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Book ; Online: Age, biostratigraphic and paleomagnetic events at DSDP Leg 94, supplementary data to: Baldauf, Jack G; Thomas, Ellen; Clement, Bradford M; Takayama, Toshiaki; Weaver, Philip PE; Backman, Jan; Jenkins, G; Mudie, Peta J; Westberg-Smith, MJ (1987): Magnetostratigraphic and biostratigraphic synthesis, Deep Sea Drilling Project Leg 94. In: Ruddiman, WF; Kidd, RB; Thomas, E; et al. (eds.), Initial Reports of the Deep Sea Drilling Project (U.S. Govt. Printing Office), 94, 1159-1205

Baldauf, Jack G / Backman, Jan / Clement, Bradford M / Jenkins, G / Mudie, Peta J / Takayama, Toshiaki / Thomas, Ellen / Weaver, Philip PE / Westberg-Smith, MJ

1987

Abstract: During DSDP Leg 94 sediment was recovered from 22 holes at six sites situated between 37° and 53°N in the North Atlantic. Paleomagnetic, calcareous nannofossil, foraminiferal, diatom, radiolarian, and dinocyst stratigraphic studies were completed. The ... ...

Abstract	During DSDP Leg 94 sediment was recovered from 22 holes at six sites situated between 37° and 53°N in the North Atlantic. Paleomagnetic, calcareous nannofossil, foraminiferal, diatom, radiolarian, and dinocyst stratigraphic studies were completed. The excellent magnetostratigraphic results, the near-complete recovery, and the abundant fossil content of the sediment allowed refinement of these stratigraphies, especially for the upper Pliocene-Holocene. Because the Leg 94 sites span middle and high North Atlantic latitudes, it is possible to use them to evaluate the synchrony of late Pliocene to Holocene datums.
Language	English
Dates of publication	1987-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.2973/dsdp.proc.94.146.1987
DOI	10.1594/PANGAEA.788798
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Palliative and End-of-Life Care for People Living with Motor Neurone Disease: Ongoing Challenges and Necessity for Shifting Directions.

Velaga, Vivek C / Cook, Angus / Auret, Kirsten / Jenkins, Tom / Thomas, Geoff / Aoun, Samar M

Brain sciences

2023 Volume 13, Issue 6

Abstract: Although the progressive clinical trajectory of motor neurone disease (MND) is widely understood, multiple challenges remain preventing optimal end-of-life care for this population with unique needs from the patient, carer and service provider ... ...

Abstract	Although the progressive clinical trajectory of motor neurone disease (MND) is widely understood, multiple challenges remain preventing optimal end-of-life care for this population with unique needs from the patient, carer and service provider perspectives. This paper reports on the experiences, gaps in service and unmet needs of MND patients and family carers and explores public health palliative care approaches that would facilitate coordinated and integrated care to respond to their changing needs. This is a qualitative study of responses to questions in an online consumer survey (353 respondents) in Western Australia (2020), focusing on a subset of 29 current and bereaved carers of people with MND who have used health services in the last five years. The analysis identified themes, highlighting the insufficient integration of services across health and social care; poor and unequal access to coordinated palliative care; significant gaps in the knowledge base of the workforce and a failure to meet the consumer expectations of person-centred care. For palliative care to be accessible to those living with MND and other under-served conditions, there needs to be a shift to more comprehensive, inclusive and sustainable options, such as the public health approach to palliative/end-of-life care that engages the assets of local communities in partnership with health services, one example being the "Compassionate Communities Connectors" model of care. Further considerations include advocacy for policy changes, fostering partnerships and developing indicators for evaluating the impact of the proposed models of care. The end result is not only better care but substantial savings for the health system.
Language	English
Publishing date	2023-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13060920
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cross-linked phosphorylated RS4 wheat starch reduces glucose and insulin responses after 3 days of pre-feeding in healthy adults: an acute, double-blind, randomized controlled clinical trial.

Wolever, Thomas M S / Maningat, Clodualdo C / Seib, Paul A / Campbell, Janice E / Jenkins, Alexandra L

International journal of food sciences and nutrition

2023 Volume 74, Issue 5, Page(s) 621–629

Abstract: When this project was designed, there was no evidence that adding resistant starch to available carbohydrate (avCHO) reduced glycaemic and insulinaemic responses (GIR). We compared GIR elicited by a cookie containing cross-linked phosphorylated RS4 wheat ...

