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  1. Article ; Online: Latent Tuberculosis Infection. Reply.

    Shah, Maunank / Dorman, Susan E

    The New England journal of medicine

    2022  Volume 386, Issue 13, Page(s) e33

    MeSH term(s) Humans ; Latent Tuberculosis/diagnosis
    Language English
    Publishing date 2022-03-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2200195
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  2. Article ; Online: Latent Tuberculosis Infection.

    Shah, Maunank / Dorman, Susan E

    The New England journal of medicine

    2021  Volume 385, Issue 24, Page(s) 2271–2280

    MeSH term(s) Adult ; Algorithms ; Antitubercular Agents/administration & dosage ; Child ; Drug Therapy, Combination ; Humans ; Isoniazid/administration & dosage ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/drug therapy ; Male ; Mycobacterium tuberculosis ; Rifamycins/administration & dosage ; Risk Factors ; Tuberculin Test
    Chemical Substances Antitubercular Agents ; Rifamycins ; Isoniazid (V83O1VOZ8L)
    Language English
    Publishing date 2021-12-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcp2108501
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  3. Article ; Online: Diagnosis of HIV-associated tuberculosis.

    Dorman, Susan E

    Current opinion in HIV and AIDS

    2018  Volume 13, Issue 6, Page(s) 462–468

    Abstract: Purpose of review: The current review highlights recent advances in tuberculosis (TB) diagnostics that are relevant for clinicians engaged in the care of HIV-positive adults.: Recent findings: The first section focuses on newly available tools, ... ...

    Abstract Purpose of review: The current review highlights recent advances in tuberculosis (TB) diagnostics that are relevant for clinicians engaged in the care of HIV-positive adults.
    Recent findings: The first section focuses on newly available tools, highlighting recent progress. The second section focuses on new diagnostic approaches that are not yet widely available or implemented, but have considerable potential to improve the management of TB/HIV coinfected persons. The final section speculates about future directions that may be fruitful.
    Summary: Advances in Mycobacterium tuberculosis nucleic acid amplification-based genotypic tests stand to improve case detection and drug susceptibility testing in the near term. Identification of human gene expression signatures that are associated with TB and/or TB risk, and the identification of novel M. tuberculosis targets coupled with exploitation of advances in biosensor technology may transform TB diagnosis in the future.
    MeSH term(s) Animals ; Diagnostic Tests, Routine ; HIV Infections/complications ; HIV Infections/virology ; HIV-1/physiology ; Humans ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/isolation & purification ; Mycobacterium tuberculosis/physiology ; Tuberculosis/complications ; Tuberculosis/diagnosis ; Tuberculosis/microbiology
    Language English
    Publishing date 2018-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0000000000000497
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  4. Article ; Online: Four-Month Rifapentine Regimens for Tuberculosis. Reply.

    Phillips, Patrick P J / Kurbatova, Ekaterina V / Dorman, Susan E

    The New England journal of medicine

    2021  Volume 386, Issue 11, Page(s) 1095–1096

    MeSH term(s) Humans ; Rifampin/analogs & derivatives ; Rifampin/therapeutic use ; Tuberculosis/drug therapy
    Chemical Substances Rifampin (VJT6J7R4TR) ; rifapentine (XJM390A33U)
    Language English
    Publishing date 2021-10-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2114483
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  5. Article: A Case of Peritoneal Tuberculosis Mimicking Ovarian Cancer in a Young Female.

    Nissim, Oriel / Ervin, F Richard / Dorman, Susan E / Jandhyala, Deeksha

    Case reports in obstetrics and gynecology

    2022  Volume 2022, Page(s) 4687139

    Abstract: Background: Tuberculosis causes significant morbidity and mortality globally. Peritoneal tuberculosis can have a similar presentation to ovarian cancer.: Case: We present a case of a 42-year-old female referred to gynecology oncology with imaging ... ...

    Abstract Background: Tuberculosis causes significant morbidity and mortality globally. Peritoneal tuberculosis can have a similar presentation to ovarian cancer.
    Case: We present a case of a 42-year-old female referred to gynecology oncology with imaging findings of enlarged right ovary, omental caking, and elevated CA-125 (1289 U/mL). A diagnostic laparoscopy revealed diffuse studding of intraperitoneal surfaces. Histopathological examination of omental and abdominal wall biopsies showed granulomas, but stains and cultures for mycobacteria were negative. Antimicrobial treatment for tuberculosis was initiated. Within eight weeks, there was clear clinical and radiographic improvement, consistent with a diagnosis of peritoneal tuberculosis.
    Conclusion: This case highlights the importance of including peritoneal tuberculosis in the differential diagnosis when evaluating for ovarian cancer in women with epidemiologic risk factors for tuberculosis.
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627654-9
    ISSN 2090-6692 ; 2090-6684
    ISSN (online) 2090-6692
    ISSN 2090-6684
    DOI 10.1155/2022/4687139
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  6. Article ; Online: Inhaled nitric oxide for adults with pulmonary non-tuberculous mycobacterial infection.

