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Article: Sudden shortening of the paced AV delay: is this normal pacemaker function?

Pinter, Arnold / Dorian, Paul

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

2015 Volume 23, Issue 2, Page(s) 141–142

Language	English
Publishing date	2015-01-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2211468-3
ISSN	1876-6250 ; 1568-5888 ; 0929-7456
ISSN (online)	1876-6250
ISSN	1568-5888 ; 0929-7456
DOI	10.1007/s12471-014-0644-7
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Article: Sudden shortening of the paced AV delay: is this normal pacemaker function?

Pinter, Arnold / Dorian, Paul

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

2015 Volume 23, Issue 2, Page(s) 147–148

Language	English
Publishing date	2015-01-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2211468-3
ISSN	1876-6250 ; 1568-5888 ; 0929-7456
ISSN (online)	1876-6250
ISSN	1568-5888 ; 0929-7456
DOI	10.1007/s12471-014-0645-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Relationship Between Left Ventricular Strain Assessment by Cardiac Magnetic Resonance Imaging and Response to Cardiac Resynchronization Therapy.

Rathi, Abhishek / Kanee, Lauren / Limoges, Maude / Connelly, Kim A / Jimenez Juan, Laura / Kirpalani, Anish / Angaran, Paul / Pinter, Arnold / Yan, Andrew T / Deva, Djeven P

Journal of thoracic imaging

2022 Volume 37, Issue 4, Page(s) W58–W59

Abstract: Although cardiac resynchronization therapy (CRT) is an established treatment for heart failure with reduced ejection fraction, 30 to 50% patients are non-responders. In this retrospective single-centre study, 19 patients underwent cardiac MRI pre-CRT, ... ...

Abstract	Although cardiac resynchronization therapy (CRT) is an established treatment for heart failure with reduced ejection fraction, 30 to 50% patients are non-responders. In this retrospective single-centre study, 19 patients underwent cardiac MRI pre-CRT, and global left ventricular (LV) strain and late gadolinium enhancement (LGE) were measured by a blinded reader. LV reverse remodeling was independently assessed using transthoracic echocardiogram before and after CRT implant. Both LV strain and extent of LGE correlated significantly with measures of reverse LV remodeling (reduction in LV volume and improvement in LV ejection fraction). These findings suggest that CMR derived strain analysis and scar evaluation may be useful preimplant predictors of response to CRT. Larger prospective multi-center studies are needed to confirm these findings and to further evaluate the role of CMR strain imaging in guiding CRT treatment decisions.
MeSH term(s)	Cardiac Resynchronization Therapy/methods ; Contrast Media ; Gadolinium ; Heart Failure/diagnostic imaging ; Heart Failure/therapy ; Humans ; Magnetic Resonance Imaging ; Prospective Studies ; Retrospective Studies ; Treatment Outcome ; Ventricular Function, Left ; Ventricular Remodeling
Chemical Substances	Contrast Media ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2022-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	632900-7
ISSN	1536-0237 ; 0883-5993
ISSN (online)	1536-0237
ISSN	0883-5993
DOI	10.1097/RTI.0000000000000652
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Zs.A 2187: Show issues

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Article ; Online: Unexpected High Prevalence of Cardiovascular Disease Risk Factors and Psychiatric Disease Among Young People With Sudden Cardiac Arrest.

Allan, Katherine S / Morrison, Laurie J / Pinter, Arnold / Tu, Jack V / Dorian, Paul

Journal of the American Heart Association

2019 Volume 8, Issue 2, Page(s) e010330

Abstract: Background It is believed that most sudden cardiac arrests ( SCA s) in young people occur in previously healthy people with rare risk factors for sudden death. Few studies have investigated large populations with complete ascertainment. Our objective was ...

