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Article ; Online: Partisan divide and Racial/Ethnic disparities in COVID-19 vaccine hesitancy among Parents/Guardians and vaccine uptake among children in the U.S.

Shijia Yan, Alice / Jay Sehgal, Neil

2024 Volume 42, Issue 9, Page(s) 2150–2154

Abstract: Objectives: We undertook an observational study to assess the impact of state-level partisanship and parents'/guardians' race/ethnicity on their degree of COVID-19 vaccine hesitancy.: Material and methods: We observed a pooled cross-section of 59,280 ...

Abstract	Objectives: We undertook an observational study to assess the impact of state-level partisanship and parents'/guardians' race/ethnicity on their degree of COVID-19 vaccine hesitancy. Material and methods: We observed a pooled cross-section of 59,280 U.S. adults residing with children in the same household between June 29 and November 14, 2022. Using household-weighted logistic regression models, we evaluated the association between partisanship, race/ethnicity, and vaccine hesitancy, while controlling for other social determinants of COVID-19 vaccine hesitancy. Results and conclusions: We found that children were less likely to receive a COVID-19 vaccine if they resided in Republican as compared to Democratic states, with the difference in probability greatest among those households where parents/guardians identified as White. We also found that children were less likely to receive a COVID-19 vaccine if their parents/guardians identified as White as compared to any other race/ethnicity, with the differences in probability greatest among households in Republican states.
MeSH term(s)	Adult ; Child ; Humans ; COVID-19 Vaccines ; COVID-19/prevention & control ; Vaccines ; Ethnicity ; Parents ; Vaccination
Chemical Substances	COVID-19 Vaccines ; Vaccines
Language	English
Publishing date	2024-03-11
Publishing country	Netherlands
Document type	Observational Study ; Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2024.03.022
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Zs.MO 458: Show issues

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Article ; Online: Integrating External Controls by Regression Calibration for Genome-Wide Association Study.

Zhu, Lirong / Yan, Shijia / Cao, Xuewei / Zhang, Shuanglin / Sha, Qiuying

Genes

2024 Volume 15, Issue 1

Abstract: Genome-wide association studies (GWAS) have successfully revealed many disease-associated genetic variants. For a case-control study, the adequate power of an association test can be achieved with a large sample size, although genotyping large samples is ...

Abstract	Genome-wide association studies (GWAS) have successfully revealed many disease-associated genetic variants. For a case-control study, the adequate power of an association test can be achieved with a large sample size, although genotyping large samples is expensive. A cost-effective strategy to boost power is to integrate external control samples with publicly available genotyped data. However, the naive integration of external controls may inflate the type I error rates if ignoring the systematic differences (batch effect) between studies, such as the differences in sequencing platforms, genotype-calling procedures, population stratification, and so forth. To account for the batch effect, we propose an approach by integrating External Controls into the Association Test by Regression Calibration (iECAT-RC) in case-control association studies. Extensive simulation studies show that iECAT-RC not only can control type I error rates but also can boost statistical power in all models. We also apply iECAT-RC to the UK Biobank data for M72 Fibroblastic disorders by considering genotype calling as the batch effect. Four SNPs associated with fibroblastic disorders have been detected by iECAT-RC and the other two comparison methods, iECAT-Score and Internal. However, our method has a higher probability of identifying these significant SNPs in the scenario of an unbalanced case-control association study.
MeSH term(s)	Genome-Wide Association Study ; Calibration ; Case-Control Studies ; Computer Simulation ; Genotype
Language	English
Publishing date	2024-01-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes15010067
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Article ; Online: Cortical microstructural brain network mediates the association between personality trait of agreeableness and life satisfaction.

Wu, Huijun / Fan, Shijia / Yan, Chuyao / Wang, Hao

Cerebral cortex (New York, N.Y. : 1991)

2023 Volume 34, Issue 1

Abstract: Personality traits are commonly regarded as relatively stable, whereas life satisfaction can fluctuate with time and circumstances, shaped by external influences and personal encounters. The correlation between personality traits and life satisfaction is ...

Abstract	Personality traits are commonly regarded as relatively stable, whereas life satisfaction can fluctuate with time and circumstances, shaped by external influences and personal encounters. The correlation between personality traits and life satisfaction is well-established, yet the underlying neural mechanisms of the myelin-based microstructural brain network connecting them remain unclear. Here, we constructed individual-level whole-brain myelin microstructural networks from the MRI data of 1,043 healthy adults and performed correlation analysis to detect significant personality trait-related and life satisfaction-related subnetworks. A mediation analysis was used to verify whether the shared structural basis of personality traits and life satisfaction significantly mediated their association. The results showed that agreeableness positively correlated with life satisfaction. We identified a shared structural basis of the personality trait of agreeableness and life satisfaction. The regions comprising this overlapping network include the superior parietal lobule, inferior parietal lobule, and temporoparietal junction. Moreover, the shared microstructural connections mediate the association between the personality trait of agreeableness and life satisfaction. This large-scale neuroimaging investigation substantiates a mediation framework for understanding the microstructural connections between personality and life satisfaction, offering potential targets for assessment and interventions to promote human well-being.
MeSH term(s)	Adult ; Humans ; Personality ; Brain/diagnostic imaging ; Magnetic Resonance Imaging ; Parietal Lobe ; Personal Satisfaction
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhad410
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Zs.A 3235: Show issues

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Article ; Online: Analysis of 15 anti-obesity drugs in urine using thermal-assisted paper spray mass spectrometry.

