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Article ; Online: Predicting Satisfaction of Parents of Pediatric Patients: Perceived Quality of Providers' Communication Mitigates Negative Effects of Shorter than Desired Consultations.

Richards, Adam S / Semelsberger, Joanne / Middleton, Anna E / Richards, B Stephens

2023 , Page(s) 1–11

Abstract: ... a clinical consultation. Specifically, we assessed whether perceptions of their provider's communication ... with their provider rating and intent to recommend the provider's office. Using patient satisfaction survey ...

Abstract	This research investigated the predictors of satisfaction for parents of pediatric patients after a clinical consultation. Specifically, we assessed whether perceptions of their provider's communication quality influenced the degree to which their (dis)satisfaction with consultation length associated with their provider rating and intent to recommend the provider's office. Using patient satisfaction survey data collected after initial clinical visits to a pediatric hospital (
Language	English
Publishing date	2023-06-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1038723-7
ISSN	1532-7027 ; 1041-0236
ISSN (online)	1532-7027
ISSN	1041-0236
DOI	10.1080/10410236.2023.2219372
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Article ; Online: Targeted deletion of NR2F2 and VCAM1 in theca cells impacts ovarian follicular development: insights into polycystic ovary syndrome?†.

Candelaria, Nicholes R / Richards, JoAnne S

Biology of reproduction

2023 Volume 110, Issue 4, Page(s) 782–797

Abstract: Defining features of polycystic ovary syndrome (PCOS) include elevated expression of steroidogenic genes, theca cell androgen biosynthesis, and peripheral levels of androgens. In previous studies, we identified vascular cell adhesion molecule 1 (VCAM1) ... ...

Abstract	Defining features of polycystic ovary syndrome (PCOS) include elevated expression of steroidogenic genes, theca cell androgen biosynthesis, and peripheral levels of androgens. In previous studies, we identified vascular cell adhesion molecule 1 (VCAM1) as a selective androgen target gene in specific NR2F2/SF1 (+/+) theca cells. By deleting NR2F2 and VCAM1 selectively in CYP17A1 theca cells in mice, we documented that NR2F2 and VCAM1 impact distinct and sometimes opposing theca cell functions that alter ovarian follicular development in vivo: including major changes in ovarian morphology, steroidogenesis, gene expression profiles, immunolocalization images (NR5A1, CYP11A1, NOTCH1, CYP17A1, INSL3, VCAM1, NR2F2) as well as granulosa cell functions. We propose that theca cells impact follicle integrity by regulating androgen production and action, as well as granulosa cell differentiation/luteinization in response to androgens and gonadotropins that may underlie PCOS.
MeSH term(s)	Animals ; Female ; Mice ; Androgens/metabolism ; COUP Transcription Factor II/genetics ; COUP Transcription Factor II/metabolism ; Granulosa Cells/metabolism ; Polycystic Ovary Syndrome/genetics ; Polycystic Ovary Syndrome/metabolism ; Theca Cells/metabolism ; Vascular Cell Adhesion Molecule-1/genetics ; Vascular Cell Adhesion Molecule-1/metabolism
Chemical Substances	Androgens ; COUP Transcription Factor II ; NR2F2 protein, human ; Vascular Cell Adhesion Molecule-1
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1118-6
ISSN	1529-7268 ; 0006-3363
ISSN (online)	1529-7268
ISSN	0006-3363
DOI	10.1093/biolre/ioae010
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Article ; Online: WOMEN IN REPRODUCTIVE SCIENCE: Discovering science and the ovary: a career of joy.

Richards, JoAnne S

Reproduction (Cambridge, England)

2019 Volume 158, Issue 6, Page(s) F69–F80

Abstract: My career has been about discovering science and learning the joys of the discovery process itself. It has been a challenging but rewarding process filled with many exciting moments and wonderful colleagues and students. Although I went to college to ... ...

Abstract	My career has been about discovering science and learning the joys of the discovery process itself. It has been a challenging but rewarding process filled with many exciting moments and wonderful colleagues and students. Although I went to college to become a French major, I ultimately stumbled into research while pursuing a Masters Degree in teaching. Thus, my research career began in graduate school where I was studying NAD kinase in the ovary as a possible regulator of steroidogenesis, a big issue in the late 1960s. After a short excursion of teaching in North Dakota, I became a postdoctoral fellow at the University of Michigan, where radio-immuno assays and radio receptor assays had just come on the scene and were transforming endocrinology from laborious bioassays to quantitative science and of course these assays related to the ovary. From there I went to Baylor College of Medicine, a mecca of molecular biology, cloning genes and generating mouse models. It has been a fascinating and joyous journey.
MeSH term(s)	Animals ; Biomedical Research/history ; Disease Models, Animal ; Female ; History, 20th Century ; History, 21st Century ; Humans ; Molecular Biology/history ; Ovarian Neoplasms/physiopathology ; Ovary/cytology ; Ovary/physiology ; Reproduction ; United States
Language	English
Publishing date	2019-02-20
Publishing country	England
Document type	Biography ; Historical Article ; Journal Article ; Review
ZDB-ID	2034501-X
ISSN	1741-7899 ; 1470-1626 ; 1476-3990
ISSN (online)	1741-7899
ISSN	1470-1626 ; 1476-3990
DOI	10.1530/REP-18-0513
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Article: The Ovarian Cycle.