Abstract	Background It is believed that most sudden cardiac arrests ( SCA s) in young people occur in previously healthy people with rare risk factors for sudden death. Few studies have investigated large populations with complete ascertainment. Our objective was to use multisource records to identify and classify all out-of-hospital cardiac arrests in the Greater Toronto Area (population 6.6 million) in people aged 2 to 45 years from 2009 to 2012. Methods and Results Expert reviewers employed a systematic process, with emergency medical services, in-hospital and coroner records, to adjudicate the cause of death as SCA from cardiac or noncardiac causes. We report the adjudicated etiologies, circumstances, triggers, and characteristics of the SCA cohort. Of 2937 eligible out-of-hospital cardiac arrest cases, 608 (20.7%) SCA s had an adjudicated etiology of cardiac cause (120 survivors and 488 nonsurvivors). Two thirds of these SCA patients had a history of cardiovascular disease, and over 50% had been diagnosed with ≥1 cardiovascular disease risk factor. Moreover, 20.1% of SCA s were diagnosed with psychiatric disease and 30% had central nervous system drugs prescribed. Over 30% of SCA patients had central nervous system active drugs, including drugs of abuse detected postmortem, with opioids and ethanol being detected most frequently. Potentially heritable structural cardiac diseases accounted for only 6.9% of SCA events, with acquired cardiac diseases comprising the rest. Conclusions The underlying causes of SCA , in people aged 2 to 45 years, often occur in those with previously diagnosed cardiovascular diseases, and are associated with contributory factors including prescribed medications, recreational drugs, and a concomitant psychiatric history.
MeSH term(s)	Adolescent ; Adult ; Cardiopulmonary Resuscitation/methods ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/epidemiology ; Child ; Child, Preschool ; Emergency Medical Services/methods ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Mental Disorders/complications ; Mental Disorders/epidemiology ; Middle Aged ; Ontario/epidemiology ; Out-of-Hospital Cardiac Arrest/epidemiology ; Out-of-Hospital Cardiac Arrest/etiology ; Out-of-Hospital Cardiac Arrest/therapy ; Prevalence ; Retrospective Studies ; Risk Assessment/methods ; Risk Factors ; Survival Rate/trends ; Young Adult
Language	English
Publishing date	2019-01-19
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.118.010330
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Article ; Online: Microvolt QRS Alternans Without Microvolt T-Wave Alternans in Human Cardiomyopathy: A Novel Risk Marker of Late Ventricular Arrhythmias.

Suszko, Adrian / Nayyar, Sachin / Labos, Christopher / Nanthakumar, Kumaraswamy / Pinter, Arnold / Crystal, Eugene / Chauhan, Vijay S

Journal of the American Heart Association

2020 Volume 9, Issue 17, Page(s) e016461

Abstract: Background Action potential alternans can induce ventricular tachyarrhythmias and manifest on the surface ECG as T-wave alternans (TWA) and QRS alternans (QRSA). We sought to evaluate microvolt QRSA in cardiomyopathy patients in relation to TWA and ... ...

Abstract	Background Action potential alternans can induce ventricular tachyarrhythmias and manifest on the surface ECG as T-wave alternans (TWA) and QRS alternans (QRSA). We sought to evaluate microvolt QRSA in cardiomyopathy patients in relation to TWA and ventricular tachyarrhythmia outcomes. Methods and Results Prospectively enrolled cardiomyopathy patients (n=100) with prophylactic defibrillators had 12-lead ECGs recorded during ventricular pacing from 100 to 120 beats/min. QRSA and TWA were quantified in moving 128-beat segments using the spectral method. Segments were categorized as QRSA positive (QRSA+) and/or TWA positive (TWA+) based on ≥2 precordial leads having alternans magnitude >0 and signal:noise >3. Patients were similarly categorized based on having ≥3 consecutive segments with alternans. TWA+ and QRSA+ occurred together in 31% of patients and alone in 18% and 14% of patients, respectively. Although TWA magnitude (1.4±0.4 versus 4.7±1.0 µV,
MeSH term(s)	Aged ; Algorithms ; Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/physiopathology ; Arrhythmias, Cardiac/prevention & control ; Canada/epidemiology ; Cardiomyopathies/complications ; Cardiomyopathies/physiopathology ; Cardiomyopathies/therapy ; Case-Control Studies ; Defibrillators, Implantable/adverse effects ; Electrocardiography/methods ; Female ; Heart Ventricles/pathology ; Heart Ventricles/physiopathology ; Humans ; Male ; Middle Aged ; Noise/adverse effects ; Prospective Studies ; Risk Factors ; Tachycardia, Ventricular/etiology ; Tachycardia, Ventricular/physiopathology ; Tachycardia, Ventricular/prevention & control
Language	English
Publishing date	2020-08-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.119.016461
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Device therapy: Who may and who may not benefit from an ICD?