    Flume, Patrick A / Garcia, Bryan A / Wilson, Dulaney / Steed, Lisa / Dorman, Susan E / Winthrop, Kevin

    Respiratory medicine

    2022  Volume 206, Page(s) 107069

    Abstract: Question: There is an increasing prevalence of nontuberculous mycobacteria pulmonary disease (NTM-PD) in the US. Treatment of NTM-PD typically requires multiple medications, which can be associated with unpleasant morbidity and eradication of infection ... ...

    Abstract Question: There is an increasing prevalence of nontuberculous mycobacteria pulmonary disease (NTM-PD) in the US. Treatment of NTM-PD typically requires multiple medications, which can be associated with unpleasant morbidity and eradication of infection is difficult. Therefore, there is a critical need for novel effective and well-tolerated therapies. Recent in vitro data and case reports have suggested that nitric oxide, inhaled as a gas (gNO), has antimicrobial activity against NTM. We sought to investigate the effect of gNO in patients with NTM-PD in an open-label proof of concept trial.
    Methods: Eligible participants had NTM-PD with persistently positive respiratory cultures for NTM even if on antibiotic treatment. Participants were treated with gNO for 50 min three times daily, five days per week, for three weeks (total of 15 treatment days).
    Results: Ten participants, of whom nine were on long-term NTM antibiotic therapy, were enrolled. All participants completed the regimen without interruption or discontinuation. Small increases in methemoglobin were noted during treatment, and all resolved to baseline within 2 h. Four participants (40%) met the primary outcome measure of negative sputum cultures after three weeks of therapy. Following treatment discontinuation, three of these participants were again culture positive during the 3-month post-treatment monitoring period, although with measures suggesting low bacterial burden.
    Answer: Patients tolerated a 3-week regimen of gNO without safety concerns, and despite highly refractory disease four individuals completed the study with negative cultures, although three were again positive in subsequent months. These data support further investigation of gNO as a potential therapy for NTM-PD.
    MeSH term(s) Adult ; Humans ; Anti-Bacterial Agents/therapeutic use ; Lung Diseases/microbiology ; Mycobacterium Infections, Nontuberculous/microbiology ; Nitric Oxide/therapeutic use ; Nontuberculous Mycobacteria ; Pneumonia/complications ; Retrospective Studies ; Proof of Concept Study
    Chemical Substances Anti-Bacterial Agents ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2022-12-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2022.107069
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  7. Article ; Online: Pharmacokinetic-Pharmacodynamic Evidence from a Phase 3 Trial to Support Flat-Dosing of Rifampicin for Tuberculosis.

    Ngo, Huy X / Xu, Ava Y / Velásquez, Gustavo E / Zhang, Nan / Chang, Vincent K / Kurbatova, Ekaterina V / Whitworth, William C / Sizemore, Erin / Bryant, Kia / Carr, Wendy / Weiner, Marc / Dooley, Kelly E / Engle, Melissa / Dorman, Susan E / Nahid, Payam / Swindells, Susan / Chaisson, Richard E / Nsubuga, Pheona / Lourens, Madeleine /
    Dawson, Rodney / Savic, Radojka M

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  

    Abstract: Background: The optimal dosing strategy for rifampicin in treating drug-susceptible tuberculosis (TB) is still highly debated. In the Phase 3 clinical trial Study 31/ACTG 5349 (NCT02410772), all participants in the control regimen arm received 600 mg ... ...

    Abstract Background: The optimal dosing strategy for rifampicin in treating drug-susceptible tuberculosis (TB) is still highly debated. In the Phase 3 clinical trial Study 31/ACTG 5349 (NCT02410772), all participants in the control regimen arm received 600 mg rifampicin daily as a flat dose. Here, we evaluated relationships between rifampicin exposure and efficacy and safety outcomes.
    Methods: We analyzed rifampicin concentration time profiles using population nonlinear mixed-effects models. We compared simulated rifampicin exposure from flat- and weight-banded dosing. We evaluated the effect of rifampicin exposure on stable culture conversion at 6 months, TB-related unfavorable outcomes at 9, 12, and 18 months using Cox proportional hazard models, and all trial-defined safety outcomes using logistic regression.
    Results: Our model derived rifampicin exposure ranged from 4.57 mg·h/L to 140.0 mg·h/L with a median of 41.8 mg·h/L. Pharmacokinetic simulations demonstrated that flat-dosed rifampicin provided exposure coverage similar to weight-banded dose. Exposure-efficacy analysis (N=680) showed that participants with rifampicin exposure below the median experienced similar hazards of stable culture conversion and TB-related unfavorable outcomes compared to those with exposure above the median. Exposure-safety analysis (N=722) showed that increased rifampicin exposure was not associated with increased grade 3 or higher adverse events, or serious adverse events.
    Conclusions: Flat-dosing of rifampicin at 600 mg daily may be a reasonable alternative to the incumbent weight-banded dosing strategy for the standard of care 6-month regimen. Future research should assess the optimal dosing strategy for rifampicin, at doses higher than the current recommendation.
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciae119
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  8. Article: Long-term Safety and Tolerability of Omadacycline for the Treatment of

