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  1. Article: Enhancing obSTORM imaging performance with cubic spline PSF modeling.

    Koo, Donghoon / Lee, Minchol / Lee, Youngseop / Kim, Jeongmin

    Biomedical optics express

    2023  Volume 14, Issue 10, Page(s) 5075–5084

    Abstract: Oblique plane microscopy-based single molecule localization microscopy (obSTORM) has shown great potential for super-resolution imaging of thick biological specimens. Despite its compatibility with tissues and small animals, prior uses of the Gaussian ... ...

    Abstract Oblique plane microscopy-based single molecule localization microscopy (obSTORM) has shown great potential for super-resolution imaging of thick biological specimens. Despite its compatibility with tissues and small animals, prior uses of the Gaussian point spread function (PSF) model have resulted in limited imaging resolution and a narrow axial localization range. This is due to the poor fit of the Gaussian PSF model with the actual PSF shapes in obSTORM. To overcome these limitations, we have employed cubic splines for a more accurate modeling of the experimental PSF shapes. This refined PSF model enhances three-dimensional localization precision, leading to significant improvements in obSTORM imaging of mouse retina tissues, such as an approximately 1.2 times increase in imaging resolution, seamless stitching of single molecules between adjacent optical sections, and a doubling of the sectional interval in volumetric obSTORM imaging due to the extended axial range of usable section thickness. The cubic spline PSF model thus offers a path towards more accurate and faster volumetric obSTORM imaging of biological specimens.
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.500323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A non-invasive, sensitive assay for active TB: combined cell-free DNA detection and FluoroSpot assays.

    Kim, J Y / Koo, B / Lim, S Y / Cha, H H / Kim, M J / Chong, Y P / Choi, S-H / Lee, S-O / Kim, Y S / Shin, Y / Kim, S-H

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2023  Volume 27, Issue 10, Page(s) 790–792

    MeSH term(s) Humans ; Tuberculosis/diagnosis ; Cell-Free Nucleic Acids/analysis
    Chemical Substances Cell-Free Nucleic Acids
    Language English
    Publishing date 2023-09-26
    Publishing country France
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.23.0180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4776: Show issues Location:
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    Zs.MO 261: Show issues

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  3. Article: The effect of hypoxic ischemic encephalopathy towards multi-organ complications and its early outcome at a Malaysian district hospital.

    Chong, W H / Ong, H Y / Ooi, J S / Eleen Khaw, Y Y / Lim, L M / Tew, M M / Koo, H W / Aishah, A R / Goh, P W

    The Medical journal of Malaysia

    2024  Volume 79, Issue 2, Page(s) 184–190

    Abstract: Introduction: Hypoxic ischemic encephalopathy (HIE) is a clinically defined syndrome of disturbed neurologic function in the newborn with evidence of perinatal asphyxia. Stages of HIE are categorised into mild, moderate or severe based on the Sarnat ... ...

