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  1. Article ; Online: Frequency shifts of free water signals from compact bone: Simulations and measurements using a UTE-FID sequence.

    Fischer, Anja / Martirosian, Petros / Machann, Jürgen / Fränkle, Bernd / Schick, Fritz

    Magnetic resonance in medicine

    2024  Volume 92, Issue 1, Page(s) 257–268

    Abstract: ... introduced UTE-FID technique providing spatially resolved FID-spectra was used to measure the frequency ... between free water in spherical pores and in canals parallel to B: Conclusion: Spatially resolved UTE ...

    Abstract Purpose: Free water in cortical bone is either contained in nearly cylindrical structures (mainly Haversian canals oriented parallel to the bone axis) or in more spherically shaped pores (lacunae). Those cavities have been reported to crucially influence bone quality and mechanical stability. Susceptibility differences between bone and water can lead to water frequency shifts dependent on the geometric characteristics. The purpose of this study is to calculate and measure the frequency distribution of the water signal in MRI in dependence of the microscopic bone geometry.
    Methods: Finite element modeling and analytical approaches were performed to characterize the free water components of bone. The previously introduced UTE-FID technique providing spatially resolved FID-spectra was used to measure the frequency distribution pixel-wise for different orientations of the bone axis.
    Results: The frequency difference between free water in spherical pores and in canals parallel to B
    Conclusion: Spatially resolved UTE-FID examinations allow the determination of the frequency distribution of signals from free water in cortical bone. This frequency distribution indicates the composition of the signal contributions from nearly spherical cavities and cylindrical canals which allows for further characterization of bone structure and status.
    MeSH term(s) Humans ; Magnetic Resonance Imaging/methods ; Computer Simulation ; Body Water/diagnostic imaging ; Algorithms ; Reproducibility of Results ; Models, Biological ; Sensitivity and Specificity ; Image Interpretation, Computer-Assisted/methods ; Water/chemistry ; Bone and Bones/diagnostic imaging ; Image Enhancement/methods ; Finite Element Analysis
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2024-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.30027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Stadtzeiten und Energiekonsum: Ein sozialoekologisches Modell zur Abschaetzung von Zeitverwendung und Energiestoffwechsel (UTE)

    Fischer, Marina

    Abstract: Das Projekt UTE zielt darauf ab, den Zusammenhang zwischen Zeitverwendung und Energieverbrauch ... zu wesentlichen Einschraenkungen in der Entscheidungsfreiheit von Haushalten oder Personen. UTE ... fuer Wien entwickelt wird. In UTE wird dieses Modell um Annahmen ueber Anforderungen hinsichtlich ...