Pinter, Arnold / Dorian, Paul

Nature reviews. Cardiology

2010 Volume 8, Issue 1, Page(s) 10–12

MeSH term(s)	Arrhythmias, Cardiac/complications ; Arrhythmias, Cardiac/mortality ; Arrhythmias, Cardiac/therapy ; Clinical Trials as Topic ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Defibrillators, Implantable ; Electric Countershock/instrumentation ; Evidence-Based Medicine ; Humans ; Patient Selection ; Registries ; Risk Assessment ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2010-11-16
Publishing country	England
Document type	News
ZDB-ID	2490375-9
ISSN	1759-5010 ; 1759-5002
ISSN (online)	1759-5010
ISSN	1759-5002
DOI	10.1038/nrcardio.2010.183
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Zs.A 6019: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 98: Show issues

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Article ; Online: Pseudo-ventricular tachycardia mimicking malignant arrhythmia in a patient with rapid atrial fibrillation.

Barake, Walid / Baranchuk, Adrian / Pinter, Arnold

American journal of critical care : an official publication, American Association of Critical-Care Nurses

2014 Volume 23, Issue 3, Page(s) 270–272

Abstract: Artifacts can simulate arrhythmias such as atrial flutter, atrial fibrillation, and ventricular tachycardia. A case of pseudo-ventricular tachycardia is outlined in a patient with newly diagnosed atrial fibrillation, which made the diagnosis a special ... ...

Abstract	Artifacts can simulate arrhythmias such as atrial flutter, atrial fibrillation, and ventricular tachycardia. A case of pseudo-ventricular tachycardia is outlined in a patient with newly diagnosed atrial fibrillation, which made the diagnosis a special challenge. Characteristic signs of pseudo-ventricular tachycardia are described. This case reinforces the importance of recognizing artifacts to avoid unnecessary interventions, especially in the telemetry and critical care units.
MeSH term(s)	Adrenergic beta-1 Receptor Antagonists/therapeutic use ; Artifacts ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Bisoprolol/therapeutic use ; Diagnosis, Differential ; Diagnostic Errors ; Electrocardiography ; Factor Xa Inhibitors/therapeutic use ; Humans ; Male ; Middle Aged ; Morpholines/therapeutic use ; Rivaroxaban ; Tachycardia, Ventricular/complications ; Tachycardia, Ventricular/diagnosis ; Tachycardia, Ventricular/drug therapy ; Thiophenes/therapeutic use ; Treatment Outcome ; Unnecessary Procedures
Chemical Substances	Adrenergic beta-1 Receptor Antagonists ; Factor Xa Inhibitors ; Morpholines ; Thiophenes ; Rivaroxaban (9NDF7JZ4M3) ; Bisoprolol (Y41JS2NL6U)
Language	English
Publishing date	2014-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1130987-8
ISSN	1937-710X ; 1062-3264
ISSN (online)	1937-710X
ISSN	1062-3264
DOI	10.4037/ajcc2014150
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Zs.A 3502: Show issues

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Article ; Online: Advances in Antiarrhythmic Drug Therapy: New and Emerging Therapies.

Pinter, Arnold / Dorian, Paul

Cardiac electrophysiology clinics

2010 Volume 2, Issue 3, Page(s) 471–478

Abstract: Despite major advances in the nonpharmacologic therapy for arrhythmias in the past decades, there is still a substantial role for antiarrhythmic drugs especially in the treatment of atrial fibrillation and ventricular tachycardia, the most effective of ... ...

Abstract	Despite major advances in the nonpharmacologic therapy for arrhythmias in the past decades, there is still a substantial role for antiarrhythmic drugs especially in the treatment of atrial fibrillation and ventricular tachycardia, the most effective of which is amiodarone. Dronedarone has been developed by modifying the amiodarone molecule, thus retaining its multichannel blocking action while still reducing its toxicity. New potassium channel blockers such as vernakalant are currently under development for the treatment of atrial fibrillation and flutter. So-called upstream therapies such as renin-angiotension system antagonists, statins, and n-3 polyunsaturated fatty acids offer promise for the treatment of antiarrhythmia. This article reviews dronedarone, which is already approved and available; antiarrhythmic agents that are the most advanced in development; and upstream therapy for atrial fibrillation.
Language	English
Publishing date	2010-09
Publishing country	United States
Document type	Journal Article
ISSN	1877-9190
ISSN (online)	1877-9190
DOI	10.1016/j.ccep.2010.06.005
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Article ; Online: Lack of difference in T wave variability between patients at risk of sudden cardiac death and healthy subjects.

Levitt, Kevin / Aves, Theresa / Dorian, Paul / Pinter, Arnold

Journal of electrocardiology

2014 Volume 47, Issue 2, Page(s) 251–256

Abstract: Background: T wave variability (Tvar) is a proposed method to predict sudden cardiac death (SCD). The purpose of this trial was to evaluate the reproducibility of Tvar measurements over time and demonstrate a difference in Tvar between patient ... ...

