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  1. Article ; Online: To trust or not to trust in the thrall of the COVID-19 pandemic: Conspiracy endorsement and the role of adverse childhood experiences, epistemic trust, and personality functioning.

    Kampling, Hanna / Riedl, David / Hettich, Nora / Lampe, Astrid / Nolte, Tobias / Zara, Sandra / Ernst, Mareike / Brähler, Elmar / Sachser, Cedric / Fegert, Jörg M / Gingelmaier, Stephan / Fonagy, Peter / Krakau, Lina / Kruse, Johannes

    Social science & medicine (1982)

    2023  Volume 341, Page(s) 116526

    Abstract: Rationale: Conspiracy endorsement is a public health challenge for the successful containment of the COVID-19 pandemic. While usually considered a societal phenomenon, little is known about the equally important developmental backdrops and personality ... ...

    Abstract Rationale: Conspiracy endorsement is a public health challenge for the successful containment of the COVID-19 pandemic. While usually considered a societal phenomenon, little is known about the equally important developmental backdrops and personality characteristics like mistrust that render an individual prone to conspiracy endorsement. There is a growing body of evidence implying a detrimental role of adverse childhood experiences (ACEs) - a highly prevalent developmental burden - in the development of epistemic trust and personality functioning. This study aimed to investigate the association between ACEs and conspiracy endorsement in the general population, specifically questioning a mediating role of epistemic trust and personality functioning.
    Methods: Based on cross-sectional data from a representative German survey collected during the COVID-19 pandemic (N = 2501), we conducted structural equation modelling (SEM) where personality functioning (OPD-SQS) and epistemic trust (ETMCQ) were included as mediators of the association between ACEs and conspiracy endorsement. Bootstrapped confidence intervals (5000 samples, 95%-CI) are presented for all paths.
    Results: ACEs were significantly associated with conspiracy endorsement (β = 0.25, p < 0.001) and explained 6% of its variance. Adding epistemic trust and personality functioning as mediators increased the explained variance of conspiracy endorsement to 19% while the direct association between ACEs and conspiracy endorsement was diminished (β = 0.12, p < 0.001), indicating an indirect effect of personality functioning and epistemic trust in the association between ACEs and conspiracy endorsement. Fit indices confirmed good model fit.
    Conclusions: Establishing an association between ACEs and conspiracy endorsement further increases the evidence for early childhood adversities' far-reaching and detrimental effects. By including epistemic trust and personality functioning, these findings contribute to a deeper understanding of the underlying mechanisms in the way that ACEs may be associated with conspiracy endorsement.
    MeSH term(s) Child, Preschool ; Humans ; Adverse Childhood Experiences ; Cross-Sectional Studies ; Pandemics ; COVID-19/epidemiology ; Personality
    Language English
    Publishing date 2023-12-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 4766-1
    ISSN 1873-5347 ; 0037-7856 ; 0277-9536
    ISSN (online) 1873-5347
    ISSN 0037-7856 ; 0277-9536
    DOI 10.1016/j.socscimed.2023.116526
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  2. Article ; Online: Cervical metastases of squamous cell carcinoma of the maxilla: a retrospective study of 9 years.

    Kruse, Astrid L D / Grätz, Klaus W

    Head & neck oncology

    2009  Volume 1, Page(s) 28

    Abstract: Purpose: Metastases of squamous cell carcinoma of the tongue and the mouth floor have been well studied. Concerning maxilla squamous cell carcinomas, however, only a few studies have been performed. The question is whether a prophylactic neck dissection ...

