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Article ; Online: In Vivo

Alekhmimi, Nuha / Ramadan, Qasem / Cialla-May, Dana / Popp, Jürgen / Al-Kattan, Khaled / Alhoshani, Ali / Zourob, Mohammed

ACS omega

2024 Volume 9, Issue 3, Page(s) 3609–3615

Abstract: Matrix metalloproteinases (MMPs) are zinc-dependent proteinases that are capable of cleavage of extracellular matrix (ECM) proteins and enzymes and play an important role in lung dysfunction. Specifically, MMP-2 is produced in the lung by alveolar ... ...

Abstract	Matrix metalloproteinases (MMPs) are zinc-dependent proteinases that are capable of cleavage of extracellular matrix (ECM) proteins and enzymes and play an important role in lung dysfunction. Specifically, MMP-2 is produced in the lung by alveolar epithelial and endothelial cells and other immune cells, such as macrophages. MMP-2 regulatory pathway is initiated in alveolar macrophages during acute lung injury (ALI), which may increase pulmonary inflammation. Therefore, there is a critical need for fast and reliable techniques to track the acute respiratory distress syndrome (ARDS). Here, we describe near-infrared fluorescence resonance energy transfer (NI-FRET) MMP-2-based probe for the
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c07614
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Article: Gastrointestinal stromal tumor in North Africa and the middle east: updates in presentation and management from an 11-year retrospective cohort.

Farhat, Fadi / Hussein, Marwa / Sbaity, Eman / Alsharm, Abdullah / Rasul, Kakil / Khairallah, Saad / Assi, Tarek / Allahverdi, Niloofar / Othman, Ahmad / Kattan, Joseph

Hospital practice (1995)

2024 Volume 51, Issue 5, Page(s) 275–287

Abstract: Objectives: This study described the epidemiological, clinical, and survival profiles of patients with gastrointestinal stromal tumor (GIST) in North Africa and the Middle East (AfME).: Methods: This regional, multicenter, observational, ... ...

Abstract	Objectives: This study described the epidemiological, clinical, and survival profiles of patients with gastrointestinal stromal tumor (GIST) in North Africa and the Middle East (AfME). Methods: This regional, multicenter, observational, retrospective study collected 11-year data on demographics, medical history, disease characteristics, current treatment approaches of GIST, the safety of the most common tyrosine kinase inhibitors (TKIs), second cancers, and survival status. Results: Data of 201 eligible patients were analyzed: mean age was 56.9 ± 12.6 years; 111 (55.2%) patients were men, 21 (10.4%) patients had previous personal malignancy. The most common clinical presentation of GIST was dysphagia [92 (45.8%) patients]. The stomach was the most common primary site in 120 (60.7%) patients, 171 (85.1%) patients had localized disease at diagnosis. 198 (98.5%) GIST cases were CD117/CD34-positive. Imatinib was used in the neoadjuvant (18/21 patients), adjuvant (85/89 patients), and first-line metastatic treatment (28/33 patients) settings. The most common non-hematological toxicity associated with TKIs was vomiting in 32/85 (37.6%) patients. Overall, 100 (49.8%) patients (95%CI: 42.8-56.7%) were alive and disease-free while 30 (14.9%) patients were alive with active disease. Conclusion: Presentation of GIST in our AfME population is consistent with global reports, being more frequent in patients >50 years old and having the stomach as the most common primary site. Unlike what is usually reported, though, we did have more patients with lymphatic spread of the disease. Despite the global trend and advances in the treatment of GIST according to molecular profile, this is still far to happen in our population given the lack of access to molecular profiles and the high associated cost.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Africa, Northern/epidemiology ; Antineoplastic Agents/adverse effects ; Gastrointestinal Neoplasms/diagnosis ; Gastrointestinal Neoplasms/drug therapy ; Gastrointestinal Neoplasms/epidemiology ; Gastrointestinal Stromal Tumors/diagnosis ; Gastrointestinal Stromal Tumors/drug therapy ; Gastrointestinal Stromal Tumors/epidemiology ; Imatinib Mesylate/adverse effects ; Middle East/epidemiology ; Retrospective Studies
Chemical Substances	Antineoplastic Agents ; Imatinib Mesylate (8A1O1M485B)
Language	English
Publishing date	2024-01-10
Publishing country	England
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	2570453-9
ISSN	2377-1003 ; 2154-8331 ; 8750-2836
ISSN (online)	2377-1003
ISSN	2154-8331 ; 8750-2836
DOI	10.1080/21548331.2023.2277682
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Article ; Online: Correction: Comparison of the clinical characteristics of SARS-CoV-2 Delta (B.1.617.2) and Omicron (B.1.1.529) infected patients from a single hospitalist service.

