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  1. Article ; Online: Effects of esaxerenone, a nonsteroidal mineralocorticoid receptor blocker, independent of urinary sodium/potassium ratio and salt intake.

    Morimoto, Satoshi / Ichihara, Atsuhiro

    Hypertension research : official journal of the Japanese Society of Hypertension

    2024  Volume 47, Issue 4, Page(s) 970–971

    MeSH term(s) Humans ; Antihypertensive Agents/therapeutic use ; Sodium Chloride, Dietary ; Receptors, Mineralocorticoid ; Hypertension/physiopathology ; Potassium ; Sodium ; Pyrroles ; Sulfones
    Chemical Substances Antihypertensive Agents ; Sodium Chloride, Dietary ; esaxerenone (N62TGJ04A1) ; Receptors, Mineralocorticoid ; Potassium (RWP5GA015D) ; Sodium (9NEZ333N27) ; Pyrroles ; Sulfones
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-024-01579-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3898: Show issues Location:
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  2. Article ; Online: Late age at menopause positively associated with obesity-mediated hypertension.

    Morimoto, Satoshi / Ichihara, Atsuhiro

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 5, Page(s) 1163–1164

    MeSH term(s) Female ; Humans ; Blood Pressure ; Obesity/complications ; Obesity/physiopathology ; Menopause/physiology ; Hypertension/etiology
    Language English
    Publishing date 2023-02-28
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01237-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Lowering of blood pressure by chemical ablation of the unilateral adrenal gland in spontaneously hypertensive rats.

    Morimoto, Satoshi / Ichihara, Atsuhiro

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 47, Issue 2, Page(s) 551–552

    MeSH term(s) Rats ; Animals ; Blood Pressure ; Rats, Inbred SHR ; Adrenal Glands ; Hyperaldosteronism/surgery
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01515-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Preeclampsia up to date-What's going on?

    Bokuda, Kanako / Ichihara, Atsuhiro

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 8, Page(s) 1900–1907

    Abstract: Preeclampsia is a hypertensive disorder in pregnancy characterized by placental malperfusion and subsequent multi-organ injury. It accounts for approximately 14% of maternal deaths and 10-25% of perinatal deaths globally. In addition, preeclampsia has ... ...

    Abstract Preeclampsia is a hypertensive disorder in pregnancy characterized by placental malperfusion and subsequent multi-organ injury. It accounts for approximately 14% of maternal deaths and 10-25% of perinatal deaths globally. In addition, preeclampsia has been attracting attentions for its association with risks for developing chronic diseases in later life for both mother and child. This mini-review discusses on latest knowledge on prediction, prevention, management, and long-term outcomes of preeclampsia and also touches on association between COVID-19 and preeclampsia. HTN hypertension, HDP hypertensive disorders of pregnancy, PE preeclampsia, BP blood pressure, cfDNA cell-free DNA, ST2 human suppression of tumorigenesis 2, sFlt-1 soluble fms-like tyrosine kinase-1, PIGF placental growth factor, VEGF vascular endothelial growth factor, VEGFR VEGF receptor, TGFβ transforming growth factor β, ENG endoglin, sENG soluble ENG, PRES posterior reversible encephalopathy syndrome, AKI acute kidney injury, CVD cardiovascular disease, ESKD end-stage kidney disease, ACE angiotensinogen converting enzyme, Ang angiotensin.
    MeSH term(s) Female ; Humans ; Pregnancy ; Biomarkers ; COVID-19/metabolism ; Endoglin/metabolism ; Hypertension/metabolism ; Placenta/metabolism ; Placenta Growth Factor ; Posterior Leukoencephalopathy Syndrome ; Pre-Eclampsia ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor Receptor-1
    Chemical Substances Biomarkers ; Endoglin ; Placenta Growth Factor (144589-93-5) ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1)
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Journal Article ; Review ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01323-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Prediction of endogenous mineralocorticoid receptor activity by depressor effects of mineralocorticoid receptor antagonists in patients with primary aldosteronism.

    Ikemoto, Makiko / Morimoto, Satoshi / Ichihara, Atsuhiro

    Hypertension research : official journal of the Japanese Society of Hypertension

    2024  

    Abstract: Patients with primary aldosteronism have an increased risk of developing cardiovascular disease. The response to mineralocorticoid receptor antagonists varies among individuals, indicating diverse mineralocorticoid receptor activities in these patients. ... ...

