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  1. Article ; Online: The Polypill at 20 - What Have We Learned?

    Wang, Thomas J

    The New England journal of medicine

    2022  Volume 387, Issue 11, Page(s) 1034–1036

    MeSH term(s) Antihypertensive Agents/therapeutic use ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/prevention & control ; Drug Combinations ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Medication Adherence
    Chemical Substances Antihypertensive Agents ; Drug Combinations ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2210020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer

    Wang, Zhefang / Bruns, Christiane / Zander, Thomas

    2020  

    Institution Klinik und Poliklinik für Allgemein-, Viszeral- und Tumorchirurgie
    Author's details vorgelegt von Zhefang Wang ; 1. Gutachterin oder Gutachter: Universitätsprofessorin Dr. med. C.J. Bruns, 2. Gutachterin oder Gutachter: Privatdozent Dr. med. Th. Zander ; aus dem Zentrum für Operative Medizin der Universität zu Köln, Klinik und Poliklinik für Allgemein-, Viszeral-, Tumor- und Transplantationschirurgie
    Subject code 610
    Language English
    Size 91 Seiten, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2020
    Note Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT020666938
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Online ; Thesis: IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer

    Wang, Zhefang / Bruns, Christiane / Zander, Thomas

    2020  

    Institution Klinik und Poliklinik für Allgemein-, Viszeral- und Tumorchirurgie
    Author's details vorgelegt von Zhefang Wang ; 1. Gutachterin oder Gutachter: Universitätsprofessorin Dr. med. C.J. Bruns, 2. Gutachterin oder Gutachter: Privatdozent Dr. med. Th. Zander ; aus dem Zentrum für Operative Medizin der Universität zu Köln, Klinik und Poliklinik für Allgemein-, Viszeral-, Tumor- und Transplantationschirurgie
    Subject code 610
    Language English
    Size 1 Online-Ressource (91 Seiten), Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2020
    Note Zusammenfassung in deutscher und englischer Sprache ; Open Access
    HBZ-ID HT020652462
    DOI 10.4126/FRL01-006424486
    Database Repository for Life Sciences

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  4. Article ; Online: Managing government debt.

    Jiang, Wei / Sargent, Thomas J / Wang, Neng / Yang, Jinqiang

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 11, Page(s) e2318365121

    Abstract: To construct a stochastic version of [R. J. Barro, ...

    Abstract To construct a stochastic version of [R. J. Barro,
    MeSH term(s) Government ; Gross Domestic Product
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2318365121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Evolution of the Cardiovascular Biomarker Study.

    Wang, Thomas J

    Circulation

    2020  Volume 142, Issue 15, Page(s) 1422–1424

    MeSH term(s) Biomarkers ; Humans ; Myocardial Infarction
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-10-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.120.049682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Effectiveness of Manual Hysteroscopic Tissue Removal Device for Intrauterine Polyps in Infertile Women in Both Operating and Office Settings.

    Wang, Chen / Chen, Hui / Morgan, India / Prytkova, Valeriya / Kohl-Thomas, Belinda / Parry, J Preston / Lindheim, Steven R

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A unique presentation of subretinal fluid in a type III torpedo maculopathy phenotype.

    Wang, Derrick J / Mendel, Thomas A

    American journal of ophthalmology case reports

    2023  Volume 33, Page(s) 101971

    Abstract: Purpose: To report a rare type III torpedo maculopathy lesion with a unique manifestation of subretinal fluid.: Observations: A nine-year-old patient was referred to retina for an evaluation of a hypopigmented oval-shaped lesion in the temporal ... ...

    Abstract Purpose: To report a rare type III torpedo maculopathy lesion with a unique manifestation of subretinal fluid.
    Observations: A nine-year-old patient was referred to retina for an evaluation of a hypopigmented oval-shaped lesion in the temporal macula with an area of inferior subretinal fluid in the right eye. The lesion demonstrated inner and outer retinal and retinal pigment epithelial attenuation, intraretinal and subretinal fluid, a serous neurosensory retinal detachment, and inner choroidal excavation on optical coherence tomography. Fundus autofluorescence showed a lane of downward-tracking fluid. Intravenously administered fluorescein angiography revealed a window defect in the area of the torpedo lesion suggesting choroidal flush.
    Conclusions and importance: The case is the third documented case of torpedo maculopathy with subretinal fluid in the literature with a unique combination of intraretinal cystic changes and dependent descending subretinal fluid, somewhat akin to a Best disease outside of the fovea with choroidal excavation. The morphology of torpedo maculopathy continues to expand as more cases are revealed.
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Case Reports
    ISSN 2451-9936
    ISSN (online) 2451-9936
    DOI 10.1016/j.ajoc.2023.101971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Gastric varices.

    Wang, Thomas J / Ryou, Marvin

    Current opinion in gastroenterology

    2023  Volume 39, Issue 6, Page(s) 490–495

    Abstract: Purpose of review: Gastric varices are a rare cause of gastrointestinal bleeding in patients with portal hypertension. There have been significantly advances within endoscopic ultrasound for treatment of gastric varices over the past 5 years in addition ...