Richards, JoAnne S

Vitamins and hormones

2018 Volume 107, Page(s) 1–25

Abstract: The "ovarian cycle" is an exquisite and dynamic endocrine system that includes ovarian events, hypothalamic-pituitary interactions, uterine endometrial and myometrial changes during implantation and pregnancy, cervical alterations in structure, and ... ...

Abstract	The "ovarian cycle" is an exquisite and dynamic endocrine system that includes ovarian events, hypothalamic-pituitary interactions, uterine endometrial and myometrial changes during implantation and pregnancy, cervical alterations in structure, and breast development. The ovarian cycle and the steroid hormones produced by the ovary also impact epithelial cancer development in the ovary, uterus, cervix, and breast. This chapter provides a personal view of recent developments that occur in this complex endocrine environment.
MeSH term(s)	Animals ; Breast/physiology ; Breast/physiopathology ; Female ; Genital Diseases, Female/pathology ; Genital Diseases, Female/physiopathology ; Genitalia, Female/physiology ; Genitalia, Female/physiopathology ; Humans ; Hypothalamo-Hypophyseal System/physiology ; Hypothalamo-Hypophyseal System/physiopathology ; Menstrual Cycle ; Models, Biological ; Ovary/cytology ; Ovary/pathology ; Ovary/physiology ; Ovary/physiopathology ; Pregnancy
Language	English
Publishing date	2018-02-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	201161-x
ISSN	2162-2620 ; 0083-6729
ISSN (online)	2162-2620
ISSN	0083-6729
DOI	10.1016/bs.vh.2018.01.009
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Article: From Follicular Development and Ovulation to Ovarian Cancers: An Unexpected Journey.

Richards, JoAnne S

Vitamins and hormones

2018 Volume 107, Page(s) 453–472

Abstract: Follicular development and ovulation are complex development processes that are regulated by multiple, interacting pathways and cell types. The oocyte, cumulus cells, granulosa cells, and theca cells communicate to impact follicular development and ... ...

Abstract	Follicular development and ovulation are complex development processes that are regulated by multiple, interacting pathways and cell types. The oocyte, cumulus cells, granulosa cells, and theca cells communicate to impact follicular development and ovulation. Many hormones and cytokines control intracellular regulatory networks and transcription factors, some of which are cell type specific. Molecular biology approaches and mutant mouse models have contributed immensely to our knowledge of what genes and signaling cascades impact each stage of follicular development and ovulation, and how the alteration of gene expression profiles and the activation of specific signaling pathways can impact ovarian cancer development in ovarian surface epithelial cells as well as granulosa cells. This chapter explores how pathways controlling normal follicle development and ovulation can be diverted to abnormal development.
MeSH term(s)	Animals ; Carcinoma, Ovarian Epithelial ; Female ; Follicular Phase ; Genetic Predisposition to Disease ; Granulosa Cell Tumor/genetics ; Granulosa Cell Tumor/pathology ; Granulosa Cell Tumor/physiopathology ; Humans ; Infertility, Female/etiology ; Models, Biological ; Mutation ; Neoplasms, Glandular and Epithelial/genetics ; Neoplasms, Glandular and Epithelial/pathology ; Neoplasms, Glandular and Epithelial/physiopathology ; Oogenesis ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/physiopathology ; Ovary/pathology ; Ovary/physiopathology ; Ovulation ; Receptors, Progesterone/genetics ; Receptors, Progesterone/metabolism
Chemical Substances	Receptors, Progesterone
Language	English
Publishing date	2018-02-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	201161-x
ISSN	2162-2620 ; 0083-6729
ISSN (online)	2162-2620
ISSN	0083-6729
DOI	10.1016/bs.vh.2018.01.019
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Article ; Online: Large-scale DNA demethylation occurs in proliferating ovarian granulosa cells during mouse follicular development

Tomoko Kawai / JoAnne S. Richards / Masayuki Shimada

Communications Biology, Vol 4, Iss 1, Pp 1-

2021 Volume 15

Abstract: Tomoko Kawai et al. investigate DNA methylation patterns during granulosa cell differentiation and proliferation. Their results suggest that sequential epigenetic events are essential for progressive changes in granulosa cell differentiation. ...

