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  1. Book ; Online: The Road to Pathogenesis: Charting the Development of LSCs and Pre-LSCs

    Ito, Keisuke / Levine, Ross L.

    2019  

    Keywords Medicine ; Oncology ; Leukemia Stem Cells ; pre-leukemic stem cells ; Leukemia ; stem cell biology
    Size 1 electronic resource (138 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230552
    ISBN 9782889457670 ; 2889457672
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: 15 years after a giant leap for cancer genomics.

    Cai, Sheng F / Levine, Ross L

    Nature

    2023  Volume 623, Issue 7989, Page(s) 920–921

    MeSH term(s) Humans ; Neoplasms/genetics ; Genomics
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-023-03626-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Health Policy Education for Medical Students: Time to Rethink?

    Crosson, Francis J / Levine, Sharon L / Ross, Murray N

    The Permanente journal

    2023  Volume 27, Issue 3, Page(s) 10–13

    MeSH term(s) Humans ; Students, Medical ; Health Education ; Curriculum ; Educational Status ; Health Policy ; Education, Medical
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2062823-7
    ISSN 1552-5775 ; 1552-5775
    ISSN (online) 1552-5775
    ISSN 1552-5775
    DOI 10.7812/TPP/23.045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Oncogenic IDH1 Mutation Imparts Therapeutically Targetable Metabolic Dysfunction in Multiple Tumor Types.

    Robinson, Troy M / Levine, Ross L

    Cancer discovery

    2023  Volume 13, Issue 2, Page(s) 266–268

    Abstract: Summary: In this issue of Cancer Discovery, Thomas and colleagues leverage mass spectrometry metabolomics, stable isotope labeling, and functional studies to explore metabolic vulnerabilities in cancers harboring mutations in isocitrate dehydrogenase ( ... ...

    Abstract Summary: In this issue of Cancer Discovery, Thomas and colleagues leverage mass spectrometry metabolomics, stable isotope labeling, and functional studies to explore metabolic vulnerabilities in cancers harboring mutations in isocitrate dehydrogenase (IDH). The authors present compelling data to support the claim that dysregulated lipid synthesis underpins a synthetic lethal target in cancers with IDH1, but not IDH2, mutations. See related article by Thomas et al., p. 496 (9).
    MeSH term(s) Humans ; Mutation ; Neoplasms/drug therapy ; Neoplasms/genetics ; Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/metabolism ; Lipogenesis ; Lipids
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41) ; Lipids ; IDH1 protein, human (EC 1.1.1.42.)
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-22-1325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cancer did not stay home for COVID-19.

    Levine, Ross L

    Science advances

    2020  Volume 6, Issue 37

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Humans ; Neoplasms/therapy ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-11
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abd7487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Author Correction: Clonal hematopoiesis, aging and Alzheimer's disease.

    Sánchez Vela, Pablo / Trowbridge, Jennifer J / Levine, Ross L

    Nature medicine

    2023  Volume 30, Issue 1, Page(s) 305

    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-023-02718-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Clonal hematopoiesis, aging and Alzheimer's disease.

    Sánchez Vela, Pablo / Trowbridge, Jennifer J / Levine, Ross L

    Nature medicine

    2023  Volume 29, Issue 7, Page(s) 1605–1606

    MeSH term(s) Humans ; Aging/genetics ; Alzheimer Disease/genetics ; Cardiovascular Diseases ; Clonal Hematopoiesis ; Hematopoiesis/genetics ; Mutation/genetics
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type News ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-023-02406-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Unlocking the secrets to Janus kinase activation.

    Levine, Ross L / Hubbard, Stevan R

    Science (New York, N.Y.)

    2022  Volume 376, Issue 6589, Page(s) 139–140

    Abstract: The full-length structure of a Janus kinase provides insights for drug development. ...

    Abstract The full-length structure of a Janus kinase provides insights for drug development.
    MeSH term(s) Drug Development ; Enzyme Activation ; Janus Kinase 2 ; Janus Kinases
    Chemical Substances Janus Kinase 2 (EC 2.7.10.2) ; Janus Kinases (EC 2.7.10.2)
    Language English
    Publishing date 2022-04-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abo7788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The hematopoietic saga of clonality in sickle cell disease.

    Stonestrom, Aaron J / Levine, Ross L

    The Journal of clinical investigation

    2022  Volume 132, Issue 5

    Abstract: Sickle cell disease (SCD) is associated with an increased risk of vascular-occlusive events and of leukemia. Clonal hematopoiesis (CH) may increase both risks. In turn, physiologic abnormalities in SCD may modify the incidence and/or distribution of ... ...

    Abstract Sickle cell disease (SCD) is associated with an increased risk of vascular-occlusive events and of leukemia. Clonal hematopoiesis (CH) may increase both risks. In turn, physiologic abnormalities in SCD may modify the incidence and/or distribution of genetic alterations in CH. In a recent issue of the JCI, Liggett et al. found no difference in CH rate between individuals with versus without SCD. Here we contextualize this report and discuss the complex interplay between CH and SCD with particular attention to consequences for emerging gene therapies. We further consider the limitations in our current understanding of these topics that must be addressed in order to optimize therapeutic strategies for SCD.
    MeSH term(s) Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/genetics ; Anemia, Sickle Cell/therapy ; Genetic Therapy ; Humans ; Mutation
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI158251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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