    Abstract Introduction: Hypoxic ischemic encephalopathy (HIE) is a clinically defined syndrome of disturbed neurologic function in the newborn with evidence of perinatal asphyxia. Stages of HIE are categorised into mild, moderate or severe based on the Sarnat classification. Neurological dysfunction constitutes a part of the wide spectrum of hypoxic ischemic insult as affected infants can have co-existing multi-organ dysfunction which further contributes to morbidities and mortality. This study aims to determine the relationship between the severity of HIE with multi-organ complications and early clinical outcomes.
    Materials and methods: All neonates who were admitted to the NICU at Hospital Sultan Abdul Halim between January 2018 to December 2022, who fulfilled the inclusion criteria were included. Demographic data, clinical course and investigation results were retrospectively obtained from the medical records.
    Results: From a total of 90 infants (n = 90) who fulfilled our inclusion criteria, 31 (34%) were mild, 31 (34%) were moderate and 28 (31%) were severe HIE. The mean maternal age was 27 years. Common antenatal issues include diabetes mellitus (37.8%) and anaemia (22.2%). The Apgar scores at 1 and 5 minutes, initial resuscitation requiring intubation, chest compression and adrenaline were associated with higher severity of HIE (p < 0.05). Coagulation dysfunction was the most common complication (79.7%), followed by respiratory dysfunction (33.3%), cardiac dysfunction (28.9%), renal dysfunction (16.1%), haematological dysfunction (15.6%) and hepatic dysfunction (12%). Respiratory and haematological dysfunctions were significantly associated with higher mortality (p < 0.05). There was a significant longer hospital stay (p = 0.023), longer duration of ventilation (p < 0.001) and increase in frequency of seizures (p < 0.001) when comparing moderate and severe HIE patients to mild HIE patients. With increasing severity of HIE, there was also statistically significant higher mortality (p < 0.001).
    Conclusions: There is a significant relationship between multiorgan dysfunction, the severity of HIE and mortality. Early anticipation of multi-organ injury is crucial for optimal early management which would reduce the mortality and improve the neurological outcome of the patients.
    MeSH term(s) Infant, Newborn ; Infant ; Humans ; Female ; Pregnancy ; Adult ; Hypoxia-Ischemia, Brain/complications ; Hypoxia-Ischemia, Brain/therapy ; Retrospective Studies ; Hospitals, District ; Hypoxia ; Asphyxia Neonatorum/complications
    Language English
    Publishing date 2024-03-30
    Publishing country Malaysia
    Document type Journal Article
    ZDB-ID 604286-7
    ISSN 0300-5283
    ISSN 0300-5283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1206: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: CAMx–UNIPAR simulation of secondary organic aerosol mass formed from multiphase reactions of hydrocarbons under the Central Valley urban atmospheres of California

    Y. Jo / M. Jang / S. Han / A. Madhu / B. Koo / Y. Jia / Z. Yu / S. Kim / J. Park

    Atmospheric Chemistry and Physics, Vol 24, Pp 487-

    2024  Volume 508

    Abstract: The UNIfied Partitioning-Aerosol phase Reaction (UNIPAR) model was integrated into the Comprehensive Air quality Model with extensions (CAMx) to process secondary organic aerosol (SOA) formation by capturing multiphase reactions of hydrocarbons (HCs) in ... ...

    Abstract The UNIfied Partitioning-Aerosol phase Reaction (UNIPAR) model was integrated into the Comprehensive Air quality Model with extensions (CAMx) to process secondary organic aerosol (SOA) formation by capturing multiphase reactions of hydrocarbons (HCs) in regional scales. SOA growth was simulated using a wide range of anthropogenic HCs, including 10 aromatics and linear alkanes with different carbon lengths. The atmospheric processes of biogenic HCs (isoprene, terpenes, and sesquiterpene) were simulated for major oxidation paths (ozone, OH radicals, and nitrate radicals) to predict day and night SOA formation. The UNIPAR model streamlined the multiphase partitioning of the lumping species originating from semi-explicitly predicted gas products and their heterogeneous chemistry to form non-volatile oligomeric species in both organic aerosol and inorganic aqueous phase. The CAMx–UNIPAR model predicted SOA formation at four ground urban sites (San Jose, Sacramento, Fresno, and Bakersfield) in California, United States, during wintertime 2018. Overall, the simulated mass concentrations of the total organic matter, consisting of primary organic aerosol and SOA, showed a good agreement with the observations. The simulated SOA mass in the urban areas of California was predominated by alkane and terpene oxidation products. During the daytime, low-volatility products originating from the autoxidation of long-chain alkanes considerably contributed to the SOA mass. In contrast, a significant amount of nighttime SOA was produced by the reaction of terpene with ozone or nitrate radicals. The spatial distributions of anthropogenic SOA associated with aromatic and alkane HCs were noticeably affected by the southward wind direction, owing to the relatively long lifetime of their atmospheric oxidation, whereas those of biogenic SOA were nearly insensitive to wind direction. During wintertime 2018, the impact of inorganic aerosol hygroscopicity on the total SOA budget was not evident because of the small contribution of aromatic ...
    Keywords Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 660
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Copernicus Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Article ; Online: Can we trust large language models to summarize food policy research papers and generate research briefs?