Abstract	Tomoko Kawai et al. investigate DNA methylation patterns during granulosa cell differentiation and proliferation. Their results suggest that sequential epigenetic events are essential for progressive changes in granulosa cell differentiation.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The impact of prior care experience on nursing students' compassionate values and behaviours: A mixed methods study.

Field-Richards, Sarah Elizabeth / Aubeeluck, Aimee / Callaghan, Patrick / Keeley, Philip / Redsell, Sarah Anne / Spiby, Helen / Stacey, Gemma / Lymn, Joanne S

International journal of nursing studies

2024 Volume 153, Page(s) 104732

Abstract: ... Methods Study framework.: Setting(s): Three United Kingdom universities.: Participants: Pre ...

Abstract	Background: Compassion is critical to the provision of high-quality healthcare and is foregrounded internationally as an issue of contemporary concern. Paid care experience prior to nurse training has been suggested as a potential means of improving compassion, which has been characterised by the values and behaviours of care, compassion, competence, communication, courage, and commitment. There is however a dearth of evidence to support the effectiveness of prior care experience as a means of improving compassion in nursing. Objective: To explore the impact of paid prior care experience on the values and behaviours of pre-registration nursing students indicated as characterising compassionate care. Design: Longitudinal mixed methods design employing a modified concurrent triangulation strategy, comprising two work packages. Work package 1 was qualitative, and work package 2 adopted a concurrent embedded strategy with a dominant quantitative component. Research is reported in accordance with the Good Reporting of a Mixed Methods Study framework. Setting(s): Three United Kingdom universities. Participants: Pre-registration nursing students attending one of three universities, and individuals who had previously participated in a Health Education England paid prior care experience pilot. Participant numbers at time point 1 were questionnaires n = 220, telephone interviews n = 10, and focus groups n = 8. Methods: Work package 1 consisted of longitudinal semi-structured telephone interviews. Work package 2 comprised validated online questionnaires measuring emotional intelligence, compassion satisfaction and fatigue, resilience, psychological empowerment, and career commitment (as proxies of compassionate values and behaviours), and focus groups. Qualitative data were thematically analysed. Quantitative data were analysed via Analysis of Variance in SPSS v 26. Results: Qualitative findings suggest that prior care experience has both positive and negative effects on students' compassionate values and behaviours, however positive effects do not extend to qualification. No statistically significant differences were found in any of the quantitative outcome measures between participants with and without paid prior care experience. A statistically significant increase in compassion fatigue was identified in both groups of participants post-qualification. Paid prior care experience did not prevent participants from experiencing reality shock on becoming a student or on qualification. Conclusions: There is insufficient evidence of longitudinal beneficial impact to recommend paid prior care experience as an effective intervention to foster nursing students' compassionate values and behaviours. These findings do not support mandating a period of paid care experience as a prerequisite for entry into nurse education. Registration: N/A. Tweetable abstract Insufficient evidence of longitudinal beneficial impact to recommend prior care experience as an effective intervention to foster nursing student compassion @PriorCareExp @Sarah_F_R.
Language	English
Publishing date	2024-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	80148-3
ISSN	1873-491X ; 0020-7489
ISSN (online)	1873-491X
ISSN	0020-7489
DOI	10.1016/j.ijnurstu.2024.104732
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Article ; Online: Large-scale DNA demethylation occurs in proliferating ovarian granulosa cells during mouse follicular development.

Kawai, Tomoko / Richards, JoAnne S / Shimada, Masayuki

Communications biology

2021 Volume 4, Issue 1, Page(s) 1334

Abstract: ... decreased and Tet methylcytosine dioxygenase 2 (TET2) significantly increased in S-phase granulosa cells ...

