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  1. Article ; Online: Economic evaluation of a new blood pressure target for hypertensive patients in Taiwan.

    Minegishi, Shintaro / Nishiyama, Akira

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 3, Page(s) 784–786

    MeSH term(s) Humans ; Blood Pressure ; Cost-Benefit Analysis ; Taiwan ; Hypertension/physiopathology ; Cardiovascular Diseases ; Cardiology
    Language English
    Publishing date 2023-01-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-022-01125-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3898: Show issues Location:
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  2. Article ; Online: Inhibiting SGLTs diminishes sympathetic output by reducing rostral ventrolateral medulla (RVLM) neuron activity.

    Rahman, Asadur / Nishiyama, Akira

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 47, Issue 2, Page(s) 571–572

    MeSH term(s) Rats ; Animals ; Rats, Wistar ; Sodium-Glucose Transporter 2 ; Neurons ; Blood Pressure/physiology
    Chemical Substances Sodium-Glucose Transporter 2
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01522-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3898: Show issues Location:
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  3. Article: Possible renoprotective mechanisms of SGLT2 inhibitors.

    Nishiyama, Akira / Kitada, Kento

    Frontiers in medicine

    2023  Volume 10, Page(s) 1115413

    Abstract: Treatment with a sodium glucose cotransporter 2 (SGLT2) inhibitor in patients with chronic kidney disease reduces the renal risk independent of changes in blood glucose concentrations and blood pressure. However, the precise mechanism responsible for ... ...

    Abstract Treatment with a sodium glucose cotransporter 2 (SGLT2) inhibitor in patients with chronic kidney disease reduces the renal risk independent of changes in blood glucose concentrations and blood pressure. However, the precise mechanism responsible for this SGLT2 inhibitor-induced renoprotective effect is unclear. We have previously shown that SGLT2 inhibitors induce antihypertensive effects with decreased sympathetic nerve activity, which is associated with transient natriuresis. Furthermore, treatment with an SGLT2 inhibitor improves renal ischemia by producing vascular endothelial growth factor-a in the renal tubules. Other studies have suggested that ketone body production, changes in glomerular hemodynamics, and intrarenal metabolic changes and a reduction in oxidative stress due to decreased tubulointerstitial glucose levels may also be involved in the renoprotective effects of SGLT2 inhibitors. In this review, we summarize the mechanism responsible for the SGLT2 inhibitor-induced renoprotective effects, including our recent hypothesis regarding an "aestivation-like response," which is a biological defense response to starvation.
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1115413
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  4. Article ; Online: Potential Role of the Skin in Hypertension Risk Through Water Conservation.

    Kitada, Kento / Nishiyama, Akira

    Hypertension (Dallas, Tex. : 1979)

    2023  Volume 81, Issue 3, Page(s) 468–475

    Abstract: Previous basic and clinical investigations have identified various pathogenic factors and determinants of risk that contribute to hypertension. Nevertheless, the pathogenesis of hypertension has not been fully elucidated. Moreover, despite the ... ...

    Abstract Previous basic and clinical investigations have identified various pathogenic factors and determinants of risk that contribute to hypertension. Nevertheless, the pathogenesis of hypertension has not been fully elucidated. Moreover, despite the availability of antihypertensive medications for the management of blood pressure, treatments that address the full spectrum of the pathophysiological defects underpinning hypertension remain to be identified. To further investigate the mechanisms of primary hypertension, it is imperative to consider novel potential aspects, such as fluid management by the skin, in addition to the conventional risk factors. There is a close association between body fluid regulation and blood pressure, and the kidney, which, as the principal organ responsible for body fluid homeostasis, is the primary target for research in the field of hypertension. In addition, the skin functions as a biological barrier, potentially contributing to body fluid regulation. In this review, we propose the hypothesis that changes in skin water conservation are associated with hypertension risk based on recent findings. Further studies are required to clarify whether this novel hypothesis is limited to specific hypertension or applies to physiological blood pressure regulation.
    MeSH term(s) Humans ; Conservation of Water Resources ; Hypertension/epidemiology ; Hypertension/etiology ; Hypertension/drug therapy ; Blood Pressure/physiology ; Antihypertensive Agents/therapeutic use ; Antihypertensive Agents/pharmacology ; Kidney
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.20700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1488: Show issues Location:
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  5. Article ; Online: Revisiting blood pressure and body fluid status.

    Kitada, Kento / Nishiyama, Akira

    Clinical science (London, England : 1979)

    2023  Volume 137, Issue 9, Page(s) 755–767

    Abstract: Homeostasis of body fluid is a key component for maintaining health. An imbalance of body sodium and water causes various pathological states, such as dehydration, volume overload, hypertension, cardiovascular and renal diseases, and metabolic disorders. ...

    Abstract Homeostasis of body fluid is a key component for maintaining health. An imbalance of body sodium and water causes various pathological states, such as dehydration, volume overload, hypertension, cardiovascular and renal diseases, and metabolic disorders. Conventional concepts regarding physiology and pathophysiology of body sodium and water balance have been established by several assumptions. These assumptions are that the kidneys are the master regulator of body sodium and water content, and that sodium moves inside the body in parallel with water. However, recent clinical and basic studies have proposed alternative concepts. These concepts are that body sodium and water balance are regulated by various organs and multiple factors, such as physical activity and the environment, and that sodium accumulates locally in tissues independently of the blood status and/or water. Various concerns remain unclear, and the regulatory mechanism of body sodium, fluid, and blood pressure needs to be readdressed. In the present review article, we discuss novel concepts regarding the regulation of body sodium, water, and blood pressure with a particular focus on the systemic water conservation system and fluid loss-triggered elevation in blood pressure.
    MeSH term(s) Humans ; Blood Pressure/physiology ; Hypertension ; Sodium/metabolism ; Body Fluids/metabolism ; Water
    Chemical Substances Sodium (9NEZ333N27) ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-05-17
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20220500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Future Prospects of Onco-Hypertension.

