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  1. Article ; Online: Siloed thinking is limiting health care delivery.

    Reynolds, Paul N

    Respirology (Carlton, Vic.)

    2024  Volume 29, Issue 4, Page(s) 346

    MeSH term(s) Humans ; Delivery of Health Care
    Language English
    Publishing date 2024-02-20
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.14691
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    Zs.A 4957: Show issues Location:
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  2. Article ; Online: Guidelines? Nice if you can afford it.

    Reynolds, Paul N

    Respirology (Carlton, Vic.)

    2022  Volume 28, Issue 2, Page(s) 189

    Language English
    Publishing date 2022-12-26
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.14442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pulmonary arterial hypertension: In Asia, as elsewhere, still a lethal disease despite modern treatment.

    Reynolds, Paul N

    Respirology (Carlton, Vic.)

    2018  Volume 24, Issue 2, Page(s) 99–100

    MeSH term(s) Asia ; Ethnic Groups ; Familial Primary Pulmonary Hypertension ; Follow-Up Studies ; Humans ; Hypertension, Pulmonary
    Language English
    Publishing date 2018-11-08
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13438
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    Zs.A 4957: Show issues Location:
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  4. Article ; Online: Twenty-five years of Respirology: From the Editors.

    Bardin, Philip G / Reynolds, Paul N

    Respirology (Carlton, Vic.)

    2019  Volume 25, Issue 1, Page(s) 6

    Language English
    Publishing date 2019-12-16
    Publishing country Australia
    Document type Editorial
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13751
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    Zs.A 4957: Show issues Location:
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  5. Article ; Online: Factor structure and measurement invariance of the Mood and Feelings Questionnaire: a cross-cultural study among Thai and British adolescents.

    Supreeyaporn, Nanthaka / Watson, Rebecca / Damrongpanit, Suntonrapot / Orchard, Faith / Reynolds, Shirley / Jenkins, Paul E

    European child & adolescent psychiatry

    2023  

    Abstract: ... of the MFQ-C as a prerequisite for its use in cross-cultural comparisons between Thai (N = 1272) and British ... samples (N = 1817) by using multigroup confirmatory factor analysis (MGCFA). The latent means of Thai and ...

    Abstract The Mood and Feelings Questionnaire-child self-report (MFQ-C) is a widely used measure of child and adolescent depression. This study evaluated possible factor solutions and examined the measurement invariance of the MFQ-C as a prerequisite for its use in cross-cultural comparisons between Thai (N = 1272) and British samples (N = 1817) by using multigroup confirmatory factor analysis (MGCFA). The latent means of Thai and British samples were also examined. A five-factor structure of the MFQ-C was confirmed through confirmatory factor analysis. A partial scalar invariant model was supported, and thus latent means were compared, with British adolescents reporting significantly higher mean MFQ-C scores than Thai adolescents on four of the five factors (Vegetative Symptoms, Suicidality, Cognitive Symptoms, Agitated Distress). There was no difference for the Core Symptoms factor. The findings also suggest that the MFQ-C is a valid measure to assess depression in Thai and British adolescents and maybe useful in cross-cultural comparisons of adolescent depression.
    Language English
    Publishing date 2023-07-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1118299-4
    ISSN 1435-165X ; 1018-8827 ; 1433-5719
    ISSN (online) 1435-165X
    ISSN 1018-8827 ; 1433-5719
    DOI 10.1007/s00787-023-02268-8
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    Zs.A 3524: Show issues Location:
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  6. Article ; Online: Nurturing Respirology.

    Bardin, Philip / Reynolds, Paul N

    Respirology (Carlton, Vic.)

    2018  Volume 24, Issue 2, Page(s) 92

    Language English
    Publishing date 2018-12-07
    Publishing country Australia
    Document type Editorial
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13466
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  7. Article ; Online: The Effect of Diesel Exhaust Particles on Adipose Tissue Mitochondrial Function and Inflammatory Status.

    Warren, Cali E / Campbell, Kennedy M / Kirkham, Madison N / Saito, Erin R / Remund, Nicole P / Cayabyab, Kevin B / Kim, Iris J / Heimuli, Micah S / Reynolds, Paul R / Arroyo, Juan A / Bikman, Benjamin T

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: Air pollution poses a significant global health risk, with fine particulate matter ( ... ...

    Abstract Air pollution poses a significant global health risk, with fine particulate matter (PM
    MeSH term(s) Animals ; Vehicle Emissions/toxicity ; Mitochondria/metabolism ; Mitochondria/drug effects ; Mice ; Particulate Matter/adverse effects ; Particulate Matter/toxicity ; Adipose Tissue/metabolism ; Adipose Tissue/drug effects ; Inflammation/metabolism ; Inflammation/chemically induced ; Inflammation/pathology ; Male ; Mice, Inbred C57BL ; Energy Metabolism/drug effects ; Adipokines/metabolism ; Air Pollutants/adverse effects ; Air Pollutants/toxicity ; Adipocytes/metabolism ; Adipocytes/drug effects
    Chemical Substances Vehicle Emissions ; Particulate Matter ; Adipokines ; Air Pollutants
    Language English
    Publishing date 2024-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084322
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  8. Article ; Online: A multicentre study assessing the role of routine colonoscopy after acute uncomplicated diverticulitis and the incidence of colorectal cancer diagnosis.