    Abstract Purpose: Metastases of squamous cell carcinoma of the tongue and the mouth floor have been well studied. Concerning maxilla squamous cell carcinomas, however, only a few studies have been performed. The question is whether a prophylactic neck dissection should be performed in these tumors.
    Patients and material: In the Department of Craniomaxillofacial Surgery at the University Hospital of Zurich, 30 patients who had been treated for squamous cell carcinoma of the maxilla were examined retrospectively. Special attention was paid to direct and late metastasis, survival rate, and treatment.
    Results: Of the 59 patients with upper jaw carcinomas over a 9-year period, only about half (30 patients) had a squamous cell carcinoma of the upper jaw. Of those patients, 27% had an upper lesion on the right side, 33% on the left. Of the 11 patients (36.7%) presenting positive lymph nodes, 4 patients had direct positive lymph nodes while 7 patients had later positive lymph nodes; and 71.4% of the late metastasis appeared during the first year.
    Conclusion: Because of the 36.7% of patients presenting metastases in the cervical lymph nodes, elective neck treatment should be considered in cases even with a negative clinical examination.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/secondary ; Female ; Humans ; Lymphatic Metastasis ; Male ; Maxillary Neoplasms/pathology ; Middle Aged ; Neck ; Retrospective Studies
    Language English
    Publishing date 2009-07-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2473460-3
    ISSN 1758-3284 ; 1758-3284
    ISSN (online) 1758-3284
    ISSN 1758-3284
    DOI 10.1186/1758-3284-1-28
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  3. Article ; Online: Oral carcinoma after hematopoietic stem cell transplantation--a new classification based on a literature review over 30 years.

    Kruse, Astrid L D / Grätz, Klaus W

    Head & neck oncology

    2009  Volume 1, Page(s) 29

    Abstract: Background: Patients undergoing hematopoietic stem cell transplantation (HSCT) have a higher risk of developing secondary solid tumors, in particular squamous cell carcinoma, because of several risk factors, including full-body irradiation (TBI), ... ...

    Abstract Background: Patients undergoing hematopoietic stem cell transplantation (HSCT) have a higher risk of developing secondary solid tumors, in particular squamous cell carcinoma, because of several risk factors, including full-body irradiation (TBI), chemotherapy, and chronic graft versus host disease (GVHD). Based on the review presented here, a classification of oral changes is suggested in order to provide a tool to detect high-risk patients.
    Methods and results: The literature over the last 30 years was reviewed for development of malignoma of the oral cavity after HSCT. Overall, 64 cases were found. In 16 out of 30 cases, the tongue was the primary location, followed by the salivary gland (10 out of 30); 56.4% appeared in a latency time of 5 to 9 years after HSCT. In 76.6%, GVHD was noticed before the occurrence of oral malignancy. Premalignant changes of the oral mucosa were mucositis, xerostomia, and lichenoid changes, developing into erosive form.
    Conclusion: All physicians involved in the treatment of post-HSCT patients should be aware of the increased risk, even after 5 years from the development of oral malignancy, in particular when oral graft versus host changes are visible. In order to develop evidence based management, screening and offer adequate therapy as early as possible in this patient group, multicenter studies, involving oncologists and head and neck surgeons, should be established.
    MeSH term(s) Adult ; Aged ; Female ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Male ; Middle Aged ; Mouth Neoplasms/classification ; Mouth Neoplasms/etiology ; Neoplasms, Second Primary/etiology
    Language English
    Publishing date 2009-07-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2473460-3
    ISSN 1758-3284 ; 1758-3284
    ISSN (online) 1758-3284
    ISSN 1758-3284
    DOI 10.1186/1758-3284-1-29
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  4. Article ; Online: New classification of maxillary ameloblastic carcinoma based on an evidence-based literature review over the last 60 years.

    Kruse, Astrid L D / Zwahlen, Roger A / Grätz, Klaus W

    Head & neck oncology

    2009  Volume 1, Page(s) 31

    Abstract: Background: The ameloblastic carcinoma is a rare malignant odontogenic tumor which rather occurs in the mandible than in the maxilla. Its rarity and in this context somewhat speculative histopathogenesis may account for diagnostic difficulties. Current ... ...