    Minegishi, Shintaro / Nishiyama, Akira / Yano, Yuichiro / Node, Koichi

    Hypertension (Dallas, Tex. : 1979)

    2023  Volume 80, Issue 7, Page(s) e123–e124

    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Letter
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.21011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Possible renoprotective mechanisms of SGLT2 inhibitors

    Akira Nishiyama / Kento Kitada

    Frontiers in Medicine, Vol

    2023  Volume 10

    Abstract: Treatment with a sodium glucose cotransporter 2 (SGLT2) inhibitor in patients with chronic kidney disease reduces the renal risk independent of changes in blood glucose concentrations and blood pressure. However, the precise mechanism responsible for ... ...

    Abstract Treatment with a sodium glucose cotransporter 2 (SGLT2) inhibitor in patients with chronic kidney disease reduces the renal risk independent of changes in blood glucose concentrations and blood pressure. However, the precise mechanism responsible for this SGLT2 inhibitor-induced renoprotective effect is unclear. We have previously shown that SGLT2 inhibitors induce antihypertensive effects with decreased sympathetic nerve activity, which is associated with transient natriuresis. Furthermore, treatment with an SGLT2 inhibitor improves renal ischemia by producing vascular endothelial growth factor-a in the renal tubules. Other studies have suggested that ketone body production, changes in glomerular hemodynamics, and intrarenal metabolic changes and a reduction in oxidative stress due to decreased tubulointerstitial glucose levels may also be involved in the renoprotective effects of SGLT2 inhibitors. In this review, we summarize the mechanism responsible for the SGLT2 inhibitor-induced renoprotective effects, including our recent hypothesis regarding an “aestivation-like response,” which is a biological defense response to starvation.
    Keywords SGLT2 inhibitor ; chronic kidney disease (CKD) ; diabetic kidney disease (DKD) ; renal function ; metabolism ; aestivation-like response ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Blood pressure control with renin-angiotensin system inhibitors in hypertension patients with cancer - good or bad?

    Kidoguchi, Satoshi / Nishiyama, Akira

    Hypertension research : official journal of the Japanese Society of Hypertension

    2022  Volume 46, Issue 2, Page(s) 529–531

    MeSH term(s) Humans ; Blood Pressure/drug effects ; Renin-Angiotensin System/drug effects ; Electronic Health Records ; Retrospective Studies ; Antihypertensive Agents/therapeutic use ; Antihypertensive Agents/pharmacology ; Hypertension/complications ; Hypertension/drug therapy ; Hypertension/physiopathology ; Neoplasms/complications ; Neoplasms/drug therapy
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-022-01110-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3898: Show issues Location:
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  9. Article ; Online: Pathophysiological mechanisms of mineralocorticoid receptor-dependent cardiovascular and chronic kidney disease.

    Nishiyama, Akira

    Hypertension research : official journal of the Japanese Society of Hypertension

    2018  Volume 42, Issue 3, Page(s) 293–300

    Abstract: Accumulating evidence has indicated the potential contributions of aldosterone and mineralocorticoid receptor (MR) to the pathophysiology of cardiovascular disease (CVD) and chronic kidney disease (CKD). Patients with primary aldosteronism have a higher ... ...

    Abstract Accumulating evidence has indicated the potential contributions of aldosterone and mineralocorticoid receptor (MR) to the pathophysiology of cardiovascular disease (CVD) and chronic kidney disease (CKD). Patients with primary aldosteronism have a higher risk of CVD and CKD than those with essential hypertension. MR is strongly expressed in endothelial cells, vascular smooth muscle cells, cardiomyocytes, fibroblasts, macrophages, glomerular mesangial cells, podocytes, and proximal tubular cells. In these cardiovascular and renal cells, aldosterone-induced cell injury is prevented by MR blockade. Interestingly, MR antagonists elicit beneficial effects on CVD and CKD in subjects with low or normal plasma aldosterone levels. Recent studies have shown that during development of CVD and CKD, cardiovascular and renal MR is activated by glucocorticoid and ligand-independent mechanisms, such as Rac1 signaling pathways. These data indicate that inappropriate activation of local MR contributes to cardiovascular and renal tissue injury through aldosterone-dependent and -independent mechanisms. In this review, recent findings on the specific role of cardiovascular and renal MR in the pathogenesis of CVD and CKD are summarized.
    MeSH term(s) Animals ; Cardiovascular Diseases/physiopathology ; Humans ; Hyperaldosteronism/physiopathology ; Receptors, Mineralocorticoid ; Renal Insufficiency, Chronic/physiopathology
    Chemical Substances Receptors, Mineralocorticoid
    Language English
    Publishing date 2018-12-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-018-0158-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Renin-Angiotensin-Aldosterone System in Metabolic Diseases and Other Pathologies.

    Ortiz, Rudy M / Satou, Ryousuke / Zhuo, Jia L / Nishiyama, Akira

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: It has been our pleasure to have been able to develop two special issues within the International Journal of Molecular Sciences: ...

    Abstract It has been our pleasure to have been able to develop two special issues within the International Journal of Molecular Sciences:
    MeSH term(s) Humans ; Renin-Angiotensin System ; Metabolic Diseases ; Aldosterone ; Renin/metabolism ; Angiotensin II/metabolism
    Chemical Substances Aldosterone (4964P6T9RB) ; Renin (EC 3.4.23.15) ; Angiotensin II (11128-99-7)
    Language English
    Publishing date 2023-04-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24087413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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