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Article ; Online: Medical Mistrust Among Food Insecure Individuals in Appalachia.

Thomas, Melissa K / Amstutz, Ciara / Orr-Roderick, Debra / Horter, Julia / Holben, David H

2023 Volume 46, Issue 3, Page(s) 192–202

Abstract: This study focused on the relationship between food insecurity and medical mistrust within Appalachia. Food insecurity has negative consequences on health, while medical mistrust can lead to a decrease in health care use, creating additive consequences ... ...

Abstract	This study focused on the relationship between food insecurity and medical mistrust within Appalachia. Food insecurity has negative consequences on health, while medical mistrust can lead to a decrease in health care use, creating additive consequences to already vulnerable populations. Medical mistrust has been defined in various ways, with measures addressing health care organizations and individual health care providers. To determine whether food insecurity has an additive impact on medical mistrust, a cross-sectional survey was completed by 248 residents in Appalachia Ohio while attending community or mobile clinics, food banks, or the county health department. More than one-quarter of the respondents had high levels of mistrust toward health care organizations. Those with high food insecurity levels were more likely to have higher levels of medical mistrust than those with lower levels of food insecurity. Individuals with higher self-identified health issues and older participants had higher medical mistrust scores. Screening for food insecurity in primary care can reduce the impact of mistrust on patient adherence and health care access by increasing patient-centered communication. These findings present a unique perspective on how to identify and mitigate medical mistrust within Appalachia and call attention to the need for further research on the root causes among food insecure residents.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Trust ; Food Supply ; Appalachian Region ; Food Insecurity
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	449879-3
ISSN	1550-5057 ; 0160-6379
ISSN (online)	1550-5057
ISSN	0160-6379
DOI	10.1097/FCH.0000000000000362
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Article ; Online: The mean ten-year results of metal-on-metal hybrid hip resurfacing arthroplasty.

Amstutz, H C / Le Duff, M J

The bone & joint journal

2018 Volume 100-B, Issue 11, Page(s) 1424–1433

Abstract: Aims: This study presents the long-term survivorship, risk factors for prosthesis survival, and an assessment of the long-term effects of changes in surgical technique in a large series of patients treated by metal-on-metal (MoM) hip resurfacing ... ...

Abstract	Aims: This study presents the long-term survivorship, risk factors for prosthesis survival, and an assessment of the long-term effects of changes in surgical technique in a large series of patients treated by metal-on-metal (MoM) hip resurfacing arthroplasty (HRA). Patients and methods: Between November 1996 and January 2012, 1074 patients (1321 hips) underwent HRA using the Conserve Plus Hip Resurfacing System. There were 787 men (73%) and 287 women (27%) with a mean age of 51 years (14 to 83). The underlying pathology was osteoarthritis (OA) in 1003 (75.9%), developmental dysplasia of the hip (DDH) in 136 (10.3%), avascular necrosis in 98 (7.4%), and other conditions, including inflammatory arthritis, in 84 (6.4%). Results: The mean follow-up time was 10.5 years (1 to 20). Using revision for any reason as the endpoint, the overall survivorship at 15 years was 89.4% (95% confidence interval (CI) 86.8 to 91.4). There was a substantial increase between the first and second generation of surgical technique (86.6% vs 90.1%; p = 0.05). Men with idiopathic OA had a 15-year survivorship of 94.5% and women, 82.2% (p = 0.001); gender was not a risk factor after stratification by component size and aetiology. Using revision for excessive wear (ion levels > 7 µg/l associated with symptoms or adverse local tissue reactions) as the endpoint, the 15-year survivorship was 98.5%. Risk factors for revision for all modes of failure were an underlying pathology of hip dysplasia, a contact patch to rim (CPR) distance of 7 mm or less, an age at surgery of 55 years or less, and a femoral component size of 46 mm or less. Specific risk factors for aseptic failure of the femoral component were early surgical technique, a cementless metaphyseal stem, and a body mass index of 24 kg/m Conclusion: HRA is a viable concept; metal-on-metal bearings are well suited for this procedure when a well-designed device is properly implanted. The best results were obtained in men with OA, but survivorship was better for other underlying pathologies and for women after changes were made to the technique of implantation. Lifetime durability is a possible outcome for many patients despite a high level of activity. Cite this article: Bone Joint J 2018;100-B:1424-33.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip/instrumentation ; Arthroplasty, Replacement, Hip/methods ; Female ; Femur Head Necrosis/surgery ; Follow-Up Studies ; Hip Dislocation, Congenital/surgery ; Hip Prosthesis ; Humans ; Kaplan-Meier Estimate ; Male ; Metal-on-Metal Joint Prostheses ; Middle Aged ; Osteoarthritis, Hip/surgery ; Prosthesis Design ; Prosthesis Failure/etiology ; Reoperation ; Risk Factors ; Young Adult
Language	English
Publishing date	2018-11-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2697156-2
ISSN	2049-4408 ; 2049-4394
ISSN (online)	2049-4408
ISSN	2049-4394
DOI	10.1302/0301-620X.100B11.BJJ-2017-1459.R2
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Article: Knee-joint replacement.

