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  1. Article ; Online: Solitary Peripheral Coxsackie Retinopathy.

    Breazzano, Mark P

    Ophthalmology. Retina

    2023  Volume 7, Issue 4, Page(s) 324

    MeSH term(s) Humans ; Antibodies, Viral ; Retinal Diseases
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Journal Article
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2023.01.009
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  2. Article ; Online: Comment on: 'Incidence of chorioretinitis and endophthalmitis in hospitalized patients with fungemia'.

    Breazzano, Mark P

    Eye (London, England)

    2022  Volume 36, Issue 9, Page(s) 1854

    MeSH term(s) Chorioretinitis/epidemiology ; Endophthalmitis/epidemiology ; Fungemia/epidemiology ; Humans ; Incidence
    Language English
    Publishing date 2022-01-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-021-01905-3
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  3. Article ; Online: Endogenous Candida endophthalmitis: Has it been discerned from a cotton wool spot in the retina?

    Breazzano, Mark P

    The Journal of infection

    2021  Volume 84, Issue 2, Page(s) 248–288

    MeSH term(s) Candida ; Candidiasis/diagnosis ; Endophthalmitis/diagnosis ; Eye Infections, Fungal ; Humans ; Retina
    Language English
    Publishing date 2021-09-15
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2021.09.011
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  4. Article ; Online: Choroidal origin of endogenous Candida endophthalmitis.

    Breazzano, Mark P

    BMC ophthalmology

    2020  Volume 20, Issue 1, Page(s) 283

    Abstract: Endogenous Candida endophthalmitis (ECE) has been established with microscopic histopathology, both by autopsy and experimentation, to primarily originate from and involve the choroid. Zhuang et al. examined a series of patients with ECE using spectral- ... ...

    Abstract Endogenous Candida endophthalmitis (ECE) has been established with microscopic histopathology, both by autopsy and experimentation, to primarily originate from and involve the choroid. Zhuang et al. examined a series of patients with ECE using spectral-domain optical coherence tomography (SD-OCT) imaging and present a new classification scheme. The authors conclude the majority of lesions are primarily retinal in location without report of choroidal involvement. This discrepancy may be explained by posterior shadowing artifact and lack of discernment from associated retinal findings like infarction. These considerations are necessary in reviewing SD-OCT, characterizing ECE, and proposing new classification systems.
    MeSH term(s) Candida ; Choroid ; Endophthalmitis/diagnosis ; Eye Infections, Fungal/diagnosis ; Humans ; Tomography, Optical Coherence
    Language English
    Publishing date 2020-07-13
    Publishing country England
    Document type Letter
    ZDB-ID 2050436-6
    ISSN 1471-2415 ; 1471-2415
    ISSN (online) 1471-2415
    ISSN 1471-2415
    DOI 10.1186/s12886-020-01540-8
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  5. Article ; Online: Novel

    Priluck, Aaron Z / Breazzano, Mark P

    Ophthalmic genetics

    2022  Volume 44, Issue 2, Page(s) 186–190

    Abstract: Background: MFSD8: Materials and methods: We present a case of : Results: A 57-year-old female presented for subacute, unilateral blurriness in her right eye. Best corrected visual acuity was 20/250 and 20/50 in the right and left eyes, ... ...

    Abstract Background: MFSD8
    Materials and methods: We present a case of
    Results: A 57-year-old female presented for subacute, unilateral blurriness in her right eye. Best corrected visual acuity was 20/250 and 20/50 in the right and left eyes, respectively. Fundus examination and multimodal imaging revealed blunted foveal reflexes and optical gap with subfoveal ellipsoid zone loss in both eyes, right greater than left. Full field electroretinography results were within normal limits while the Arden ratio on electro-oculography was abnormal in both eyes, right more so than left. Genetic testing revealed apparently causative compound heterozygous mutations in the
    Conclusions: To authors' knowledge, this report is first description of this combination of mutations in the
    MeSH term(s) Female ; Humans ; Adult ; Middle Aged ; Macular Degeneration/diagnosis ; Macular Degeneration/genetics ; Retinal Dystrophies/diagnosis ; Retinal Dystrophies/genetics ; Mutation ; Electroretinography ; Visual Acuity ; Tomography, Optical Coherence ; Membrane Transport Proteins/genetics
    Chemical Substances MFSD8 protein, human ; Membrane Transport Proteins
    Language English
    Publishing date 2022-07-08
    Publishing country England
    Document type Case Reports ; Review ; Journal Article
    ZDB-ID 1199279-7
    ISSN 1744-5094 ; 0167-6784 ; 1381-6810
    ISSN (online) 1744-5094
    ISSN 0167-6784 ; 1381-6810
    DOI 10.1080/13816810.2022.2092758
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  6. Article ; Online: Outcomes and Clinical Features Predictive of Fungal Endophthalmitis.

    Priluck, Aaron Z / Huang, Peng / Breazzano, Mark P

    American journal of ophthalmology

    2023  Volume 251, Page(s) 104–114

    Abstract: ... department or inpatient setting (P = .0002) vs outpatient, greater visual acuity (P = .049), artificial ... indwelling line present (P = .0004), sepsis within past 6 months (P = .0002), prior/current hepatitis C ... diagnosis (P = .044), total parenteral nutrition (P = .0028), complicated diabetes mellitus (P = .035 ...