    Kim, MinAh / Koo, Jawoo / Jung, Yunchul

    2023  

    Abstract: Generative large language models (LLMs), while widely accessible and capable of simulating policy recommendations, pose challenges in the assessment of their accuracy. Users, including policy ana lysts and decision-makers, bear the responsibility of ... ...

    Abstract Generative large language models (LLMs), while widely accessible and capable of simulating policy recommendations, pose challenges in the assessment of their accuracy. Users, including policy ana lysts and decision-makers, bear the responsibility of evaluating the outcomes from these models. A significant limitation of LLMs is their potential to overlook critical, context-specific factors. For example, in formulating food policies, it is vital to consider regional climate and environmental variables that influence water and resource availability. Nonetheless, due to their reliance on word sequencing probabilities from training datasets, LLMs might propose similar policies for distinct regions. Despite these limitations, LLMs offer considerable advantages for rapid policy analysis, particularly when resources are constrained. They serve as quick, accessible, and cost-effective tools for policy research and development, requiring minimal training and infrastructure. In our study, we assessed the efficacy of LLMs in generating policy briefs by inputting an IFPRI discussion paper into three different LLM-based approaches: a standard chatbot without extra data, a Retrieval Aug mented Generation model integrating semantic search with LLM, and a custom-developed Brief Generator designed to create policy summaries from AI-analyzed paper structures. Our findings revealed that none of the LLM-generated briefs fully captured the original paper's intent, underscor ing the need for further research. Future investigations should focus on gathering more empirical data with diverse text types and volumes to better understand these outcomes.

    Non-PR

    IFPRI1

    CPA; Natural Resources and Resilience (NRR); Transformation Strategies
    Keywords policies ; artificial intelligence ; technological changes ; data
    Subject code 303
    Language English
    Publisher International Food Policy Research Institute (IFPRI)
    Publishing country us
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A complete reference genome for the soybean cv. Jack.

    Huang, Yicheng / Koo, Dal-Hoe / Mao, Yizhou / Herman, Eliot M / Zhang, Jianwei / Schmidt, Monica A

    Plant communications

    2023  Volume 5, Issue 2, Page(s) 100765

    MeSH term(s) Glycine max/genetics ; Genome, Plant
    Language English
    Publishing date 2023-11-14
    Publishing country China
    Document type Journal Article
    ISSN 2590-3462
    ISSN (online) 2590-3462
    DOI 10.1016/j.xplc.2023.100765
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  7. Article ; Online: A cascade of magnetic phase transitions and a 1/3-magnetization plateau in selenite-selenate Co

    Murtazoev, A F / Berdonosov, P S / Lyssenko, K A / Dolgikh, V A / Geidorf, M Y / Volkova, O S / Koo, H-J / Whangbo, M-H / Vasiliev, A N

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 28, Page(s) 9664–9672

    Abstract: We prepared a new compound, ... ...

    Abstract We prepared a new compound, Co
    Language English
    Publishing date 2023-07-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt01620j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A combination of organic and inorganic cations in the synthesis of transition metal nitrates: preparation and characterization of canted rectangular Ising antiferromagnet (PyH)CsCo

    Vorobyova, A A / Lyssenko, K A / Chistyakov, G D / Morozov, I V / Ovchenkov, Y A / Vasilchikova, T M / Koo, H-J / Whangbo, M-H / Volkova, O S / Vasiliev, A N

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 47, Page(s) 18010–18017

    Abstract: Pyridinium cesium cobalt nitrate, (PyH) ... ...