    Title variant Urban Time and Energy: A socioecological model for assessing time-use and energy metabolism (UTE)
    Institution Universitaet Klagenfurt, Institut fuer Soziale Oekologie, Schottenfeldgasse 29, 1070, Wien, AT
    Abstract Das Projekt UTE zielt darauf ab, den Zusammenhang zwischen Zeitverwendung und Energieverbrauch in Staedten zu analysieren. Zeitverwendungsstrukturen von Haushaltsmitgliedern (wie Zeitknappheit, zeitliche Abstimmung von Aktivitaeten), der Energiebedarf der Haushalte und die raeumliche Stadtplanung beeinflussen einander. Verfuegbare Zeit - ebenso sehr wie verfuegbares Geld - bestimmen alltaegliche Entscheidungen von Haushalten betreffend Wohnort, Konsum oder Transport. All diese Aktivitaeten verbrauchen Energie (Transportenergie, Heiz/Kuehlenergie, etc.). Zeitmangel fuehrt oftmals zu hoeherem Finanz- oder Energieaufwand und zu wesentlichen Einschraenkungen in der Entscheidungsfreiheit von Haushalten oder Personen. UTE will Handlungsoptionen fuer kuenftige Entwicklungen erforschen, die auf Veraenderungen der soziooekonomischen Strukturen von Haushalten und auf Veraenderungen von Rahmenbedingungen - wie zeitpolitischen Massnahmen - basieren. Ergebnis dieses Projekts ist ein integriertes Modell zur Analyse des Zusammenhangs von Zeitverwendung und Energieverbrauch in Staedten. Zeit-Raum-Energie Szenarien zeigen dabei moegliche Energieeinsparpotenziale auf. Verschiedene politische Massnahmen, wie Intervalle der oeffentlichen Verkehrsmittel, Arbeitszeitflexibilitaet, Oeffnungszeiten von oeffentlichen Einrichtungen oder raeumliche Planung und Infrastruktur, veraendern laufend gesellschaftliche Zeitverwendungsmuster. Gleichzeitig wirken sie sich auf die wirtschaftliche Leistung (Synergien, Produktion und Verbrauchsgewohnheiten, Einkommen, etc.) und die natuerliche Umwelt (Energiefluesse) aus. Das integrierte Modell analysiert den Entscheidungsfindungsprozess in Haushalten im Verhaeltnis zu ihrem Energieverbrauch (vorwiegend Transport- und Heizenergie) mit dem Nachhaltigkeitsdreieck, in welchem jede der Ecken eine der zentralen Dimensionen der Nachhaltigkeit (sozial / oekologisch / oekonomisch) repraesentiert. Das Modell baut auf einem Wohnstandortentscheidungsmodell auf, dass z.Z. im Rahmen des FP7 Projekts SUME (Nachhaltiger staedtischer Energiestoffwechsel in europaeischen Staedten) fuer Wien entwickelt wird. In UTE wird dieses Modell um Annahmen ueber Anforderungen hinsichtlich Zeitverwendung von unterschiedlichen Haushaltstypen sowie zu zeitstrukturierenden Dienstleistungen und Infrastruktur in urbanen Raeumen erweitert. Das Projekt stellt Modellkonzepte fuer drei verschiedene Stadien der Stadtentwicklung bereit: Stadterneuerung-, Stadtneubau-, Stadtentwicklungsgebiet. Das Modell kann zur Unterstuetzung in Entscheidungsfindungsprozessen von kommunalen Verwaltungen, Stadtplanungs- und Stadtentwicklungsabteilungen, Politik und Zivilgesellschaft angewendet werden. Es koennen damit zeitpolitische Massnahmen und integrierte Planungsprozesse einer kommunalen Verwaltung administriert und geleitet werden, die Zeitpolitik, Partizipation und Energieeinsparung beruecksichtigen. Dem kommt die einfach handhabbare und benutzerfreundliche Oberflaeche entgegen. (...);The project UTE aims to analyse the link between time use and energy use in cities. Time-use structure of urban household members (phenomena such as 'time squeeze' or synchronization of activities of different persons), the energy demand of households and the spatial organisation of cities entail each other. Available time - as much as available money - governs everyday decision making of household members concerning living space, consumption patterns and means of transportation. All of these activities are energy consuming (transport energy, heating/cooling energy, etc.). Consequently, lack of time often translates into spending more money and more energy, severely constraining individual and household choices. UTE aims to explore the options for future development which depend on internal choices (of households) as well as on changes in the framework conditions, such as time-policy measures. The principal outcome of the project is a model-based integrated understanding of the interrelation between time use and energy use in a city. Time-space-energy scenarios will highlight the potential of time-use structures for energy-use reduction. Several policy measures such as public transport intervals, flexibility of working time, opening hours of public services, spatial planning and infrastructure have changed and will change society's patterns of time use and have an effect on both the economic performance (synergies, production and consumption patterns, income, etc.) and the natural environment (energy flows). The model analyses the decision-finding process of households ac-cording to their energy use (mostly transport and heating energy) using a 'sustainability triangle' in which each corner represents one of the core sustainability dimensions (social / ecological / economic dimension). The developed model will build upon a residential location decision model currently developed for Vienna in the FP 7 project SUME (Sustainable Urban Metabolism in European cities). UTE will make major steps forward extending this simple model with assumptions about time-use requirements of households and time-affecting services and infrastructure in urban areas. This project will be able to provide toy models for three types of urban areas (urban renewal area, new residential area, urban development area). The project's poten-tial for successful application is to develop a decision support tool which can be used by stakeholders of communal administration, urban development and planning bodies in politics and civil society. This tool can trigger and guide time-policy measures of the city's administration and planning processes which integrate time policy, participatory processes and energy saving. The prominent feature of the planned agent-based model is that it can easily be handled by actors outside the scientific community through its user-friendly interface. (...)
    Keywords Energieverbrauch ; Energiebedarf ; Stadtplanung ; Stadtoekonomie ; Szenario ; Energieeinsparung ; Minderungspotenzial ; Oeffentliches Verkehrsmittel ; Oeffentliche Einrichtung ; Raumplanung ; Infrastrukturplanung ; Synergismus ; Waermeenergie ; Grossstadt ; Dienstleistung ; Staedtische Infrastruktur ; Stadtentwicklung ; Stadterneuerung ; Energienutzung ; Gebaeude ; Energietransport ; Energieszenario ; Oeffentliche Dienste ; Nachhaltigkeit ; Entscheidungsmodell ; Konsumverhalten ; Energiebilanz ; Staedtischer Raum ; Wohngebiet ; Interessengruppe ; Stadtplanung und -entwicklung ; Sozialoekologie ; Innenstadt ; Raeumliche Mobilitaet ; Prognosemodell ; Zeitverlauf ; Privathaushalt ; Standortbedingung ; Wohnung ; Verkehrsmobilitaet ; Modellierung ; Handlungsorientierung ; Kausalzusammenhang ; Entscheidungshilfe ; Kommunalpolitik ; Einkommenseffekt ; Einkommensverteilung ; Sozialstruktur ; Integrierte Planungsmethode ; Heizung ; Transportvorgang ; Arbeitsbedingung ; Entscheidungsprozess ; Sozialvertraeglichkeit ; Oekologische Nachhaltigkeit ; Wirtschaftliche Aspekte ; Vergleichsuntersuchung ; Neubau ; Stadtsoziologie ; Wien
    Document type Book
    Remark project start: 09/01/2011 project end: 08/31/2014 grant ID:
    Database Environmental research database (UFORDAT) of the German Federal Environment Agency (UBA)

