Article ; Online: J-Aggregate-Based FRET Monitoring of Drug Release from Polymer Nanoparticles with High Drug Loading.
Angewandte Chemie (International ed. in English)
2020 Volume 59, Issue 45, Page(s) 20065–20074
Abstract: ... We developed a J-aggregate-based Förster-resonance energy-transfer (FRET) method to investigate the release ... nanoparticles. Single-dye-loaded nanoparticles form J-aggregates because of the high dye-loading (50 wt ... with high dye-loading using FRET pairs exhibited not only FRET but also a J-aggregate red-shift (116 nm ...
| Abstract | Understanding drug-release kinetics is critical for the development of drug-loaded nanoparticles. We developed a J-aggregate-based Förster-resonance energy-transfer (FRET) method to investigate the release of novel high-drug-loading (50 wt %) nanoparticles in comparison with low-drug-loading (0.5 wt %) nanoparticles. Single-dye-loaded nanoparticles form J-aggregates because of the high dye-loading (50 wt %), resulting in a large red-shift (≈110 nm) in the fluorescence spectrum. Dual-dye-loaded nanoparticles with high dye-loading using FRET pairs exhibited not only FRET but also a J-aggregate red-shift (116 nm). Using this J-aggregate-based FRET method, dye-core-polymer-shell nanoparticles showed two release processes intracellularly: the dissolution of the dye aggregates into dye molecules and the release of the dye molecules from the polymer shell. Also, the high-dye-loading nanoparticles (50 wt %) exhibited a slow release kinetics in serum and relatively quick release in cells, demonstrating their great potential in drug delivery. |
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| MeSH term(s) | Drug Carriers/chemistry ; Drug Liberation ; Fluorescence Resonance Energy Transfer/methods ; Microscopy, Electron, Transmission ; Nanoparticles/chemistry ; Polymers/chemistry |
| Chemical Substances | Drug Carriers ; Polymers |
| Language | English |
| Publishing date | 2020-09-15 |
| Publishing country | Germany |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. |
| ZDB-ID | 2011836-3 |
| ISSN | 1521-3773 ; 1433-7851 |
| ISSN (online) | 1521-3773 |
| ISSN | 1433-7851 |
| DOI | 10.1002/anie.202008018 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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