Jiang, Shijia / Zhao, Junbo / Yan, Hui / Xiang, Ping / Shen, Min

Analytical methods : advancing methods and applications

2023 Volume 15, Issue 35, Page(s) 4434–4441

Abstract: Anti-obesity drugs, used to suppress appetite and reduce fat absorption, have been circulated and traded illegally worldwide. The traditional methods of liquid chromatography tandem mass spectrometry (LC-MS/MS) and gas chromatography-mass spectrometry ( ... ...

Abstract	Anti-obesity drugs, used to suppress appetite and reduce fat absorption, have been circulated and traded illegally worldwide. The traditional methods of liquid chromatography tandem mass spectrometry (LC-MS/MS) and gas chromatography-mass spectrometry (GC-MS) for analyzing these drugs in
MeSH term(s)	Chromatography, Liquid ; Tandem Mass Spectrometry ; Body Fluids ; Gas Chromatography-Mass Spectrometry ; Anti-Obesity Agents
Chemical Substances	Anti-Obesity Agents
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/d3ay00559c
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Article ; Online: Tumor-associated macrophages in immunotherapy.

Yan, Shijia / Wan, Guohui

The FEBS journal

2021 Volume 288, Issue 21, Page(s) 6174–6186

Abstract: Tumor-associated macrophages (TAMs) are essential components of the tumor microenvironment involved in the progression and metastasis of cancer. They are intimately involved in angiogenesis and immunosuppression in normal and malignant tissues, as well ... ...

Abstract	Tumor-associated macrophages (TAMs) are essential components of the tumor microenvironment involved in the progression and metastasis of cancer. They are intimately involved in angiogenesis and immunosuppression in normal and malignant tissues, as well as pro-fibrotic activities. With the development of immunotherapy, eradication of cancer cells through activation of the innate immune system has achieved inspiring results, whereas only a handful of patients show a durable response. The tumor-suppressive environment has been investigated with respect to playing a vital role in cancer relapse. In this review, we uncover the heterogeneity of the origin of TAMs, as well as the functions of TAMs in tumor progression associated with intricate regulatory networks in the tumor microenvironment, aiming to inspire therapeutic insight for tumor immunotherapy.
MeSH term(s)	Humans ; Immunity, Innate/genetics ; Immunity, Innate/physiology ; Immunotherapy/methods ; Tumor Microenvironment/genetics ; Tumor Microenvironment/physiology ; Tumor-Associated Macrophages/immunology ; Tumor-Associated Macrophages/metabolism
Language	English
Publishing date	2021-02-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.15726
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Zs.A 260: Show issues

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Article ; Online: A rapidly progressing, painful ulcer at a surgical wound site.

Rao, Shijia / Tang, Yan / Li, Ji / Shi, Wei

BMJ (Clinical research ed.)

2022 Volume 376, Page(s) e068211

MeSH term(s)	Administration, Intravenous ; Adult ; Anti-Bacterial Agents/administration & dosage ; Cesarean Section/adverse effects ; Combined Modality Therapy/methods ; Drainage ; Female ; Humans ; Immunoglobulins, Intravenous/administration & dosage ; Pyoderma Gangrenosum/diagnosis ; Pyoderma Gangrenosum/microbiology ; Pyoderma Gangrenosum/therapy ; Surgical Wound Infection/diagnosis ; Surgical Wound Infection/microbiology ; Surgical Wound Infection/therapy ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Immunoglobulins, Intravenous
Language	English
Publishing date	2022-02-16
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj-2021-068211
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Article ; Online: Modulating Polarization in Second Harmonic Generation through Symmetry Evolution in Plasmonic Lattices.

He, Shijia / Wang, Yi / Wang, Tianyu / Wu, Dongda / La, Junqiao / Hu, Jiang / Zheng, Yan / Lv, Fanzhou / Huang, Yudie / Wang, Wenxin

ACS nano

2024 Volume 18, Issue 12, Page(s) 8745–8753

Abstract: We report a strategy for preparing cost-effective plasmonic square lattices with tunable unit structures of circles, crosses, and circle-cross pairs on a centimeter scale. The asymmetrical electromagnetic (EM) field distribution of the lattice enhances ... ...