    Mingora, Christina M / Bullington, Wendy / Faasuamalie, Paige E / Levin, Adrah / Porter, Gabriella / Stadnick, Ryan / Varley, Cara D / Addrizzo-Harris, Doreen / Daley, Charles L / Olivier, Kenneth N / Winthrop, Kevin L / Dorman, Susan E / Flume, Patrick A

    Open forum infectious diseases

    2023  Volume 10, Issue 7, Page(s) ofad335

    Abstract: Background: Mycobacterium abscessus: Methods: We conducted a multicenter retrospective chart review of adults with : Results: Analysis included 117 patients. Among patients with : Conclusions: This study reports data supporting long-term safety ...

    Abstract Background: Mycobacterium abscessus
    Methods: We conducted a multicenter retrospective chart review of adults with
    Results: Analysis included 117 patients. Among patients with
    Conclusions: This study reports data supporting long-term safety and tolerability of omadacycline along with signal of effectiveness in treatment of
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad335
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  9. Article ; Online: New diagnostic tests for tuberculosis: bench, bedside, and beyond.

    Dorman, Susan E

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2010  Volume 50 Suppl 3, Page(s) S173–7

    Abstract: Current tools and strategies for diagnosis of tuberculosis (TB) are inadequate, particularly in settings with a high prevalence of human immunodeficiency virus (HIV) infection. Several promising new tools are at advanced stages of development and ... ...

    Abstract Current tools and strategies for diagnosis of tuberculosis (TB) are inadequate, particularly in settings with a high prevalence of human immunodeficiency virus (HIV) infection. Several promising new tools are at advanced stages of development and evaluation. This review describes some of those promising new technologies and the key barriers to their effective implementation.
    MeSH term(s) Clinical Laboratory Techniques/methods ; Diagnostic Tests, Routine/methods ; Humans ; Point-of-Care Systems ; Tuberculosis/diagnosis
    Language English
    Publishing date 2010-05-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1086/651488
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  10. Article ; Online: Time-to-positivity of Mycobacterium avium complex in broth culture associates with culture conversion.

    Mingora, Christina M / Garcia, Bryan A / Mange, Kevin C / Yuen, Dayton W / Ciesielska, Monika / van Ingen, Jakko / Flume, Patrick A / Dorman, Susan E

    BMC infectious diseases

    2022  Volume 22, Issue 1, Page(s) 246

    Abstract: Background: Mycobacterial time to positivity (TTP) in liquid culture media has predictive value for longer term outcomes in pulmonary tuberculosis, but has not been thoroughly studied in nontuberculous mycobacterial pulmonary disease. This study sought ... ...

    Abstract Background: Mycobacterial time to positivity (TTP) in liquid culture media has predictive value for longer term outcomes in pulmonary tuberculosis, but has not been thoroughly studied in nontuberculous mycobacterial pulmonary disease. This study sought to evaluate for association between TTP and sputum culture conversion to negative in pulmonary disease caused by Mycobacterium avium complex (MAC).
    Methods: Data from the CONVERT trial (NCT02344004) that evaluated efficacy of guideline-based-therapy with or without amikacin liposome inhalation suspension in adults with refractory MAC-PD (Mycobacterium avium complex pulmonary disease) were analyzed. We evaluated TTP measures for sputum obtained prior to study treatment initiation and at monthly visits, assessing reproducibility of measures as well as association of TTP with culture conversion on treatment.
    Results: Data from 71 participants with at least one screening visit TTP value were analyzed. For participants who provided more than one sputum sample at a given visit, there was moderate between-sample reliability, with median intraclass correlation coefficient 0.62 (IQR 0.50, 0.70). Median TTP at screening was longer in those participants who subsequently achieved vs. did not achieve culture conversion (10.5 [IQR 9.4] days vs. 4.2 [IQR 2.8] days, p = 0.0002). Individuals with culture conversion by study treatment month 6 were more likely to have a screening TTP > 5 days compared to those who did not achieve culture conversion (OR 15.4, 95% CI 1.9, 716.7, p = 0.0037) and had increasing TTPs over time.
    Conclusions: TTP prior to and on treatment is associated with microbiological treatment response in patients with MAC-PD.
    MeSH term(s) Adult ; Anti-Bacterial Agents/therapeutic use ; Humans ; Mycobacterium avium Complex ; Mycobacterium avium-intracellulare Infection/diagnosis ; Mycobacterium avium-intracellulare Infection/drug therapy ; Mycobacterium avium-intracellulare Infection/microbiology ; Reproducibility of Results ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-03-12
    Publishing country England
    Document type Clinical Study ; Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-022-07250-4
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