Radhakrishnan, N / Liu, M / Idowu, B / Bansari, A / Rathi, K / Magar, S / Mundhra, L / Sarmiento, J / Ghaffar, U / Kattan, J / Jones, R / George, J / Yang, Y / Southwick, F

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 870

Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Published Erratum
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08827-3
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Article ; Online: What the oncologist needs to know about COVID-19 infection in cancer patients.

Rassy, Elie / Khoury-Abboud, Rita-Maria / Ibrahim, Nathalie / Kattan, Clarisse / Assi, Tarek / Kattan, Joseph

Future oncology (London, England)

2020 Volume 16, Issue 17, Page(s) 1153–1156

MeSH term(s)	Antineoplastic Agents/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19 ; Clinical Decision-Making ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Disease Progression ; Humans ; Medical Oncology/trends ; Neoplasms/drug therapy ; Neoplasms/epidemiology ; Oncologists ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Vulnerable Populations
Chemical Substances	Antineoplastic Agents ; Antiviral Agents
Keywords	covid19
Language	English
Publishing date	2020-04-23
Publishing country	England
Document type	Editorial
ZDB-ID	2274956-1
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon-2020-0312
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Article ; Online: Developing a Clinical Prediction Score: Comparing Prediction Accuracy of Integer Scores to Statistical Regression Models.

Subramanian, Vigneshwar / Mascha, Edward J / Kattan, Michael W

Anesthesia and analgesia

2021 Volume 132, Issue 6, Page(s) 1603–1613

Abstract: ... data set. Simulated independent training and test sets (n = 1000) were randomly generated ...

Abstract	Researchers often convert prediction tools built on statistical regression models into integer scores and risk classification systems in the name of simplicity. However, this workflow discards useful information and reduces prediction accuracy. We, therefore, investigated the impact on prediction accuracy when researchers simplify a regression model into an integer score using a simulation study and an example clinical data set. Simulated independent training and test sets (n = 1000) were randomly generated such that a logistic regression model would perform at a specified target area under the receiver operating characteristic curve (AUC) of 0.7, 0.8, or 0.9. After fitting a logistic regression with continuous covariates to each data set, continuous variables were dichotomized using data-dependent cut points. A logistic regression was refit, and the coefficients were scaled and rounded to create an integer score. A risk classification system was built by stratifying integer scores into low-, intermediate-, and high-risk tertiles. Discrimination and calibration were assessed by calculating the AUC and index of prediction accuracy (IPA) for each model. The optimism in performance between the training set and test set was calculated for both AUC and IPA. The logistic regression model using the continuous form of covariates outperformed all other models. In the simulation study, converting the logistic regression model to an integer score and subsequent risk classification system incurred an average decrease of 0.057-0.094 in AUC, and an absolute 6.2%-17.5% in IPA. The largest decrease in both AUC and IPA occurred in the dichotomization step. The dichotomization and risk stratification steps also increased the optimism of the resulting models, such that they appeared to be able to predict better than they actually would on new data. In the clinical data set, converting the logistic regression with continuous covariates to an integer score incurred a decrease in externally validated AUC of 0.06 and a decrease in externally validated IPA of 13%. Converting a regression model to an integer score decreases model performance considerably. Therefore, we recommend developing a regression model that incorporates all available information to make the most accurate predictions possible, and using the unaltered regression model when making predictions for individual patients. In all cases, researchers should be mindful that they correctly validate the specific model that is intended for clinical use.
MeSH term(s)	Area Under Curve ; Computer Simulation/statistics & numerical data ; Computer Simulation/trends ; Forecasting ; Humans ; Models, Statistical ; ROC Curve ; Regression Analysis ; Stroke/diagnosis ; Stroke/epidemiology
Language	English
Publishing date	2021-01-15
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0000000000005362
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Article ; Online: Comparative genomic characterization of melanoma of known and unknown primary.