    Abstract Pyridinium cesium cobalt nitrate, (PyH)CsCo
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt03159d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Suspected human intravenous immunoglobulin‐induced acute haemolytic anaemia in a dog

    Koo, Y. / Yun, T. / Chae, Y. / Lee, D. / Choi, D. / Oh, J. / Kim, J. / Kim, H. / Yang, M. P. / Kang, B. T.

    journal of small animal practice. 2022 June, v. 63, no. 6

    2022  

    Abstract: A 2‐year‐old mixed breed dog presented with a 1‐year history of crust and erosion on the nasal planum. Because histopathological examination revealed ruptured intraepidermal pustules and superficial dermal inflammation, the dog was diagnosed with ... ...

    Abstract A 2‐year‐old mixed breed dog presented with a 1‐year history of crust and erosion on the nasal planum. Because histopathological examination revealed ruptured intraepidermal pustules and superficial dermal inflammation, the dog was diagnosed with pemphigus foliaceus. Human intravenous immunoglobulin was administered in two consecutive doses of 0.5 g/kg/day due to poor therapeutic response to previous immunosuppressive therapy. From Day 3 after the first dose of human intravenous immunoglobulin, tachypnoea, pale mucous membrane, haemoglobinuria and haemoglobinemia were observed, thus confirming haemolytic anaemia. Other drug‐induced haemolytic anaemias were excluded because no additional drugs had been administered before the haemolysis occurred. Immune‐mediated haemolytic anaemia was also excluded because the direct antiglobulin test was negative. Two transfusions were performed, and haemolysis was not observed from Day 4 of haemolytic anaemia onset. In conclusion, human intravenous immunoglobulin‐induced haemolytic anaemia should be considered in dogs that develop haemolysis following the administration of human intravenous immunoglobulin.
    Keywords dogs ; hemolysis ; hemolytic anemia ; histopathology ; humans ; immunoglobulins ; immunosuppression ; inflammation ; intravenous injection ; mixed breeds ; mucosa ; nose ; small animal practice
    Language English
    Dates of publication 2022-06
    Size p. 482-485.
    Publishing place Blackwell Publishing Ltd
    Document type Article
    Note Case Reports
    ZDB-ID 410743-3
    ISSN 1748-5827 ; 0022-4510 ; 1748-5827
    ISSN (online) 1748-5827
    ISSN 0022-4510 ; 1748-5827
    DOI 10.1111/jsap.13449
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 590: Show issues Location:
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  10. Article ; Online: Microrobotics for Precision Biofilm Diagnostics and Treatment.

    Babeer, A / Oh, M J / Ren, Z / Liu, Y / Marques, F / Poly, A / Karabucak, B / Steager, E / Koo, H

    Journal of dental research

    2022  Volume 101, Issue 9, Page(s) 1009–1014

    Abstract: Advances in small-scale robotics and nanotechnology are providing previously unimagined opportunities for new diagnostic and therapeutic approaches with high precision, control, and efficiency. We designed microrobots for tetherless biofilm treatment and ...

    Abstract Advances in small-scale robotics and nanotechnology are providing previously unimagined opportunities for new diagnostic and therapeutic approaches with high precision, control, and efficiency. We designed microrobots for tetherless biofilm treatment and retrieval using iron oxide nanoparticles (NPs) with dual catalytic-magnetic functionality as building blocks. We show 2 distinct microrobotic platforms. The first system is formed from NPs that assemble into aggregated microswarms under magnetic fields that can be controlled to disrupt and retrieve biofilm samples for microbial analysis. The second platform is composed of 3-dimensional (3D) micromolded opacifier-infused soft helicoids with embedded catalytic-magnetic NPs that can be visualized via existing radiographic imaging techniques and controlled magnetically inside the root canal, uninterrupted by the soft and hard tissues surrounding the teeth in an ex vivo model. These microrobots placed inside the root canal can remove biofilms and be efficiently guided with microscale precision. The proof-of-concept paradigm described here can be adapted to target difficult-to-reach anatomical spaces in other natural and implanted surfaces in an automated and tether-free manner.
    MeSH term(s) Biofilms
    Language English
    Publishing date 2022-04-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/00220345221087149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 262: Show issues

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