Amstutz, H C

California medicine

2008 Volume 118, Issue 3, Page(s) 31–32

Language	English
Publishing date	2008-08-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	390024-1
ISSN	0008-1264 ; 0093-4038
ISSN	0008-1264 ; 0093-4038
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Zs.A 168: Show issues

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Article ; Online: Mutation Spectrum in Liquid Versus Solid Biopsies From Patients With Advanced Gastroenteropancreatic Neuroendocrine Carcinoma.

Knappskog, Stian / Grob, Tobias / Venizelos, Andreas / Amstutz, Ursula / Hjortland, Geir O / Lothe, Inger M / Kersten, Christian / Hofsli, Eva / Sundlöv, Anna / Elvebakken, Hege / Garresori, Herish / Couvelard, Anne / Svensson, Johanna / Sorbye, Halfdan / Perren, Aurel

JCO precision oncology

2023 Volume 7, Page(s) e2200336

Abstract: Purpose: Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are rare and have a poor prognosis. Most GEP-NEC are diagnosed with metastatic disease, with only minor biopsies available for molecular diagnostics. We assessed the applicability of ... ...

Abstract	Purpose: Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are rare and have a poor prognosis. Most GEP-NEC are diagnosed with metastatic disease, with only minor biopsies available for molecular diagnostics. We assessed the applicability of liquid biopsies for molecular profiling of GEP-NEC. Materials and methods: We performed massive parallel sequencing of 76 cancer-related genes in circulating tumor DNA from 50 patients with advanced GEP-NEC and compared findings to previous analyses of solid tumor biopsies from the same patients. Plasma samples were collected before therapy, and the median time span between blood and tissue sampling was 25 days. Results: We detected 178 somatic mutations in the liquid biopsies, 127 (71%) were also detected in the solid biopsies, whereas 51 (29%) were unique to the liquid biopsies. In the same 76 genes, we previously detected 199 somatic mutations (single nucleotide variants) in solid biopsies, of which 127 (64%) were also now detected in liquid biopsies. In exploratory subgroup assessments, concordance was higher in patients with liver metastases ( Conclusion: Liquid biopsy analyses may be an applicable alternative to solid biopsies in GEP-NEC. Liquid biopsies may add additional mutations compared with tumor biopsies alone and could be useful for biomarker assessment in clinical trials for these patients.
MeSH term(s)	Humans ; Pancreatic Neoplasms/drug therapy ; Carcinoma, Neuroendocrine/drug therapy ; Biomarkers, Tumor/genetics ; Mutation ; Biopsy
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2023-02-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.22.00336
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Article ; Online: Hip resurfacing for osteonecrosis: two- to 18-year results of the Conserve Plus design and technique.

Amstutz, H C / Le Duff, M J

The bone & joint journal

2016 Volume 98-B, Issue 7, Page(s) 901–909

Abstract: Aims: Hip resurfacing arthroplasty (HRA) is an alternative to conventional total hip arthroplasty for patients with osteonecrosis (ON) of the femoral head. Our aim was to report the long-term outcome of HRA, which is not currently known.: Patients and ...