Abstract	During ovarian follicular development, granulosa cells proliferate and progressively differentiate to support oocyte maturation and ovulation. To determine the underlying links between proliferation and differentiation in granulosa cells, we determined changes in 1) the expression of genes regulating DNA methylation and 2) DNA methylation patterns, histone acetylation levels and genomic DNA structure. In response to equine chorionic gonadotropin (eCG), granulosa cell proliferation increased, DNA methyltransferase (DNMT1) significantly decreased and Tet methylcytosine dioxygenase 2 (TET2) significantly increased in S-phase granulosa cells. Comprehensive MeDIP-seq analyses documented that eCG treatment decreased methylation of promoter regions in approximately 40% of the genes in granulosa cells. The expression of specific demethylated genes was significantly increased in association with specific histone modifications and changes in DNA structure. These epigenetic processes were suppressed by a cell cycle inhibitor. Based on these results, we propose that the timing of sequential epigenetic events is essential for progressive, stepwise changes in granulosa cell differentiation.
MeSH term(s)	Animals ; Cell Differentiation ; Cell Proliferation ; DNA Demethylation ; Female ; Granulosa Cells/cytology ; Granulosa Cells/metabolism ; Mice ; Ovarian Follicle/growth & development ; Ovarian Follicle/metabolism
Language	English
Publishing date	2021-11-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-021-02849-w
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Article ; Online: Polyploid giant cancer cells and ovarian cancer: new insights into mitotic regulators and polyploidy†.

Richards, JoAnne S / Candelaria, Nicholes R / Lanz, Rainer B

Biology of reproduction

2021 Volume 105, Issue 2, Page(s) 305–316

Abstract: Current first-line treatment of patients with high-grade serous ovarian cancer (HGSOC) involves the use of cytotoxic drugs that frequently lead to recurrent tumors exhibiting increased resistance to the drugs and poor patient survival. Strong evidence is ...

Abstract	Current first-line treatment of patients with high-grade serous ovarian cancer (HGSOC) involves the use of cytotoxic drugs that frequently lead to recurrent tumors exhibiting increased resistance to the drugs and poor patient survival. Strong evidence is accumulating to show that HGSOC tumors and cell lines contain a subset of cells called polyploidy giant cancer cells (PGCCs) that act as stem-like, self-renewing cells. These PGCCs appear to play a key role in tumor progression by generating drug-resistant progeny produced, in part, as a consequence of utilizing a modified form of mitosis known as endoreplication. Thus, developing drugs to target PGCCs and endoreplication may be an important approach for reducing the appearance of drug-resistant progeny. In the review, we discuss newly identified regulatory factors that impact mitosis and which may be altered or repurposed during endoreplication in PGCCs. We also review recent papers showing that a single PGCC can give rise to tumors in vivo and spheroids in culture. To illustrate some of the specific features of PGCCs and factors that may impact their function and endoreplication compared to mitosis, we have included immunofluorescent images co-localizing p53 and specific mitotic regulatory, phosphoproteins in xenografts derived from commonly used HGSOC cell lines.
MeSH term(s)	Animals ; Female ; Giant Cells/physiology ; Humans ; Mice ; Mitosis ; Ovarian Neoplasms/genetics ; Polyploidy
Language	English
Publishing date	2021-05-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1118-6
ISSN	1529-7268 ; 0006-3363
ISSN (online)	1529-7268
ISSN	0006-3363
DOI	10.1093/biolre/ioab102
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Article ; Online: Endocrine, Paracrine, and Autocrine Signaling Pathways That Regulate Ovulation.

Richards, JoAnne S / Ascoli, Mario

Trends in endocrinology and metabolism: TEM

2018 Volume 29, Issue 5, Page(s) 313–325

Abstract: The central role of luteinizing hormone (LH) and its receptor (LHCGR) in triggering ovulation has been recognized for decades. Because the LHCGR is present in the mural (outermost) granulosa cell layer of preovulatory follicles (POFs), the LH-initiated ... ...

Abstract	The central role of luteinizing hormone (LH) and its receptor (LHCGR) in triggering ovulation has been recognized for decades. Because the LHCGR is present in the mural (outermost) granulosa cell layer of preovulatory follicles (POFs), the LH-initiated signal has to be transmitted to another somatic cell type (cumulus granulosa cells) and the oocyte to release a fertilizable oocyte. Recent studies have shown that activation of the LHCGR initiates vectorial transfer of information among the two somatic cell types and the oocyte and the molecules and signaling pathways involved are now better understood. This review summarizes the newer developments on the complex signaling pathways that regulate ovulation.
MeSH term(s)	Animals ; Autocrine Communication/genetics ; Autocrine Communication/physiology ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Female ; Humans ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/genetics ; Mitogen-Activated Protein Kinase 3/metabolism ; Ovulation/genetics ; Ovulation/physiology ; Paracrine Communication/genetics ; Paracrine Communication/physiology ; Receptors, LH/genetics ; Receptors, LH/metabolism
Chemical Substances	Receptors, LH ; ErbB Receptors (EC 2.7.10.1) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24)
Language	English
Publishing date	2018-03-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1042384-9
ISSN	1879-3061 ; 1043-2760
ISSN (online)	1879-3061
ISSN	1043-2760
DOI	10.1016/j.tem.2018.02.012
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