    Abstract Background: The ameloblastic carcinoma is a rare malignant odontogenic tumor which rather occurs in the mandible than in the maxilla. Its rarity and in this context somewhat speculative histopathogenesis may account for diagnostic difficulties. Current classifications do not consider benign histopathological features at the primary and malignant features at the metastatic tumour site. Based on an evidence-based literature review, a recommendation for a novel classification is presented.
    Methods: An evidence-based literature review over the last 60 years regarding ameloblastic carcinoma of the maxilla was conducted.
    Results: An overall of 26 cases were found (mean age: 54.4 (583 years); male to female ratio: 2.7 to 1). In 54% the primary diagnosis was ameloblastic carcinoma, 34.6% revealed pulmonary metastases, however, only in one patient cervical lymph node metastasis could be found. Whereas two cases did not reveal malignant histopathology at the primary, they revealed malignant features at their metastatic sites. Nineteen of 26 patients (73,1%) were controlled during a median follow-up time of 54,3 months (6 to 156 months); 6 patients died of disease after a median time of 62,7 months (7 to 156 months) after initial diagnosis.
    Conclusion: It is of utmost importance to be aware of that ameloblastomas may be capable to degenerate into a "malignant" disease with recurrence and metastasis. In addition to local long-term control, special attention should be paid to potential pulmonary involvement.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Ameloblastoma/classification ; Ameloblastoma/pathology ; Child ; Child, Preschool ; Evidence-Based Medicine ; Female ; Humans ; Male ; Maxillary Neoplasms/classification ; Maxillary Neoplasms/pathology ; Middle Aged ; Neoplasm Recurrence, Local
    Language English
    Publishing date 2009-08-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2473460-3
    ISSN 1758-3284 ; 1758-3284
    ISSN (online) 1758-3284
    ISSN 1758-3284
    DOI 10.1186/1758-3284-1-31
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  5. Article ; Online: Extranodal manifestation of Rosai-Dorfman disease without involvement of lymph nodes.

    Kruse, Astrid L D / Gengler, Carole / Grätz, Klaus W / Obwegeser, Joachim A

    The Journal of craniofacial surgery

    2010  Volume 21, Issue 6, Page(s) 1733–1736

    Abstract: Background: Rosai-Dorfman disease is an uncommon sinus histiocytosis with massive lymphadenopathy. Rosai-Dorfman disease without lymphadenopathy is extremely rare. Extranodal pseudotumoral masses can occur--and have been identified and described--in the ...

    Abstract Background: Rosai-Dorfman disease is an uncommon sinus histiocytosis with massive lymphadenopathy. Rosai-Dorfman disease without lymphadenopathy is extremely rare. Extranodal pseudotumoral masses can occur--and have been identified and described--in the orbit, skin, bone, and upper respiratory tract. Because of its rareness, Rosai-Dorfman is seldom considered in the clinical differential diagnosis, particularly if extranodal manifestations predominate.
    Methods and results: We present herein a patient with extranodal manifestation of Rosai-Dorfman disease in the orbit and parotid without typical initial lymph node involvement that reacted on steroid therapy.
    Conclusions: The correct diagnosis of this entity with the knowledge that it can occur without lymphadenopathy is important. For these patients, diagnosis must be based on histologic and immunohistopathologic findings after surgical biopsy. Steroid therapy can be used for treatment.
    MeSH term(s) Adenoma, Pleomorphic/diagnosis ; Adult ; Dexamethasone/therapeutic use ; Diagnosis, Differential ; Glucocorticoids/therapeutic use ; Histiocytosis, Sinus/diagnosis ; Humans ; Lacrimal Apparatus Diseases/diagnosis ; Lymph Nodes/pathology ; Male ; Maxillary Sinus/pathology ; Orbital Diseases/diagnosis ; Paranasal Sinus Diseases/diagnosis ; Parotid Diseases/diagnosis
    Chemical Substances Glucocorticoids ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2010-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0b013e3181f403ad
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    Zs.MO 175: Show issues

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  6. Article: Epistemic trust and personality functioning mediate the association between adverse childhood experiences and posttraumatic stress disorder and complex posttraumatic stress disorder in adulthood.

    Kampling, Hanna / Kruse, Johannes / Lampe, Astrid / Nolte, Tobias / Hettich, Nora / Brähler, Elmar / Sachser, Cedric / Fegert, Jörg M / Gingelmaier, Stephan / Fonagy, Peter / Krakau, Lina / Zara, Sandra / Riedl, David

    Frontiers in psychiatry

    2022  Volume 13, Page(s) 919191

    Abstract: Background: Adverse childhood experiences (ACEs) are associated with posttraumatic and complex posttraumatic stress disorder symptoms in adulthood (PTSD/cPTSD), as well as reduced epistemic trust (trust in the authenticity and personal relevance of ... ...