    Abstract Purpose: To analyze intravitreal antifungal injections performed at a tertiary center to determine (1) risk factors increasing fungal endophthalmitis likelihood at the time of patient presentation, (2) prognostic factors at presentation, and (3) validity of American Academy of Ophthalmology (Academy) ophthalmologic Candida septicemia (candidemia) screening guidelines.
    Design: Single-center, retrospective clinical case-control study.
    Methods: Clinical course, visual outcome, and final diagnosis were analyzed for 75 patients (81 eyes) receiving intravitreal antifungal injections between 2014 and 2021. Features were compared between fungal endophthalmitis and clinically similar diseases (masquerades).
    Results: Fungal endophthalmitis was more likely than masquerade based on injection in emergency department or inpatient setting (P = .0002) vs outpatient, greater visual acuity (P = .049), artificial indwelling line present (P = .0004), sepsis within past 6 months (P = .0002), prior/current hepatitis C diagnosis (P = .044), total parenteral nutrition (P = .0028), complicated diabetes mellitus (P = .035), actively treated cancer (P = .021), immunosuppressive medication within past year (P = .035), immunocompromising condition number (P = .031), and delayed pain (P = .0094) and vision loss (P = .020) onset. Visual acuity at presentation correlated with visual outcome (R
    Conclusions: Many conditions can mimic fungal endophthalmitis, but certain risk factors should raise its suspicion. Regardless of diagnosis, presenting vision correlates with final vision. Lastly, no patients with fungal endophthalmitis were asymptomatic or identified by screening, further supporting current Academy candidemia screening guidelines.
    MeSH term(s) Humans ; Antifungal Agents/therapeutic use ; Fungi ; Candidemia/complications ; Candidemia/drug therapy ; Retrospective Studies ; Case-Control Studies ; Vitrectomy/adverse effects ; Eye Infections, Fungal/diagnosis ; Eye Infections, Fungal/drug therapy ; Eye Infections, Fungal/microbiology ; Endophthalmitis/diagnosis ; Endophthalmitis/drug therapy ; Intravitreal Injections
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80030-2
    ISSN 1879-1891 ; 0002-9394
    ISSN (online) 1879-1891
    ISSN 0002-9394
    DOI 10.1016/j.ajo.2023.02.011
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  7. Article ; Online: Split Down the Middle of the Fovea.

    Breazzano, Mark P / Chang, Stanley

    JAMA ophthalmology

    2021  Volume 139, Issue 9, Page(s) 1037–1038

    MeSH term(s) Fovea Centralis ; Humans ; Visual Fields
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2020.6869
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  8. Article ; Online: Multimodal Imaging of a novel MFSD8/CLN7 mutation associated with non-syndromic symmetric adult-onset macular dystrophy.

    Gelormini, Francesco / Vallino, Veronica / Breazzano, Mark P / Pasini, Barbara / Reibaldi, Michele / Borrelli, Enrico

    Retinal cases & brief reports

    2024  

    Abstract: ... that the MFSD8/CLN7 gene exhibited a homozygous variant, specifically p.Ala484Val (c.1451C>T). This variant was ...

    Abstract Purpose: To report multimodal imaging features of a novel MFSD8/CLN7 pathogenic variant associated with bilateral and symmetric non-syndromic macular dystrophy.
    Methods: A 63-year-old female patient presented complaining of a gradual subjective decline in visual acuity in both eyes over the previous months. This patient underwent a comprehensive ophthalmological assessment, including multimodal retinal imaging and electrophysiological testing. Given suspicion for a hereditary retinal disorder, genetic testing was pursued.
    Results: The eye examination revealed blunted foveal reflexes and no lesions or abnormalities in the equatorial or anterior retinal periphery. Multimodal imaging showed a bilateral and almost symmetrical subfoveal interruption of the outer retinal layers including an optical gap. Genetic testing revealed that the MFSD8/CLN7 gene exhibited a homozygous variant, specifically p.Ala484Val (c.1451C>T). This variant was identified as the likely causative factor for the condition.
    Conclusion: We herein describe the clinical findings of a previously unreported homozygous variant in the MFSD8/CLN7 gene, resulting in a non-syndromic form of bilateral central macular dystrophy.
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000001553
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  9. Article: Expanded Spectrum Torpedo Retinopathy: A Case Series.

    Jiao, George / Goldburg, Samantha R / Breazzano, Mark P / Pandey, Avi

    Case reports in ophthalmology

    2023  Volume 14, Issue 1, Page(s) 209–213

    Abstract: Torpedo lesions in the retina are rare, and their clinical significance has not been well established. This case series highlights patients with atypical torpedo lesions with varying orientations and pigmentation patterns. We describe the first ... ...

    Abstract Torpedo lesions in the retina are rare, and their clinical significance has not been well established. This case series highlights patients with atypical torpedo lesions with varying orientations and pigmentation patterns. We describe the first documented case of an inferiorly oriented lesion, to our knowledge, and add to the few previous descriptions of double-torpedo lesions.
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2577666-6
    ISSN 1663-2699
    ISSN 1663-2699
    DOI 10.1159/000530005
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  10. Article ; Online: Screening for Ocular Findings Among Patients With Candidemia: Isn't It Time to Change Practice?

    Breazzano, Mark P / Bond, John B / Lum, Flora / Olsen, Timothy W

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 75, Issue 7, Page(s) 1270–1271

    MeSH term(s) Candidemia/diagnosis ; Humans ; Research
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac349
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