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  1. Article ; Online: Unraveling the smoker's paradox: impact of smoking on outcomes in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention.

    Hausenloy, Derek J / Sia, Ching-Hui / Ko, Junsuk

    Polish archives of internal medicine

    2023  Volume 133, Issue 9

    MeSH term(s) Humans ; Smokers ; Smoking/adverse effects ; ST Elevation Myocardial Infarction/surgery ; Tobacco Smoking ; Percutaneous Coronary Intervention ; Treatment Outcome
    Language English
    Publishing date 2023-09-29
    Publishing country Poland
    Document type Journal Article ; Comment
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 360: Show issues Location:
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  2. Article ; Online: Combining Invasive Coronary Physiology With CMR for Long-Term Risk-Stratification in STEMI: Ready for Clinical Application?

    Hausenloy, Derek J / Bulluck, Heerajnarain

    JACC. Cardiovascular imaging

    2021  Volume 14, Issue 10, Page(s) 1960–1962

    MeSH term(s) Coronary Circulation ; Humans ; Percutaneous Coronary Intervention/adverse effects ; Predictive Value of Tests ; ST Elevation Myocardial Infarction/diagnostic imaging ; ST Elevation Myocardial Infarction/therapy
    Language English
    Publishing date 2021-06-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2021.04.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Remote Ischemic Conditioning: Challenges and Opportunities.

    Zhao, Wenbo / Hausenloy, Derek J / Hess, David C / Yellon, Derek M / Ji, Xunming

    Stroke

    2023  Volume 54, Issue 8, Page(s) 2204–2207

    Abstract: Remote ischemic conditioning (RIC) has been investigated as a promising, safe, and well-tolerated nonpharmacological therapy for cardio-cerebrovascular disease over the past 3 decades; variable results have been found when it is used in cerebrovascular ... ...

    Abstract Remote ischemic conditioning (RIC) has been investigated as a promising, safe, and well-tolerated nonpharmacological therapy for cardio-cerebrovascular disease over the past 3 decades; variable results have been found when it is used in cerebrovascular versus cardiovascular disease. For patients with cardiovascular disease, milestone studies suggest that the roles of RIC may be limited. Recently, however, 2 large trials investigating RIC in patients with cerebrovascular disease found promising results, which may reignite the field's research prospects after its setbacks in the cardiovascular field. This perspectives article highlights several important clinical trials of RIC in the cardio-cerebrovascular disease and describes the many challenges of RIC in clinical translation. Finally, based on the available evidence, several promising research directions such as chronic RIC, early initiation in target population, improvement of compliance, better understanding of dosing, and identification of specific biomarkers are proposed and should be investigated before RIC can become applied into clinical practice for patient benefit.
    MeSH term(s) Humans ; Cardiovascular Diseases ; Ischemic Postconditioning/methods
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.123.043279
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  4. Article ; Online: Prognostically relevant cardiac troponin elevations with percutaneous coronary interventions.

    Bulluck, Heerajnarain / Thygesen, Kristian / Hausenloy, Derek J

    European heart journal

    2021  

    Language English
    Publishing date 2021-12-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab862
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    Zs.MO 640: Show issues

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  5. Article ; Online: A future for remote ischaemic conditioning in high-risk patients.

    Hausenloy, Derek J / Ntsekhe, Mpiko / Yellon, Derek M

    Basic research in cardiology

    2020  Volume 115, Issue 3, Page(s) 35

    MeSH term(s) Animals ; Humans ; Ischemic Preconditioning, Myocardial/methods ; Myocardial Infarction/complications ; Myocardial Infarction/therapy ; Myocardial Reperfusion Injury/etiology ; Myocardial Reperfusion Injury/prevention & control
    Language English
    Publishing date 2020-04-25
    Publishing country Germany
    Document type Editorial
    ZDB-ID 189755-x
    ISSN 1435-1803 ; 0300-8428 ; 0175-9418
    ISSN (online) 1435-1803
    ISSN 0300-8428 ; 0175-9418
    DOI 10.1007/s00395-020-0794-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Combination Therapy to Target Reperfusion Injury After ST-Segment-Elevation Myocardial Infarction: A More Effective Approach to Cardioprotection.