    Abstract Patients with primary aldosteronism have an increased risk of developing cardiovascular disease. The response to mineralocorticoid receptor antagonists varies among individuals, indicating diverse mineralocorticoid receptor activities in these patients. This study explored the factors linked to the efficacy of blood pressure reduction through mineralocorticoid receptor antagonists in patients with primary aldosteronism. We examined the relationship between the reduction in blood pressure and patient characteristics in a group of 41 patients with primary aldosteronism (24 males, mean age 55 ± 13 years, including 34 patients diagnosed with bilateral primary aldosteronism) before and after undergoing treatment with mineralocorticoid receptor antagonists. Significant reductions in office blood pressure were observed 3 and 6 months after treatment initiation. Single correlation analyses showed that the urinary chloride-to-potassium ratio displayed the strongest positive association with blood pressure reduction, surpassing plasma aldosterone concentration, plasma renin activity, and urinary sodium-to-potassium ratio, at 3 and 6 months. Multiple correlation analyses revealed a consistent and independent positive correlation between the urinary chloride-to-potassium ratio and blood pressure reduction at 3 and 6 months. The optimal threshold for the urinary chloride-to-potassium ratio with respect to its ability to lower blood pressure, was determined as 3.18. These results imply that the urinary chloride-to-potassium ratio may be independently associated with the effectiveness of blood pressure reduction facilitated by mineralocorticoid receptor antagonists. Moreover, it could potentially serve as a valuable predictor of the effectiveness of these agents and function as an indicator of endogenous mineralocorticoid receptor activity in patients with primary aldosteronism.
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-024-01651-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Assessment of cardiovascular disease risk by plasma renin activity changes in patients with primary aldosteronism on mineralocorticoid receptor antagonist treatment.

    Morimoto, Satoshi / Ichihara, Atsuhiro

    Hypertension research : official journal of the Japanese Society of Hypertension

    2022  Volume 45, Issue 9, Page(s) 1517–1519

    MeSH term(s) Aldosterone/blood ; Cardiovascular Diseases/etiology ; Humans ; Hyperaldosteronism/blood ; Mineralocorticoid Receptor Antagonists/pharmacology ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Renin/blood
    Chemical Substances Mineralocorticoid Receptor Antagonists ; Aldosterone (4964P6T9RB) ; Renin (EC 3.4.23.15)
    Language English
    Publishing date 2022-07-14
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-022-00979-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Tight control of blood pressure in pregnant women with nonsevere hypertension: expectations for decreasing adverse maternal and fetal pregnancy outcomes.

    Ohkuchi, Akihide / Ichihara, Atsuhiro

    Hypertension research : official journal of the Japanese Society of Hypertension

    2022  Volume 45, Issue 5, Page(s) 926–928

    MeSH term(s) Blood Pressure/physiology ; Female ; Humans ; Hypertension, Pregnancy-Induced ; Motivation ; Pregnancy ; Pregnancy Outcome ; Pregnant Women
    Language English
    Publishing date 2022-02-25
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-022-00881-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Association between overweight and growth hormone secretion in patients with non-functioning pituitary tumors.

    Seki, Yasufumi / Ichihara, Atsuhiro

    PloS one

    2022  Volume 17, Issue 4, Page(s) e0267324

    Abstract: Introduction: Growth hormone (GH) deficiency (GHD) is often complicated by non-functioning pituitary tumors (NFPTs); however, its prevalence remains unclear because preoperative screening for GHD with provocative tests is not recommended. Accordingly, ... ...