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  3. Book: Borreliose

    Fischer, Ute / Siegmund, Bernhard

    Zeckeninfektion mit Tarnkappe

    (Erlebnis Gesundheit)

    2021  

    Author's details Ute Fischer (Reinheim), Bernhard Siegmund (Reinheim) ; mit Beirägen von Harald Bennefeld (Bad Elster), Wolfgang Maes (Neuss)
    Series title Erlebnis Gesundheit
    Keywords Lyme-Krankheit
    Subject Lyme-Borreliose ; Erythema-migrans-Krankheit ; Zeckenborreliose ; Borrelia-burgdorferi-Infektion ; Lyme disease
    Language German
    Size 298 Seiten, Illustrationen
    Edition 7. Auflage
    Publisher S. Hirzel Verlag
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    Note Impressum: 7., völlig neu bearbeitete Auflage
    HBZ-ID HT020918708
    ISBN 978-3-7776-2816-5 ; 3-7776-2816-6 ; 978377630311 ; 9783776303117 ; 3776303115
    Database Catalogue ZB MED Medicine, Health

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  4. Book: Borreliose

    Fischer, Ute / Siegmund, Bernhard

    Zeckeninfektion mit Tarnkappe

    2010  

    Author's details Ute Fischer ; Bernhard Siegmund
    Keywords Lyme-Krankheit
    Subject Lyme-Borreliose ; Erythema-migrans-Krankheit ; Zeckenborreliose ; Borrelia-burgdorferi-Infektion ; Lyme disease
    Subject code 616.9246
    Language German
    Size 237 S. : Ill.
    Edition 6., völlig neu bearb. Aufl.
    Publisher Hirzel
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT016485899
    ISBN 978-3-7776-1798-5 ; 3-7776-1798-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
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  5. Book ; Online ; Thesis: Vergleich des Transkriptoms mikrodissezierter Neuroblastome mit fetalen Neuroblasten

    Beutenmüller, Ute Susanne / Fischer, Matthias / Heukamp, Lukas Carl

    2014  

    Institution Klinik und Poliklinik für Kinder- und Jugendmedizin
    Author's details vorgelegt von Ute Susanne Beutenmüller ; 1. Berichterstatter: Professor Dr. med. M. Fischer, 2. Berichterstatter: Privatdozent Dr. med. L. Heukamp ; aus dem Zentrum für Kinder- und Jugendmedizin der Universität zu Köln, Klinik und Poliklinik für Kinder- und Jugendmedizin
    Subject code 610
    Language German
    Size VI, 132 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2014
    HBZ-ID HT018375087
    DOI 10.4126/38m-005759106
    Database Repository for Life Sciences

    Full text online

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  6. Book ; Thesis: Vergleich des Transkriptoms mikrodissezierter Neuroblastome mit fetalen Neuroblasten

    Beutenmüller, Ute Susanne / Fischer, Matthias / Heukamp, Lukas Carl

    2014  

    Institution Klinik und Poliklinik für Kinder- und Jugendmedizin
    Author's details vorgelegt von Ute Susanne Beutenmüller ; 1. Berichterstatter: Professor Dr. med. M. Fischer, 2. Berichterstatter: Privatdozent Dr. med. L. Heukamp ; aus dem Zentrum für Kinder- und Jugendmedizin der Universität zu Köln, Klinik und Poliklinik für Kinder- und Jugendmedizin
    Subject code 610
    Language German
    Size VI, 132 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2014
    HBZ-ID HT018458412
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2014 D 812 order for loan Magazin