    Hausenloy, Derek J / Yellon, Derek M

    Circulation

    2017  Volume 136, Issue 10, Page(s) 904–906

    MeSH term(s) Acetylcysteine ; Humans ; Myocardial Infarction ; Percutaneous Coronary Intervention ; Reperfusion Injury ; ST Elevation Myocardial Infarction
    Chemical Substances Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2017-09-06
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.117.029859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Translating Cardioprotection for Patient Benefit: The EU-CARDIOPROTECTION COST Action.

    Hausenloy, Derek J / Heusch, Gerd

    Journal of the American College of Cardiology

    2019  Volume 73, Issue 15, Page(s) 2001–2003

    MeSH term(s) Cardiotonic Agents/administration & dosage ; European Union ; Health Workforce/organization & administration ; Heart Failure/etiology ; Heart Failure/prevention & control ; Humans ; Myocardial Infarction/complications ; Myocardial Infarction/diagnosis ; Myocardial Infarction/therapy ; Patient Safety ; Research Design ; Risk Assessment
    Chemical Substances Cardiotonic Agents
    Language English
    Publishing date 2019-04-15
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2019.03.020
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    Zs.MO 196: Show issues

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  8. Article ; Online: Unravelling the Interplay between Cardiac Metabolism and Heart Regeneration.

    Yu, Fan / Cong, Shuo / Yap, En Ping / Hausenloy, Derek J / Ramachandra, Chrishan J

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Ischemic heart disease (IHD) is the leading cause of heart failure (HF) and is a significant cause of morbidity and mortality globally. An ischemic event induces cardiomyocyte death, and the ability for the adult heart to repair itself is challenged by ... ...

    Abstract Ischemic heart disease (IHD) is the leading cause of heart failure (HF) and is a significant cause of morbidity and mortality globally. An ischemic event induces cardiomyocyte death, and the ability for the adult heart to repair itself is challenged by the limited proliferative capacity of resident cardiomyocytes. Intriguingly, changes in metabolic substrate utilisation at birth coincide with the terminal differentiation and reduced proliferation of cardiomyocytes, which argues for a role of cardiac metabolism in heart regeneration. As such, strategies aimed at modulating this metabolism-proliferation axis could, in theory, promote heart regeneration in the setting of IHD. However, the lack of mechanistic understanding of these cellular processes has made it challenging to develop therapeutic modalities that can effectively promote regeneration. Here, we review the role of metabolic substrates and mitochondria in heart regeneration, and discuss potential targets aimed at promoting cardiomyocyte cell cycle re-entry. While advances in cardiovascular therapies have reduced IHD-related deaths, this has resulted in a substantial increase in HF cases. A comprehensive understanding of the interplay between cardiac metabolism and heart regeneration could facilitate the discovery of novel therapeutic targets to repair the damaged heart and reduce risk of HF in patients with IHD.
    MeSH term(s) Infant, Newborn ; Humans ; Heart ; Myocytes, Cardiac/metabolism ; Myocardial Ischemia/metabolism ; Heart Failure/metabolism ; Cell Proliferation
    Language English
    Publishing date 2023-06-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241210300
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  9. Article ; Online: Modulating NAD

    Bulluck, Heerajnarain / Hausenloy, Derek J

    Nature medicine

    2018  Volume 24, Issue 9, Page(s) 1306–1307

    MeSH term(s) Acute Kidney Injury ; Humans ; Kidney ; NAD
    Chemical Substances NAD (0U46U6E8UK)
    Language English
    Publishing date 2018-09-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-018-0181-9
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  10. Article ; Online: Why did remote ischaemic conditioning not improve clinical outcomes in acute myocardial infarction in the CONDI-2/ERIC-PPCI trial?

    Hausenloy, Derek J / Bøtker, Hans Erik

    Cardiovascular research

    2019  Volume 115, Issue 14, Page(s) e161–e163

    MeSH term(s) Animals ; Europe ; Humans ; Ischemic Preconditioning/adverse effects ; Ischemic Preconditioning/methods ; Ischemic Preconditioning/mortality ; Multicenter Studies as Topic ; Myocardial Infarction/diagnosis ; Myocardial Infarction/mortality ; Myocardial Infarction/physiopathology ; Myocardial Infarction/therapy ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/mortality ; Randomized Controlled Trials as Topic ; Recovery of Function ; Regional Blood Flow ; Risk Factors ; Treatment Outcome ; Upper Extremity/blood supply ; Ventricular Function, Left
    Language English
    Publishing date 2019-10-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvz242
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