    Abstract Background: Adverse childhood experiences (ACEs) are associated with posttraumatic and complex posttraumatic stress disorder symptoms in adulthood (PTSD/cPTSD), as well as reduced epistemic trust (trust in the authenticity and personal relevance of interpersonally transmitted information) and impaired personality functioning. The present work aims to investigate the predictive value of epistemic trust-the capacity for social learning-on the mediating effect of personality functioning in the association of ACEs and PTSD/cPTSD.
    Methods: We conducted structural equation modeling (SEM) based on representative data of the German population (
    Results: N
    Conclusion: We add to previous research emphasizing the association between ACEs and PTSD/cPTSD symptoms. Offering insights on underlying mechanisms, we show that epistemic trust and personality functioning are relevant mediators. Since both are modifiable by psychotherapy, knowledge about the role of these constructs can inform research on psychotherapeutic interventions and prevention.
    Language English
    Publishing date 2022-08-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.919191
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  7. Article ; Online: Tibial stress fracture after fibular graft harvesting: an unusual complication.

    Lison, Ines / Bredell, Marius G / Luebbers, Heinz T / Grätz, Klaus W / Kruse, Astrid L D

    The Journal of craniofacial surgery

    2010  Volume 21, Issue 4, Page(s) 1082–1083

    Abstract: Introduction: Fibular grafts are commonly used in reconstructive head and neck surgery, and several complications have been reported. Tibial stress fracture, however, is rare.: Patient: A 65-year-old woman presented with a tibial stress fracture 10 ... ...

    Abstract Introduction: Fibular grafts are commonly used in reconstructive head and neck surgery, and several complications have been reported. Tibial stress fracture, however, is rare.
    Patient: A 65-year-old woman presented with a tibial stress fracture 10 weeks after a vascularized fibular flap had been harvested for a mandibular defect due to osteoradionecrosis. The main symptom was activity-related pain after a period of no complaints.
    Conclusions: One should be aware of the complications, particularly after weeks or months, in cases of activity-related pain in the lower extremities. Prevention can be implemented by an awareness of the need to build up the muscles for supporting the tibia in the initial healing phase.
    MeSH term(s) Aged ; Female ; Fibula/transplantation ; Fracture Fixation, Internal/methods ; Fractures, Stress/etiology ; Fractures, Stress/surgery ; Humans ; Mandible/radiation effects ; Mandible/surgery ; Osteoradionecrosis/surgery ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Tibial Fractures/etiology ; Tibial Fractures/surgery
    Language English
    Publishing date 2010-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0b013e3181e1e7a7
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  8. Article ; Online: Apocrine hidrocystoma of the cheek.

    Kruse, Astrid L D / Zwahlen, Roger / Bredell, Marius G / Riener, Marc O / Grätz, Klaus W

    The Journal of craniofacial surgery

    2010  Volume 21, Issue 2, Page(s) 594–596

    Abstract: Background: Apocrine hidrocystoma is an uncommon benign cystic proliferation of the apocrine sweat glands. Malignant melanoma, eccrine hidrocystoma, angioma, and follicular cysts have to be considered as differential diagnoses.: Methods and results: ... ...

    Abstract Background: Apocrine hidrocystoma is an uncommon benign cystic proliferation of the apocrine sweat glands. Malignant melanoma, eccrine hidrocystoma, angioma, and follicular cysts have to be considered as differential diagnoses.
    Methods and results: A 63-year-old man is presented with a dark mass measuring 2 x 2 cm on his right cheek. An exocrine tumor or, more unlikely, a melanoma was considered as a differential diagnosis. Pathologically, the lesion was determined to be an apocrine hidrocystoma.
    Conclusions: This benign lesion can be excised by a narrow margin. Therefore, knowledge of this benign entity in head and neck surgery including the differential diagnosis can prevent an unnecessarily large defect by too large margins.
    MeSH term(s) Cheek/pathology ; Diagnosis, Differential ; Facial Neoplasms/diagnosis ; Follicular Cyst/diagnosis ; Hemangioma/diagnosis ; Hidrocystoma/diagnosis ; Humans ; Male ; Melanoma/diagnosis ; Middle Aged ; Skin Diseases/diagnosis ; Sweat Gland Neoplasms/diagnosis
    Language English
    Publishing date 2010-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0b013e3181d08c77
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  9. Article ; Online: Temporomandibular disorders associated with metastases to the temporomandibular joint: a review of the literature and 3 additional cases.

