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Article ; Online: Tuning the C/N Ratio of C-Rich Graphitic Carbon Nitride (g-C

Gashi, Arianit / Parmentier, Julien / Fioux, Philippe / Marsalek, Roman

Chemistry (Weinheim an der Bergstrasse, Germany)

2022 Volume 28, Issue 14, Page(s) e202103605

Abstract: C-rich graphitic carbonitride materials (CN ...

Abstract	C-rich graphitic carbonitride materials (CN
Language	English
Publishing date	2022-02-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202103605
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Article ; Online: Telomeric i-motifs and C-strands inhibit parallel G-quadruplex extension by telomerase.

El-Khoury, Roberto / Roman, Morgane / Assi, Hala Abou / Moye, Aaron L / Bryan, Tracy M / Damha, Masad J

Nucleic acids research

2023 Volume 51, Issue 19, Page(s) 10395–10410

Abstract: ... extension of a G-quadruplex. Overall, this study highlights a potential inhibitory role for the telomeric C ... Telomeric C-rich repeated DNA sequences fold into tetrahelical i-motif structures in vitro ... about their potential role in human telomere biology. In this study, we explore the effect of telomeric C-strands and ...

Abstract	Telomeric C-rich repeated DNA sequences fold into tetrahelical i-motif structures in vitro at acidic pH. While studies have suggested that i-motifs may form in cells, little is known about their potential role in human telomere biology. In this study, we explore the effect of telomeric C-strands and i-motifs on the ability of human telomerase to extend G-rich substrates. To promote i-motif formation at neutral pH, we use telomeric sequences where the cytidines have been substituted with 2'-fluoroarabinocytidine. Using FRET-based studies, we show that the stabilized i-motifs resist hybridization to concomitant parallel G-quadruplexes, implying that both structures could exist simultaneously at telomeric termini. Moreover, through telomerase activity assays, we show that both unstructured telomeric C-strands and telomeric i-motifs can inhibit the activity and processivity of telomerase extension of parallel G-quadruplexes and linear telomeric DNA. The data suggest at least three modes of inhibition by C-strands and i-motifs: direct hybridization to the substrate DNA, hybridization to nascent product DNA resulting in early telomerase dissociation, and interference with the unique mechanism of telomerase unwinding and extension of a G-quadruplex. Overall, this study highlights a potential inhibitory role for the telomeric C-strand in telomere maintenance.
MeSH term(s)	Humans ; G-Quadruplexes ; Telomerase/metabolism ; DNA/chemistry ; Nucleic Acid Hybridization ; Telomere/metabolism
Chemical Substances	Telomerase (EC 2.7.7.49) ; DNA (9007-49-2)
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkad764
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Article ; Online: Effects of G-Quadruplex-Binding Plant Secondary Metabolites on c-MYC Expression

Roman G. Zenkov / Kirill I. Kirsanov / Anna M. Ogloblina / Olga A. Vlasova / Denis S. Naberezhnov / Natalia Y. Karpechenko / Timur I. Fetisov / Ekaterina A. Lesovaya / Gennady A. Belitsky / Nina G. Dolinnaya / Marianna G. Yakubovskaya

International Journal of Molecular Sciences, Vol 23, Iss 16, p

2022 Volume 9209

Abstract: Guanine-rich DNA sequences tending to adopt noncanonical G-quadruplex (G4) structures are over ... was evaluated using a fluorescent indicator displacement assay. c-MYC G4 folding topology and thermal ... circular dichroism. The effects of promising PSMs on c-MYC expression were assessed using luciferase reporter assay ...