Abstract	When this project was designed, there was no evidence that adding resistant starch to available carbohydrate (avCHO) reduced glycaemic and insulinaemic responses (GIR). We compared GIR elicited by a cookie containing cross-linked phosphorylated RS4 wheat starch (Fibersym®) (RS4
MeSH term(s)	Humans ; Adult ; Insulin ; Starch ; Glucose ; Triticum ; Blood Glucose ; Glycemic Index ; Dietary Carbohydrates ; Postprandial Period ; Cross-Over Studies
Chemical Substances	Insulin ; Starch (9005-25-8) ; Glucose (IY9XDZ35W2) ; Blood Glucose ; Dietary Carbohydrates
Language	English
Publishing date	2023-07-20
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1121877-0
ISSN	1465-3478 ; 0963-7486
ISSN (online)	1465-3478
ISSN	0963-7486
DOI	10.1080/09637486.2023.2236809
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Article ; Online: Dietary Nitrate Metabolism in Porcine Ocular Tissues Determined Using

Park, Ji Won / Piknova, Barbora / Tunau-Spencer, Khalid J / Thomas, Samantha M / Cai, Hongyi / Walter, Peter J / Jenkins, Audrey / Hellinga, David / Parver, Leonard M / Schechter, Alan N

Nutrients

2024 Volume 16, Issue 8

Abstract: ... Nitrate ( ... ...

Abstract	Nitrate (NO
MeSH term(s)	Animals ; Nitrates/metabolism ; Swine ; Dietary Supplements ; Nitrites/metabolism ; Eye/metabolism ; Nitrogen Isotopes ; Cornea/metabolism ; Diet ; Aqueous Humor/metabolism ; Vitreous Body/metabolism ; Nitric Oxide/metabolism ; Animal Feed/analysis
Chemical Substances	Nitrates ; sodium nitrate (8M4L3H2ZVZ) ; Nitrites ; Nitrogen Isotopes ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2024-04-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16081154
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Article ; Online: Bone mineral density in young adults 5 to 11 years after adolescent metabolic and bariatric surgery for severe obesity compared to peers.

Wasserman, Halley / Jenkins, Todd / Inge, Thomas / Ryder, Justin / Michalsky, Marc / Sisley, Stephanie / Xie, Changchun / Kalkwarf, Heidi J

International journal of obesity (2005)

2024 Volume 48, Issue 4, Page(s) 575–583

Abstract: ... recruited for comparison.: Results: In cases (RYGB: mean age 26.8 ± 1.9 years, mean BMI 42.1 ± 9.9 kg/m ...

Abstract	Objective: Metabolic and bariatric surgery (MBS) is associated with decreased bone mineral density (BMD) in adults. The long-term impact of MBS during adolescence on BMD is unknown. We report bone health status 5 to 11 years after Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) from the Teen-LABS study cohort. Methods: Between 2016 and 2022, BMD was measured by dual energy x-ray absorptiometry (DXA) in 106 young adults who had undergone MBS as adolescents. Volumetric BMD by peripheral quantitative computed tomography was measured on a subset. Ninety-one controls who had not undergone MBS were recruited for comparison. Results: In cases (RYGB: mean age 26.8 ± 1.9 years, mean BMI 42.1 ± 9.9 kg/m Conclusion: BMD, especially of the hip and femoral neck, was lower in young adults who underwent MBS during adolescence compared to matched peers who had not undergone MBS. BMD Z-scores of the femoral neck were inversely associated with time since MBS but were not associated with BMI change.
MeSH term(s)	Humans ; Adolescent ; Young Adult ; Adult ; Bone Density ; Obesity, Morbid/surgery ; Gastric Bypass/methods ; Bariatric Surgery ; Absorptiometry, Photon
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	752409-2
ISSN	1476-5497 ; 0307-0565
ISSN (online)	1476-5497
ISSN	0307-0565
DOI	10.1038/s41366-023-01453-8
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Article ; Online: Associations between marital status and weight loss trajectories entering into early adulthood: a Teen-LABS study.

Pratt, Keeley J / Boles, Richard E / Michalsky, Marc P / Inge, Thomas H / Jenkins, Todd M

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

2023 Volume 20, Issue 4, Page(s) 376–382

Abstract: Background: Among adolescents who underwent metabolic and bariatric surgery (MBS), it is unclear how relationships and specifically marital status (MS) may be associated with long-term weight loss.: Objective: In this analysis, we tested for ... ...