    Singh, Kaushiki / Liptrot, Sarah / Tou, Sam / Mehigan, Brian / McCormick, Paul / Ravi, Narayasamy / Reynolds, John / Al Chalabi, Hasan

    International journal of colorectal disease

    2023  Volume 38, Issue 1, Page(s) 84

    Abstract: ... with acute diverticulitis between the three centres. All patients had CT verified diverticulitis. A 90.8% (n ... diagnosis of colorectal carcinoma was made in 1.28% (n = 64).: Conclusion: Routine colonoscopy following ...

    Abstract Purpose: The low rates of colonic malignancy detected on interval colonoscopy for patients diagnosed with diverticulitis have led recent studies to question the utility of the practice. The aim of this study was to assess the detection rate of colorectal cancer on colonoscopy for patients with a first episode of acute uncomplicated diverticulitis across three separate centres in Ireland and the UK.
    Methods: A retrospective review was performed of patients with a first episode of acute, uncomplicated diverticulitis who underwent interval colonoscopy at three separate centres in the UK and Ireland between 2007 and 2019. The follow-up period was one year.
    Results: A total of 5485 patients were admitted with acute diverticulitis between the three centres. All patients had CT verified diverticulitis. A 90.8% (n = 4982) underwent subsequent colonic evaluation with colonoscopy. Of these, a histologically proven diagnosis of colorectal carcinoma was made in 1.28% (n = 64).
    Conclusion: Routine colonoscopy following an episode of acute, uncomplicated diverticulitis may not be necessary in every patient. It may be appropriate to reserve this more invasive investigation for those with higher risk factors for malignancy.
    MeSH term(s) Humans ; Diverticulitis, Colonic/diagnostic imaging ; Diverticulitis, Colonic/epidemiology ; Incidence ; Tomography, X-Ray Computed ; Diverticulitis/complications ; Colonoscopy ; Colonic Neoplasms/complications ; Retrospective Studies ; Acute Disease
    Language English
    Publishing date 2023-03-28
    Publishing country Germany
    Document type Multicenter Study ; Journal Article
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-023-04374-0
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    Zs.A 2121: Show issues Location:
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  9. Article: BLTR1 Is Decreased in Steroid Resistant Pro-Inflammatory CD28nullCD8+ T Lymphocytes in Patients with COPD-The Spillover Hypothesis Explained?

    Hodge, Greg / Jersmann, Hubertus / Holmes, Mark / Asare, Patrick / Roscioli, Eugene / Reynolds, Paul N / Hodge, Sandra

    Biology

    2023  Volume 12, Issue 9

    Abstract: Introduction: Pro-inflammatory CD8+ T cells are increased in the lungs and also in the peripheral circulation of both smokers and chronic obstructive pulmonary disease (COPD) patients. The reason for this is unclear but has been described as a spillover ...

    Abstract Introduction: Pro-inflammatory CD8+ T cells are increased in the lungs and also in the peripheral circulation of both smokers and chronic obstructive pulmonary disease (COPD) patients. The reason for this is unclear but has been described as a spillover from cells in the lungs that may cause the systemic inflammation noted in COPD. We have recently shown an increase in steroid-resistant CD28nullCD8+ senescent lymphocytes in the lungs and peripheral blood in COPD. Leukotreine B4 (LB4) receptor 1 (BLTR1) is involved in recruitment of CD8+ T cells to sites of inflammation, and we hypothesized that it may be involved in the migration of these senescent lymphocytes from the lungs in COPD.
    Methods: Via flow cytometry and Western blot BLTR1, IFNγ, and TNFα expression were measured in peripheral blood, BAL, and large proximal and small distal airway CD28±, CD8± T, and NKT-like cells from COPD patients and healthy control subjects (±prednisolone) following in vitro stimulation. Chemotaxis of leucocyte subsets was determined (±LB4 ± prednisolone).
    Results: There was an increase in BLTR1-CD28nullCD8+ lymphocytes in the lungs and blood in patients with COPD compared with controls. BLTR1-CD28nullCD8+ T and NKT-like cells produce more IFN/TNF than BLTR+ cells and fail to migrate to LTB4. Treatment with 1 µM prednisolone in vitro resulted in upregulation of BLTR1 expression in pro-inflammatory CD28nullCD8+ cells and migration to LB4.
    Conclusions: Loss of BLTR1 is associated with an increased inflammatory potential of CD28nullCD8+ T cells and may allow these pro-inflammatory steroid-resistant cells to migrate to peripheral blood. Treatment strategies that upregulate BLTR1 may reduce systemic inflammation and associated co-morbidity in patients with COPD.
    Language English
    Publishing date 2023-09-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12091261
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  10. Article ; Online: UV-C LED-induced cyclobutane pyrimidine dimer formation, lesion repair and mutagenesis in the biofilm-forming diatom,

    Whitworth, Paul / Aldred, Nick / Finlay, John A / Reynolds, Kevin J / Plummer, Joseph / Clare, Anthony S

    Biofouling

    2024  Volume 40, Issue 1, Page(s) 76–87

    Abstract: The use of ultraviolet-C (UV-C) irradiation in marine biofouling control is a relatively new and potentially disruptive technology. This study examined effects of UV-C exposure on the biofilm-forming diatom, ...

    Abstract The use of ultraviolet-C (UV-C) irradiation in marine biofouling control is a relatively new and potentially disruptive technology. This study examined effects of UV-C exposure on the biofilm-forming diatom,
    MeSH term(s) Pyrimidine Dimers ; Diatoms/genetics ; Biofilms ; DNA Repair ; Mutagenesis ; Ultraviolet Rays
    Chemical Substances Pyrimidine Dimers
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article
    ISSN 1029-2454
    ISSN (online) 1029-2454
    DOI 10.1080/08927014.2024.2319178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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