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  7. Book: MR-Atlas.com

    Fischer, Wolfgang

    Lehrbuch und Fallsammlung zur MRT des Bewegungsapparates

    2021  

    Author's details Wolfgang Fischer. Unter Mitarbeit von Frank Roemer [und 6 weiteren]
    Keywords Musculoskeletal Diseases / diagnosis ; Magnetic Resonance Imaging ; Magnetresonanztomographie ; Bildgebung ; Radiologie ; Bewegungsapparat ; Krankheit ; Kernspintomografie
    Subject Kernspintomographie ; NMR-Tomographie ; Magnetische Kernresonanztomographie ; MR-Tomographie ; Kernspinresonanztomographie ; MRI ; Magnetic resonance imaging ; IRM ; Magnetresonanztomographie ; Magnetresonanztomografie ; MRT ; NMR-Tomografie ; Nukleare Kernspintomographie ; MR-Bildgebung ; Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos ; Bewegungsorgan ; Stützapparat ; Haltungsapparat
    Subject code 616.707548
    Language German
    Size 756 Seiten, 5614 Illustrationen, 31 cm
    Edition 3. Auflage
    Publisher mr-verlag
    Publishing place Augsburg
    Publishing country Germany
    Document type Book
    HBZ-ID HT020871147
    ISBN 978-3-9816491-5-4 ; 3-9816491-5-X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2021 C 18 on loan 0 Vormerkungen

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  8. Book: Borreliose

    Fischer, Ute / Siegmund, Bernhard

    Zeckeninfektion mit Tarnkappe

    2007  

    Author's details Ute Fischer ; Bernhard Siegmund
    Keywords Lyme-Krankheit
    Subject Lyme-Borreliose ; Erythema-migrans-Krankheit ; Zeckenborreliose ; Borrelia-burgdorferi-Infektion ; Lyme disease
    Subject code 616.9246
    Language German
    Size 190 S. : Ill., graph. Darst.
    Edition 5., völlig neubearb. Aufl.
    Publisher Hirzel
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    Note Literatur- und URL-Verz. S. 177 - 179
    HBZ-ID HT015055631
    ISBN 978-3-7776-1478-6 ; 3-7776-1478-5
    Database Catalogue ZB MED Medicine, Health

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  9. Article ; Online: Exploring Simple Particle-Based Signal Amplification Strategies in a Heterogeneous Sandwich Immunoassay with Optical Detection.

    Geißler, Daniel / Wegner, K David / Fischer, Christin / Resch-Genger, Ute

    Analytical chemistry

    2024  Volume 96, Issue 13, Page(s) 5078–5085

    Abstract: Heterogeneous sandwich immunoassays are widely used for biomarker detection in bioanalysis and medical diagnostics. The high analyte sensitivity of the current "gold standard" enzyme-linked immunosorbent assay (ELISA) originates from the signal- ... ...

    Abstract Heterogeneous sandwich immunoassays are widely used for biomarker detection in bioanalysis and medical diagnostics. The high analyte sensitivity of the current "gold standard" enzyme-linked immunosorbent assay (ELISA) originates from the signal-generating enzymatic amplification step, yielding a high number of optically detectable reporter molecules. For future point-of-care testing (POCT) and point-of-need applications, there is an increasing interest in more simple detection strategies that circumvent time-consuming and temperature-dependent enzymatic reactions. A common concept to aim for detection limits comparable to those of enzymatic amplification reactions is the usage of polymer nanoparticles (NP) stained with a large number of chromophores. We explored different simple NP-based signal amplification strategies for heterogeneous sandwich immunoassays that rely on an extraction-triggered release step of different types of optically detectable reporters. Therefore, streptavidin-functionalized polystyrene particles (PSP) are utilized as carriers for (i) the fluorescent dye coumarin 153 (C153) and (ii) hemin (hem) molecules catalyzing the luminol reaction enabling chemiluminescence (CL) detection. Additionally, (iii) NP labeling with hemin-based microperoxidase MP11 was assessed. For each amplification approach, the PSP was first systematically optimized regarding size, loading concentration, and surface chemistry. Then, for an immunoassay for the inflammation marker C-reactive protein (CRP), the analyte sensitivity achievable with optimized PSP systems was compared with the established ELISA concept for photometric and CL detection. Careful optimization led to a limit of detection (LOD) of 0.1 ng/mL for MP11-labeled PSP and CL detection, performing similarly well to a photometric ELISA (0.13 ng/mL), which demonstrates the huge potential of our novel assay concept.
    MeSH term(s) Hemin ; Immunoassay ; Enzyme-Linked Immunosorbent Assay ; Nanoparticles/chemistry ; Biomarkers
    Chemical Substances Hemin (743LRP9S7N) ; Biomarkers
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c03691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Borreliose

    Fischer, Ute / Siegmund, Bernhard

    Zeckeninfektion mit Tarnkappe

    2003  

    Author's details Ute Fischer ; Bernhard Siegmund
    Keywords Borreliose
    Language German
    Size 160 S. : Ill.
    Edition 2., neu bearb. Aufl.
    Publisher Hirzel
    Publishing place Stuttgart u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT013702228
    ISBN 3-7776-1233-2 ; 978-3-7776-1233-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2003 A 5031 order for loan Magazin

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