Rassy, E / Boussios, S / Chebly, A / Farra, C / Kattan, J / Pavlidis, N

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2021 Volume 23, Issue 11, Page(s) 2302–2308

Abstract: Background: This study aims to genomically characterize melanoma of unknown primary (MUP) in comparison to melanomas of cutaneous primary (MCP).: Methods: Eligible cases were collected from the MSK-IMPACT™ Clinical Sequencing Cohort published in the ... ...

Abstract	Background: This study aims to genomically characterize melanoma of unknown primary (MUP) in comparison to melanomas of cutaneous primary (MCP). Methods: Eligible cases were collected from the MSK-IMPACT™ Clinical Sequencing Cohort published in the cBioPortal database. Genomic analysis was performed using a hybridization-capture-based next-generation sequencing assay designed to detect mutations, small insertions and deletions, copy number alterations, and genomic rearrangements. Results: Among 462 patients of whom 18.4% had MUP, brain metastasis was more common among patients with MUP (23% vs 7.1%). The differences in genomic profiling between MCP and MUP did not reach statistical significance. The 187 MCP and 44 MUP patients treated with immune checkpoint inhibitors had a median overall survival of 49 and 44 months, respectively (p = 0.705). Conclusions: The differences in somatic mutation patterns and survival outcomes were not statistically significant. These findings may allude to similar carcinogenic processes but should be considered exploratory and interpreted with caution.
MeSH term(s)	Brain Neoplasms/secondary ; DNA Copy Number Variations ; Databases, Genetic ; Female ; Gene Deletion ; Gene Rearrangement ; Genes, Neurofibromatosis 1 ; Genes, p53 ; Genetic Profile ; Genomics ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Lung Neoplasms/secondary ; Male ; Melanoma/drug therapy ; Melanoma/genetics ; Melanoma/mortality ; Melanoma/secondary ; Mutation ; Neoplasms, Unknown Primary/drug therapy ; Neoplasms, Unknown Primary/genetics ; Neoplasms, Unknown Primary/mortality ; Neoplasms, Unknown Primary/pathology ; Protein-Tyrosine Kinases/genetics ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins B-raf/genetics ; Skin Neoplasms/drug therapy ; Skin Neoplasms/genetics ; Skin Neoplasms/mortality ; Skin Neoplasms/pathology ; Telomerase/genetics
Chemical Substances	Proto-Oncogene Proteins ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; ROS1 protein, human (EC 2.7.10.1) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; TERT protein, human (EC 2.7.7.49) ; Telomerase (EC 2.7.7.49)
Language	English
Publishing date	2021-05-02
Publishing country	Italy
Document type	Comparative Study ; Journal Article
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-021-02629-2
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Article ; Online: Menstrual cycle changes increased following COVID-19 mRNA vaccination: Social media validation and self-controlled case series analysis

Shetty, Aishwarya N / Kattan, Gonzalo Sepulveda / Javed, Muhammad / Pearce, Christopher / Clothier, Hazel J / Buttery, Jim P

medRxiv

Abstract: Objectives - To investigate if there was an increase in menstrual abnormality related presentation post COVID-19 vaccination. Design - BERTopic machine learning, with a guided topic modelling option was used to analyse mentions of menstrual change in ... ...