Abstract	Background: Among adolescents who underwent metabolic and bariatric surgery (MBS), it is unclear how relationships and specifically marital status (MS) may be associated with long-term weight loss. Objective: In this analysis, we tested for associations between the MS of adolescents who underwent MBS and the MS of their primary caregiver and weight loss trajectory over 8 years. Setting: Teen-LABS participating sites. Methods: This sample included 231 participants (75.3% female, 71.4% White, 68.0% Roux-en-Y gastric bypass, 27.7% vertical sleeve gastrectomy, 4.3% laparoscopic adjustable gastric band). A linear mixed model was conducted with the dependent variable percent body mass index (BMI) change from preoperatively through 8 years with between-participant factors (1) participant MS, (2) caregiver MS, and (3) interaction between caregiver and participant MS. Results: One third of participants and 87% of caregivers were ever married (EM). Compared with never-married (NM) participants and caregivers (-14.6%), EM participants and caregivers (-20.6%), EM participants and NM caregivers (-25.9%), and NM participants and EM caregivers (-19.8%), each had significantly greater BMI loss at 8 years (each P < .05). No other group comparisons achieved statistical significance. Conclusions: NM participants with NM caregivers had less favorable long-term BMI. Additional research is needed to better understand how relationships affect behavior change and weight loss after MBS.
MeSH term(s)	Humans ; Female ; Adolescent ; Adult ; Male ; Obesity, Morbid/surgery ; Obesity, Morbid/complications ; Body-Weight Trajectory ; Gastric Bypass ; Marital Status ; Weight Loss ; Gastrectomy ; Laparoscopy ; Treatment Outcome ; Retrospective Studies
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2274243-8
ISSN	1878-7533 ; 1550-7289
ISSN (online)	1878-7533
ISSN	1550-7289
DOI	10.1016/j.soard.2023.11.009
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Article ; Online: Reflections on measures of social isolation among older adults.

Pomeroy, Mary Louise / Mehrabi, Fereshteh / Jenkins, Emerald / O'Sullivan, Roger / Lubben, James / Cudjoe, Thomas K M

Nature aging

2023 Volume 3, Issue 12, Page(s) 1463–1464

MeSH term(s)	Social Isolation ; Loneliness
Language	English
Publishing date	2023-08-28
Publishing country	United States
Document type	Letter
ISSN	2662-8465
ISSN (online)	2662-8465
DOI	10.1038/s43587-023-00472-4
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Article ; Online: Azithromycin Induced Asthma Remission in Adults With Persistent Uncontrolled Asthma: A Secondary Analysis of a Randomized, Double-Blind, Placebo-Controlled Trial.

Thomas, Dennis / McDonald, Vanessa M / Stevens, Sean / Baraket, Melissa / Hodge, Sandra / James, Alan / Jenkins, Christine / Marks, Guy B / Peters, Matthew / Reynolds, Paul / Upham, John W / Yang, Ian A / Gibson, Peter G

Chest

2024

Abstract: Background: Asthma remission is a potential treatment goal.: Research question: Does adding azithromycin to standard therapy in patients with persistent uncontrolled asthma induce remission compared with placebo?: Study design and methods: This ... ...

Abstract	Background: Asthma remission is a potential treatment goal. Research question: Does adding azithromycin to standard therapy in patients with persistent uncontrolled asthma induce remission compared with placebo? Study design and methods: This secondary analysis used data from the AMAZES clinical trial-a double-blind placebo-controlled trial that evaluated the safety and efficacy of azithromycin on asthma exacerbations. The primary remission definition (referred to as clinical remission) was zero exacerbations and zero oral corticosteroids during the previous 6 months evaluated at 12 months and a 5-item Asthma Control Questionnaire score ≤ 1 at 12 months. Secondary remission definitions included clinical remission plus lung function criteria (postbronchodilator FEV Results: A total of 335 participants (41.5% male; median age, 61.01 years; quartile 1-3, 51.03-68.73) who completed the 12-month treatment period were included in the analysis. Twelve months of treatment with azithromycin induced asthma remission in a subgroup of patients, and a significantly higher proportion in the azithromycin arm achieved both clinical remission (50.6% vs 38.9%; P = .032) and clinical remission plus lung function criteria (50.8% vs 37.1%; P = .029) compared with placebo, respectively. In addition, a higher proportion of the azithromycin group achieved complete remission (23% vs 13.7%; P = .058). Sensitivity analyses supported these findings. Baseline factors (eg, better asthma-related quality of life, absence of oral corticosteroid burst in the previous year) predicted the odds of achieving clinical remission. Azithromycin induced remission in both eosinophilic and noneosinophilic asthma. Interpretation: Adults with persistent symptomatic asthma achieved a higher remission rate when treated with azithromycin. Remission on treatment may be an achievable treatment target in moderate/severe asthma, and future studies should consider remission as an outcome measure.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2024.02.048
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Article: Genetically Confirmed Malignant Hyperthermia in a Six-Week-Old Infant: A Case Report.