Abstract	Guanine-rich DNA sequences tending to adopt noncanonical G-quadruplex (G4) structures are over-represented in promoter regions of oncogenes. Ligands recognizing G4 were shown to stabilize these DNA structures and drive their formation regulating expression of corresponding genes. We studied the interaction of several plant secondary metabolites (PSMs) with G4s and their effects on gene expression in a cellular context. The binding of PSMs with G4s formed by the sequences of well-studied oncogene promoters and telomeric repeats was evaluated using a fluorescent indicator displacement assay. c-MYC G4 folding topology and thermal stability, as well as the PMS influence on these parameters, were demonstrated by UV-spectroscopy and circular dichroism. The effects of promising PSMs on c-MYC expression were assessed using luciferase reporter assay and qPR-PCR in cancer and immortalized cultured cells. The ability of PMS to multi-targeting cell signaling pathways was analyzed by the pathway-focused gene expression profiling with qRT-PCR. The multi-target activity of a number of PSMs was demonstrated by their interaction with a set of G4s mimicking those formed in the human genome. We have shown a direct G4-mediated down regulation of c-MYC expression by sanguinarine, quercetin, kaempferol, and thymoquinone; these effects being modulated by PSM’s indirect influence via cell signaling pathways.
Keywords	G-quadruplex ; G4-binding ligands ; plant secondary metabolites ; luciferase reporter assay ; c-MYC promoter ; fluorescent indicator displacement ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	500
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Importance of Assessing Compliance with Conservative Treatment of Primary Hyperoxaluria Type 1: A Case Report of a Patient with I244T/c.969-3C>G Mutation.

Medina, Paloma Gutiérrez / Román, Laura Espinosa

The Permanente journal

2019 Volume 24

Abstract: Introduction: Primary hyperoxaluria type 1 (PH1) is an autosomal recessive inherited disorder that progresses to end-stage renal disease. Patients experience excessive urinary oxalate excretion, which causes nephrocalcinosis and recurrent urolithiasis. ... ...

Abstract	Introduction: Primary hyperoxaluria type 1 (PH1) is an autosomal recessive inherited disorder that progresses to end-stage renal disease. Patients experience excessive urinary oxalate excretion, which causes nephrocalcinosis and recurrent urolithiasis. When the glomerular filtration rate declines, calcium oxalate accumulates in extrarenal tissues, causing end-organ damage. More than 190 responsible mutations have been documented, with some genotype-phenotype differences reported. Regardless of the genetic basis, prompt diagnosis and treatment are decisive for the long-term outcome. If the condition advances to chronic kidney disease stage 4 or 5, a combined liver-kidney transplant should be considered. Case presentation: We describe a 5-month-old asymptomatic female patient with bilateral diffuse nephrocalcinosis and nephrolithiasis. Laboratory and genetic findings confirmed PH1. She was promptly administered conservative treatment consisting of high fluid intake, calcium oxalate crystallization inhibitors, and pyridoxine. Nephrocalcinosis and urolithiasis disappeared after 2 years of treatment. As far as we know, this is a unique case of a patient with an I244T/null mutation diagnosed after the neonatal period and with normal renal function, who remained asymptomatic during an 18-year follow-up. This case is also unique because of the long-term therapeutic success. Discussion: Physicians need a high level of suspicion to diagnose this rare disease. It has been previously demonstrated that early conservative treatment improves long-term outcomes, averting preemptive transplant during childhood. This case report emphasizes the importance of encouraging compliance with this approach, reinforces the need for good physician-patient communication, and raises awareness of the problems that might arise during conservative PH1 treatment.
MeSH term(s)	Adolescent ; Calcium Oxalate/antagonists & inhibitors ; Conservative Treatment/methods ; Female ; Fluid Therapy/methods ; Follow-Up Studies ; Guideline Adherence ; Humans ; Hyperoxaluria, Primary/diagnosis ; Hyperoxaluria, Primary/therapy ; Infant ; Mutation ; Pyridoxine/therapeutic use ; Treatment Outcome ; Vitamin B Complex/therapeutic use
Chemical Substances	Vitamin B Complex (12001-76-2) ; Calcium Oxalate (2612HC57YE) ; Pyridoxine (KV2JZ1BI6Z)
Language	English
Publishing date	2019-12-30
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2062823-7
ISSN	1552-5775 ; 1552-5775
ISSN (online)	1552-5775
ISSN	1552-5775
DOI	10.7812/TPP/19.136
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Article: Der Andere im Selbst? Zum Problem der Alterität bei C. G. Jung

Lesmeister, Roman

Analytische Psychologie

2012 Volume 43, Issue 1 = Heft 167, Page(s) 8

Language	German
Document type	Article
ZDB-ID	124667-7
ISSN	0301-3006
Database	Current Contents Medicine

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Article ; Online: The Relation between eNOS -786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, -384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease.

Kincl, Vladimír / Máchal, Jan / Drozdová, Adéla / Panovský, Roman / Vašků, Anna

Disease markers

2015 Volume 2015, Page(s) 232048

Abstract: Aim: The purpose of this study is to determine the association between eotaxin 426 C/T, -384 A/G ... 67 G/A, eNOS -786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD ... as significant predictors of all-cause death. Further analysis showed that eotaxin 67 G/A (GA + AA versus GG) and ...