Abstract	Aims: Hip resurfacing arthroplasty (HRA) is an alternative to conventional total hip arthroplasty for patients with osteonecrosis (ON) of the femoral head. Our aim was to report the long-term outcome of HRA, which is not currently known. Patients and methods: Long-term survivorship, clinical scores and radiographic results for 82 patients (99 hips) treated with HRA for ON over a period of 18 years were reviewed retrospectively. The mean age of the 67 men and 15 women at the time of surgery was 40.8 years (14 to 64). Patients were resurfaced regardless of the size of the osteonecrotic lesion. Results: The mean clinical follow-up was 10.8 years (2 to 18). The mean University of California, Los Angeles hip scores at the last follow-up were 9.3, 9.4, 9.2 and 6.8 for pain, walking, function and activity, respectively. A total of six hips underwent revision surgery, four for loosening of the femoral component and two for loosening of the acetabular component. Using any revision as an end point, the 15-year Kaplan-Meier survivorship was 90.3%. There were no wear-related failures. There were no femoral failures among the hips reconstructed with a cemented metaphyseal stem. A total of five hips showed narrowing of the femoral neck; all stabilised and remain asymptomatic, 21 showed signs of femoral neck impingement. Conclusion: To our knowledge, this is the first report of a series of HRA performed for ON with 15-year survivorship. Our data confirm that patients with advanced stages of ON of the femoral head are excellent candidates for HRA. Cite this article: Bone Joint J 2016;98-B:901-9.
MeSH term(s)	Adolescent ; Adult ; Arthroplasty, Replacement, Hip/methods ; Chromium ; Cobalt ; Debridement ; Female ; Femur Head Necrosis/classification ; Femur Head Necrosis/diagnostic imaging ; Femur Head Necrosis/surgery ; Follow-Up Studies ; Hip Prosthesis ; Humans ; Male ; Metal-on-Metal Joint Prostheses ; Middle Aged ; Prosthesis Design ; Reoperation ; Retrospective Studies ; Young Adult
Chemical Substances	Chromium (0R0008Q3JB) ; Cobalt (3G0H8C9362)
Language	English
Publishing date	2016-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2697156-2
ISSN	2049-4408 ; 2049-4394
ISSN (online)	2049-4408
ISSN	2049-4394
DOI	10.1302/0301-620X.98B7.36676
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Zs.A 6989: Show issues

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Article ; Online: Risk factors for wear-related failures after hip resurfacing in patients with a low contact patch to rim distance.

Amstutz, H C / Le Duff, M J / Bhaurla, S K

The bone & joint journal

2017 Volume 99-B, Issue 7, Page(s) 865–871

Abstract: Aims: A contact patch to rim (CPR) distance of < 10 mm has been associated with edge-loading and excessive wear. However, not all arthroplasties with a low CPR distance show problems with wear. Therefore, CPR distance may not be the only variable ... ...

Abstract	Aims: A contact patch to rim (CPR) distance of < 10 mm has been associated with edge-loading and excessive wear. However, not all arthroplasties with a low CPR distance show problems with wear. Therefore, CPR distance may not be the only variable affecting the post-operative metal ion concentrations. Patients and methods: We used multiple logistic regression to determine what variables differed between the patients who had high and low cobalt (CoS) and chromium (CrS) serum ion concentrations within a cohort of patients with low (< 10 mm) CPR distances. A total of 56 patients treated with unilateral hip resurfacing arthroplasty (HRA) had CoS and CrS ion studies performed more than one year after surgery. The mean age of the patients at the time of surgery was 51.7 years (29 to 70), with 38 women (68%) and 18 men (32%). Results: It was seen that 47 patients had low ion levels (< 7µg/L) and nine had high ion levels (≥ 7µg/L). We found increased risks of high wear with decreasing CPR distance. Conclusion: The use of CPR distance measurements to predict hips at risk for elevated wear is needed for all patients with HRA. We recommend that patients with low CPR distances have at least one serum ion study performed while patients with CPR distance > 10 mm do not need routine ion studies. We believe that patients with low CPR distance and low ions do not need repeat ion studies unless the patient becomes symptomatic or has substantial radiographic changes. Cite this article:
MeSH term(s)	Adult ; Aged ; Arthroplasty, Replacement, Hip/adverse effects ; Biomechanical Phenomena ; Chromium/blood ; Cobalt/blood ; Female ; Hip Prosthesis/adverse effects ; Humans ; Male ; Middle Aged ; Prosthesis Design ; Prosthesis Failure ; Risk Factors
Chemical Substances	Chromium (0R0008Q3JB) ; Cobalt (3G0H8C9362)
Language	English
Publishing date	2017-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2697156-2
ISSN	2049-4408 ; 2049-4394
ISSN (online)	2049-4408
ISSN	2049-4394
DOI	10.1302/0301-620X.99B7.BJJ-2016-1369.R1
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Article: Hydroxyapatite-coated versus grit-blasted femoral stems.