    Abstract Introduction: Growth hormone (GH) deficiency (GHD) is often complicated by non-functioning pituitary tumors (NFPTs); however, its prevalence remains unclear because preoperative screening for GHD with provocative tests is not recommended. Accordingly, we attempted to clarify the characteristics of GHD in unoperated patients with NFPT.
    Materials and methods: We retrospectively reviewed adult patients with non-functioning pituitary adenoma (NFPA) and Rathke's cyst who underwent preoperative GH-releasing peptide-2 (GHRP-2) tests from January 2013 to December 2016. We investigated the association between peak GH response to GHRP-2 and background characteristics.
    Results: Among 104 patients (85 NFPA and 19 Rathke's cysts), 45 (43%) presented severe GHD, as diagnosed using GHRP-2 tests. Body mass index (β = -0.210, P = 0.007), free thyroxine (β = 0.440, P < 0.001), and tumor height (β = -0.254, P < 0.001) were significant variables for determining the peak GH response to GHRP-2 in multiple regression analyses. Overweight (odds ratio, 3.86; 95% confidence interval, 1.02-14.66) was significantly associated with severe GHD after adjustment for age, sex, creatinine, free thyroxine, tumor height and clinical diagnosis. The regression slopes between tumor height and peak GH response to GHRP-2 significantly differed between overweight patients and non-overweight individuals, as determined by analysis of covariance (P = 0.040). In the 48 patients who underwent postoperative GHRP-2 tests, severe postoperative GHD was significantly more common in overweight patients than non-overweight individuals (100% vs. 48%, P < 0.001).
    Conclusion: We observed a negative synergistic effect between overweight and tumor size on GH secretion in patients with NFPTs, indicating that GH provocation tests for diagnosing underestimated GHD could be considered in overweight unoperated patients with large NFPTs.
    MeSH term(s) Adult ; Growth Hormone ; Growth Hormone-Releasing Hormone ; Human Growth Hormone ; Humans ; Overweight/complications ; Pituitary Neoplasms/complications ; Pituitary Neoplasms/diagnosis ; Pituitary Neoplasms/surgery ; Retrospective Studies ; Thyroxine
    Chemical Substances Human Growth Hormone (12629-01-5) ; Growth Hormone (9002-72-6) ; Growth Hormone-Releasing Hormone (9034-39-3) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0267324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Association between overweight and growth hormone secretion in patients with non-functioning pituitary tumors.

    Yasufumi Seki / Atsuhiro Ichihara

    PLoS ONE, Vol 17, Iss 4, p e

    2022  Volume 0267324

    Abstract: Introduction Growth hormone (GH) deficiency (GHD) is often complicated by non-functioning pituitary tumors (NFPTs); however, its prevalence remains unclear because preoperative screening for GHD with provocative tests is not recommended. Accordingly, we ... ...

    Abstract Introduction Growth hormone (GH) deficiency (GHD) is often complicated by non-functioning pituitary tumors (NFPTs); however, its prevalence remains unclear because preoperative screening for GHD with provocative tests is not recommended. Accordingly, we attempted to clarify the characteristics of GHD in unoperated patients with NFPT. Materials and methods We retrospectively reviewed adult patients with non-functioning pituitary adenoma (NFPA) and Rathke's cyst who underwent preoperative GH-releasing peptide-2 (GHRP-2) tests from January 2013 to December 2016. We investigated the association between peak GH response to GHRP-2 and background characteristics. Results Among 104 patients (85 NFPA and 19 Rathke's cysts), 45 (43%) presented severe GHD, as diagnosed using GHRP-2 tests. Body mass index (β = -0.210, P = 0.007), free thyroxine (β = 0.440, P < 0.001), and tumor height (β = -0.254, P < 0.001) were significant variables for determining the peak GH response to GHRP-2 in multiple regression analyses. Overweight (odds ratio, 3.86; 95% confidence interval, 1.02-14.66) was significantly associated with severe GHD after adjustment for age, sex, creatinine, free thyroxine, tumor height and clinical diagnosis. The regression slopes between tumor height and peak GH response to GHRP-2 significantly differed between overweight patients and non-overweight individuals, as determined by analysis of covariance (P = 0.040). In the 48 patients who underwent postoperative GHRP-2 tests, severe postoperative GHD was significantly more common in overweight patients than non-overweight individuals (100% vs. 48%, P < 0.001). Conclusion We observed a negative synergistic effect between overweight and tumor size on GH secretion in patients with NFPTs, indicating that GH provocation tests for diagnosing underestimated GHD could be considered in overweight unoperated patients with large NFPTs.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Efficacy of esaxerenone-a nonsteroidal mineralocorticoid receptor blocker-on nocturnal hypertension.

    Morimoto, Satoshi / Ichihara, Atsuhiro

    Hypertension research : official journal of the Japanese Society of Hypertension

    2021  Volume 45, Issue 2, Page(s) 376–377

    MeSH term(s) Humans ; Hypertension/drug therapy ; Pyrroles ; Receptors, Mineralocorticoid ; Sulfones
    Chemical Substances Pyrroles ; Receptors, Mineralocorticoid ; Sulfones ; esaxerenone (N62TGJ04A1)
    Language English
    Publishing date 2021-11-26
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-021-00803-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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