Edwards, Christopher M / Jenkins, Thomas K / Gravenstein, Nikolaus / Gunnett, Amy M / Martin, Timothy W

Cureus

2022 Volume 14, Issue 7, Page(s) e27010

Abstract: A six-week-old 3.9-kg infant presented for microlaryngoscopy and diaphragmatic hernia repair. While positioning for laparoscopy after microlaryngoscopy, the infant developed muscle rigidity, worsening hypercarbia, tachycardia, and early hyperthermia. ... ...

Abstract	A six-week-old 3.9-kg infant presented for microlaryngoscopy and diaphragmatic hernia repair. While positioning for laparoscopy after microlaryngoscopy, the infant developed muscle rigidity, worsening hypercarbia, tachycardia, and early hyperthermia. Sevoflurane was discontinued, and the clinical picture indicating malignant hyperthermia (MH) resolved without dantrolene. Subsequent genetic testing revealed that both the patient and his father carried a mutation in the
Language	English
Publishing date	2022-07-19
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.27010
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Article ; Online: Looking after each other in a crisis-Lessons from Novichok and the parallels with Covid-19.

Jenkins, Kate S M / Thomas, Jess / Duggan, Megan / Scott, Hannah / Lang, Jenny

Nursing in critical care

2021 Volume 28, Issue 1, Page(s) 30–35

Abstract: Background: In March 2018, three patients were admitted to the Emergency Department of a District General Hospital. Originally suspected of having suffered an opiate overdose, it became clear that they were the victims of anti-cholinesterase poisoning- ... ...

Abstract	Background: In March 2018, three patients were admitted to the Emergency Department of a District General Hospital. Originally suspected of having suffered an opiate overdose, it became clear that they were the victims of anti-cholinesterase poisoning-the Soviet era poison Novichok. Twenty-five days later, two further patients were admitted with the same symptoms. One of these patients died 8 days later and the second remained in hospital for 3 weeks. A Clinical Psychologist was present on the unit throughout the major incident and all staff directly involved received psycho-educational support regarding self-care. Aims: To examine the psychological impact of the longest running major incident in NHS history on the staff directly involved. Design: A cross-sectional design was used, with structured questionnaires administered retrospectively. Methods: A link to an electronic survey was emailed to every member of staff in the organization. The survey included the Hospital Anxiety and Depression Scale, the Maslach Burnout Inventory, the Impact of Events Scale-Revised (to both the March and June events). Results: 540/4000 hospital staff responded (13.5% response rate) with a 29/59 (49%) response rate in intensive care staff. Frontline staff had significantly lower scores on anxiety (P < .05 for the June incident), depressive symptoms (P < .05 March and June) and subscales of burnout than managers (depersonalization P < .05). On the remaining two burnout subscales and on anxiety scores for those involved in March, results trended towards significance (P < .1). Conclusions: Staff in management roles during major incidents may experience higher levels of psychological distress than staff in front line clinical roles and should be encouraged to seek psychological support. Relevance to clinical practice: This article informs teams of the psychological impact of major incidents on staff in intensive care settings.
MeSH term(s)	Humans ; COVID-19 ; Cross-Sectional Studies ; Retrospective Studies ; Burnout, Professional/psychology ; Surveys and Questionnaires
Chemical Substances	novichok
Language	English
Publishing date	2021-07-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2011956-2
ISSN	1478-5153 ; 1362-1017
ISSN (online)	1478-5153
ISSN	1362-1017
DOI	10.1111/nicc.12677
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