Abstract	Aim: The purpose of this study is to determine the association between eotaxin 426 C/T, -384 A/G, 67 G/A, eNOS -786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD. Methods: From total of 1161 patients referred to coronary angiography, 532 patients with angiographically confirmed CAD were selected. Their long-term outcome was followed up using hospital database. Subsequent events were assessed in this study: death or combined endpoint-myocardial infarction, unstable angina pectoris, revascularization, heart failure hospitalization, and cardioverter-defibrillator implantation. Results: The multivariate Cox regression model identified age, smoking, and 3-vessel disease as significant predictors of all-cause death. Further analysis showed that eotaxin 67 G/A (GA + AA versus GG) and eotaxin -384 A/G (GG versus GA + AA) were significant independent prognostic factors when added into the model: HR (95% CI) 2.81 (1.35-5.85), p = 0.006; HR (95% CI) 2.63 (1.19-5.83), p = 0.017; eotaxin -384 A/G was significantly associated with the event-free survival, but it did not provide the prognostic information above the effect of two- or three-vessel disease. Conclusion: The A allele in eotaxin 67 G/A polymorphism is associated with worse survival in CAD patients.
MeSH term(s)	Aged ; Case-Control Studies ; Chemokine CCL11/genetics ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/genetics ; Female ; Humans ; Male ; Matrix Metalloproteinase 13/genetics ; Middle Aged ; Nitric Oxide Synthase Type III/genetics ; Polymorphism, Single Nucleotide
Chemical Substances	Chemokine CCL11 ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; MMP13 protein, human (EC 3.4.24.-) ; Matrix Metalloproteinase 13 (EC 3.4.24.-)
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604951-5
ISSN	1875-8630 ; 0278-0240
ISSN (online)	1875-8630
ISSN	0278-0240
DOI	10.1155/2015/232048
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Zs.A 1856: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: C. G. Jungs Hiob-Schrift: Eine Empörung im Grenzland von Religion und Tiefenpsychologie

Lesmeister, Roman

Analytische Psychologie

2014 Volume 45, Issue 2 = Heft 176, Page(s) 186

Language	German
Document type	Article
ZDB-ID	124667-7
ISSN	0301-3006
Database	Current Contents Medicine

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Article: Erinnerung an den 50. Todestag C. G. Jungs

Lesmeister, Roman

Analytische Psychologie

2011 Volume 42, Issue 3 = Heft 165, Page(s) 372

Language	German
Document type	Article
ZDB-ID	124667-7
ISSN	0301-3006
Database	Current Contents Medicine

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Article: Effect of Microenvironment on the Geometrical Structure of d(A)₅ d(T)₅ and d(G)₅ d(C)₅ DNA Mini-Helixes and the Dickerson Dodecamer: A Density Functional Theory Study

Gorb, Leonid / Pekh, Anatolii / Nyporko, Alexey / Ilchenko, Mykola / Golius, Anastasiia / Zubatiuk, Tetiana / Zubatyuk, Roman / Dubey, Igor / Hovorun, Dmytro M / Leszczynski, Jerzy

Journal of physical chemistry. 2020 Sept. 25, v. 124, no. 42

2020

Abstract: We report a comprehensive quantum-chemical study on d(A)₅·d(T)₅ and d(G)₅·d(C)₅ DNA mini-helixes ... of the spatial structure of d(A)₅·d(T)₅ and d(G)₅ d(C)₅ DNA mini-helixes all the way from vacuum to water bulk ...

