indicated that female-restricted vaccination is problematic. Extended catch-up of vaccination with concomitant screening, and outreach to vulnerable groups were highlighted. Although birth cohorts with high coverage of HPV vaccination at school are protected against HPV, and HPVs have a very low reproductive rate in women above age 35, adult women below age 30 have inadequate direct protection. In addition to herd protection from gender-neutral vaccination, this group can be protected by offering concomitant catch-up HPV vaccination and HPV screening. Furthermore, hepatitis B vaccination experiences indicate that elimination cannot be achieved without prioritizing vulnerable/migrant populations. The long-lasting durability of vaccination-induced antibody responses suggests prolonged protection with HPV vaccines when adequately administrated. Finally, cost-effectiveness modelling suggests that high-coverage HPV vaccination in multiple population segments will be resource-saving due to reduced need for screening. In summary, the workshop found that strategically optimal deployment of vaccination will accelerate elimination of HPV and cervical cancer.
MeSH term(s)	Adult ; Humans ; Female ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/prevention & control ; Uterine Cervical Neoplasms/diagnosis ; Papillomavirus Infections ; Papillomavirus Vaccines/therapeutic use ; Mass Screening ; Vaccination
Chemical Substances	Papillomavirus Vaccines
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.34839
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Zs.MO 576: Show issues

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Article: New Insights for the Pathogenesis of COVID-19-Related Dysgeusia

Mariz, B A L A / Brandão, T B / Ribeiro, A C P / Lopes, M A / Santos-Silva, A R

J Dent Res

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32531174
Database	COVID19

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Article ; Online: New Insights for the Pathogenesis of COVID-19-Related Dysgeusia

Mariz, B.A.L.A. / Brandão, T.B. / Ribeiro, A.C.P. / Lopes, M.A. / Santos-Silva, A.R.

Journal of Dental Research

2020 Volume 99, Issue 10, Page(s) 1206–1206

Keywords	General Dentistry ; covid19
Language	English
Publisher	SAGE Publications
Publishing country	us
Document type	Article ; Online
ZDB-ID	80207-4
ISSN	1544-0591 ; 0022-0345
ISSN (online)	1544-0591
ISSN	0022-0345
DOI	10.1177/0022034520936638
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Article ; Online: CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma.

Silva, L-C / Fonseca, F-P / Almeida, O-P / Mariz, B-A / Lopes, M-A / Radhakrishnan, R / Sharma, M / Kowalski, L-P / Vargas, P-A

Medicina oral, patologia oral y cirugia bucal

2020 Volume 25, Issue 1, Page(s) e49–e55

Abstract: Background: The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral ... ...

Abstract	Background: The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). Material and methods: Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL¸ 45 of OSCC and 8 of normal epithelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified. Results: A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium. Conclusion: The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation.
MeSH term(s)	Antigens, CD ; Carcinoma, Squamous Cell ; Humans ; Lectins, C-Type ; Leukoplakia, Oral ; Mannose-Binding Lectins ; Mouth Neoplasms ; Oral Submucous Fibrosis ; Retrospective Studies
Chemical Substances	Antigens, CD ; CD207 protein, human ; Lectins, C-Type ; Mannose-Binding Lectins
Language	English
Publishing date	2020-01-01
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2171573-7
ISSN	1698-6946 ; 1698-4447
ISSN (online)	1698-6946
ISSN	1698-4447
DOI	10.4317/medoral.23177
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