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  1. Article ; Online: Biofluid-based biomarkers for Alzheimer's disease-related pathologies: An update and synthesis of the literature.

    Zetterberg, Henrik

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2022  Volume 18, Issue 9, Page(s) 1687–1693

    Abstract: The past few years have seen an explosion in sensitive and specific assays for cerebrospinal fluid (CSF) and blood biomarkers for Alzheimer's disease (AD) and related disorders, as well as some novel assays based on pathological seed-induced protein ... ...

    Abstract The past few years have seen an explosion in sensitive and specific assays for cerebrospinal fluid (CSF) and blood biomarkers for Alzheimer's disease (AD) and related disorders, as well as some novel assays based on pathological seed-induced protein misfolding in patient samples. Here, I review this exciting field that promises to transform dementia diagnostics and disease monitoring. I discuss data on biomarkers for amyloid beta (Aβ) and tau pathology, neurodegeneration, and glial activation, mention the most promising biomarkers for α-synuclein and TDP-43 pathology, and highlight the need for further research into common co-pathologies. Finally, I consider practical aspects of blood-based biomarker-supported AD diagnostics and emphasize the importance of biomarker interpretation in a full clinical context.
    MeSH term(s) Alzheimer Disease/cerebrospinal fluid ; Amyloid beta-Peptides/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; DNA-Binding Proteins ; Humans ; alpha-Synuclein/cerebrospinal fluid ; tau Proteins/cerebrospinal fluid
    Chemical Substances Amyloid beta-Peptides ; Biomarkers ; DNA-Binding Proteins ; alpha-Synuclein ; tau Proteins
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.12618
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  2. Article ; Online: Glial fibrillary acidic protein: a blood biomarker to differentiate neurodegenerative from psychiatric diseases.

    Zetterberg, Henrik

    Journal of neurology, neurosurgery, and psychiatry

    2021  Volume 92, Issue 12, Page(s) 1253

    MeSH term(s) Biomarkers ; Glial Fibrillary Acidic Protein ; Humans ; Intermediate Filaments ; Mental Disorders/diagnosis
    Chemical Substances Biomarkers ; Glial Fibrillary Acidic Protein
    Language English
    Publishing date 2021-09-03
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2021-326994
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  3. Article ; Online: Neurofilament light in blood - What more is needed for clinical implementation in multiple sclerosis?

    Zetterberg, Henrik

    EBioMedicine

    2020  Volume 57, Page(s) 102826

    MeSH term(s) Humans ; Intermediate Filaments ; Multiple Sclerosis ; Multiple Sclerosis, Relapsing-Remitting ; Neurofilament Proteins
    Chemical Substances Neurofilament Proteins
    Language English
    Publishing date 2020-06-20
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2020.102826
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  4. Article ; Online: Is There a Value of Neurofilament Light as a Biomarker for Neurodegeneration in Parkinson's Disease?

    Zetterberg, Henrik

    Movement disorders : official journal of the Movement Disorder Society

    2020  Volume 35, Issue 7, Page(s) 1111–1112

    MeSH term(s) Biomarkers ; Humans ; Intermediate Filaments ; Neurofilament Proteins ; Parkinson Disease
    Chemical Substances Biomarkers ; Neurofilament Proteins
    Language English
    Publishing date 2020-07-21
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.28101
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  5. Article ; Online: Neurofilament light in blood – What more is needed for clinical implementation in multiple sclerosis?

    Henrik Zetterberg

    EBioMedicine, Vol 57, Iss , Pp 102826- (2020)

    2020  

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  6. Article ; Online: Plasma neurofilament light in progressive multiple sclerosis.

    Zetterberg, Henrik

    Acta neurologica Scandinavica

    2019  Volume 141, Issue 1, Page(s) 14–15

    MeSH term(s) Demyelinating Diseases ; Humans ; Intermediate Filaments ; Multiple Sclerosis ; Neurofilament Proteins
    Chemical Substances Neurofilament Proteins
    Language English
    Publishing date 2019-10-16
    Publishing country Denmark
    Document type Editorial ; Comment
    ZDB-ID 90-5
    ISSN 1600-0404 ; 0001-6314
    ISSN (online) 1600-0404
    ISSN 0001-6314
    DOI 10.1111/ane.13184
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  7. Article ; Online: Microglia and amyloid plaque formation in Alzheimer's disease - Evidence, possible mechanisms, and future challenges.

    Fruhwürth, Stefanie / Zetterberg, Henrik / Paludan, Søren R

    Journal of neuroimmunology

    2024  Volume 390, Page(s) 578342

    Abstract: Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline that severely affects patients and their families. Genetic and environmental risk factors, such as viral infections, synergize to accelerate the aging-associated ... ...