    Abstract Purpose of review: Gastric varices are a rare cause of gastrointestinal bleeding in patients with portal hypertension. There have been significantly advances within endoscopic ultrasound for treatment of gastric varices over the past 5 years in addition to the conventional endoscopic and endovascular therapies. In this review, we will review the latest literature on gastric varices with emphasis on changes to the conventional classification systems and comparisons among the different treatment options for gastric varices in terms of efficacy and safety.
    Recent findings: There have been new guidelines proposed by the American Gastrointestinal Association on a simpler classification system compared to the conventional Sarin classification. In addition, endoscopic ultrasound guided coil embolization, a novel treatment pioneered over the past 5 years for gastric varices, has shown increased efficacy and reduced adverse event profile compared to cyanoacrylate glue, the more traditional therapy for gastric variceal bleeding. Options for endovascular therapy overall have not significantly changed over the recent years.
    Summary: Based on our literature review, we recommend a step-up approach with initial medical and endoscopic management with consideration of endovascular therapies when initial therapies fail.
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632571-3
    ISSN 1531-7056 ; 0267-1379
    ISSN (online) 1531-7056
    ISSN 0267-1379
    DOI 10.1097/MOG.0000000000000974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Fatty acid isomerism: analysis and selected biological functions.

    Wang, Zhen / Yang, Tingxiang / Brenna, J Thomas / Wang, Dong Hao

    Food & function

    2024  Volume 15, Issue 3, Page(s) 1071–1088

    Abstract: The biological functions of fatty acids and the lipids in which they are esterified are determined by their chain length, double bond position and geometry and other structural motifs such as the presence of methyl branches. Unusual isomeric features in ... ...

    Abstract The biological functions of fatty acids and the lipids in which they are esterified are determined by their chain length, double bond position and geometry and other structural motifs such as the presence of methyl branches. Unusual isomeric features in fatty acids of human foods such as conjugated double bonds or chain branching found in dairy products, some seeds and nuts, and marine foods potentially have important effects on human health. Recent advancements in identifying fatty acids with unusual double bond positions and pinpointing the position of methyl branches have empowered the study of their biological functions. We present recent advances in fatty acid structural elucidation by mass spectrometry in comparison with the more traditional methods. The double bond position can be determined by purely instrumental methods, specifically solvent-mediated covalent adduct chemical ionization (SM-CACI) and ozone induced dissociation (OzID), with charge inversion methods showing promise. Prior derivatization using the Paternò-Büchi (PB) reaction to yield stable structures that, upon collisional activation, yield the double bond position has emerged. The chemical ionization (CI) based three ion monitoring (MRM) method has been developed to simultaneously identify and quantify low-level branched chain fatty acids (BCFAs), unattainable by electron ionization (EI) based methods. Accurate identification and quantification of unusual fatty acid isomers has led to research progress in the discovery of biomarkers for cancer, diabetes, nonalcoholic fatty liver disease (NAFLD) and atherosclerosis. Modulation of eicosanoids, weight loss and the health significance of BCFAs are also presented. This review clearly shows that the improvement of analytical capacity is critical in the study of fatty acid biological functions, and stronger coupling of the methods discussed here with fatty acid mechanistic research is promising in generating more refined outcomes.
    MeSH term(s) Humans ; Fatty Acids/chemistry ; Isomerism ; Mass Spectrometry/methods ; Food ; Solvents
    Chemical Substances Fatty Acids ; Solvents
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo03716a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Defining the optimal technique for endoscopic ultrasound shear wave elastography

    Thomas J. Wang / Marvin Ryou

    Clinical Endoscopy, Vol 56, Iss 2, Pp 229-

    a combined benchtop and animal model study with comparison to transabdominal shear wave elastography

    2023  Volume 238

    Abstract: Background/Aims Shear wave elastography (SWE) is used for liver fibrosis staging based on stiffness measurements. It can be performed using endoscopic ultrasound (EUS) or a transabdominal approach. Transabdominal accuracy can be limited in patients with ... ...

    Abstract Background/Aims Shear wave elastography (SWE) is used for liver fibrosis staging based on stiffness measurements. It can be performed using endoscopic ultrasound (EUS) or a transabdominal approach. Transabdominal accuracy can be limited in patients with obesity because of the thick abdomen. Theoretically, EUS-SWE overcomes this limitation by internally assessing the liver. We aimed to define the optimal technique for EUS-SWE for future research and clinical use and compare its accuracy with that of transabdominal SWE. Methods Benchtop study: A standardized phantom model was used. The compared variables included the region of interest (ROI) size, depth, and orientation and transducer pressure. Porcine study: Phantom models with varying stiffness values were surgically implanted between the hepatic lobes. Results For EUS-SWE, a larger ROI size of 1.5 cm and a smaller ROI depth of 1 cm demonstrated a significantly higher accuracy. For transabdominal SWE, the ROI size was nonadjustable, and the optimal ROI depth ranged from 2 to 4 cm. The transducer pressure and ROI orientation did not significantly affect the accuracy. There were no significant differences in the accuracy between transabdominal SWE and EUS-SWE in the animal model. The variability among the operators was more pronounced for the higher stiffness values. Small lesion measurements were accurate only when the ROI was entirely situated within the lesion. Conclusions We defined the optimal viewing windows for EUS-SWE and transabdominal SWE. The accuracy was comparable in the non-obese porcine model. EUS-SWE may have a higher utility for evaluating small lesions than transabdominal SWE.
    Keywords animal models ; elastography ; imaging phantoms ; liver fibrosis ; swine ; Internal medicine ; RC31-1245 ; Diseases of the digestive system. Gastroenterology ; RC799-869
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Korean Society of Gastrointestinal Endoscopy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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