Abstract	We report a comprehensive quantum-chemical study on d(A)₅·d(T)₅ and d(G)₅·d(C)₅ DNA mini-helixes and the Dickerson dodecamer d[CGCGAATTCGCG]. The research was performed to model the evolution of the spatial structure of d(A)₅·d(T)₅ and d(G)₅ d(C)₅ DNA mini-helixes all the way from vacuum to water bulk. The influence of external factors such as the presence of counterions and the extent of hydration was included. Also, for comparison, limited calculations have been carried out on the Dickerson dodecamer. The study has been performed at the density functional theory level using B97D3 and ωB97XD exchange–correlation functionals augmented by the Def2SVP basis set. We found that the (dA)₅·(dT)₅ anion when placed in vacuum forms a DNA duplex, which possesses an intermediate form between a helix and a ladder. The presence of compensating Na⁺ counterions or explicit microhydration of minor and major grooves stabilizes a DNA mini-helix of B-shape. Factors such as water bulk play a minor role. Somewhat different behavior has been found in the case of the (dG)₅·(dC)₅ duplex. In this case, we observe the formation of B-type mini-helixes even for the (dG)₅·(dC)₅ anion placed in vacuum. This is due to an additional stabilization originated from the appearance of an extra hydrogen bond, compared to an AT base pair. To assess whether the obtained results are transferable to different sizes of mini-helixes, similar calculations have been performed for the duplex formed by the Dickerson dodecamer which contains a total of 12 dG·dC and dA·dT base pairs. It has been found that in vacuum, analogous to the d(A)₅·d(T)₅ duplex, this system possesses a shape which is also quite close to a ladder. However, the presence of factors such as hydration restores the B-type geometry. Also, our results completely in line with the results of electrospray-ionization experiments suggest that uncompensated by counterions the DNA backbone preserves the duplex geometry in vacuum. We present arguments that this state is kinetically unstable.
Keywords	DNA ; density functional theory ; evolution ; geometry ; hydrogen bonding
Language	English
Dates of publication	2020-0925
Size	p. 9343-9353.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ISSN	1520-5207
DOI	10.1021/acs.jpcb.0c06154
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Ryanodine receptor mutations presenting as idiopathic ventricular fibrillation: a report on two novel familial compound mutations, c.6224T>C and c.13781A>G, with the clinical presentation of idiopathic ventricular fibrillation.

Paech, Christian / Gebauer, Roman Antonin / Karstedt, Jens / Marschall, Christoph / Bollmann, Andreas / Husser, Daniela

Pediatric cardiology

2014 Volume 35, Issue 8, Page(s) 1437–1441

Abstract: Idiopathic ventricular fibrillation (IVF) is a rare genetically determined disease causing unexpected cardiac death in otherwise healthy individuals. This study identified two novel, functional heterozygous mutations in the ryanodine receptor 2 (RyR2) ... ...

Abstract	Idiopathic ventricular fibrillation (IVF) is a rare genetically determined disease causing unexpected cardiac death in otherwise healthy individuals. This study identified two novel, functional heterozygous mutations in the ryanodine receptor 2 (RyR2) gene in a family with IVF. In the presented case all the patients received a thorough diagnostic workup to exclude structural heart disease. Blood was drawn from the patients, and genetic testing was performed including amplification and sequencing of splice locations in two exons of the RyR2 gene. The mutations were detected in five symptomatic family members. The genetic status of the five affected family members remains unclear. No clinically affected patient is without mutation. At this writing, one family member with confirmed mutation is asymptomatic. The differentiation between catecholaminergic polymorphic ventricular tachycardia (CPVT) and IVF remains a difficult issue, mainly based on clinical characteristics and gross genetic classification. In our case, the family history, exercise testing, and epinephrine stress testing do not suggest an association of arrhythmia and adrenergic triggers, which makes CPVT rather unlikely despite the fact that genetic testing showed RyR2 mutations. Currently, knowledge concerning the functional meaning of genetic mutations is growing. Future exploration of these functional aspects might give further impetus to allocation of these patients to a specific diagnosis.
MeSH term(s)	Adolescent ; Adult ; Child ; Child, Preschool ; Death, Sudden, Cardiac/etiology ; Electrocardiography ; Epinephrine ; Exercise Test/methods ; Family ; Female ; Genetic Predisposition to Disease ; Genetic Testing ; Humans ; Male ; Middle Aged ; Mutation ; Pedigree ; Ryanodine Receptor Calcium Release Channel/genetics ; Tachycardia, Ventricular/complications ; Tachycardia, Ventricular/diagnosis ; Tachycardia, Ventricular/diagnostic imaging ; Tachycardia, Ventricular/genetics ; Ultrasonography ; Ventricular Fibrillation/complications ; Ventricular Fibrillation/diagnosis ; Ventricular Fibrillation/diagnostic imaging ; Ventricular Fibrillation/genetics ; Young Adult
Chemical Substances	Ryanodine Receptor Calcium Release Channel ; Epinephrine (YKH834O4BH)
Language	English
Publishing date	2014-06-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-014-0950-2
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