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  1. Article ; Online: Human papilloma virus and atherosclerotic cardiovascular disease.

    Chan, Noel C / Lawson, James S / Hirsh, Jack

    European heart journal

    2024  Volume 45, Issue 12, Page(s) 1083–1085

    MeSH term(s) Humans ; Human Papillomavirus Viruses ; Cardiovascular Diseases ; Atherosclerosis
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Unresolved issues in the use of direct acting oral anticoagulants.

    Chan, Noel / Hirsh, Jack

    Expert review of cardiovascular therapy

    2023  Volume 21, Issue 12, Page(s) 913–921

    Abstract: Introduction: Currently approved direct oral anticoagulants (DOACs) target thrombin or coagulation factor Xa. Administered in fixed doses without routine laboratory monitoring, DOACs have simplified the approach to oral anticoagulation, when previously ... ...

    Abstract Introduction: Currently approved direct oral anticoagulants (DOACs) target thrombin or coagulation factor Xa. Administered in fixed doses without routine laboratory monitoring, DOACs have simplified the approach to oral anticoagulation, when previously the choice was limited to vitamin K antagonists (VKAs).
    Area covered: We discuss a) unresolved issues related to optimal use of DOACs and b) new developments including the potential for FXIa inhibitors to be effective and safer anticoagulants.
    Expert opinion: By simplifying oral anticoagulation, DOACs have facilitated the uptake of anticoagulation. The DOACs are approved for stroke prevention in atrial fibrillation and for the prevention and treatment of venous thromboembolism, and their indications are expanding to include the prevention of atherothrombosis. DOACs have now replaced vitamin K antagonists (VKAs) for most indications, but not all. DOACs are inferior to VKAs for patients with mechanical heart valves, left ventricular assist device, rheumatic atrial fibrillation, and those with antiphospholipid syndrome, and their safety and efficacy are uncertain in some populations (e.g. advanced renal and liver disease). Impediments to use include concerns for bleeding and cost. The newly developed FXIa and FXIIa inhibitors have the potential to be safer than current anticoagulants, but phase 3 trials are needed to confirm their clinical efficacy and safety.
    MeSH term(s) Humans ; Factor Xa Inhibitors/therapeutic use ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Anticoagulants/adverse effects ; Hemorrhage/chemically induced ; Fibrinolytic Agents/therapeutic use ; Vitamin K ; Administration, Oral ; Stroke/etiology ; Stroke/prevention & control ; Stroke/drug therapy
    Chemical Substances Factor Xa Inhibitors ; Anticoagulants ; Fibrinolytic Agents ; Vitamin K (12001-79-5)
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1080/14779072.2023.2271388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: FRAIL-AF Study: More Bleeding With DOACs Compared With VKAs in Patients With Frailty?

    Godoy, Alejandro / Chan, Noel C / Bhagirath, Vinai / Eikelboom, John W / Hirsh, Jack

    The Canadian journal of cardiology

    2024  

    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Editorial
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2023.12.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Guidelines for antithrombotic therapy

    Hirsh, Jack

    2005  

    Author's details Jack Hirsh
    Keywords Thrombosis / drug therapy ; Fibrinolytic Agents / therapeutic use ; Cardiovascular Diseases / drug therapy
    Language English
    Size 121 S. : Ill., graph. Darst.
    Edition 5. ed.
    Publisher Dekker
    Publishing place Hamilton u.a.
    Publishing country Canada
    Document type Book
    HBZ-ID HT014042414
    ISBN 1-55009-266-9 ; 978-1-55009-266-0
    Database Catalogue ZB MED Medicine, Health

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  5. Book ; Conference proceedings: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy

    Hirsh, Jack

    evidence-based guidelines

    (Chest ; 126,3, Suppl.)