Abstract	Objectives - To investigate if there was an increase in menstrual abnormality related presentation post COVID-19 vaccination. Design - BERTopic machine learning, with a guided topic modelling option was used to analyse mentions of menstrual change in relation to COVID-19 vaccination on the social media platform Reddit. Self-controlled case series (SCCS) analysis using general practice data collected via the POpulation Level Analysis and Reporting (POLAR) tool with permission from Primary Health Networks (PHNs) as the de-identified dataset owners in Victoria and New South Wales. Setting: Globally for social media analysis. Victoria and New South Wales (NSW), Australia for POLAR. Participants: For social media analysis, people who made a Reddit post about menstrual concerns post COVID-19 vaccine. For the SCCS analysis, people who presented to a POLAR GP registered practice with a new menstrual abnormality diagnosis. Exposures: COVID-19 vaccination with adenovirus vector [AstraZenecas Vaxzervria ChadOx1-S], mRNA [Pfizer-BioNTechs Comirnaty BNT162b2 and Modernas Spikevax] or protein-subunit [Novavaxs Nuvaxovid]). Outcomes and Measures: Scraped social media posts were pre-processed, analysed for positive, negative, and neutral sentiments and topic modelled. Menstrual abnormality presentations of interest were isolated from the general practice dataset aggregated by POLAR, by searching for relevant SNOMED CT codes. Similarly, relative incidence (RI) was calculated for all COVID-19 vaccine types. Results: Social media analysis saw peaks in menstrual change posts on Reddit since the global COVID-19 vaccine rollout. The SCCS analysis demonstrates an increase in general practice presentations of menstrual abnormality diagnosis following mRNA vaccines (RI= 1.14, 95% CI: 1.07 to 1.22, P <0.001). Conclusions and Relevance: This study demonstrates an increase in menstrual abnormality presentations following COVID-19 mRNA vaccination. Our findings validate the concerns raised on social media so people who are vaccinated or are considering future vaccines feel heard, supported, and validated. Our analysis highlights the importance of using large real-world datasets to gather reliable evidence for public health decision making.
Keywords	covid19
Language	English
Publishing date	2023-10-31
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2023.10.26.23297643
Database	COVID19

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Article ; Online: Comparison of the clinical characteristics of SARS-CoV-2 Delta (B.1.617.2) and Omicron (B.1.1.529) infected patients from a single hospitalist service.

Radhakrishnan, N / Liu, M / Idowu, B / Bansari, A / Rathi, K / Magar, S / Mundhra, L / Sarmiento, J / Ghaffar, U / Kattan, J / Jones, R / George, J / Yang, Y / Southwick, F

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 747

Abstract: Background: While existing evidence suggests less severe clinical manifestations and lower mortality are associated with the Omicron variant as compared to the Delta variant. However, these studies fail to control for differences in health systems ... ...

Abstract	Background: While existing evidence suggests less severe clinical manifestations and lower mortality are associated with the Omicron variant as compared to the Delta variant. However, these studies fail to control for differences in health systems facilities and providers. By comparing patients hospitalized on a single medical service during the Delta and Omicron surges we were able to conduct a more accurate comparison of the two varaints' clinical manifestations and outcomes. Methods: We conducted a prospective study of 364 Omicron (BA.1) infected patients on a single hospitalist service and compared these findings to a retrospective analysis of 241 Delta variant infected patients managed on the same service. We examined differences in symptoms, laboratory measures, and clinical severity between the two variants and assessed potential risk drivers for case mortality. Findings: Patients infected with Omicron were older and had more underlying medical conditions increasing their risk of death. Although they were less severely ill and required less supplemental oxygen and dexamethasone, in-hospital mortality was similar to Delta cases, 7.14% vs. 4.98% for Delta (q-value = 0.38). Patients older than 60 years or with immunocompromised conditions had much higher risk of death during hospitalization, with estimated odds ratios of 17.46 (95% CI: 5.05, 110.51) and 2.80 (1.03, 7.08) respectively. Neither vaccine history nor variant type played a significant role in case fatality. The Rothman score, NEWS-2 score, level of neutrophils, level of care, age, and creatinine level at admission were highly predictive of in-hospital death. Interpretation: In hospitalized patients, the Omicron variant is less virulent than the Delta variant but is associated with a comparable mortality. Clinical and laboratory features at admission are informative about the risk of death.
MeSH term(s)	Humans ; COVID-19 ; Hospital Mortality ; Hospitalists ; Prospective Studies ; Retrospective Studies ; SARS-CoV-2
Language	English
Publishing date	2023-10-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08714-x
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Article: Role of the Pedicled Mentalis Muscle Flap in Closure of Chin Implants in Genioplasty.