    Kruse, Astrid L D / Luebbers, Heinz-Theo / Obwegeser, Joachim A / Edelmann, Lars / Graetz, Klaus W

    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics

    2010  Volume 110, Issue 2, Page(s) e21–8

    Abstract: Introduction: Metastases involving the oral cavity account for 1% to 8% of all malignancies in the oral cavity Involvement of the temporomandibular joint (TMJ) is uncommon.: Method and results: We conducted a review of the literature between 1954 and ...

    Abstract Introduction: Metastases involving the oral cavity account for 1% to 8% of all malignancies in the oral cavity Involvement of the temporomandibular joint (TMJ) is uncommon.
    Method and results: We conducted a review of the literature between 1954 and 2008 regarding metastases to the TMJ. In total, 48 patients were found and in 28 patients a previous history of malignant neoplasm was known. The primary tumor was most commonly found in the breast (34%), followed by the lung (21%). Adenocarcinoma was predominant (72.97%). Three new patients with TMJ pain as a first symptom for a disseminated tumor are also examined here.
    Conclusion: Establishing an exact diagnosis of metastatic lesions in the TMJ can provide a diagnostic challenge. Clinicians should include the suspicion of cancer in the differential diagnosis, in particular when patients have a previous history of malignant neoplasm or do not respond to treatment appropriately.
    MeSH term(s) Adenocarcinoma/secondary ; Aged ; Aged, 80 and over ; Breast Neoplasms/pathology ; Carcinoma/secondary ; Female ; Humans ; Lung Neoplasms/pathology ; Male ; Mandibular Condyle/pathology ; Mandibular Neoplasms/secondary ; Temporomandibular Joint Disorders/etiology ; Thyroid Neoplasms/pathology
    Language English
    Publishing date 2010-08
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 202468-8
    ISSN 1528-395X ; 0030-4220 ; 1079-2104
    ISSN (online) 1528-395X
    ISSN 0030-4220 ; 1079-2104
    DOI 10.1016/j.tripleo.2010.02.031
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  10. Article ; Online: Factors influencing survival of free-flap in reconstruction for cancer of the head and neck: a literature review.

    Kruse, Astrid L D / Luebbers, Heinz T / Grätz, Klaus W / Obwegeser, Joachim A

    Microsurgery

    2010  Volume 30, Issue 3, Page(s) 242–248

    Abstract: Microvascular free tissue transfer is a reliable technique for head and neck reconstruction with success rates of 90-99%. Currently, there is no consensus concerning antithrombotic agents, antibiotics, or monitoring techniques. Therefore, the aim of this ...

    Abstract Microvascular free tissue transfer is a reliable technique for head and neck reconstruction with success rates of 90-99%. Currently, there is no consensus concerning antithrombotic agents, antibiotics, or monitoring techniques. Therefore, the aim of this study was to review current literature dealing with microvascular free-tissue transfer and factors influencing the outcome. In addition to excellent microsurgical techniques, coupling devices are a promising new technique, but are not useful in all arteries. Antibiotics should be given in three doses, as a more lengthy dosage time seems to have no advantage. The risk for elderly patients can be best assessed by the American Society of Anesthesiologists (ASA) score, but early mobilization, including intense chest physiotherapy, is important. Anticoagulation can be considered in cases of small vessels, significant size mismatch, vein graft, or vessels of poor quality. Monitoring should be done hourly during the first 24 hours and then every 4 hours for the next 2 postoperative days.
    MeSH term(s) Age Factors ; Aged ; Anastomosis, Surgical ; Anti-Bacterial Agents/administration & dosage ; Antibiotic Prophylaxis ; Anticoagulants/administration & dosage ; Diabetes Complications ; Head and Neck Neoplasms/surgery ; Humans ; Microsurgery ; Middle Aged ; Monitoring, Physiologic ; Radiotherapy ; Reconstructive Surgical Procedures ; Salvage Therapy ; Surgical Flaps/blood supply ; Suture Techniques/instrumentation ; Tissue Survival/radiation effects ; Vascular Surgical Procedures
    Chemical Substances Anti-Bacterial Agents ; Anticoagulants
    Language English
    Publishing date 2010
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605524-2
    ISSN 1098-2752 ; 0738-1085
    ISSN (online) 1098-2752
    ISSN 0738-1085
    DOI 10.1002/micr.20758
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