    2004  

    Institution American College of Chest Physicians
    Event/congress Conference on Antithrombotic and Thrombolytic Therapy (7, 2004)
    Author's details guest ed.: Jack Hirsh
    Series title Chest ; 126,3, Suppl.
    Collection
    Language English
    Size S. 163S - 703S : graph. Darst.
    Publisher American College of Chest Physicians
    Publishing place Northbrook, Ill
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT014146739
    Database Catalogue ZB MED Medicine, Health

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  6. Book: Guidelines for antithrombotic therapy

    Hirsh, Jack

    summary of the American College of Chest Physicians recommendations 2000

    2001  

    Author's details Jack Hirsh
    Language English
    Size 68 S. : Ill., graph. Darst.
    Edition 4. ed.
    Publisher Dekker
    Publishing place Hamilton u.a.
    Publishing country Canada
    Document type Book
    HBZ-ID HT013194466
    ISBN 1-55009-156-5 ; 978-1-55009-156-4
    Database Catalogue ZB MED Medicine, Health

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  7. Book ; Conference proceedings: Modulating the coagulation cascade

    Hirsh, Jack

    new targets for antithrombotics and anticoagulants ; [proceedings of a symposium held during the 73rd scientific sessions of the American Heart Association]

    (American heart journal ; 142,2, Suppl.)

    2001  

    Institution American Heart Association
    Author's details guest ed.: Jack Hirsh
    Series title American heart journal ; 142,2, Suppl.
    Collection
    Language English
    Size S29 S. : graph. Darst.
    Publisher Mosby
    Publishing place St. Louis, Mo
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT013134237
    Database Catalogue ZB MED Medicine, Health

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  8. Book: Teaching clinical research methodology by example

    Hirsh, Jack

    2017  

    Author's details Jack Hirsh
    MeSH term(s) Evidence-Based Medicine ; Research Design
    Language English
    Size p. ;, cm.
    Document type Book
    Note Includes index.
    ISBN 9781607952831 ; 1607952831 ; 9781607959526 ; 1607959526
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article ; Online: Letter by de Vries et al Regarding Article "Off-Label Under- and Overdosing of Direct Oral Anticoagulants in Patients With Atrial Fibrillation: A Meta-Analysis".

    de Vries, Tim A C / Hirsh, Jack / Chan, Noel C

    Circulation. Cardiovascular quality and outcomes

    2022  Volume 15, Issue 5, Page(s) e008982

    MeSH term(s) Administration, Oral ; Anticoagulants ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Humans ; Off-Label Use ; Stroke/drug therapy
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-04-28
    Publishing country United States
    Document type Letter ; Meta-Analysis ; Comment
    ZDB-ID 2483197-9
    ISSN 1941-7705 ; 1941-7713
    ISSN (online) 1941-7705
    ISSN 1941-7713
    DOI 10.1161/CIRCOUTCOMES.122.008982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Solving the mystery of excessive warfarin-induced bleeding: a personal historical perspective.

    Hirsh, Jack

    Thrombosis and haemostasis

    2014  Volume 112, Issue 5, Page(s) 853–856

    MeSH term(s) Anticoagulants/adverse effects ; Anticoagulants/history ; Anticoagulants/therapeutic use ; Hemorrhage/chemically induced ; History, 20th Century ; History, 21st Century ; Humans ; International Normalized Ratio ; Ontario ; Prothrombin Time ; Venous Thrombosis/drug therapy ; Venous Thrombosis/prevention & control ; Vitamin K/antagonists & inhibitors ; Warfarin/adverse effects ; Warfarin/history ; Warfarin/therapeutic use
    Chemical Substances Anticoagulants ; Vitamin K (12001-79-5) ; Warfarin (5Q7ZVV76EI)
    Language English
    Publishing date 2014-11
    Publishing country Germany
    Document type Autobiography ; Historical Article ; Journal Article
    ZDB-ID 518294-3
    ISSN 0340-6245
    ISSN 0340-6245
    DOI 10.1160/TH14-05-0433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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