Abstract	We report a strategy for preparing cost-effective plasmonic square lattices with tunable unit structures of circles, crosses, and circle-cross pairs on a centimeter scale. The asymmetrical electromagnetic (EM) field distribution of the lattice enhances second harmonic generation (SHG) under oblique incidence. The SHG signals are progressively strengthened as the unit symmetry decreases from
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c11312
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Article ; Online: Enhanced photocatalytic activity of Ag@g-C

Yang, Libin / Bo, Chang / Wu, Runjin / Xu, Shijia / Li, Qian / Ding, Yan / Gao, Chenyu

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 24, Page(s) 16371–16379

Abstract: Photocatalysis, as a form of solar energy conversion, has considerable development prospects for solving energy exhaustion and environmental pollution. Promoting the utilisation of photocarriers is the key way to enhance photocatalytic activity and ... ...

Abstract	Photocatalysis, as a form of solar energy conversion, has considerable development prospects for solving energy exhaustion and environmental pollution. Promoting the utilisation of photocarriers is the key way to enhance photocatalytic activity and quantum efficiency. The g-C
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp01455j
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Article ; Online: Bacterial lipopolysaccharide with different administration routes affects intestinal mucosal morphological, immunological, and microbial barrier functions in goslings.

Xi, Yumeng / Li, Yue / Ying, Shijia / Yan, Junshu / Shi, Zhendan

Poultry science

2023 Volume 102, Issue 5, Page(s) 102599

Abstract: The current study was conducted to evaluate the effects of different administration routes of bacterial lipopolysaccharide (LPS) on intestinal mucosal morphological, immunological, and microbial barrier functions in goslings. First, we compared ... ...

Abstract	The current study was conducted to evaluate the effects of different administration routes of bacterial lipopolysaccharide (LPS) on intestinal mucosal morphological, immunological, and microbial barrier functions in goslings. First, we compared intestinal villi morphology of goslings under intraperitoneal or oral LPS treatment through hematoxylin and eosin staining. Then, we determined the signatures of the microbiome in the ileum mucosa of goslings subjected to oral LPS treatment at 0, 2, 4, and 8 mg/kg BW by 16S sequencing, and analyzed the changes in intestinal barrier functions and permeability, levels of LPS in the ileum mucosa, plasma, and liver tissue, and the induced inflammatory response of Toll-like receptor 4 (TLR4). As a result, intraperitoneal LPS injection resulted in a thicker intestinal wall in the ileum within a short time, whereas villus height was less affected; in contrast, oral LPS treatment exerted a stronger influence on villus height but not on intestinal wall thickness. We also found that oral LPS treatment affected the structure of the intestinal microbiome, reflected by changes in the clustering of intestinal microbiota. The average abundance of Muribaculaceae showed an increasing trend with increasing LPS levels, and that of the genus Bacteroides decreased, compared with the control group. In addition, oral LPS treatment with 8 mg/kg BW affected the intestinal epithelial morphology, damage the mucosal immune barrier, downregulated the expression of tight junction proteins, increased circulating D-lactate levels, and stimulated the secretion of various inflammatory mediators and activation of the TLR4/MyD88/NFκB pathway. This study presented the injuries of intestinal mucosal barrier function induced by LPS challenges in goslings and provided a scientific model for searching the novel strategies to attenuate the immunological stress and gut injury caused by LPS.
MeSH term(s)	Animals ; Lipopolysaccharides/toxicity ; Toll-Like Receptor 4/metabolism ; Geese ; Chickens ; Intestinal Mucosa
Chemical Substances	Lipopolysaccharides ; Toll-Like Receptor 4
Language	English
Publishing date	2023-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102599
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Article ; Online: Gene-Based Association Tests Using New Polygenic Risk Scores and Incorporating Gene Expression Data.

Yan, Shijia / Sha, Qiuying / Zhang, Shuanglin

Genes

2022 Volume 13, Issue 7

Abstract: Recently, gene-based association studies have shown that integrating genome-wide association studies (GWAS) with expression quantitative trait locus (eQTL) data can boost statistical power and that the genetic liability of traits can be captured by ... ...

Abstract	Recently, gene-based association studies have shown that integrating genome-wide association studies (GWAS) with expression quantitative trait locus (eQTL) data can boost statistical power and that the genetic liability of traits can be captured by polygenic risk scores (PRSs). In this paper, we propose a new gene-based statistical method that leverages gene-expression measurements and new PRSs to identify genes that are associated with phenotypes of interest. We used a generalized linear model to associate phenotypes with gene expression and PRSs and used a score-test statistic to test the association between phenotypes and genes. Our simulation studies show that the newly developed method has correct type I error rates and can boost statistical power compared with other methods that use either gene expression or PRS in association tests. A real data analysis figure based on UK Biobank data for asthma shows that the proposed method is applicable to GWAS.
MeSH term(s)	Gene Expression ; Genome-Wide Association Study ; Phenotype ; Quantitative Trait Loci/genetics ; Risk Factors
Language	English
Publishing date	2022-06-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes13071120
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