    Abstract Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline that severely affects patients and their families. Genetic and environmental risk factors, such as viral infections, synergize to accelerate the aging-associated neurodegeneration. Genetic risk factors for late-onset AD (LOAD), which accounts for most AD cases, are predominantly implicated in microglial and immune cell functions. As such, microglia play a major role in formation of amyloid beta (Aβ) plaques, the major pathological hallmark of AD. This review aims to provide an overview of the current knowledge regarding the role of microglia in Aβ plaque formation, as well as their impact on morphological and functional diversity of Aβ plaques. Based on this discussion, we seek to identify challenges and opportunities in this field with potential therapeutic implications.
    Language English
    Publishing date 2024-04-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 8335-5
    ISSN 1872-8421 ; 0165-5728
    ISSN (online) 1872-8421
    ISSN 0165-5728
    DOI 10.1016/j.jneuroim.2024.578342
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  8. Article ; Online: Neurofilament light chain as neuronal injury marker - what is needed to facilitate implementation in clinical laboratory practice?

    Arslan, Burak / Zetterberg, Henrik

    Clinical chemistry and laboratory medicine

    2023  Volume 61, Issue 7, Page(s) 1140–1149

    Abstract: Neurobiomarkers have attracted significant attention over the last ten years. One promising biomarker is the neurofilament light chain protein (NfL). Since the introduction of ultrasensitive assays, NfL has been developed into a widely used axonal damage ...

    Abstract Neurobiomarkers have attracted significant attention over the last ten years. One promising biomarker is the neurofilament light chain protein (NfL). Since the introduction of ultrasensitive assays, NfL has been developed into a widely used axonal damage marker of relevance to the diagnosis, prognostication, follow-up, and treatment monitoring of a range of neurological disorders, including multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer's disease. The marker is increasingly used clinically, as well as in clinical trials. Even if we have validated precise, sensitive, and specific assays for NfL quantification in both cerebrospinal fluid and blood, there are analytical, as well as pre- and post-analytical aspects of the total NfL testing process, including biomarker interpretation, to consider. Although the biomarker is already in use in specialised clinical laboratory settings, a more general use requires some further work. In this review, we provide brief basic information and opinions on NfL as a biomarker of axonal injury in neurological diseases and pinpoint additional work needed to facilitate biomarker implementation in clinical practice.
    MeSH term(s) Humans ; Laboratories, Clinical ; Intermediate Filaments ; Neurofilament Proteins ; Alzheimer Disease ; Biomarkers ; Nervous System Diseases/diagnosis
    Chemical Substances Neurofilament Proteins ; Biomarkers
    Language English
    Publishing date 2023-03-07
    Publishing country Germany
    Document type Review ; Journal Article
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2023-0036
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    Zs.A 121: Show issues Location:
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  9. Article: The iterative process of fluid biomarker development and validation in Alzheimer's disease.

    Bendlin, Barbara B / Zetterberg, Henrik

    Alzheimer's & dementia (Amsterdam, Netherlands)

    2022  Volume 14, Issue 1, Page(s) e12341

    Language English
    Publishing date 2022-07-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 2832898-X
    ISSN 2352-8729
    ISSN 2352-8729
    DOI 10.1002/dad2.12341
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  10. Article ; Online: Blood-based biomarkers in Alzheimer's disease - moving towards a new era of diagnostics.

    Arslan, Burak / Zetterberg, Henrik / Ashton, Nicholas J

    Clinical chemistry and laboratory medicine

    2024  Volume 62, Issue 6, Page(s) 1063–1069

    Abstract: Alzheimer's disease (AD), a primary cause of dementia globally, is traditionally diagnosed via cerebrospinal fluid (CSF) measures and positron emission tomography (PET). The invasiveness, cost, and limited accessibility of these methods have led to ... ...

    Abstract Alzheimer's disease (AD), a primary cause of dementia globally, is traditionally diagnosed via cerebrospinal fluid (CSF) measures and positron emission tomography (PET). The invasiveness, cost, and limited accessibility of these methods have led to exploring blood-based biomarkers as a promising alternative for AD diagnosis and monitoring. Recent advancements in sensitive immunoassays have identified potential blood-based biomarkers, such as Aβ42/Aβ40 ratios and phosphorylated tau (p-tau) species. This paper briefly evaluates the clinical utility and reliability of these biomarkers across various AD stages, highlighting challenges like refining plasma Aβ42/Aβ40 assays and enhancing the precision of p-tau, particularly p-tau181, p-tau217, and p-tau231. The discussion also covers other plasma biomarkers like neurofilament light (NfL), glial fibrillary acidic protein (GFAP), and synaptic biomarkers, assessing their significance in AD diagnostics. The need for ongoing research and development of robust assays to match the performance of CSF and PET biomarkers is underscored. In summary, blood-based biomarkers are increasingly crucial in AD diagnosis, follow-up, prognostication, treatment response evaluation, and population screening, particularly in primary care settings. These developments are set to revolutionize AD diagnostics, offering earlier and more accessible detection and management options.
    MeSH term(s) Alzheimer Disease/diagnosis ; Alzheimer Disease/blood ; Humans ; Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; tau Proteins/blood ; tau Proteins/cerebrospinal fluid ; Amyloid beta-Peptides/blood ; Amyloid beta-Peptides/cerebrospinal fluid ; Positron-Emission Tomography
    Chemical Substances Biomarkers ; tau Proteins ; Amyloid beta-Peptides
    Language English
    Publishing date 2024-01-23
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2023-1434
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