Abstract	Background: T wave variability (Tvar) is a proposed method to predict sudden cardiac death (SCD). The purpose of this trial was to evaluate the reproducibility of Tvar measurements over time and demonstrate a difference in Tvar between patient populations at risk for ventricular arrhythmias and healthy subjects. Methods: Sixty subjects were enrolled in into 3 groups: healthy subjects (Population I), patients at high risk of SCD (Population II), and patients with a recent ventricular tachyarrhythmia event (Population III). Recording and analysis of T wave amplitude variance (TAV) as a measure of Tvar was performed at baseline and 3 months. Results: TAV could not be interpreted in 12 of 43 patients in Populations II and III due to PVCs or noise. No subject had a TAV value suggestive of high risk of SCD as per a previously defined cutoff of >59 μV. Median (range) values of TAV in μV at baseline for Populations I, II and III were 26 (15-39), 21 (13-43), and 24 (18-41), respectively (p = 0.39). TAV was reproducible within population's from baseline to 3 months (p = 0.27, 0.53, 0.17 for Populations I, II and III, respectively). There was no significant difference between TAV values of high risk patients and healthy subjects. Conclusion: Tvar was reproducible primarily in patients with left ventricular dysfunction. However, the role of Tvar as a risk stratifying tool remains inconclusive.
MeSH term(s)	Adult ; Case-Control Studies ; Death, Sudden, Cardiac ; Electrocardiography ; Electrocardiography, Ambulatory ; Female ; Heart Conduction System/physiopathology ; Humans ; Male ; Middle Aged ; Reproducibility of Results ; Risk Assessment ; Risk Factors
Language	English
Publishing date	2014-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	410286-1
ISSN	1532-8430 ; 0022-0736
ISSN (online)	1532-8430
ISSN	0022-0736
DOI	10.1016/j.jelectrocard.2013.12.007
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Zs.A 701: Show issues

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Article ; Online: New approaches to atrial fibrillation management: treat the patient, not the ECG.

Pinter, Arnold / Dorian, Paul

Cardiovascular therapeutics

2010 Volume 28, Issue 5, Page(s) 302–310

Abstract: Atrial fibrillation causes a significant burden on patients and the health care system. The main goals of atrial fibrillation therapy are to improve symptoms and reduce morbidity. There have been significant recent developments in both stoke prophylaxis ... ...

Abstract	Atrial fibrillation causes a significant burden on patients and the health care system. The main goals of atrial fibrillation therapy are to improve symptoms and reduce morbidity. There have been significant recent developments in both stoke prophylaxis and rhythm/rate control. The results of the ACTIVE W study emphasize the importance of effective oral anticoagulant therapy in patients with moderate-to-high risk for stroke. The RE-LY study showed superiority of dabigatran, an oral direct thrombin inhibitor, over warfarin in the prevention of stroke, or systemic embolism. Dronedarone, a new antiarrhythmic drug with multiple class effects, has been recently approved by the US Food and Drug Administration for the treatment of atrial fibrillation. Dronedarone has moderate rhythm and rate control efficacy; however, dronedarone significantly reduced cardiovascular hospitalization, cardiovascular death, and stroke in the large ATHENA trial. There is also an important shift in the paradigm of the goals of atrial fibrillation therapy. Instead of focusing solely on the electrocardiographic outcomes of treatment and considering "rhythm versus rate control," one needs to consider "symptom control" as well as patient well-being. This review will suggest that patient based outcomes rather than ECG-based outcomes should be the primary goals of treatment. Original reports and reviews on specific topics were identified through Medline. Randomized controlled trials were selected as the primary source of information. Analysis included critical review of the evidence available to date.
MeSH term(s)	Anti-Arrhythmia Agents/therapeutic use ; Anticoagulants/therapeutic use ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/therapy ; Catheter Ablation ; Electrocardiography ; Humans ; Predictive Value of Tests ; Stroke/etiology ; Stroke/prevention & control ; Treatment Outcome
Chemical Substances	Anti-Arrhythmia Agents ; Anticoagulants
Language	English
Publishing date	2010-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2428378-2
ISSN	1755-5922 ; 1755-5914
ISSN (online)	1755-5922
ISSN	1755-5914
DOI	10.1111/j.1755-5922.2010.00135.x
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