Amstutz, H C

The Journal of bone and joint surgery. British volume

2002 Volume 84, Issue 8, Page(s) 1206–7; author reply 1207

MeSH term(s)	Coated Materials, Biocompatible ; Femur Head ; Hip Prosthesis ; Humans ; Hydroxyapatites ; Prosthesis Design ; Surface Properties
Chemical Substances	Coated Materials, Biocompatible ; Hydroxyapatites
Language	English
Publishing date	2002-11
Publishing country	England
Document type	Comment ; Comparative Study ; Letter
ZDB-ID	220626-2
ISSN	2044-5377 ; 0301-620X ; 0447-9076
ISSN (online)	2044-5377
ISSN	0301-620X ; 0447-9076
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Article: Arthroplasty options for advanced osteonecrosis.

Amstutz, H C

Orthopedics

2000 Volume 23, Issue 9, Page(s) 927–928

MeSH term(s)	Arthroplasty, Replacement, Hip ; Femur Head Necrosis/surgery ; Humans
Language	English
Publishing date	2000-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	424447-3
ISSN	0147-7447
ISSN	0147-7447
DOI	10.3928/0147-7447-20000901-16
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Zs.A 1487: Show issues

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Article: Are there differences in Hip Biomechanics after hybrid and cementless resurfacing arthroplasty?

Le Duff, M J / Bhaurla, S K / Takamura, K B / Amstutz, H C / Liu, F-C

Acta orthopaedica Belgica

2016 Volume 82, Issue 3, Page(s) 516–521

Abstract: There is a paucity of information regarding the clinical performance of the fully cementless metal-on-metal hip resurfacing designs. We compared the biomechanical reconstruction between the two hips of a group of patients treated with a hybrid ... ...

Abstract	There is a paucity of information regarding the clinical performance of the fully cementless metal-on-metal hip resurfacing designs. We compared the biomechanical reconstruction between the two hips of a group of patients treated with a hybrid resurfacing design on one side and a new, fully cementless version of the same resurfacing design on the other side.We retrospectively identified 20 patients with a hybrid hip resurfacing on one side and a fully cementless device on the contralateral side. The cemented femoral components were implanted with a target angle stem to shaft angle of 140° while the cementless femoral components were implanted with the aim to replicate the natural neck to shaft angle.No significant differences were observed post-operatively in femoral offset or leg length despite implantation with a larger metaphyseal stem to femoral shaft angle in the hybrid group. Both hybrid and cementless designs provide similar biomechanical reconstructions.
Language	English
Publishing date	2016-08
Publishing country	Belgium
Document type	Journal Article
ZDB-ID	210367-9
ISSN	0001-6462 ; 1784-407X
ISSN	0001-6462 ; 1784-407X
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Zs.A 37: Show issues

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Article: Redox Flow Batteries, Hydrogen and Distributed Storage.

Dennison, C R / Vrubel, Heron / Amstutz, Véronique / Peljo, Pekka / Toghill, Kathryn E / Girault, Hubert H

Chimia

2016 Volume 69, Issue 12, Page(s) 753–758

Abstract: Social, economic, and political pressures are causing a shift in the global energy mix, with a preference toward renewable energy sources. In order to realize widespread implementation of these resources, large-scale storage of renewable energy is needed. ...

Abstract	Social, economic, and political pressures are causing a shift in the global energy mix, with a preference toward renewable energy sources. In order to realize widespread implementation of these resources, large-scale storage of renewable energy is needed. Among the proposed energy storage technologies, redox flow batteries offer many unique advantages. The primary limitation of these systems, however, is their limited energy density which necessitates very large installations. In order to enhance the energy storage capacity of these systems, we have developed a unique dual-circuit architecture which enables two levels of energy storage; first in the conventional electrolyte, and then through the formation of hydrogen. Moreover, we have begun a pilot-scale demonstration project to investigate the scalability and technical readiness of this approach. This combination of conventional energy storage and hydrogen production is well aligned with the current trajectory of modern energy and mobility infrastructure. The combination of these two means of energy storage enables the possibility of an energy economy dominated by renewable resources.
Language	English
Publishing date	2016-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1516-7
ISSN	0009-4293
ISSN	0009-4293
DOI	10.2533/chimia.2015.753
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