Mrad, Mohamed Amir / Kattan, Abdullah E / Shah Mardan, Qutaiba N M / Almarghoub, Mohammed A / Yaremchuk, Michael J

Plastic and reconstructive surgery. Global open

2021 Volume 9, Issue 8, Page(s) e3728

Abstract: With the purpose of obtaining an aesthetically pleasing chin appearance, genioplasty or chin augmentation can be performed through osteotomy or chin implantation, with the latter available in different sizes and materials such as silicone and porous ... ...

Abstract	With the purpose of obtaining an aesthetically pleasing chin appearance, genioplasty or chin augmentation can be performed through osteotomy or chin implantation, with the latter available in different sizes and materials such as silicone and porous polyethylene. The implants are traditionally placed in a subperiosteal or supraperiosteal plane with different advantages and disadvantages to each. This procedure has evolved through time with many techniques and modifications; and this article is an addition to this ongoing refinement by advocating for closure of the mentalis muscle (a paired chin muscle originating from the incisor fossa to the chin skin) over the implant after securing its position with screws (in the case of porous polyethylene) or creating a snug pocket (in the case of silicone). In this retrospective analysis, 15 patients underwent this procedure with an excellent outcome. A single patient developed numbness in the mandibular nerve territory, while another one developed a fistulating radicular cyst that was unrelated to this technique. In addition to the simple learning curve, the potential advantages of this technique include less chances of fistula formation, implant exposure, infection, extrusion, or malpositioning. Prospective studies with more subjects are required to cement our findings.
Language	English
Publishing date	2021-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2851682-5
ISSN	2169-7574 ; 2169-7574
ISSN (online)	2169-7574
ISSN	2169-7574
DOI	10.1097/GOX.0000000000003728
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Article: Consensus on the management of platinum-sensitive high-grade serous epithelial ovarian cancer in Lebanon.

Abdallah, Reem / Atallah, David / Bitar, Nizar / Chahine, Georges / Ghanem, Hady / Ghosn, Marwan / Kattan, Joseph / Nasr, Fadi / Makdessi, Joseph / Shamseddine, Ali

Gynecologic oncology reports

2023 Volume 47, Page(s) 101186

Abstract: Ovarian cancer is the most lethal gynecologic cancer. The high grade serous epithelial (HGSE) subtype is the most aggressive and it often presents at advanced stages, while screening programs have not proven beneficial. Management of the advanced stages ( ...

Abstract	Ovarian cancer is the most lethal gynecologic cancer. The high grade serous epithelial (HGSE) subtype is the most aggressive and it often presents at advanced stages, while screening programs have not proven beneficial. Management of the advanced stages (FIGO III and IV), which constitute the majority of diagnoses, usually consists of platinum-based chemotherapy and cytoreductive surgery (primary or interval) followed by maintenance therapy. Currently, the standard-of-care for advanced newly diagnosed HGSE ovarian cancer, as per international medical societies, starts with upfront cytoreductive surgery, followed by platinum-based chemotherapy (mostly carboplatin and paclitaxel) and/or anti-angiogenic agent bevacizumab, then maintenance therapy with a poly(ADP-ribose) polymerase (PARP) inhibitor with/without/or bevacizumab (continued). PARP inhibitor use depends on the patient's genetic signature, mainly the breast cancer gene (BRCA) mutation and the homologous recombination deficiency (HRD) status. Therefore, genetic testing is recommended at diagnosis to inform treatment and prognosis. In line with the evolving standard-of-care for ovarian cancer, a panel of experts in treating advanced ovarian cancer convened to lay down practical recommendations on the management of advanced ovarian cancer in Lebanon; since the currently applicable guidelines by the Lebanese Ministry of Public Health for cancer treatment have not been updated yet to reflect the treatment paradigm shift brought upon by the development and approval of PARP inhibitors. The current work reviews the leading clinical trials on PARP inhibitors (as maintenance for newly diagnosed advanced and platinum-sensitive relapsed ovarian cancer), presents international recommendations, and proposes treatment algorithms for optimal local practice.
Language	English
Publishing date	2023-04-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2818505-5
ISSN	2352-5789
ISSN	2352-5789
DOI	10.1016/j.gore.2023.101186
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